Eric Huang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism
    Yulei Shang
    Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 11:e1001527. 2013
  2. pmc Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
    Mianzhi Tang
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Neural Dev 8:8. 2013
  3. pmc Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions
    Eric J Huang
    Department of Pathology, University of California, San Francisco, CA, USA
    Brain Pathol 20:1069-76. 2010
  4. ncbi request reprint Craniofacial defects of blastogenesis: duplication of pituitary with cleft palate and orophgaryngeal tumors
    Anne Slavotinek
    Department of Pediatrics, Division of Genetics, University of California San Francisco, 553 Parnassus Street, Rm U 585P, San Francisco, CA 94143, USA
    Am J Med Genet A 135:13-20. 2005
  5. ncbi request reprint Trk receptors: roles in neuronal signal transduction
    Eric J Huang
    Department of Pathology, University of California Veterans Administration Medical Center, San Francisco, California 94143, USA
    Annu Rev Biochem 72:609-42. 2003
  6. pmc Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
    Eric J Huang
    Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 19:138-51. 2005
  7. pmc Notch-1 activation and dendritic atrophy in prion disease
    Nako Ishikura
    Department of Pathology Neuropathology, Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:886-91. 2005
  8. pmc Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
    Amanda K Wiggins
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 167:257-67. 2004
  9. pmc Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco and Pathology, Service 113B, VA Medical Center, 94121, USA
    J Neurobiol 66:882-95. 2006
  10. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism
    Yulei Shang
    Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 11:e1001527. 2013
    ..Our results reveal a previously unrecognized role of HIPK proteins in connecting TGF-β signaling pathway with the transcriptional programs critical for angiogenesis in early embryonic development...
  2. pmc Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
    Mianzhi Tang
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Neural Dev 8:8. 2013
    ..This prevailing view has been based primarily on in vitro culture results, and the exact in vivo function of Shh signaling in the patterning and neurogenesis of the ventral midbrain (vMB) remains unclear...
  3. pmc Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions
    Eric J Huang
    Department of Pathology, University of California, San Francisco, CA, USA
    Brain Pathol 20:1069-76. 2010
    ..Furthermore, our study represents the first detailed characterizations of neuropathological findings in rapidly progressive juvenile ALS patients with a mutation in the FUS/TLS gene...
  4. ncbi request reprint Craniofacial defects of blastogenesis: duplication of pituitary with cleft palate and orophgaryngeal tumors
    Anne Slavotinek
    Department of Pediatrics, Division of Genetics, University of California San Francisco, 553 Parnassus Street, Rm U 585P, San Francisco, CA 94143, USA
    Am J Med Genet A 135:13-20. 2005
    ..However, the precise inductive mechanism resulting in DPG remains unknown...
  5. ncbi request reprint Trk receptors: roles in neuronal signal transduction
    Eric J Huang
    Department of Pathology, University of California Veterans Administration Medical Center, San Francisco, California 94143, USA
    Annu Rev Biochem 72:609-42. 2003
    ..p75NTR also influences the conformations of Trk receptors; this modifies ligand-binding specificity and affinity with important developmental consequences...
  6. pmc Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
    Eric J Huang
    Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 19:138-51. 2005
    ..Taken together, our data provide evidence for previously unidentified functions of Numb and Numblike in sensory axon arborization by regulating Notch1 via the endocytic-lysosomal pathways...
  7. pmc Notch-1 activation and dendritic atrophy in prion disease
    Nako Ishikura
    Department of Pathology Neuropathology, Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:886-91. 2005
    ..Whether diminishing Notch-1 activation in vivo can prevent or even reverse neurodegeneration in prion disease remains to be established...
  8. pmc Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
    Amanda K Wiggins
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 167:257-67. 2004
    ..Together, these data indicate that HIPK2, through regulation of Brn3a-dependent gene expression, is a critical component in the transcriptional machinery that controls sensory neuron survival...
  9. pmc Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco and Pathology, Service 113B, VA Medical Center, 94121, USA
    J Neurobiol 66:882-95. 2006
    ..These results provide insights into the use of neurotrophic factors as therapeutic agents for ALS...
  10. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
  11. pmc Acetylation of tau inhibits its degradation and contributes to tauopathy
    Sang Won Min
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 67:953-66. 2010
    ..Inhibiting p300 with a small molecule promoted tau deacetylation and eliminated p-tau associated with tauopathy. Modulating tau acetylation could be a new therapeutic strategy to reduce tau-mediated neurodegeneration...
  12. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007
    ..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration...
  13. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
  14. pmc Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2
    Tiina M Kauppinen
    Department of Neurology, University of California, San Francisco, and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 103:7136-41. 2006
    ..These results suggest that PARP1 phosphorylation by ERK1/2 is required for maximal PARP-1 activation after DNA damage...
  15. ncbi request reprint Selective neuronal vulnerability and inadequate stress response in superoxide dismutase mutant mice
    Stephen Lynn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    Free Radic Biol Med 38:817-28. 2005
    ..Other major classes of differentially expressed genes include lipid biosynthesis and ROS metabolism...
  16. ncbi request reprint Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons
    Epaminondas Doxakis
    School of Biosciences, Biomedical Building 3, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
    Curr Biol 14:1761-5. 2004
    ..These findings identify HIPK2 as a novel participant in programmed cell death in the developing peripheral nervous system...
  17. ncbi request reprint Morphological correlates of intrinsic electrical excitability in neurons of the deep cerebellar nuclei
    Carlos D Aizenman
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurophysiol 89:1738-47. 2003
    ....

Research Grants6

  1. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2006
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  2. Molecular Mechanisms of Sensory Neurogenesis
    Eric Huang; Fiscal Year: 2006
    ..abstract_text> ..
  3. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2007
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  4. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2009
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  5. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2005
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in neurodegenerative diseases ..