Research Topics
| Laurence HuangSummaryAffiliation: University of California Country: USA Publications
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Publications
Pneumocystis colonization in HIV-infected patientsLaurence Huang
Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
J Eukaryot Microbiol 50:616-7. 2003
Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistanceLaurence Huang
University of California San Francisco, USA
Emerg Infect Dis 10:1721-8. 2004..We review studies of DHPS mutations in P. jirovecii and summarize the evidence for resistance to sulfamethoxazole and dapsone...- Intensive care of patients with HIV infectionLaurence Huang
HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, USA
N Engl J Med 355:173-81. 2006 - Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumoniaLaurence Huang
HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
J Eukaryot Microbiol 53:S114-6. 2006 - Application of an mRNA-based molecular viability assay to oropharyngeal washes for the diagnosis of Pneumocystis pneumonia in HIV-infected patients. A pilot studyLaurence Huang
Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
J Eukaryot Microbiol 50:618-20. 2003 - HIV-associated opportunistic pneumoniasLaurence Huang
Division of Pulmonary, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
Respirology 14:474-85. 2009.... - Clinical and translational research in pneumocystis and pneumocystis pneumoniaL Huang
Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California San Francisco 94110, USA
Parasite 18:3-11. 2011.... - Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase geneL Huang
Positive Health Program, Ward 84, San Francisco General Hospital, San Francisco, CA 94110, USA
J Infect Dis 182:1192-8. 2000.... - HIV-associated Pneumocystis pneumoniaLaurence Huang
Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Proc Am Thorac Soc 8:294-300. 2011.... - Pneumocystis dihydropteroate synthase mutations in patients with Pneumocystis pneumonia who are newly diagnosed with HIV infectionKristina Crothers
Division of Pulmonary and Critical Care Medicine and Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
J Eukaryot Microbiol 50:609-10. 2003 - Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutationsKristina Crothers
Positive Health Program and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
AIDS 19:801-5. 2005..The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity and mortality of Pneumocystis pneumonia (PCP) in HIV-positive patients is unclear... - Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort studyJ Lucian Davis
Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e16321. 2011..Few studies have evaluated the clinical impact of these tests in low-income countries with high burdens of TB and HIV... - Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosisAdithya Cattamanchi
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
BMC Infect Dis 9:53. 2009..Sputum concentration increases the sensitivity of smear microscopy for the diagnosis of tuberculosis (TB), but few studies have investigated this method in human immunodeficiency virus (HIV)-infected individuals... - Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infectionAdithya Cattamanchi
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, USA
BMC Infect Dis 10:75. 2010..Our objective was to examine the accuracy of a commercial IGRA for diagnosis of active tuberculosis in HIV-infected persons... - Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patientsAdithya Cattamanchi
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 7:e39838. 2012..However, assessment of local immune responses has been reported to improve the accuracy of TB diagnosis... - Interferon-γ release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysisJohn Z Metcalfe
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, CA, USA
J Infect Dis 204:S1120-9. 2011..The diagnostic value of interferon-γ release assays (IGRAs) for active tuberculosis in low- and middle-income countries is unclear... - Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosisJ Lucian Davis
Department of Medicine, San Francisco General Hospital and University of California, San Francisco, California 94110, USA
Clin Infect Dis 48:725-32. 2009..Few studies have assessed their performance among patients infected with HIV, and no studies have assessed their performance with oral wash specimens, which may be easier to obtain than sputum samples... - Survival for patients With HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapyKrista Powell
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Chest 135:11-7. 2009..The combination antiretroviral therapy (ART) era (1996 to the present) has been associated with improved survival among HIV-infected outpatients, but ICU data from 2000 to the present are limited... - Current issues in critical care of the human immunodeficiency virus-infected patientAlison Morris
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Crit Care Med 34:42-9. 2006.... - Integrated strategies to optimize sputum smear microscopy: a prospective observational studyAdithya Cattamanchi
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Respir Crit Care Med 183:547-51. 2011..The standard approach to smear microscopy involves sputum collection over multiple days and examination of sputum smears by light microscopy (LM), an insensitive and time-consuming technique... - Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumoniaAlison Morris
Department of Medicine, San Francisco General Hospital, San Francisco, California, USA
AIDS 17:73-80. 2003..Highly active antiretroviral therapy (HAART) might alter the course of PCP either via effects on the immune system or through anti- actions; however, HAART has not been studied in patients acutely ill with PCP... - A 36-year-old man with AIDS and relapsing, nonproductive coughJ Lucian Davis
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
Chest 131:1929-31. 2007..We discuss the implications for current diagnosis and management of HIV-associated pulmonary diseases... - Clinical and radiographic factors do not accurately diagnose smear-negative tuberculosis in HIV-infected inpatients in Uganda: a cross-sectional studyJ Lucian Davis
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e9859. 2010..Therefore, we sought to assess the accuracy of symptoms, physical signs, and radiographic findings for diagnosing tuberculosis in this population in a low-income country with a high incidence of tuberculosis... - Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in UgandaChristina Yoon
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
PLoS ONE 7:e48599. 2012..The clinical impact of Xpert MTB/RIF for tuberculosis (TB) diagnosis in high HIV-prevalence settings is unknown... - HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy eraKristina Crothers
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
Am J Respir Crit Care Med 183:388-95. 2011..In aging HIV-infected populations comorbid diseases are important determinants of morbidity and mortality. Pulmonary diseases have not been systematically assessed in the combination antiretroviral therapy (ART) era... - HIV and chronic obstructive pulmonary disease: is it worse and why?Alison Morris
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Proc Am Thorac Soc 8:320-5. 2011.... - Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependenceDavid G Morris
Interstitial Lung Disease Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94142 0854, USA
Chest 124:929-35. 2003..The chronic granulomatous inflammation of sarcoidosis has been hypothesized to depend on the CD4+ T-helper lymphocyte. HIV infection, which depletes these cells, has been reported to attenuate the manifestations of sarcoidosis... - Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV infection: an observational cohort studyMatthew W Fei
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
Scand J Infect Dis 41:672-8. 2009..14, 95% CI 1.59-6.18, p=0.001). This study demonstrates a continued need for HIV education and earlier HIV testing, particularly in patients with high-risk sexual behavior... - Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptomsRobert J Blount
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA
PLoS ONE 7:e51545. 2012..Little is known about the serologic responses to Pneumocystis jirovecii major surface glycoprotein (Msg) antigen in African cohorts, or the IgM responses to Msg in HIV-positive and HIV-negative persons with respiratory symptoms... 
Respiratory emergencies in HIV-infected personsCharles K Everett
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, 505 Parnassus Avenue, Box 0111, Room M1336, San Francisco, CA 94143, USA
Emerg Med Clin North Am 28:283-98, Table of Contents. 2010..This article focuses on respiratory emergencies among HIV-infected patients and discusses their typical presentation and diagnostic evaluation as well as therapeutic interventions that should be initiated in an ED...- Healthcare worker occupation and immune response to Pneumocystis jiroveciiRenuka Tipirneni
HIV AIDS Division, San Francisco General Hospital University of California, San Francisco, California, USA
Emerg Infect Dis 15:1590-7. 2009..Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person... - A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skillsMitchell D Feldman
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Clin Transl Sci 5:362-7. 2012..We also describe a number of new initiatives to support mentoring at UCSF that have evolved from the MDP. To our knowledge, this is the first evaluation of the long-term impact of a mentor training program for CT researchers... - Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysisAdithya Cattamanchi
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 56:230-8. 2011..To determine whether interferon-gamma release assays (IGRAs) improve the identification of HIV-infected individuals who could benefit from latent tuberculosis infection therapy... - Respiratory infection complicating HIV infectionJ Lucian Davis
Division of Pulmonary and Critical Care Medicine, USA
Curr Opin Infect Dis 21:184-90. 2008..Respiratory infections remain a major cause of morbidity among HIV-infected persons. Thus, knowledge of recent advances regarding HIV-associated opportunistic pneumonias is crucial for optimal care of HIV-infected persons... - Oral and airway microbiota in HIV-infected pneumonia patientsShoko Iwai
University of California San Francisco, San Francisco, California, USA
J Clin Microbiol 50:2995-3002. 2012.... - Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertensionPriscilla Y Hsue
Divisions of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
AIDS 22:825-33. 2008.... - Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapyAlison Morris
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
Am J Respir Crit Care Med 166:262-7. 2002..These patients may have an improved survival because of effects of therapy on variables such as likelihood of non-AIDS-associated admission diagnoses and serum albumin levels... - Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART eraM Patricia George
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
PLoS ONE 4:e6328. 2009..We evaluated respiratory symptoms and measured airway obstruction to identify the impact of HAART and other risk factors on respiratory symptoms and pulmonary function... - Poor performance of universal sample processing method for diagnosis of pulmonary tuberculosis by smear microscopy and culture in UgandaAdithya Cattamanchi
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
J Clin Microbiol 46:3325-9. 2008.... - A hydrophilic-interaction chromatography tandem mass spectrometry method for quantitation of serum s-adenosylmethionine in patients infected with human immunodeficiency virusPing Wang
Department of Lab Medicine, University of California, San Francisco, CA, United States
Clin Chim Acta 396:86-8. 2008..In this study, we report a robust hydrophilic-interaction liquid chromatography tandem mass spectrometry (LC-MS/MS) assay that can be used to quantitate serum SAM in clinical laboratories... - Epidemiology and clinical significance of pneumocystis colonizationAlison Morris
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Infect Dis 197:10-7. 2008..We also evaluate the clinical significance of Pneumocystis colonization and its relationship to lung disease... - When is seeing believing? The use of color Doppler ultrasound to diagnose placenta accreta in the first trimester of pregnancyS J Fisher
Department of Stomatology, University of Clifornia, San Francisco, 94143 0512, USA
Ultrasound Obstet Gynecol 19:540-2. 2002 - Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis?A Cattamanchi
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
J Clin Microbiol 48:2433-9. 2010..Further research should focus on alternative approaches to optimizing smear microscopy, such as light-emitting diode fluorescence microscopy and same-day sputum collection strategies... - Clinical and radiographic predictors of the etiology of pulmonary nodules in HIV-infected patientsR M Jasmer
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital Medical Center, and the Department of Medicine, University of California, San Francisco 94110, USA
Chest 117:1023-30. 2000..To determine the etiology and the clinical and radiographic predictors of the etiology of pulmonary nodules in a group of HIV-infected patients... - Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study GroupA M Morris
San Francisco General Hospital, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, USA
Am J Respir Crit Care Med 162:612-6. 2000..The clinical implications of these changes are unknown, but they may contribute to prolonged respiratory complaints in HIV-infected patients who have had pneumonia... - Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Pulmonary Complications of HIV Infection Study GroupL Huang
San Francisco General Hospital and University of California, 94110, USA
Chest 115:1025-32. 1999.... - Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapyA M Morris
Department of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Thorax 55:625-7. 2000.... - Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence settingA Cattamanchi
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
Int J Tuberc Lung Dis 13:1130-6. 2009..Mulago Hospital, Kampala, Uganda... - Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causesK J Edinburgh
Dept of Radiology, Univ of California, San Francisco, USA
Radiology 214:427-32. 2000..To determine whether the computed tomographic (CT) appearances of multiple pulmonary nodules in patients with acquired immunodeficiency syndrome (AIDS) can help differentiate the potential infectious and neoplastic causes... - Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumoniaJ L Davis
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
Thorax 63:329-34. 2008..Understanding risk factors for and outcomes of colonisation may provide insights into the life cycle and transmission dynamics of Pneumocystis jirovecii... - Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injuryJ L Davis
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Thorax 63:988-93. 2008..A secondary aim was to compare mortality before and after introduction of a low tidal volume ventilation protocol in 2000... - Update on the epidemiology and transmission of Pneumocystis cariniiAlison Morris
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
Microbes Infect 4:95-103. 2002..This review summarizes the current state of knowledge about the epidemiology and transmission of P. carinii and reports on evolving techniques that may improve our understanding of this organism in the future... - Association of chronic obstructive pulmonary disease severity and Pneumocystis colonizationAlison Morris
M S, Division of Pulmonary and Critical Care Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 170:408-13. 2004..001) and was independent of smoking history. We conclude that there is a strong association between Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pathogenic link with COPD progression... - Clinical and radiographic predictors of the etiology of computed tomography-diagnosed intrathoracic lymphadenopathy in HIV-infected patientsRobert M Jasmer
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital Medical Center and University of California, San Francisco, California 94110, USA
J Acquir Immune Defic Syndr 31:291-8. 2002..Opportunistic infections and lymphoma are the most common causes, and specific clinical and radiographic features can suggest these particular diagnoses... - Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort studyM W Fei
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
Thorax 64:1070-6. 2009..Although the use of antiretroviral therapy has led to dramatic declines in AIDS-associated mortality, Pneumocystis pneumonia (PCP) remains a leading cause of death in HIV-infected patients... - Recurrence of Pneumocystis carinii pneumonia in an HIV-infected patient: apparent selective immune reconstitution after initiation of antiretroviral therapyK Crothers
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
HIV Med 4:346-9. 2003.... - Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic servicesJlucian Davis
Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, California
Am J Respir Crit Care Med 184:362-7. 2011..Real-time monitoring and evaluation of adherence to widely endorsed standards of tuberculosis care might facilitate improved case finding... - Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoirXin Lin
Department of Medicine, San Francisco General Hospital, Center For AIDS Research and Department of Pathology, University of California, San Francisco, USA
J Virol 77:8227-36. 2003..In their cells, T-cell activation or exogenous Tat could induce viral replication equivalently. Thus, P-TEFb could activate the majority of the latent HIV, in this case by Tat... - Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development ProgramMitchell D Feldman
Department of Medicine, University of California, San Francisco, USA
Clin Transl Sci 2:216-21. 2009..MITs reported increased confidence in overall and specific mentoring skills after completion of the MDP. The MDP can serve as a model for other institutions to develop the next generation of clinical-translational research mentors... - Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approachesL Huang
Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
J Biol Chem 276:28327-39. 2001..This method resulted in sharply better statistical significance values for correct hits in the data base output relative to that achieved for independent searches using single sequence fragments... - Ethical consideration of incidental findings on adult brain MRI in researchJ Illes
Stanford Center for Biomedical Ethics, Department of Medicine, Stanford University, Palo Alto, CA, USA
Neurology 62:888-90. 2004..To characterize the frequency and severity of incidental findings in brain MRIs of young and older adult research volunteers, and to provide an evaluation of the ethical challenges posed by the detection of such findings... - Intensive care of patients with HIV infection: HAART warming improvement but beware of future HAART (and heart) attacksAlison Morris
Chest 125:1602-4. 2004 - A need for standardized definitions for clinical studies of PneumocystisRobert F Miller
Centre for Sexual Health and HIV Research, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, United Kingdom
J Eukaryot Microbiol 53:S87-8. 2006 - Antibody response to Pneumocystis jirovecii major surface glycoproteinKieran R Daly
Research Service 151, Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USA
Emerg Infect Dis 12:1231-7. 2006..001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies... - Performance of a molecular viability assay for the diagnosis of Pneumocystis pneumonia in HIV-infected patientsAna de Oliveira
Division of Geographic Medicine, BBRB Box 7, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Diagn Microbiol Infect Dis 57:169-76. 2007..When used in conjunction with an optimized clinical sampling protocol, this assay may become a useful tool for detecting and monitoring P. jirovecii in minimally invasive clinical samples... - An Official ATS Workshop Summary: Recent advances and future directions in pneumocystis pneumonia (PCP)Laurence Huang
Proc Am Thorac Soc 3:655-64. 2006..The workshop included 21 presentations on diverse topics, which are summarized in this report. The workshop participants identified priorities for future research, which are summarized in this document... - Current epidemiology of Pneumocystis pneumoniaAlison Morris
University of Southern California, Los Angeles, California, USA
Emerg Infect Dis 10:1713-20. 2004.... - A prospective, blinded study of quantitative touch-down polymerase chain reaction using oral-wash samples for diagnosis of Pneumocystis pneumonia in HIV-infected patientsHans Henrik Larsen
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 189:1679-83. 2004..QTD PCR of oral-wash samples can be an accurate and noninvasive method for diagnosis of PCP... - Genetic diversity of Pneumocystis carinii f. sp. hominis based on variations in nucleotide sequences of internal transcribed spacers of rRNA genesLaila F Nimri
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Clin Microbiol 40:1146-51. 2002.... - Genetic differences in Pneumocystis isolates recovered from immunocompetent infants and from adults with AIDS: Epidemiological ImplicationsCharles B Beard
Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Fort Collins, CO 80521, USA
J Infect Dis 192:1815-8. 2005..0001). The observation of different strains circulating in immunocompetent infants and HIV-infected adults suggests independent transmission cycles that warrant further study... - Analysis of variation in tandem repeats in the intron of the major surface glycoprotein expression site of the human form of Pneumocystis cariniiLiang Ma
Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 186:1647-54. 2002..Quantifying the number of repeats by denaturing gel electrophoresis is a simple and rapid-typing method that can be used alone or in combination with other methods to study the epidemiology of P. carinii... - A rose is a rose: but what about Pneumocystis pneumonia?Laurence Huang
Int J Tuberc Lung Dis 9:1297-8. 2005
Research Grants
- Molecular Epidemiology of Human P. carinii PneumoniaLaurence Huang; Fiscal Year: 2006This is a resubmission of a K23 grant application that is designed to enable Dr. Laurence Huang to acquire additional clinical research training and to develop a research program that will allow him to become an independent and successful ..
- Patient-Oriented Research and Mentoring in PneumocystisLaurence Huang; Fiscal Year: 2007..The development of rapid, non-invasive tests that can diagnosis PCP and TB effectively would be significant advances. ..
- International HIV-associated Opportunistic Pneumonias (IHOP) StudyLaurence Huang; Fiscal Year: 2009....
- International HIV-associated Opportunistic Pneumonias (IHOP) StudyLaurence Huang; Fiscal Year: 2009..The development of rapid, non-invasive methods to diagnose PCP would be a significant advance, while the demonstration of drug resistance would have serious implications, given the limited PCP treatment medications currently available. ..
- International HIV-associated Opportunistic Pneumonias (IHOP) StudyLaurence Huang; Fiscal Year: 2010....