Genomes and Genes
E J Huang
Affiliation: University of California
- Neurotrophins: roles in neuronal development and functionE J Huang
Department of Pathology, University of California, San Francisco, California 94143, USA
Annu Rev Neurosci 24:677-736. 2001..These proteins also regulate many aspects of neural function. In the mature nervous system, they control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival...
- Trk receptors: roles in neuronal signal transductionEric J Huang
Department of Pathology, University of California Veterans Administration Medical Center, San Francisco, California 94143, USA
Annu Rev Biochem 72:609-42. 2003..p75NTR also influences the conformations of Trk receptors; this modifies ligand-binding specificity and affinity with important developmental consequences...
- Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborizationEric J Huang
Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA
Genes Dev 19:138-51. 2005..Taken together, our data provide evidence for previously unidentified functions of Numb and Numblike in sensory axon arborization by regulating Notch1 via the endocytic-lysosomal pathways...
- POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expressionE J Huang
Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723 USA
Development 126:2869-82. 1999..In conclusion, our data indicate the specific functions of Brn-3a in controlling the survival and differentiation of trigeminal neurons by regulating expression of each of the three Trk receptors...
- Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neuronsE J Huang
Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Development 128:2421-32. 2001..Thus, Brn3a must control additional downstream genes that are required for axon pathfinding...
- Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkCE J Huang
Program in Neuroscience, Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723, USA
Development 126:2191-203. 1999..Therefore, our data provide evidence that NT-3 supports the survival of TrkA-, TrkB- and TrkC-expressing neurons in the trigeminal ganglion by activating directly each of these receptors in vivo...
- Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusionsEric J Huang
Department of Pathology, University of California, San Francisco, CA, USA
Brain Pathol 20:1069-76. 2010..Furthermore, our study represents the first detailed characterizations of neuropathological findings in rapidly progressive juvenile ALS patients with a mutation in the FUS/TLS gene...
- Notch-1 activation and dendritic atrophy in prion diseaseNako Ishikura
Department of Pathology Neuropathology, Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:886-91. 2005..Whether diminishing Notch-1 activation in vivo can prevent or even reverse neurodegeneration in prion disease remains to be established...
- Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survivalAmanda K Wiggins
Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
J Cell Biol 167:257-67. 2004..Together, these data indicate that HIPK2, through regulation of Brn3a-dependent gene expression, is a critical component in the transcriptional machinery that controls sensory neuron survival...
- Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neuronsMianzhi Tang
Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurosci 30:9280-91. 2010..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
- Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALSJiasheng Zhang
Department of Pathology, University of California San Francisco and Pathology, Service 113B, VA Medical Center, 94121, USA
J Neurobiol 66:882-95. 2006..These results provide insights into the use of neurotrophic factors as therapeutic agents for ALS...
- Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome miceR R Laposa
Department of Dermatology and Cancer Center, University of California, San Francisco, CA 94143 0808, USA
Proc Natl Acad Sci U S A 104:1389-94. 2007....
- Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neuronsJiasheng Zhang
Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Nat Neurosci 10:77-86. 2007..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration...
- Acetylation of tau inhibits its degradation and contributes to tauopathySang Won Min
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Neuron 67:953-66. 2010..Inhibiting p300 with a small molecule promoted tau deacetylation and eliminated p-tau associated with tauopathy. Modulating tau acetylation could be a new therapeutic strategy to reduce tau-mediated neurodegeneration...
- Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2Tiina M Kauppinen
Department of Neurology, University of California, San Francisco, and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Proc Natl Acad Sci U S A 103:7136-41. 2006..These results suggest that PARP1 phosphorylation by ERK1/2 is required for maximal PARP-1 activation after DNA damage...
- Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neuronsMianzhi Tang
VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
Development 136:2027-38. 2009..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
- Selective neuronal vulnerability and inadequate stress response in superoxide dismutase mutant miceStephen Lynn
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
Free Radic Biol Med 38:817-28. 2005..Other major classes of differentially expressed genes include lipid biosynthesis and ROS metabolism...
- Morphological correlates of intrinsic electrical excitability in neurons of the deep cerebellar nucleiCarlos D Aizenman
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurophysiol 89:1738-47. 2003....
- Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neuronsEpaminondas Doxakis
School of Biosciences, Biomedical Building 3, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
Curr Biol 14:1761-5. 2004..These findings identify HIPK2 as a novel participant in programmed cell death in the developing peripheral nervous system...