Research Topics
| Susan S HuangSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control studySusan S Huang
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, 100 Theory, Ste 110, Irvine, CA 92697, USA
Crit Care 15:R210. 2011....
Use of Medicare claims to rank hospitals by surgical site infection risk following coronary artery bypass graft surgerySusan S Huang
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 32:775-83. 2011..To evaluate whether longitudinal insurer claims data allow reliable identification of elevated hospital surgical site infection (SSI) rates...- Methicillin-resistant Staphylococcus aureus infection and hospitalization in high-risk patients in the year following detectionSusan S Huang
Division of Infectious Diseases and Health Policy Research Institute, School of Medicine, University of California Irvine, Irvine, California, United States of America
PLoS ONE 6:e24340. 2011..None have assessed the comprehensive burden of MRSA infection in the period after hospital discharge while accounting for healthcare utilization across institutions... - Continued impact of pneumococcal conjugate vaccine on carriage in young childrenSusan S Huang
Division of Infectious Diseases, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
Pediatrics 124:e1-11. 2009.... - Pneumococcal carriage and antibiotic resistance in young children before 13-valent conjugate vaccinePeter C Wroe
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Pediatr Infect Dis J 31:249-54. 2012.... - Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 eraGrace M Lee
Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
BMC Infect Dis 9:110. 2009..aureus and MRSA colonization in young children in the context of widespread use of PCV7; and (2) examine risk factors for S. aureus colonization in the post-PCV7 era, including the absence of vaccine-type S. pneumoniae colonization... 
Improving the assessment of vancomycin-resistant enterococci by routine screeningSusan S Huang
Brigham and Women s Hospital, Channing Laboratory and Department of Infection Control, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
J Infect Dis 195:339-46. 2007..Routine surveillance cultures can substantially improve prevalence and incidence estimates, and assessing the range of improvement across diverse units is important...- Inclusion of 30-day postdischarge detection triples the incidence of hospital-onset methicillin-resistant Staphylococcus aureusTaliser R Avery
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
Infect Control Hosp Epidemiol 33:114-21. 2012..Hospitalized patients are at increased risk for acquisition of methicillin-resistant Staphylococcus aureus (MRSA). As hospital length of stay shortens, hospital-acquired MRSA events may be more likely to be detected after discharge... - Risk of acquiring antibiotic-resistant bacteria from prior room occupantsSusan S Huang
Departments of Medicine and Infection Control, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:1945-51. 2006.... - Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USAGili Regev-Yochay
Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Vaccine 28:4842-6. 2010..These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage... - Emergence of 19A as virulent and multidrug resistant Pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccineStephen I Pelton
Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Boston, MA, USA
Pediatr Infect Dis J 26:468-72. 2007..Ongoing surveillance is necessary to identify emerging invasive serotypes and antimicrobial susceptibilities... - Aging population and future burden of pneumococcal pneumonia in the United StatesPeter C Wroe
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
J Infect Dis 205:1589-92. 2012..Absent intervention, the total cost of pneumococcal pneumonia will increase by $2.5 billion annually, and the demand for healthcare services for pneumococcal pneumonia, especially inpatient capacity, will double in coming decades... - Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriersRupak Datta
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
Clin Infect Dis 47:176-81. 2008.... - Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremiaSusan S Huang
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Infect Dis 43:971-8. 2006..To our knowledge, the relative impact of these interventions has not previously been ascertained... - Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004Susan S Huang
Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, USA
Pediatrics 116:e408-13. 2005..This shift toward increased carriage of nonvaccine serotypes warrants vigilance for changes in the epidemiology of invasive pneumococcal disease... - Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupantsRupak Datta
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, 100 Theory, Ste 110, Irvine, CA 92697, USA
Arch Intern Med 171:491-4. 2011..Subsequently, a cleaning intervention was shown to reduce MRSA and VRE room contamination. We now evaluate the effect of this intervention on the risk of acquiring MRSA and VRE from prior room occupants... - Predicting High Prevalence of Community Methicillin-Resistant Staphylococcus aureus Strains in Nursing HomesCourtney R Murphy
Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine, School of Medicine, Irvine, California
Infect Control Hosp Epidemiol 34:325-6. 2013..In multivariate models, carriage was associated with age less than 65 years (odds ratio, 1.2; [Formula: see text]) and Hispanic ethnicity (odds ratio, 1.2; [Formula: see text]). Interventions are needed to target CA-MRSA... - Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care unitsSusan S Huang
Brigham and Women s Hospital, Channing Laboratory and Infection Control Department, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
J Infect Dis 195:330-8. 2007..In addition, many assessments underestimate the incidence of acquisition by including prevalent carriers in the at-risk population... - Impact of an environmental cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci on surfaces in intensive care unit roomsEric R Goodman
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Infect Control Hosp Epidemiol 29:593-9. 2008.... - Serotype specific invasive capacity and persistent reduction in invasive pneumococcal diseaseInci Yildirim
Department of Pediatrics, Boston University, School of Medicine, Boston, MA, USA
Vaccine 29:283-8. 2010..g. 33F, 22F) as successful colonizers resulting in increased IPD incidence due to replacement serotypes... - Trends in antibiotic use in Massachusetts children, 2000-2009Sharon K Greene
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215 3920, USA
Pediatrics 130:15-22. 2012..Antibiotic use rates have declined dramatically since the 1990s. We aimed to determine if, when, and at what level the decline in antibiotic-dispensing rates ended and which diagnoses contributed to the trends... - Use of Medicare diagnosis and procedure codes to improve detection of surgical site infections following hip arthroplasty, knee arthroplasty, and vascular surgeryMichael S Calderwood
Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
Infect Control Hosp Epidemiol 33:40-9. 2012..To evaluate the use of routinely collected electronic health data in Medicare claims to identify surgical site infections (SSIs) following hip arthroplasty, knee arthroplasty, and vascular surgery... - Community-level predictors of pneumococcal carriage and resistance in young childrenSusan S Huang
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
Am J Epidemiol 159:645-54. 2004..5, 95% confidence interval: 1.0, 11.7). The two- to threefold odds of pneumococcal carriage conferred by certain community characteristics suggest that these measures may target communities for interventions to decrease transmission... - Methicillin-resistant Staphylococcus aureus burden in nursing homes associated with environmental contamination of common areasCourtney R Murphy
School of Social Ecology and Division of Infectious Diseases, University of California at Irvine, Irvine, California 92617, USA
J Am Geriatr Soc 60:1012-8. 2012..To determine whether environmental cleaning and contamination are associated with variation in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) between nursing homes... - Gastrointestinal disease outbreak detection using multiple data streams from electronic medical recordsSharon K Greene
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215 3920, USA
Foodborne Pathog Dis 9:431-41. 2012..This study's primary objective was to identify data streams from EMRs that may perform well for GI outbreak detection... - Patient sharing and population genetic structure of methicillin-resistant Staphylococcus aureusWeixiong Ke
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 109:6763-8. 2012..These findings suggest that concerted efforts among hospitals that share large numbers of patients may be synergistic to prevent MRSA transmission... - Risk of postdischarge infection with vancomycin-resistant enterococcus after initial infection or colonizationRupak Datta
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, CA 92697, USA
Infect Control Hosp Epidemiol 31:1290-3. 2010..Fifteen patients (8%) developed 27 VRE infections in the 18 months after detection. Among 10 postdischarge infections, 2 involved bacteremia and 3 resulted in readmission... - Frequent hospital readmissions for Clostridium difficile infection and the impact on estimates of hospital-associated C. difficile burdenCourtney R Murphy
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, California, USA
Infect Control Hosp Epidemiol 33:20-8. 2012..Clostridium difficile infection (CDI) is associated with hospitalization and may cause readmission following admission for any reason. We aimed to measure the incidence of readmissions due to CDI... - Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infectionSusan S Huang
Division of Infectious Diseases, University of California Irvine School of Medicine, Orange, CA 92868, USA
Clin Infect Dis 46:1241-7. 2008..We found that MRSA infection following initial colonization or infection is caused by the same strain in most cases, suggesting that a single successful attempt at decolonization may prevent the majority of later infection... - Parental knowledge about antibiotic use: results of a cluster-randomized, multicommunity interventionSusan S Huang
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Pediatrics 119:698-706. 2007..The goal was to determine the impact of a community-wide educational intervention on parental misconceptions likely contributing to pediatric antibiotic overprescribing... - Automated detection of infectious disease outbreaks in hospitals: a retrospective cohort studySusan S Huang
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, California, United States of America
PLoS Med 7:e1000238. 2010..Ideally, outbreak detection programs should evaluate many pathogens, using a wide array of data sources... - What is nosocomial? Large variation in hospital choice of numerators and denominators affects rates of hospital-onset methicillin-resistant Staphylococcus aureusRupak Datta
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, California 92697, USA
Infect Control Hosp Epidemiol 33:1166-9. 2012..Survey-reported denominators differed from state-reported patient-days. Numerator and denominator choices substantially impacted HO-MRSA rates... - Use of Medicare claims to identify US hospitals with a high rate of surgical site infection after hip arthroplastyMichael S Calderwood
Departmentof Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02115, USA
Infect Control Hosp Epidemiol 34:31-9. 2013..To assess the ability of Medicare claims to identify US hospitals with high rates of surgical site infection (SSI) after hip arthroplasty... - Nursing home characteristics associated with methicillin-resistant Staphylococcus aureus (MRSA) Burden and TransmissionCourtney R Murphy
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, CA, USA
BMC Infect Dis 12:269. 2012..We sought to measure MRSA burden in a large number of nursing homes and identify facility characteristics associated with high MRSA burden... - Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in miceDavid Skurnik
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 120:3220-33. 2010..aureus infections in humans could be due, in part, to interference in OPK when antibodies to CP and PNAG antigens are both present. This information could be used to better design S. aureus vaccine components... - Cluster randomized trials in comparative effectiveness research: randomizing hospitals to test methods for prevention of healthcare-associated infectionsRichard Platt
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Med Care 48:S52-7. 2010..The need for evidence about the effectiveness of therapeutics and other medical practices has triggered new interest in methods for comparative effectiveness research... - Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonizationSusan S Huang
Channing Laboratory, Brigham and Women s Hospital, Division of Infectious Diseases, Boston, MA 02115, USA
Clin Infect Dis 36:281-5. 2003..Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge... - Successful strategies for high participation in three regional healthcare surveys: an observational studyKristen R Elkins
Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine School of Medicine, Orange, California, USA
BMC Med Res Methodol 11:176. 2011..However, the success of such surveys depends upon high participation and representativeness of respondents... - Modeling community- and individual-level effects of child-care center attendance on pneumococcal carriageSusan S Huang
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
Clin Infect Dis 40:1215-22. 2005..This variation is not fully explained by risk factors at the individual level but may be explained by factors producing effects at both the individual and community levels, such as child-care center (CCC) attendance... - Quantifying interhospital patient sharing as a mechanism for infectious disease spreadSusan S Huang
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine, Irvine, California, USA
Infect Control Hosp Epidemiol 31:1160-9. 2010..Assessments of infectious disease spread in hospitals seldom account for interfacility patient sharing. This is particularly important for pathogens with prolonged incubation periods or carrier states... - Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sampleJonathan A Finkelstein
Department of Ambulatory Care and Prevention, Harvard Medical School HPHC, Boston, Massachusetts 02215, USA
Pediatrics 112:862-9. 2003..Data on carriage of resistant organisms by healthy children in communities in which immunization with PCV7 has been implemented will help to define and decrease these risks further... - Health care-associated infection: assessing the value and validity of our measuresSusan S Huang
Division of Infectious Diseases and Department of Epidemiology and Infection Prevention, University of California Irvine School of Medicine, Irvine, California, USA
Clin Infect Dis 48:1116-22. 2009.... - Healthcare utilization and cost of pneumococcal disease in the United StatesSusan S Huang
Division of Infectious Diseases and Health Policy Research Institute, University California Irvine School of Medicine, 100 Theory Ave, Suite 110, Irvine, CA 92697, USA
Vaccine 29:3398-412. 2011..Streptococcus pneumoniae continues to cause a variety of common clinical syndromes, despite vaccination programs for both adults and children. The total U.S. burden of pneumococcal disease is unknown...
Research Grants
- Improving Assessment of MRSA & VRE Transmission in ICUsSUSAN HUANG; Fiscal Year: 2007....
- Project CLEAR - Changing Lives by Eradicating Antibiotic ResistanceSusan S Huang; Fiscal Year: 2010..Findings could potentially impact best practice for the 1.8 million MRSA carriers who are discharged from U.S. hospitals each year. ..