Pengxiang Huang

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics
    Pengxiang Huang
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, Charlottesville, VA 22908, USA
    Annu Rev Physiol 72:247-72. 2010
  2. pmc Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain
    Daesung Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    Nat Struct Mol Biol 17:1027-9. 2010
  3. pmc Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    Vikas Chandra
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nature 456:350-6. 2008
  4. pmc Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    Srilatha Raghuram
    Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Nat Struct Mol Biol 14:1207-13. 2007

Collaborators

Detail Information

Publications4

  1. pmc Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics
    Pengxiang Huang
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, Charlottesville, VA 22908, USA
    Annu Rev Physiol 72:247-72. 2010
    ....
  2. pmc Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain
    Daesung Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    Nat Struct Mol Biol 17:1027-9. 2010
    ..H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications...
  3. pmc Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    Vikas Chandra
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nature 456:350-6. 2008
    ..The PPAR-gamma LBD cooperates with both DNA-binding domains (DBDs) to enhance response-element binding. The A/B segments are highly dynamic, lacking folded substructures despite their gene-activation properties...
  4. pmc Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    Srilatha Raghuram
    Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Nat Struct Mol Biol 14:1207-13. 2007
    ..Our results further indicate that heme regulation of REV-ERBs may link the control of metabolism and the mammalian clock...