Research Topics
Genomes and Genes
| Jiaoti HuangSummaryAffiliation: University of Rochester Country: USA Publications
| Collaborators
|
Detail Information
Publications
Immunohistochemical characterization of neuroendocrine cells in prostate cancerJiaoti Huang
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
Prostate 66:1399-406. 2006..Neuroendocrine (NE) cells increase in high grade/stage prostate cancer (PC) and may contribute to androgen-independent cancer. Their immunohistochemical phenotype has not been studied in detail and conflicting results have been reported...- Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinomaRongshan Li
Department of Pathology, University of Rochester, Rochester, NY 14642, USA
Arch Pathol Lab Med 128:1412-7. 2004..CONCLUSIONS: Our results showed that mucin protein HCA is overexpressed in cells of prostatic carcinoma, which may have value in diagnosis and therapy. Its role in carcinogenesis also merits further study... - Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiationStephen C Ward
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mod Pathol 23:1180-90. 2010..On the basis of immunohistochemistry, fibrolamellar carcinoma seems to show both hepatocellular and bile duct differentiation... 
The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancerLillian Huang
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
Int J Clin Exp Pathol 4:644-50. 2011..Therefore, development of ERG expression profile would not be a useful diagnostic or prognostic marker for ovarian cancer patient screening...- Function and molecular mechanisms of neuroendocrine cells in prostate cancerJiaoti Huang
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
Anal Quant Cytol Histol 29:128-38. 2007..It also discusses molecular pathways involved in NE differentiation and the effectors of the NE cells... - Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancerJiaoti Huang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
Am J Pathol 166:1807-15. 2005.... - Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancerChengyu Wu
Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Prostate 66:1125-35. 2006..Prostate cancer (PC) contains a minor component of neuroendocrine (NE) cells that may stimulate androgen-independent growth of the tumor. The mechanism of neuroendocrine differentiation remains unknown... - CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickersRochelle A Simon
Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 40:252-8. 2009.... - A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitorYi Cai
George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Cancer 123:195-201. 2008..Together, these findings provide a possible explanation how CAB with antiandrogen HF therapy might fail and provide a potential new therapeutic approach to battle prostate cancer via combination of CAB therapy with COX-2 inhibitor(s)... - CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesisGong Yang
Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 16:3875-86. 2010..Chemokine receptor CXCR2 is associated with malignancy in several cancer models; however, the mechanisms involved in CXCR2-mediated tumor growth remain elusive. Here, we investigated the role of CXCR2 in human ovarian cancer... - ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal originSean R Williamson
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 24:1120-7. 2011..TMPRSS2-ERG fusion is absent in bladder small cell carcinoma, supporting the utility of FISH in distinguishing prostate from bladder primary tumors and identifying metastatic small cell carcinoma of unknown origin... - A novel in vitro assay of tumor-initiating cells in xenograft prostate tumorsChristopher R Silvers
Department of Urology, University of Rochester School of Medicine, Rochester, New York, USA
Prostate 70:1379-87. 2010..In order to help circumvent this challenge, we sought to develop an in vitro assay of human prostate cancer initiation employing a prostate-associated mesenchymal feeder layer... - Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1Aimee M Johnson
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Elmwood Avenue, Rochester, New York, USA
BMC Urol 8:7. 2008..Furthermore, because BC growth in UPII-SV40T mice is exophytic, we speculated BC growth was dependent on angiogenesis and angiogenesis was, in turn, androgen responsive... - Small cell carcinoma of the prostate: an immunohistochemical studyJorge L Yao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, and Department of Pathology, Rochester General Hospital, Rochester, NY 14642, USA
Am J Surg Pathol 30:705-12. 2006..Immunohistochemical markers can help separate SCPC from HGPC and may be useful in histologically borderline cases. Potential therapeutic targets are identified immunohistochemically in SCPC (Bombesin/GRP, c-kit, bcl-2, and EGFR)... - Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancerYueh Chiang Hu
George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 279:33438-46. 2004.... - Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumorsLin Li
Department of Pathology, University of Rochester Medical Center, Box 626, Rochester, NY 14642, USA
Hum Pathol 39:1205-11. 2008..Immunohistochemical detection of the combined expression of IMP3 and p53 is useful in the diagnosis of high-grade urothelial tumors, particularly in small, superficial materials... - Thrombin expression in prostate: a novel findingManish Kohli
Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Invest 29:62-7. 2011..A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue... - Cell culture block array for immunocytochemical study of protein expression in cultured cellsRongshan Li
Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 13:85-90. 2005..We demonstrated the utility of this technique by studying the proliferation and neuroendocrine differentiation of prostate cancer-derived LNCaP cells cultured in vitro... - Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancerChengyu Wu
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 282:3571-83. 2007..Therefore, our study demonstrated a novel function of the AKT pathway in prostate cancer progression and identified potential targets that may be explored for the treatment of androgen-independent cancer... - Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancerGanesh S Palapattu
Department of Pathology, University of Rochester School of Medicine, Rochester, New York, USA
Prostate 69:787-98. 2009..Neuroendocrine cells do not express androgen receptor and are quiescent, features associated with CSCs. The purpose of the study was to determine the expression of CD44 in human PC and its relationship to neuroendocrine tumor cells... - Schwannoma of the kidneyStefano Gobbo
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
Mod Pathol 21:779-83. 2008..In conclusion, renal schwannoma is rare, usually arises centrally, impinging on the hilum or the pelvis, and is cured by resection. Sarcomatoid carcinoma and other spindle cell tumors should be considered in the differential diagnosis... - Soft tissue tumors of the prostate: a reviewDavid G Wagner
Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
Anal Quant Cytol Histol 29:341-50. 2007..Diagnostic immunohistochemistry is an important adjunct to histopathology for proper diagnosis and tumor subclassification... - PC3 is a cell line characteristic of prostatic small cell carcinomaSheng Tai
Department of Pathology, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1732, USA
Prostate 71:1668-79. 2011..The purpose of this study was to compare the important and relevant features of two most commonly used PC cell lines, LNCaP and PC3, with prostatic adenocarcinoma and SCNC... - Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liverJun-Yi Lei
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
Am J Clin Pathol 125:519-25. 2006..The mechanism of TTF-1 cytoplasmic staining is explored... - The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumorsJohn J Liang
Department of Pathology, New York University School of Medicine, NY, USA
J Urol 177:1918-22. 2007..We studied the expression of p44 and protein arginine methyltransferase 5 in developing fetal testis and adult testicular tumors, including seminomas and Leydig cell tumors... - High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do notJennifer J Findeis-Hosey
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 42:867-72. 2011.... - The landscape of EGFR pathways and personalized management of non-small-cell lung cancerLiang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
Future Oncol 7:519-41. 2011..The role of KRAS and BRAF mutations and ALK rearrangement in lung cancer-targeted therapy, are also reviewed... - Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progressionZhihong Zhang
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
Mod Pathol 19:1339-43. 2006..Because p16(INK4a)-positive cells were detected only in premalignant lesions and carcinomas but not in normal or benign tissues, p16(INK4a) may aid in the diagnosis of PIN and prostate cancer in difficult cases... - Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladderJorge L Yao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Arch Pathol Lab Med 128:785-7. 2004.... - Early detection and measurement of urothelial tumors in miceAimee M Johnson
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Urology 67:1309-14. 2006..This approach could provide an important alternative to serial sacrifice experimental designs, while refining statistical power and reducing animal use... - Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesisBo Liu
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
Neoplasia 10:1004-13. 2008..Our finding may improve the usage of biomarkers to distinguish these two poorly differentiated tumor types, sharing similar histologic features... - Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylationBoxiao Ding
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 287:14621-30. 2012.... - SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 proteinYin Sun
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
J Biol Chem 286:18623-32. 2011..Such a mechanistic finding provides an opportunity to design specific therapeutic interventions to treat synovial sarcoma... - Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cellsYi-Fen Lee
George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, New York 14642, USA
Cancer Res 62:6039-44. 2002..This raises a concern for using HF in the complete-androgen-ablation therapy in prostate cancer treatment and provides a possible pathway that might contribute to the HF withdrawal syndrome... - Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machineryJing Ni
Department of Urology, University of Rochester, Rochester, NY 14642, USA
Biochem Biophys Res Commun 300:357-63. 2003..Taken together, our studies suggest that VES-mediated prostate cancer cell G1/S arrest is a consequence of the regulation of multiple molecules of the cell cycle regulatory machinery... - Neurosteroid transport by the organic solute transporter OSTα-OSTβFang Fang
Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Neurochem 115:220-33. 2010..These results demonstrate that OSTα-OSTβ is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action... - Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesionsSonglin Liang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Clin Pathol 122:747-51. 2004..The correlation of HCA with the grade of esophageal dysplasia suggests its possible involvement in the pathogenesis of EAC. HCA also might provide a target for immunotherapy... - Malakoplakia of the prostate on needle core biopsy: a case report and review of the literatureDavid Wagner
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Int J Surg Pathol 15:86-9. 2007..This is a case report of prostatic malakoplakia diagnosed on needle core biopsy from a patient suspected to harbor a malignancy... - Absence of Y chromosome in human placental site trophoblastic tumorPei Hui
Department of Pathology, Yale University, New Haven, CT 06520 8023, USA
Mod Pathol 20:1055-60. 2007.... - Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell CarcinomaKurt T Patton
Department of Pathology, Northwestern University, Feinberg School of Medicine, 251 East Huron Street, Chicago, IL 60611, USA
Am J Surg Pathol 28:1045-50. 2004..Our study indicates that Ron immunostaining cannot be used to distinguish oncocytoma from chromophobe renal cell carcinoma... - Clonality of combined tumorsJiaoti Huang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
Arch Pathol Lab Med 126:437-41. 2002..However, in a minority of these tumors, different areas may be derived from different precursor cells... - A phase 2 study of carboplatin plus docetaxel in men with metastatic hormone-refractory prostate cancer who are refractory to docetaxelRobert W Ross
Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cancer 112:521-6. 2008..The authors conducted a phase 2 trial of docetaxel plus carboplatin chemotherapy in this disease setting... - Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?William K Oh
Lank Center for Genitourinary Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Cancer 109:477-86. 2007..Satraplatin plus prednisone is being investigated in a large Phase III trial as second-line chemotherapy for HRPC. Targeting neuroendocrine cells may provide a new therapeutic approach to HRPC...