Research Topics
Genomes and Genes | Hsien Sung HuangSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Chromatin immunoprecipitation in postmortem brainHsien Sung Huang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
J Neurosci Methods 156:284-92. 2006..Therefore, immunoprecipitation of micrococcal nuclease-digested tissue extracts is a feasible approach to profile histone methylation at defined genomic loci in postmortem brain...
A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortexNikolaos Mellios
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, 303 Belmont Street, Worcester, MA 01604, USA
Hum Mol Genet 17:3030-42. 2008..Collectively, our data highlight the multiple layers of regulation governing the developmental expression of BDNF in human PFC and suggest that miRNAs are involved in the fine-tuning of this neurotrophin particularly in adulthood...- Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promotersHsien Sung Huang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurosci 27:11254-62. 2007.... - Isolation of neuronal chromatin from brain tissueYan Jiang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
BMC Neurosci 9:42. 2008.... 
Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophreniaNikolaos Mellios
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
Biol Psychiatry 65:1006-14. 2009..However, it remains unclear if these mechanisms are important determinants for dysregulated NPY and SST expression in prefrontal cortex (PFC) of subjects with schizophrenia...- Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disordersSchahram Akbarian
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
Brain Res Rev 52:293-304. 2006..We propose an integrative model, with multiple molecular and cellular mechanisms contributing to transcriptional dysregulation of GAD67 and cortical dysfunction in psychosis... - Epigenetic regulation in human brain-focus on histone lysine methylationSchahram Akbarian
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusettsm USA
Biol Psychiatry 65:198-203. 2009..Together, these findings emphasize the potential significance of histone lysine methylation for orderly brain development and also as a molecular toolbox to study chromatin function in postmortem tissue... - GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophreniaHsien Sung Huang
Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 2:e809. 2007..These results suggest that chromatin remodeling mechanisms are involved in dysregulated GABAergic gene expression in schizophrenia... - RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorderHsien Sung Huang
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
Autism Res 3:153-61. 2010..Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders...