Jiaoti Huang

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Immunohistochemical characterization of neuroendocrine cells in prostate cancer
    Jiaoti Huang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Prostate 66:1399-406. 2006
  2. ncbi request reprint Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma
    Rongshan Li
    Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Arch Pathol Lab Med 128:1412-7. 2004
  3. doi request reprint Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation
    Stephen C Ward
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mod Pathol 23:1180-90. 2010
  4. pmc The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer
    Lillian Huang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Int J Clin Exp Pathol 4:644-50. 2011
  5. pmc Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer
    Jiaoti Huang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    Am J Pathol 166:1807-15. 2005
  6. ncbi request reprint Function and molecular mechanisms of neuroendocrine cells in prostate cancer
    Jiaoti Huang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Anal Quant Cytol Histol 29:128-38. 2007
  7. ncbi request reprint Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer
    Chengyu Wu
    Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Prostate 66:1125-35. 2006
  8. doi request reprint A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor
    Yi Cai
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 123:195-201. 2008
  9. doi request reprint CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers
    Rochelle A Simon
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 40:252-8. 2009
  10. doi request reprint Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of fluorescence in situ hybridization over ERG immunohistochemistry
    Lindsay A Schelling
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 44:2227-33. 2013

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Immunohistochemical characterization of neuroendocrine cells in prostate cancer
    Jiaoti Huang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Prostate 66:1399-406. 2006
    ..Neuroendocrine (NE) cells increase in high grade/stage prostate cancer (PC) and may contribute to androgen-independent cancer. Their immunohistochemical phenotype has not been studied in detail and conflicting results have been reported...
  2. ncbi request reprint Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma
    Rongshan Li
    Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Arch Pathol Lab Med 128:1412-7. 2004
    ..However, to our knowledge, expression of HCA in benign and neoplastic prostatic tissue has not been studied...
  3. doi request reprint Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation
    Stephen C Ward
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mod Pathol 23:1180-90. 2010
    ..On the basis of immunohistochemistry, fibrolamellar carcinoma seems to show both hepatocellular and bile duct differentiation...
  4. pmc The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer
    Lillian Huang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Int J Clin Exp Pathol 4:644-50. 2011
    ..Therefore, development of ERG expression profile would not be a useful diagnostic or prognostic marker for ovarian cancer patient screening...
  5. pmc Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer
    Jiaoti Huang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    Am J Pathol 166:1807-15. 2005
    ....
  6. ncbi request reprint Function and molecular mechanisms of neuroendocrine cells in prostate cancer
    Jiaoti Huang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Anal Quant Cytol Histol 29:128-38. 2007
    ..It also discusses molecular pathways involved in NE differentiation and the effectors of the NE cells...
  7. ncbi request reprint Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer
    Chengyu Wu
    Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Prostate 66:1125-35. 2006
    ..Prostate cancer (PC) contains a minor component of neuroendocrine (NE) cells that may stimulate androgen-independent growth of the tumor. The mechanism of neuroendocrine differentiation remains unknown...
  8. doi request reprint A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor
    Yi Cai
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 123:195-201. 2008
    ..Together, these findings provide a possible explanation how CAB with antiandrogen HF therapy might fail and provide a potential new therapeutic approach to battle prostate cancer via combination of CAB therapy with COX-2 inhibitor(s)...
  9. doi request reprint CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers
    Rochelle A Simon
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 40:252-8. 2009
    ....
  10. doi request reprint Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of fluorescence in situ hybridization over ERG immunohistochemistry
    Lindsay A Schelling
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 44:2227-33. 2013
    ..Therefore, it may be useful in confirming prostatic origin when molecular testing is not accessible. However, sensitivity and specificity of ERG immunohistochemistry in small cell carcinoma are decreased compared to FISH. ..
  11. pmc CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis
    Gong Yang
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 16:3875-86. 2010
    ..Chemokine receptor CXCR2 is associated with malignancy in several cancer models; however, the mechanisms involved in CXCR2-mediated tumor growth remain elusive. Here, we investigated the role of CXCR2 in human ovarian cancer...
  12. pmc Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1
    Aimee M Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Elmwood Avenue, Rochester, New York, USA
    BMC Urol 8:7. 2008
    ..Furthermore, because BC growth in UPII-SV40T mice is exophytic, we speculated BC growth was dependent on angiogenesis and angiogenesis was, in turn, androgen responsive...
  13. ncbi request reprint Cell culture block array for immunocytochemical study of protein expression in cultured cells
    Rongshan Li
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 13:85-90. 2005
    ..We demonstrated the utility of this technique by studying the proliferation and neuroendocrine differentiation of prostate cancer-derived LNCaP cells cultured in vitro...
  14. pmc ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin
    Sean R Williamson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 24:1120-7. 2011
    ..TMPRSS2-ERG fusion is absent in bladder small cell carcinoma, supporting the utility of FISH in distinguishing prostate from bladder primary tumors and identifying metastatic small cell carcinoma of unknown origin...
  15. pmc A novel in vitro assay of tumor-initiating cells in xenograft prostate tumors
    Christopher R Silvers
    Department of Urology, University of Rochester School of Medicine, Rochester, New York, USA
    Prostate 70:1379-87. 2010
    ..In order to help circumvent this challenge, we sought to develop an in vitro assay of human prostate cancer initiation employing a prostate-associated mesenchymal feeder layer...
  16. pmc Thrombin expression in prostate: a novel finding
    Manish Kohli
    Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Invest 29:62-7. 2011
    ..A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue...
  17. ncbi request reprint Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer
    Yueh Chiang Hu
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 279:33438-46. 2004
    ....
  18. doi request reprint Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors
    Lin Li
    Department of Pathology, University of Rochester Medical Center, Box 626, Rochester, NY 14642, USA
    Hum Pathol 39:1205-11. 2008
    ..Immunohistochemical detection of the combined expression of IMP3 and p53 is useful in the diagnosis of high-grade urothelial tumors, particularly in small, superficial materials...
  19. ncbi request reprint Soft tissue tumors of the prostate: a review
    David G Wagner
    Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
    Anal Quant Cytol Histol 29:341-50. 2007
    ..Diagnostic immunohistochemistry is an important adjunct to histopathology for proper diagnosis and tumor subclassification...
  20. ncbi request reprint Small cell carcinoma of the prostate: an immunohistochemical study
    Jorge L Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, and Department of Pathology, Rochester General Hospital, Rochester, NY 14642, USA
    Am J Surg Pathol 30:705-12. 2006
    ..Immunohistochemical markers can help separate SCPC from HGPC and may be useful in histologically borderline cases. Potential therapeutic targets are identified immunohistochemically in SCPC (Bombesin/GRP, c-kit, bcl-2, and EGFR)...
  21. ncbi request reprint Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver
    Jun Yi Lei
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Am J Clin Pathol 125:519-25. 2006
    ..The mechanism of TTF-1 cytoplasmic staining is explored...
  22. ncbi request reprint Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
    Chengyu Wu
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:3571-83. 2007
    ..Therefore, our study demonstrated a novel function of the AKT pathway in prostate cancer progression and identified potential targets that may be explored for the treatment of androgen-independent cancer...
  23. doi request reprint Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer
    Ganesh S Palapattu
    Department of Pathology, University of Rochester School of Medicine, Rochester, New York, USA
    Prostate 69:787-98. 2009
    ..Neuroendocrine cells do not express androgen receptor and are quiescent, features associated with CSCs. The purpose of the study was to determine the expression of CD44 in human PC and its relationship to neuroendocrine tumor cells...
  24. doi request reprint Schwannoma of the kidney
    Stefano Gobbo
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 21:779-83. 2008
    ..In conclusion, renal schwannoma is rare, usually arises centrally, impinging on the hilum or the pelvis, and is cured by resection. Sarcomatoid carcinoma and other spindle cell tumors should be considered in the differential diagnosis...
  25. pmc PC3 is a cell line characteristic of prostatic small cell carcinoma
    Sheng Tai
    Department of Pathology, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1732, USA
    Prostate 71:1668-79. 2011
    ..The purpose of this study was to compare the important and relevant features of two most commonly used PC cell lines, LNCaP and PC3, with prostatic adenocarcinoma and SCNC...
  26. ncbi request reprint Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladder
    Jorge L Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Arch Pathol Lab Med 128:785-7. 2004
    ..We have previously shown that prostatic carcinoma overexpresses HCA in comparison to benign prostatic tissue. To our knowledge, expression of HCA in other tumors has not been reported previously...
  27. doi request reprint High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not
    Jennifer J Findeis-Hosey
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 42:867-72. 2011
    ....
  28. doi request reprint The landscape of EGFR pathways and personalized management of non-small-cell lung cancer
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
    Future Oncol 7:519-41. 2011
    ..The role of KRAS and BRAF mutations and ALK rearrangement in lung cancer-targeted therapy, are also reviewed...
  29. ncbi request reprint Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression
    Zhihong Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 19:1339-43. 2006
    ..Because p16(INK4a)-positive cells were detected only in premalignant lesions and carcinomas but not in normal or benign tissues, p16(INK4a) may aid in the diagnosis of PIN and prostate cancer in difficult cases...
  30. ncbi request reprint The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors
    John J Liang
    Department of Pathology, New York University School of Medicine, NY, USA
    J Urol 177:1918-22. 2007
    ..We studied the expression of p44 and protein arginine methyltransferase 5 in developing fetal testis and adult testicular tumors, including seminomas and Leydig cell tumors...
  31. ncbi request reprint Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma
    Kurt T Patton
    Department of Pathology, Northwestern University, Feinberg School of Medicine, 251 East Huron Street, Chicago, IL 60611, USA
    Am J Surg Pathol 28:1045-50. 2004
    ..Our study indicates that Ron immunostaining cannot be used to distinguish oncocytoma from chromophobe renal cell carcinoma...
  32. ncbi request reprint Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions
    Songlin Liang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Clin Pathol 122:747-51. 2004
    ..The correlation of HCA with the grade of esophageal dysplasia suggests its possible involvement in the pathogenesis of EAC. HCA also might provide a target for immunotherapy...
  33. pmc Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis
    Bo Liu
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Neoplasia 10:1004-13. 2008
    ..Our finding may improve the usage of biomarkers to distinguish these two poorly differentiated tumor types, sharing similar histologic features...
  34. ncbi request reprint Early detection and measurement of urothelial tumors in mice
    Aimee M Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Urology 67:1309-14. 2006
    ..To establish reliable noninvasive in vivo methods to detect, measure, and monitor experimentally induced urothelial tumors in mice...
  35. pmc Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation
    Boxiao Ding
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 287:14621-30. 2012
    ....
  36. ncbi request reprint Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells
    Yi Fen Lee
    George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, New York 14642, USA
    Cancer Res 62:6039-44. 2002
    ..This raises a concern for using HF in the complete-androgen-ablation therapy in prostate cancer treatment and provides a possible pathway that might contribute to the HF withdrawal syndrome...
  37. pmc SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein
    Yin Sun
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
    J Biol Chem 286:18623-32. 2011
    ..Such a mechanistic finding provides an opportunity to design specific therapeutic interventions to treat synovial sarcoma...
  38. ncbi request reprint Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery
    Jing Ni
    Department of Urology, University of Rochester, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 300:357-63. 2003
    ..Taken together, our studies suggest that VES-mediated prostate cancer cell G1/S arrest is a consequence of the regulation of multiple molecules of the cell cycle regulatory machinery...
  39. pmc Neurosteroid transport by the organic solute transporter OSTα-OSTβ
    Fang Fang
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurochem 115:220-33. 2010
    ..These results demonstrate that OSTα-OSTβ is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action...
  40. ncbi request reprint Absence of Y chromosome in human placental site trophoblastic tumor
    Pei Hui
    Department of Pathology, Yale University, New Haven, CT 06520 8023, USA
    Mod Pathol 20:1055-60. 2007
    ....
  41. ncbi request reprint Malakoplakia of the prostate on needle core biopsy: a case report and review of the literature
    David Wagner
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Int J Surg Pathol 15:86-9. 2007
    ..This is a case report of prostatic malakoplakia diagnosed on needle core biopsy from a patient suspected to harbor a malignancy...
  42. ncbi request reprint Renal oncocytosis presenting in childhood: a case report
    Terina S Chen
    Department of Pathology and Laboratory Medicine, Rochester, New York 14642, USA
    Int J Surg Pathol 11:325-9. 2003
    ..We caution pathologists in making a malignant diagnosis in such cases, especially in younger patients...
  43. doi request reprint Erk/MAP Kinase Signaling Pathway and Neuroendocrine Differentiation of Non-Small-Cell Lung Cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, James P Wilmot Cancer Center, Rochester, New York Department of Pathology and Laboratory Medicine, Institute of Molecular Medicine, University of California, Los Angeles, California and Department of Pathology and Laboratory Medicine, University of Rochester Medical Center Rochester, New York
    J Thorac Oncol 9:50-8. 2014
    ..Although distinct clinical features and histology of SCLC and carcinoid tumors are well recognized, the clinical significance and the molecular basis of NED in NSCLC remain unclear...
  44. ncbi request reprint Clonality of combined tumors
    Jiaoti Huang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Arch Pathol Lab Med 126:437-41. 2002
    ..Tumors with mixed morphologic patterns (combined tumors) are sometimes encountered, and questions often arise regarding the mechanism of molecular pathogenesis of each component and their relationships...
  45. ncbi request reprint A phase 2 study of carboplatin plus docetaxel in men with metastatic hormone-refractory prostate cancer who are refractory to docetaxel
    Robert W Ross
    Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 112:521-6. 2008
    ..The authors conducted a phase 2 trial of docetaxel plus carboplatin chemotherapy in this disease setting...
  46. ncbi request reprint Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?
    William K Oh
    Lank Center for Genitourinary Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Cancer 109:477-86. 2007
    ..Satraplatin plus prednisone is being investigated in a large Phase III trial as second-line chemotherapy for HRPC. Targeting neuroendocrine cells may provide a new therapeutic approach to HRPC...