Hsien Sung Huang

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Chromatin immunoprecipitation in postmortem brain
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    J Neurosci Methods 156:284-92. 2006
  2. pmc A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, 303 Belmont Street, Worcester, MA 01604, USA
    Hum Mol Genet 17:3030-42. 2008
  3. ncbi request reprint Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurosci 27:11254-62. 2007
  4. pmc Isolation of neuronal chromatin from brain tissue
    Yan Jiang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Neurosci 9:42. 2008
  5. pmc Epigenetic regulation in human brain-focus on histone lysine methylation
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusettsm USA
    Biol Psychiatry 65:198-203. 2009
  6. pmc GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    Hsien Sung Huang
    Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 2:e809. 2007
  7. doi request reprint RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder
    Hsien Sung Huang
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
    Autism Res 3:153-61. 2010
  8. ncbi request reprint Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
    Brain Res Rev 52:293-304. 2006
  9. doi request reprint Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    Biol Psychiatry 65:1006-14. 2009

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Chromatin immunoprecipitation in postmortem brain
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    J Neurosci Methods 156:284-92. 2006
    ..Therefore, immunoprecipitation of micrococcal nuclease-digested tissue extracts is a feasible approach to profile histone methylation at defined genomic loci in postmortem brain...
  2. pmc A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, 303 Belmont Street, Worcester, MA 01604, USA
    Hum Mol Genet 17:3030-42. 2008
    ..Collectively, our data highlight the multiple layers of regulation governing the developmental expression of BDNF in human PFC and suggest that miRNAs are involved in the fine-tuning of this neurotrophin particularly in adulthood...
  3. ncbi request reprint Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurosci 27:11254-62. 2007
    ....
  4. pmc Isolation of neuronal chromatin from brain tissue
    Yan Jiang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Neurosci 9:42. 2008
    ....
  5. pmc Epigenetic regulation in human brain-focus on histone lysine methylation
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusettsm USA
    Biol Psychiatry 65:198-203. 2009
    ..Together, these findings emphasize the potential significance of histone lysine methylation for orderly brain development and also as a molecular toolbox to study chromatin function in postmortem tissue...
  6. pmc GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    Hsien Sung Huang
    Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 2:e809. 2007
    ..These results suggest that chromatin remodeling mechanisms are involved in dysregulated GABAergic gene expression in schizophrenia...
  7. doi request reprint RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder
    Hsien Sung Huang
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
    Autism Res 3:153-61. 2010
    ..Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders...
  8. ncbi request reprint Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
    Brain Res Rev 52:293-304. 2006
    ..We propose an integrative model, with multiple molecular and cellular mechanisms contributing to transcriptional dysregulation of GAD67 and cortical dysfunction in psychosis...
  9. doi request reprint Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    Biol Psychiatry 65:1006-14. 2009
    ..However, it remains unclear if these mechanisms are important determinants for dysregulated NPY and SST expression in prefrontal cortex (PFC) of subjects with schizophrenia...