Sharon Huang

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines
    Ioannis Papageorgiou
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 41:281-90. 2013
  2. pmc A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women
    Alice Ban Ke
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Drug Metab Dispos 41:801-13. 2013
  3. pmc Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry
    Anand K Deo
    Department of Pharmaceutics, University of Washington, P O Box 357610, Seattle, WA 98195, USA
    Drug Metab Dispos 40:852-5. 2012
  4. pmc Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion
    Brian J Kirby
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA
    Drug Metab Dispos 40:610-6. 2012
  5. pmc Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir
    Brian J Kirby
    Department of Pharmaceutics, University of Washington, Seattle, WA, USA
    Drug Metab Dispos 39:2329-37. 2011
  6. pmc Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Nucl Med Biol 35:911-7. 2008
  7. pmc Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 51:783-6. 2007
  8. ncbi request reprint Placental drug transporters
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Seattle WA 98195, USA
    Curr Drug Metab 5:125-31. 2004
  9. pmc Selection of HIV resistance associated with antiretroviral therapy initiated due to pregnancy and suspended postpartum
    Giovanina M Ellis
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    J Acquir Immune Defic Syndr 58:241-7. 2011
  10. ncbi request reprint Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022
    Jane Hitti
    University of Washington, Seattle, 98195, USA
    J Acquir Immune Defic Syndr 36:772-6. 2004

Research Grants

Collaborators

  • D Heather Watts
  • Mary E Paul
  • Sharon Nachman
  • Paul Krogstad
  • Nina Isoherranen
  • Amin Rostami-Hodjegan
  • Brian J Kirby
  • Ruth E Tuomala
  • Yurong Lai
  • Jashvant Unadkat
  • Jashvant D Unadkat
  • Lisa M Frenkel
  • Jane Hitti
  • Ioannis Papageorgiou
  • Alice Ban Ke
  • Ingrid A Beck
  • Anand K Deo
  • Giovanina M Ellis
  • Susan Grepper
  • Srikanth C Nallani
  • Ping Zhao
  • Bhagwat Prasad
  • Thor Wagner
  • Minyoung Jang
  • Lin Ye Song
  • Marta Bull
  • Jennifer McKernan-Mullin
  • Larissa Balogh
  • Susan H Eshleman
  • Andrew Wiznia
  • Dale Whittington
  • Sara Eyal
  • Francisco Chung
  • Jeanne Link
  • Mark Muzi
  • Lucy Sasongko
  • David Mankoff
  • Ann C Collier
  • Paul Deutsch
  • Lynne M Mofenson
  • Anita A Mathias
  • Kathleen A Kaiser
  • James Connor
  • Diane T Holland
  • Diane W Wara
  • Elizabeth Smith
  • Bach Yen Nguyen
  • Michael D Hughes
  • James McNamara
  • Shashi Vijay
  • Arthur Provisor
  • Laura M Stevens
  • David Baker
  • Marc Foca
  • Jorge Gandia
  • Edwin M Thorpe
  • Alice M Stek
  • Lee Jen Wei
  • Adolfo Gonzalez-Garcia
  • Amber Dahlin

Detail Information

Publications13

  1. doi request reprint Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines
    Ioannis Papageorgiou
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 41:281-90. 2013
    ....
  2. pmc A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women
    Alice Ban Ke
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Drug Metab Dispos 41:801-13. 2013
    ..Based on these data, it is prudent to conclude that the magnitude of hepatic CYP2D6 induction during T3 ranges from 100 to 200%. Our PBPK model can predict the disposition of CYP1A2, 2D6, and 3A drugs during pregnancy...
  3. pmc Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry
    Anand K Deo
    Department of Pharmaceutics, University of Washington, P O Box 357610, Seattle, WA 98195, USA
    Drug Metab Dispos 40:852-5. 2012
    ..In contrast, the single nucleotide polymorphism 21214G>A (V417I; rs2273697) was associated with significantly higher hepatic MRP2 expression...
  4. pmc Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion
    Brian J Kirby
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA
    Drug Metab Dispos 40:610-6. 2012
    ..In summary, RTV or NFV do not induce P-glycoprotein activity measured with DIG, and RIF does so only under staggered administration...
  5. pmc Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir
    Brian J Kirby
    Department of Pharmaceutics, University of Washington, Seattle, WA, USA
    Drug Metab Dispos 39:2329-37. 2011
    ....
  6. pmc Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Nucl Med Biol 35:911-7. 2008
    ..Therefore, we developed a rapid solid-phase extraction (SPE) method to separate, and then quantify, verapamil and its radiolabeled metabolites in plasma...
  7. pmc Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 51:783-6. 2007
    ..Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy...
  8. ncbi request reprint Placental drug transporters
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Seattle WA 98195, USA
    Curr Drug Metab 5:125-31. 2004
    ..In addition, we will review placental transporters that are important in modulating the exposure of the fetus to drugs and, therefore, the efficacy and toxicity of such drugs towards the fetus...
  9. pmc Selection of HIV resistance associated with antiretroviral therapy initiated due to pregnancy and suspended postpartum
    Giovanina M Ellis
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    J Acquir Immune Defic Syndr 58:241-7. 2011
    ..Compare the risk of HIV drug resistance in women stopping suppressive nelfinavir (NFV)-based or Nevirapine (NVP)-based antiretroviral therapy (ART) after pregnancy...
  10. ncbi request reprint Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022
    Jane Hitti
    University of Washington, Seattle, 98195, USA
    J Acquir Immune Defic Syndr 36:772-6. 2004
    ..To compare the safety of nelfinavir and nevirapine-based antiretroviral treatment in HIV-1-infected pregnant women...
  11. pmc Monitoring of HIV type 1 DNA load and drug resistance in peripheral blood mononuclear cells during suppressive antiretroviral therapy does not predict virologic failure
    Ingrid A Beck
    Seattle Children s Hospital Research Institute, Seattle, Washington 98101, USA
    AIDS Res Hum Retroviruses 28:780-8. 2012
    ..HIV-1 DNA concentrations did not predict virologic failure in this cohort. New drug resistance mutations were detected in the PBMCs of a minority of virologically suppressed children who subsequently failed ART...
  12. pmc Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir
    Brian J Kirby
    Department of Pharmaceutics, University of Washington, Seattle, WA, USA
    Drug Metab Dispos 39:1070-8. 2011
    ..The magnitude of these DDIs was more accurately predicted using PI CYP3A inactivation parameters generated in sandwich-cultured human hepatocytes rather than human liver microsomes...

Research Grants13

  1. Nucleoside Transporters: disposition of nucleoside drugs
    Jashvant Unadkat; Fiscal Year: 2007
    ..abstract_text> ..
  2. Mechanisms By Which Maternal And Fetal Drug Exposure Is*
    Jashvant Unadkat; Fiscal Year: 2006
    ..Once tested, we will be able to predict the magnitude of change in dose that should be instituted for a wide range of drugs whose disposition is significantly modulated by these transporters. ..
  3. Enhance Effectiveness of Anti-HIV Drugs in the CNS
    Jashvant Unadkat; Fiscal Year: 2003
    ..To test our hypothesis, using PET, that inhibition of P-gp in creases the exposure of CNS to l"1CJ-verapamil and, by inference, protease inhibitors. ..
  4. UPTAKE OF NUCLEOSIDES & NUCLEOSIDE DRUGS IN INTESTINE
    Jashvant Unadkat; Fiscal Year: 2003
    ..abstract_text> ..