Tao-sheng Huang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Report--21st century medical genetic and genomic medicine in China
    Tao sheng Huang
    Department of Pediatrics Genetics and Metabolism, Developmental and Cell Biology, University of California, Irvine, USA
    J Zhejiang Univ Sci B 6:1223-6. 2005
  2. pmc Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner
    Parvin Shahrestani
    Ecology and Evolution, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e6867. 2009
  3. pmc Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production
    Sha Tang
    Division of Human Genetics, Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4492. 2009
  4. doi request reprint Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions
    Chengkang Zhang
    Department of Pediatrics, University of California Irvine, Irvine, CA 92697, USA
    FASEB J 26:4914-24. 2012
  5. pmc A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails
    Shaohua Tang
    The prenatal diagnostic Center of Wenzhou City, Department of genetics of Wenzhou No2 Hospital, Wenzhou, China
    BMC Med Genet 8:82. 2007
  6. ncbi request reprint Four cases with hypoplastic thumbs and encephaloceles
    Taosheng Huang
    Division of Genetics and Metabolism, Children s Hospital, Boston, Massachusetts, USA
    Am J Med Genet 111:178-81. 2002
  7. pmc TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model
    Jing Liu
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, USA
    BMC Dev Biol 11:65. 2011
  8. ncbi request reprint Current advances in Holt-Oram syndrome
    Taosheng Huang
    Division of Human Genetics, Department of Pediatrics, Unversity of California, Irvine, California 92697, USA
    Curr Opin Pediatr 14:691-5. 2002
  9. ncbi request reprint TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs)
    Guifeng Sun
    Department of Pediatrics, Division of Human Genetics and Metabolism, University of California, Irvine, California 92697, USA
    J Cell Biochem 92:189-99. 2004
  10. doi request reprint TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases
    Will Yarosh
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, California 92697, USA
    Cancer Res 68:693-9. 2008

Research Grants

  1. Roles of TBX3 and its Isoform, TBX3+2a, in Breast Cancer
    Taosheng Huang; Fiscal Year: 2005
  2. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
  3. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2009
  4. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2010
  5. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2009
  6. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2009
  7. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2008
  8. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2007
  9. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. pmc Report--21st century medical genetic and genomic medicine in China
    Tao sheng Huang
    Department of Pediatrics Genetics and Metabolism, Developmental and Cell Biology, University of California, Irvine, USA
    J Zhejiang Univ Sci B 6:1223-6. 2005
  2. pmc Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner
    Parvin Shahrestani
    Ecology and Evolution, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e6867. 2009
    ..Our results suggest that heterozygous mutation of dOpa1 shows organ-specific pathogenesis and is associated with multiple organ abnormalities in an age-dependent and organ-specific manner...
  3. pmc Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production
    Sha Tang
    Division of Human Genetics, Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4492. 2009
    ..Our results, for the first time, demonstrate the important role of OPA1 in aging and lifespan, which is most likely mediated through augmented ROS production...
  4. doi request reprint Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions
    Chengkang Zhang
    Department of Pediatrics, University of California Irvine, Irvine, CA 92697, USA
    FASEB J 26:4914-24. 2012
    ..This gene-environment interaction may contribute to the complexity of pathogenesis and clinical phenotypes caused by mtDNA mutation...
  5. pmc A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails
    Shaohua Tang
    The prenatal diagnostic Center of Wenzhou City, Department of genetics of Wenzhou No2 Hospital, Wenzhou, China
    BMC Med Genet 8:82. 2007
    ..The purpose of this study is to investigate the genetic basis of Chinese family with CCD...
  6. ncbi request reprint Four cases with hypoplastic thumbs and encephaloceles
    Taosheng Huang
    Division of Genetics and Metabolism, Children s Hospital, Boston, Massachusetts, USA
    Am J Med Genet 111:178-81. 2002
    ..The literature and database were searched intensively. No similar cases were reported previously, suggesting that the constellations might represent a new genetic syndrome...
  7. pmc TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model
    Jing Liu
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, USA
    BMC Dev Biol 11:65. 2011
    ..Although many studies have shown that a dysregulation of TBX3 expression may contribute to cancer progression, no direct evidence shows TBX3 causes breast cancer...
  8. ncbi request reprint Current advances in Holt-Oram syndrome
    Taosheng Huang
    Division of Human Genetics, Department of Pediatrics, Unversity of California, Irvine, California 92697, USA
    Curr Opin Pediatr 14:691-5. 2002
    ..Efforts to understand the intracellular pathway of TBX5 would provide a unique window onto the molecular basis of common congenital heart diseases and limb malformations...
  9. ncbi request reprint TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs)
    Guifeng Sun
    Department of Pediatrics, Division of Human Genetics and Metabolism, University of California, Irvine, California 92697, USA
    J Cell Biochem 92:189-99. 2004
    ..We conclude that the GC box, T-box-like binding elements, and NKX2.5 binding site play important roles in the regulation of TBX5 expression, and that TBX5 is likely to be autoregulated as part of the mechanism of its transcription...
  10. doi request reprint TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases
    Will Yarosh
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, California 92697, USA
    Cancer Res 68:693-9. 2008
    ..TBX3 repression to its targets is dependent on HDAC activity. TBX3 may serve as a biomarker for breast cancer and have significant applications in both breast cancer diagnosis and treatment...
  11. ncbi request reprint Identification of the TBX5 transactivating domain and the nuclear localization signal
    Michael V Zaragoza
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, CA 92697, USA
    Gene 330:9-18. 2004
    ..These studies enhance our understanding of the structure-function relationship of TBX5 and suggest that truncation mutations of TBX5 could cause HOS through the loss of its transactivating domain and/or the nuclear localization signal...
  12. ncbi request reprint Left ventricular noncompaction is associated with mutations in the mitochondrial genome
    Sha Tang
    Division of Human Genetics Department of Pediatrics, University of California, Irvine, CA 92697, United States
    Mitochondrion 10:350-7. 2010
    ..Our study revealed some mtSNPs could represent pathogenic mutations, lead to compromised mitochondrial function, and be associated with LVNC...
  13. ncbi request reprint TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines
    Weiwei Fan
    Division of Genetics, Department of Pediatrics, Robert R Sprague Hall 314, University of California Irvine, Irvine, CA 92697, USA
    Cancer Res 64:5132-9. 2004
    ..A subset of human breast cancer cell lines overexpresses TBX3. Our results indicate that TBX3 and TBX3 + 2a are functionally distinctive in inhibition of senescence of MEF cells and may play a role in breast cancer...
  14. ncbi request reprint Cardiac phenotypes in chromosome 4q- syndrome with and without a deletion of the dHAND gene
    Taosheng Huang
    Division of Genetics, Department of Pediatrics, University California, Irvine, California 92697, USA
    Genet Med 4:464-7. 2002
    ..The purpose of this study is to examine the possible association between dHAND haploinsufficiency with the CVMs that occur in patients with 4q terminal deletions...

Research Grants10

  1. Roles of TBX3 and its Isoform, TBX3+2a, in Breast Cancer
    Taosheng Huang; Fiscal Year: 2005
    ..By working with both an animal model and tissue acquired from breast surgeries, the proposed research aims to optimize the clinical relevance of the work. ..
  2. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  3. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2009
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  4. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2010
    ..This study will allow us to understand how mutations of OPA1 cause optic atrophy and explore its novel function in lifespan and provide us a potential opportunity to develop treatments for the disease. ..
  5. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2009
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  6. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2009
    ..This study will allow us to understand how mutations of OPA1 cause optic atrophy and explore its novel function in lifespan and provide us a potential opportunity to develop treatments for the disease. ..
  7. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2008
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  8. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2007
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  9. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..