Laurence Huang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Evaluation of in-house PCR for diagnosis of smear-negative pulmonary tuberculosis in Kampala, Uganda
    Lydia Nakiyingi
    Infectious Diseases Institute, Makerere University College of Health Sciences, Mulago Hospital Complex, Kampala, Uganda
    BMC Res Notes 5:487. 2012
  2. ncbi request reprint Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumonia
    Laurence Huang
    HIV AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
    J Eukaryot Microbiol 53:S114-6. 2006
  3. ncbi request reprint Pneumocystis colonization in HIV-infected patients
    Laurence Huang
    Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    J Eukaryot Microbiol 50:616-7. 2003
  4. ncbi request reprint Application of an mRNA-based molecular viability assay to oropharyngeal washes for the diagnosis of Pneumocystis pneumonia in HIV-infected patients. A pilot study
    Laurence Huang
    Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    J Eukaryot Microbiol 50:618-20. 2003
  5. pmc Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance
    Laurence Huang
    University of California San Francisco, USA
    Emerg Infect Dis 10:1721-8. 2004
  6. pmc HIV-associated opportunistic pneumonias
    Laurence Huang
    Division of Pulmonary, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    Respirology 14:474-85. 2009
  7. ncbi request reprint Intensive care of patients with HIV infection
    Laurence Huang
    HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, USA
    N Engl J Med 355:173-81. 2006
  8. ncbi request reprint Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene
    L Huang
    Positive Health Program, Ward 84, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 182:1192-8. 2000
  9. pmc HIV-associated Pneumocystis pneumonia
    Laurence Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Proc Am Thorac Soc 8:294-300. 2011
  10. pmc Clinical and translational research in pneumocystis and pneumocystis pneumonia
    L Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California San Francisco 94110, USA
    Parasite 18:3-11. 2011

Detail Information

Publications86

  1. pmc Evaluation of in-house PCR for diagnosis of smear-negative pulmonary tuberculosis in Kampala, Uganda
    Lydia Nakiyingi
    Infectious Diseases Institute, Makerere University College of Health Sciences, Mulago Hospital Complex, Kampala, Uganda
    BMC Res Notes 5:487. 2012
    ..Two smear-negative sputum samples were obtained from each PTB suspect and processed simultaneously for identification of MTBC using in-house PCR and LJ culture...
  2. ncbi request reprint Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumonia
    Laurence Huang
    HIV AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
    J Eukaryot Microbiol 53:S114-6. 2006
  3. ncbi request reprint Pneumocystis colonization in HIV-infected patients
    Laurence Huang
    Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    J Eukaryot Microbiol 50:616-7. 2003
  4. ncbi request reprint Application of an mRNA-based molecular viability assay to oropharyngeal washes for the diagnosis of Pneumocystis pneumonia in HIV-infected patients. A pilot study
    Laurence Huang
    Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    J Eukaryot Microbiol 50:618-20. 2003
  5. pmc Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance
    Laurence Huang
    University of California San Francisco, USA
    Emerg Infect Dis 10:1721-8. 2004
    ..We review studies of DHPS mutations in P. jirovecii and summarize the evidence for resistance to sulfamethoxazole and dapsone...
  6. pmc HIV-associated opportunistic pneumonias
    Laurence Huang
    Division of Pulmonary, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    Respirology 14:474-85. 2009
    ....
  7. ncbi request reprint Intensive care of patients with HIV infection
    Laurence Huang
    HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, USA
    N Engl J Med 355:173-81. 2006
  8. ncbi request reprint Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene
    L Huang
    Positive Health Program, Ward 84, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 182:1192-8. 2000
    ....
  9. pmc HIV-associated Pneumocystis pneumonia
    Laurence Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Proc Am Thorac Soc 8:294-300. 2011
    ....
  10. pmc Clinical and translational research in pneumocystis and pneumocystis pneumonia
    L Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California San Francisco 94110, USA
    Parasite 18:3-11. 2011
    ....
  11. ncbi request reprint Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations
    Kristina Crothers
    Positive Health Program and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 19:801-5. 2005
    ..The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity and mortality of Pneumocystis pneumonia (PCP) in HIV-positive patients is unclear...
  12. pmc Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study
    J Lucian Davis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e16321. 2011
    ..Few studies have evaluated the clinical impact of these tests in low-income countries with high burdens of TB and HIV...
  13. ncbi request reprint Association of chronic cough and pulmonary function with 6-minute walk test performance in HIV infection
    Monica Campo
    Department of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA The Baltimore Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, Baltimore, MD University of Maryland School of Medicine, Baltimore, MD Division of Pulmonary and Critical Care Medicine and HIV AIDS Division, Department of Medicine, University of California, San Francisco, CA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA Department of Medicine, Infectious Diseases Section, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA Division of Infectious Diseases, Atlanta Veterans Affairs Medical Center Department of Medicine, Emory University School of Medicine, Atlanta, GA Pulmonary and Critical Care Section, West Los Angeles Healthcare Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA James J Peters Veterans Affairs Medical Center Department of Medicine and Infectious Diseases, Icahn School of Medicine at Mount Sinai, Bronx, NY Infectious Diseases Section, Michael E DeBakey VAMC, Houston, Texas Department of Medicine, Baylor College of Medicine, Houston, Texas and Department of Internal Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, CT Yale School of Medicine, New Haven, CT
    J Acquir Immune Defic Syndr 65:557-63. 2014
    ..Chronic lung disease has been associated with greater impairment in self-reported physical function in HIV-infected patients. We sought to study this association using objective measures of physical function and pulmonary function...
  14. pmc HIV infection is associated with reduced pulmonary diffusing capacity
    Kristina Crothers
    Department of Medicine, University of Washington, Seattle, WA Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Medicine, University of California, Los Angeles, Los Angeles, CA Department of Medicine, Atlanta Veterans Affairs Medical Center VAMC and Emory University, Atlanta, GA Department of Medicine, West Los Angeles VAMC and David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA Department of Medicine, James J Peters Bronx VAMC, Bronx, NY Department of Medicine, Michael E DeBakey Houston VAMC and Baylor College of Medicine, Houston, TX Department of Medicine, University of California, San Francisco, San Francisco, CA Department of Medicine, Clinical Trials and Survey Corporation, Owings Mills, MD Department of Medicine, Ohio State University Medical Center, Columbus, OH Department of Medicine, Johns Hopkins University, Baltimore, MD Department of Medicine, New York University School of Medicine, New York, NY Departments of Infectious Diseases and Microbiology and Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA and Departments of Medicine and Immunology, University of Pittsburgh, Pittsburgh, PA
    J Acquir Immune Defic Syndr 64:271-8. 2013
    ..Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited...
  15. ncbi request reprint Pneumocystis dihydropteroate synthase mutations in patients with Pneumocystis pneumonia who are newly diagnosed with HIV infection
    Kristina Crothers
    Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    J Eukaryot Microbiol 50:609-10. 2003
  16. pmc Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, USA
    BMC Infect Dis 10:75. 2010
    ..Our objective was to examine the accuracy of a commercial IGRA for diagnosis of active tuberculosis in HIV-infected persons...
  17. pmc Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    BMC Infect Dis 9:53. 2009
    ..Sputum concentration increases the sensitivity of smear microscopy for the diagnosis of tuberculosis (TB), but few studies have investigated this method in human immunodeficiency virus (HIV)-infected individuals...
  18. pmc Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda
    Christina Yoon
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 7:e48599. 2012
    ..The clinical impact of Xpert MTB/RIF for tuberculosis (TB) diagnosis in high HIV-prevalence settings is unknown...
  19. ncbi request reprint Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort
    Christina Yoon
    San Francisco General Hospital, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California 94110, USA
    Med Mycol 51:568-75. 2013
    ..mixed infections) - perhaps even individual DHPS mutant genotypes - so that data can be pooled to better address this issue...
  20. pmc HIV infection is associated with diffusing capacity impairment in women
    Meghan E Fitzpatrick
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA Departments of Medicine Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA and Department of Immunology, University of Pittsburgh, Pittsburgh, PA
    J Acquir Immune Defic Syndr 64:284-8. 2013
    ..Providers should be aware that DL(CO) impairment is common in HIV infection, and that either DL(CO) impairment or airflow obstruction may cause respiratory symptoms in this population...
  21. pmc Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms
    Robert J Blount
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 7:e51545. 2012
    ..Little is known about the serologic responses to Pneumocystis jirovecii major surface glycoprotein (Msg) antigen in African cohorts, or the IgM responses to Msg in HIV-positive and HIV-negative persons with respiratory symptoms...
  22. pmc Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patients
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e39838. 2012
    ..However, assessment of local immune responses has been reported to improve the accuracy of TB diagnosis...
  23. pmc Interferon-γ release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis
    John Z Metcalfe
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, CA, USA
    J Infect Dis 204:S1120-9. 2011
    ..The diagnostic value of interferon-γ release assays (IGRAs) for active tuberculosis in low- and middle-income countries is unclear...
  24. pmc Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis
    J Lucian Davis
    Department of Medicine, San Francisco General Hospital and University of California, San Francisco, California 94110, USA
    Clin Infect Dis 48:725-32. 2009
    ..Few studies have assessed their performance among patients infected with HIV, and no studies have assessed their performance with oral wash specimens, which may be easier to obtain than sputum samples...
  25. ncbi request reprint Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV
    Christina Yoon
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Curry International Tuberculosis Center, and HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda Department of Epidemiology and Biostatistics, University of California, San Francisco, CA Department of Internal Medicine, University of California, San Francisco, CA Center for Global Health, Massachusetts General Hospital, Harvard Medical School, Boston, MA Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Boston, MA and Department of Medicine, Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 65:551-6. 2014
    ..We evaluated whether testing for C-reactive protein (CRP) improves patient selection for IPT...
  26. ncbi request reprint The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients
    Shoko Iwai
    Division of Gastroenterology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e95726. 2014
    ..Ugandan pneumonia-associated airway microbiome is compositionally and functionally distinct from those detected in comparable patients in developed countries, a feature which may contribute to adverse outcomes in this population. ..
  27. pmc Mobile digital fluorescence microscopy for diagnosis of tuberculosis
    Asa Tapley
    School of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Clin Microbiol 51:1774-8. 2013
    ..Future studies should evaluate the device when operated by health workers in low-resource settings, the feasibility of image transmission and analysis by experienced microscopists, and the accuracy of automated image analysis algorithms...
  28. pmc Comparison of the respiratory microbiome in healthy nonsmokers and smokers
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:1067-75. 2013
    ..Results from 16S rDNA-encoding gene sequence-based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome...
  29. ncbi request reprint Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumonia
    Alison Morris
    Department of Medicine, San Francisco General Hospital, San Francisco, California, USA
    AIDS 17:73-80. 2003
    ..Highly active antiretroviral therapy (HAART) might alter the course of PCP either via effects on the immune system or through anti- actions; however, HAART has not been studied in patients acutely ill with PCP...
  30. pmc Survival for patients With HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy
    Krista Powell
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Chest 135:11-7. 2009
    ..The combination antiretroviral therapy (ART) era (1996 to the present) has been associated with improved survival among HIV-infected outpatients, but ICU data from 2000 to the present are limited...
  31. ncbi request reprint Current issues in critical care of the human immunodeficiency virus-infected patient
    Alison Morris
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Crit Care Med 34:42-9. 2006
    ....
  32. pmc Integrated strategies to optimize sputum smear microscopy: a prospective observational study
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    Am J Respir Crit Care Med 183:547-51. 2011
    ..The standard approach to smear microscopy involves sputum collection over multiple days and examination of sputum smears by light microscopy (LM), an insensitive and time-consuming technique...
  33. pmc Clinical and radiographic factors do not accurately diagnose smear-negative tuberculosis in HIV-infected inpatients in Uganda: a cross-sectional study
    J Lucian Davis
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e9859. 2010
    ..Therefore, we sought to assess the accuracy of symptoms, physical signs, and radiographic findings for diagnosing tuberculosis in this population in a low-income country with a high incidence of tuberculosis...
  34. ncbi request reprint A 36-year-old man with AIDS and relapsing, nonproductive cough
    J Lucian Davis
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
    Chest 131:1929-31. 2007
    ..We discuss the implications for current diagnosis and management of HIV-associated pulmonary diseases...
  35. pmc Ambient air pollution associated with suppressed serologic responses to Pneumocystis jirovecii in a prospective cohort of HIV-infected patients with Pneumocystis pneumonia
    Robert J Blount
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e80795. 2013
    ..Ambient air pollution (AAP) may be associated with increased risk for Pneumocystis pneumonia (PCP). The mechanisms underlying this association remain uncertain...
  36. pmc Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV infection: an observational cohort study
    Matthew W Fei
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    Scand J Infect Dis 41:672-8. 2009
    ..14, 95% CI 1.59-6.18, p=0.001). This study demonstrates a continued need for HIV education and earlier HIV testing, particularly in patients with high-risk sexual behavior...
  37. pmc HIV and chronic obstructive pulmonary disease: is it worse and why?
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Proc Am Thorac Soc 8:320-5. 2011
    ....
  38. ncbi request reprint Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence
    David G Morris
    Interstitial Lung Disease Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94142 0854, USA
    Chest 124:929-35. 2003
    ..The chronic granulomatous inflammation of sarcoidosis has been hypothesized to depend on the CD4+ T-helper lymphocyte. HIV infection, which depletes these cells, has been reported to attenuate the manifestations of sarcoidosis...
  39. pmc HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era
    Kristina Crothers
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
    Am J Respir Crit Care Med 183:388-95. 2011
    ..In aging HIV-infected populations comorbid diseases are important determinants of morbidity and mortality. Pulmonary diseases have not been systematically assessed in the combination antiretroviral therapy (ART) era...
  40. ncbi request reprint Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts
    Matthew R Gingo
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Pulm Med 14:75. 2014
    ..The objective of the study is to determine the impact of HIV on prevalence and incidence of respiratory disease in the current era of effective antiretroviral treatment...
  41. doi request reprint Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections
    Sofya Tokman
    Department of Internal Medicine, University of California, San Francisco, CA, USA Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Respirology 19:382-8. 2014
    ..We sought to determine if elevated serum procalcitonin is associated with increased in-hospital mortality and to combine serum procalcitonin with available clinical characteristics to create a clinically useful prognostic model...
  42. doi request reprint Respiratory emergencies in HIV-infected persons
    Charles K Everett
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, 505 Parnassus Avenue, Box 0111, Room M1336, San Francisco, CA 94143, USA
    Emerg Med Clin North Am 28:283-98, Table of Contents. 2010
    ..This article focuses on respiratory emergencies among HIV-infected patients and discusses their typical presentation and diagnostic evaluation as well as therapeutic interventions that should be initiated in an ED...
  43. pmc Healthcare worker occupation and immune response to Pneumocystis jirovecii
    Renuka Tipirneni
    HIV AIDS Division, San Francisco General Hospital University of California, San Francisco, California, USA
    Emerg Infect Dis 15:1590-7. 2009
    ..Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person...
  44. pmc A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills
    Mitchell D Feldman
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Clin Transl Sci 5:362-7. 2012
    ..We also describe a number of new initiatives to support mentoring at UCSF that have evolved from the MDP. To our knowledge, this is the first evaluation of the long-term impact of a mentor training program for CT researchers...
  45. pmc Respiratory infection complicating HIV infection
    J Lucian Davis
    Division of Pulmonary and Critical Care Medicine, USA
    Curr Opin Infect Dis 21:184-90. 2008
    ..Respiratory infections remain a major cause of morbidity among HIV-infected persons. Thus, knowledge of recent advances regarding HIV-associated opportunistic pneumonias is crucial for optimal care of HIV-infected persons...
  46. pmc Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 56:230-8. 2011
    ..To determine whether interferon-gamma release assays (IGRAs) improve the identification of HIV-infected individuals who could benefit from latent tuberculosis infection therapy...
  47. pmc Oral and airway microbiota in HIV-infected pneumonia patients
    Shoko Iwai
    University of California San Francisco, San Francisco, California, USA
    J Clin Microbiol 50:2995-3002. 2012
    ....
  48. pmc Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART era
    M Patricia George
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    PLoS ONE 4:e6328. 2009
    ..We evaluated respiratory symptoms and measured airway obstruction to identify the impact of HAART and other risk factors on respiratory symptoms and pulmonary function...
  49. pmc Poor performance of universal sample processing method for diagnosis of pulmonary tuberculosis by smear microscopy and culture in Uganda
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
    J Clin Microbiol 46:3325-9. 2008
    ....
  50. ncbi request reprint Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapy
    Alison Morris
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Am J Respir Crit Care Med 166:262-7. 2002
    ..These patients may have an improved survival because of effects of therapy on variables such as likelihood of non-AIDS-associated admission diagnoses and serum albumin levels...
  51. doi request reprint Epidemiology and clinical significance of pneumocystis colonization
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Infect Dis 197:10-7. 2008
    ..We also evaluate the clinical significance of Pneumocystis colonization and its relationship to lung disease...
  52. pmc Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension
    Priscilla Y Hsue
    Divisions of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
    AIDS 22:825-33. 2008
    ....
  53. pmc A hydrophilic-interaction chromatography tandem mass spectrometry method for quantitation of serum s-adenosylmethionine in patients infected with human immunodeficiency virus
    Ping Wang
    Department of Lab Medicine, University of California, San Francisco, CA, United States
    Clin Chim Acta 396:86-8. 2008
    ..In this study, we report a robust hydrophilic-interaction liquid chromatography tandem mass spectrometry (LC-MS/MS) assay that can be used to quantitate serum SAM in clinical laboratories...
  54. ncbi request reprint Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study Group
    A M Morris
    San Francisco General Hospital, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, USA
    Am J Respir Crit Care Med 162:612-6. 2000
    ..The clinical implications of these changes are unknown, but they may contribute to prolonged respiratory complaints in HIV-infected patients who have had pneumonia...
  55. ncbi request reprint Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Pulmonary Complications of HIV Infection Study Group
    L Huang
    San Francisco General Hospital and University of California, 94110, USA
    Chest 115:1025-32. 1999
    ....
  56. pmc Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapy
    A M Morris
    Department of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Thorax 55:625-7. 2000
    ....
  57. ncbi request reprint Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia
    J L Davis
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    Thorax 63:329-34. 2008
    ..Understanding risk factors for and outcomes of colonisation may provide insights into the life cycle and transmission dynamics of Pneumocystis jirovecii...
  58. pmc Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis?
    A Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    J Clin Microbiol 48:2433-9. 2010
    ..Further research should focus on alternative approaches to optimizing smear microscopy, such as light-emitting diode fluorescence microscopy and same-day sputum collection strategies...
  59. pmc Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting
    A Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
    Int J Tuberc Lung Dis 13:1130-6. 2009
    ..Mulago Hospital, Kampala, Uganda...
  60. ncbi request reprint Clinical and radiographic predictors of the etiology of pulmonary nodules in HIV-infected patients
    R M Jasmer
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital Medical Center, and the Department of Medicine, University of California, San Francisco 94110, USA
    Chest 117:1023-30. 2000
    ..To determine the etiology and the clinical and radiographic predictors of the etiology of pulmonary nodules in a group of HIV-infected patients...
  61. pmc Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury
    J L Davis
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Thorax 63:988-93. 2008
    ..A secondary aim was to compare mortality before and after introduction of a low tidal volume ventilation protocol in 2000...
  62. ncbi request reprint Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes
    K J Edinburgh
    Dept of Radiology, Univ of California, San Francisco, USA
    Radiology 214:427-32. 2000
    ..To determine whether the computed tomographic (CT) appearances of multiple pulmonary nodules in patients with acquired immunodeficiency syndrome (AIDS) can help differentiate the potential infectious and neoplastic causes...
  63. ncbi request reprint When is seeing believing? The use of color Doppler ultrasound to diagnose placenta accreta in the first trimester of pregnancy
    S J Fisher
    Department of Stomatology, University of Clifornia, San Francisco, 94143 0512, USA
    Ultrasound Obstet Gynecol 19:540-2. 2002
  64. pmc The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts
    Matthew R Gingo
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e58812. 2013
    ..To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART)...
  65. pmc Evaluation of respiratory disease
    Sofya Tokman
    HIV AIDS Division, Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, UCSF, San Francisco, CA 94110, USA
    Clin Chest Med 34:191-204. 2013
    ..This article presents an overview of the evaluation of respiratory disease in persons with HIV/AIDS...
  66. ncbi request reprint Clinical and radiographic predictors of the etiology of computed tomography-diagnosed intrathoracic lymphadenopathy in HIV-infected patients
    Robert M Jasmer
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital Medical Center and University of California, San Francisco, California 94110, USA
    J Acquir Immune Defic Syndr 31:291-8. 2002
    ..Opportunistic infections and lymphoma are the most common causes, and specific clinical and radiographic features can suggest these particular diagnoses...
  67. ncbi request reprint Update on the epidemiology and transmission of Pneumocystis carinii
    Alison Morris
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Microbes Infect 4:95-103. 2002
    ..This review summarizes the current state of knowledge about the epidemiology and transmission of P. carinii and reports on evolving techniques that may improve our understanding of this organism in the future...
  68. ncbi request reprint Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization
    Alison Morris
    M S, Division of Pulmonary and Critical Care Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 170:408-13. 2004
    ..001) and was independent of smoking history. We conclude that there is a strong association between Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pathogenic link with COPD progression...
  69. ncbi request reprint Recurrence of Pneumocystis carinii pneumonia in an HIV-infected patient: apparent selective immune reconstitution after initiation of antiretroviral therapy
    K Crothers
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    HIV Med 4:346-9. 2003
    ....
  70. pmc Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study
    M W Fei
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
    Thorax 64:1070-6. 2009
    ..Although the use of antiretroviral therapy has led to dramatic declines in AIDS-associated mortality, Pneumocystis pneumonia (PCP) remains a leading cause of death in HIV-infected patients...
  71. pmc Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir
    Xin Lin
    Department of Medicine, San Francisco General Hospital, Center For AIDS Research and Department of Pathology, University of California, San Francisco, USA
    J Virol 77:8227-36. 2003
    ..In their cells, T-cell activation or exogenous Tat could induce viral replication equivalently. Thus, P-TEFb could activate the majority of the latent HIV, in this case by Tat...
  72. pmc Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic services
    Jlucian Davis
    Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, California
    Am J Respir Crit Care Med 184:362-7. 2011
    ..Real-time monitoring and evaluation of adherence to widely endorsed standards of tuberculosis care might facilitate improved case finding...
  73. pmc Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program
    Mitchell D Feldman
    Department of Medicine, University of California, San Francisco, USA
    Clin Transl Sci 2:216-21. 2009
    ..MITs reported increased confidence in overall and specific mentoring skills after completion of the MDP. The MDP can serve as a model for other institutions to develop the next generation of clinical-translational research mentors...
  74. ncbi request reprint Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approaches
    L Huang
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
    J Biol Chem 276:28327-39. 2001
    ..This method resulted in sharply better statistical significance values for correct hits in the data base output relative to that achieved for independent searches using single sequence fragments...
  75. pmc Ethical consideration of incidental findings on adult brain MRI in research
    J Illes
    Stanford Center for Biomedical Ethics, Department of Medicine, Stanford University, Palo Alto, CA, USA
    Neurology 62:888-90. 2004
    ..To characterize the frequency and severity of incidental findings in brain MRIs of young and older adult research volunteers, and to provide an evaluation of the ethical challenges posed by the detection of such findings...
  76. ncbi request reprint An Official ATS Workshop Summary: Recent advances and future directions in pneumocystis pneumonia (PCP)
    Laurence Huang
    Proc Am Thorac Soc 3:655-64. 2006
    ..The workshop included 21 presentations on diverse topics, which are summarized in this report. The workshop participants identified priorities for future research, which are summarized in this document...
  77. ncbi request reprint A need for standardized definitions for clinical studies of Pneumocystis
    Robert F Miller
    Centre for Sexual Health and HIV Research, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, United Kingdom
    J Eukaryot Microbiol 53:S87-8. 2006
  78. ncbi request reprint Performance of a molecular viability assay for the diagnosis of Pneumocystis pneumonia in HIV-infected patients
    Ana de Oliveira
    Division of Geographic Medicine, BBRB Box 7, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Diagn Microbiol Infect Dis 57:169-76. 2007
    ..When used in conjunction with an optimized clinical sampling protocol, this assay may become a useful tool for detecting and monitoring P. jirovecii in minimally invasive clinical samples...
  79. pmc Antibody response to Pneumocystis jirovecii major surface glycoprotein
    Kieran R Daly
    Research Service 151, Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USA
    Emerg Infect Dis 12:1231-7. 2006
    ..001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies...
  80. pmc Genetic diversity of Pneumocystis carinii f. sp. hominis based on variations in nucleotide sequences of internal transcribed spacers of rRNA genes
    Laila F Nimri
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 40:1146-51. 2002
    ....
  81. ncbi request reprint Genetic differences in Pneumocystis isolates recovered from immunocompetent infants and from adults with AIDS: Epidemiological Implications
    Charles B Beard
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Fort Collins, CO 80521, USA
    J Infect Dis 192:1815-8. 2005
    ..0001). The observation of different strains circulating in immunocompetent infants and HIV-infected adults suggests independent transmission cycles that warrant further study...
  82. pmc Current epidemiology of Pneumocystis pneumonia
    Alison Morris
    University of Southern California, Los Angeles, California, USA
    Emerg Infect Dis 10:1713-20. 2004
    ....
  83. ncbi request reprint Intensive care of patients with HIV infection: HAART warming improvement but beware of future HAART (and heart) attacks
    Alison Morris
    Chest 125:1602-4. 2004
  84. ncbi request reprint Analysis of variation in tandem repeats in the intron of the major surface glycoprotein expression site of the human form of Pneumocystis carinii
    Liang Ma
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 186:1647-54. 2002
    ..Quantifying the number of repeats by denaturing gel electrophoresis is a simple and rapid-typing method that can be used alone or in combination with other methods to study the epidemiology of P. carinii...
  85. ncbi request reprint A prospective, blinded study of quantitative touch-down polymerase chain reaction using oral-wash samples for diagnosis of Pneumocystis pneumonia in HIV-infected patients
    Hans Henrik Larsen
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1679-83. 2004
    ..QTD PCR of oral-wash samples can be an accurate and noninvasive method for diagnosis of PCP...
  86. ncbi request reprint A rose is a rose: but what about Pneumocystis pneumonia?
    Laurence Huang
    Int J Tuberc Lung Dis 9:1297-8. 2005

Research Grants8

  1. Molecular Epidemiology of Human P. carinii Pneumonia
    Laurence Huang; Fiscal Year: 2006
    This is a resubmission of a K23 grant application that is designed to enable Dr. Laurence Huang to acquire additional clinical research training and to develop a research program that will allow him to become an independent and successful ..
  2. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2007
    ..The development of rapid, non-invasive tests that can diagnosis PCP and TB effectively would be significant advances. ..
  3. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2007
    ..The development of rapid, non-invasive methods to diagnose PCP would be a significant advance, while the demonstration of drug resistance would have serious implications, given the limited PCP treatment medications currently available. ..
  4. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2009
    ....
  5. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2009
    ..The development of rapid, non-invasive methods to diagnose PCP would be a significant advance, while the demonstration of drug resistance would have serious implications, given the limited PCP treatment medications currently available. ..
  6. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2010
    ....