Chun Ming Huang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Surfactant sodium lauryl sulfate enhances skin vaccination: molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics
    Chun Ming Huang
    Department of Dermatology, Skin Diseases Research Center, University of Alabama, Birmingham, Alabama 35294, USA
    Mol Cell Proteomics 5:523-32. 2006
  2. pmc Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids
    Chun Ming Huang
    Division of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 32:214-21. 2011
  3. ncbi request reprint Halitosis vaccines targeting FomA, a biofilm-bridging protein of fusobacteria nucleatum
    P F Liu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Taiwan
    Curr Mol Med 13:1358-67. 2013
  4. pmc Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk
    M Shu
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92121, USA
    Curr Med Chem 20:562-8. 2013
  5. ncbi request reprint Mass spectrometric proteomics profiles of in vivo tumor secretomes: capillary ultrafiltration sampling of regressive tumor masses
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Proteomics 6:6107-16. 2006
  6. ncbi request reprint Profiling human saliva endogenous peptidome via a high throughput MALDI-TOF-TOF mass spectrometry
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA
    Comb Chem High Throughput Screen 12:521-31. 2009
  7. doi request reprint In vivo secretome sampling technology for proteomics
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, San Diego, CA, USA Moores Cancer Center, University of California, San Diego, CA, USA La Jolla Institute for Molecular Medicine, San Diego, CA, USA VA San Diego Healthcare Center, San Diego, CA, USA
    Proteomics Clin Appl 1:953-62. 2007
  8. pmc A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA
    Antimicrob Agents Chemother 52:1834-6. 2008
  9. pmc In vivo tumor secretion probing via ultrafiltration and tissue chamber: implication for anti-cancer drugs targeting secretome
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA
    Recent Pat Anticancer Drug Discov 3:48-54. 2008
  10. ncbi request reprint Topical vaccination: the skin as a unique portal to adaptive immune responses
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare Center, Rm 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA
    Semin Immunopathol 29:71-80. 2007

Research Grants

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Surfactant sodium lauryl sulfate enhances skin vaccination: molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics
    Chun Ming Huang
    Department of Dermatology, Skin Diseases Research Center, University of Alabama, Birmingham, Alabama 35294, USA
    Mol Cell Proteomics 5:523-32. 2006
    ..Two secretory proteins, named as calcium-binding protein S100A9 and thymosin beta4, were identified by this novel technique. These two proteins thus may provide new insight into the enhancing effect of surfactants on skin vaccination...
  2. pmc Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids
    Chun Ming Huang
    Division of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 32:214-21. 2011
    ..These findings suggest that LipoOA hold great potential to become a new, effective, and safe antimicrobial agent for the treatment of MRSA infections...
  3. ncbi request reprint Halitosis vaccines targeting FomA, a biofilm-bridging protein of fusobacteria nucleatum
    P F Liu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Taiwan
    Curr Mol Med 13:1358-67. 2013
    ..nucleatum with P. gingivalis, which suggests FomA of F. nucleatum to be a potential target for development of vaccines or drugs against bacterial biofilm formation and its associated pathogenicities. ..
  4. pmc Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk
    M Shu
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92121, USA
    Curr Med Chem 20:562-8. 2013
    ..Lastly, we discuss the challenges and possible solutions for using the P. acnes response to predict the radiation risk...
  5. ncbi request reprint Mass spectrometric proteomics profiles of in vivo tumor secretomes: capillary ultrafiltration sampling of regressive tumor masses
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Proteomics 6:6107-16. 2006
    ..The technique involving CUF probes linked to mass spectrometric proteomics reinforces systems biology studies of cell-cell interactions and is potentially applicable to the discovery of in vivo biomarkers in human disease...
  6. ncbi request reprint Profiling human saliva endogenous peptidome via a high throughput MALDI-TOF-TOF mass spectrometry
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA
    Comb Chem High Throughput Screen 12:521-31. 2009
    ..Thus, a saliva peptidome containing peptides with -PQ C-termini, as presented here, may reinforce the development of innate-immunity-related disease monitoring using non-invasive saliva samples and mass spectrometry-based techniques...
  7. doi request reprint In vivo secretome sampling technology for proteomics
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, San Diego, CA, USA Moores Cancer Center, University of California, San Diego, CA, USA La Jolla Institute for Molecular Medicine, San Diego, CA, USA VA San Diego Healthcare Center, San Diego, CA, USA
    Proteomics Clin Appl 1:953-62. 2007
    ..Many prospective properties such as simple manipulation, dynamic sampling, pathogen clearance, online mass spectrometric coupling, and disease treatment and monitoring have made CUF probes attractive for clinical uses in the near future...
  8. pmc A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA
    Antimicrob Agents Chemother 52:1834-6. 2008
    ..A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases...
  9. pmc In vivo tumor secretion probing via ultrafiltration and tissue chamber: implication for anti-cancer drugs targeting secretome
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA
    Recent Pat Anticancer Drug Discov 3:48-54. 2008
    ..Many detection methods have been patented regarding probes and peptide used for identification of tumors...
  10. ncbi request reprint Topical vaccination: the skin as a unique portal to adaptive immune responses
    Chun Ming Huang
    Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare Center, Rm 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA
    Semin Immunopathol 29:71-80. 2007
    ..A recent study demonstrating enhanced skin vaccination by using surfactants to extract partial lamellar lipids of the stratum corneum will also be introduced in this review...
  11. ncbi request reprint Quantitative proteomes and in vivo secretomes of progressive and regressive UV-induced fibrosarcoma tumor cells: mimicking tumor microenvironment using a dermis-based cell-trapped system linked to tissue chamber
    Yang Shi
    Burnham Institute for Medical Research, La Jolla, CA, USA
    Proteomics 7:4589-600. 2007
    ..Differential tumor proteomes and in vivo secretome were thus accentuated as potential therapeutic targets to control tumor growth...
  12. ncbi request reprint Comparative proteomic profiling of murine skin
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, USA
    J Invest Dermatol 121:51-64. 2003
    ..These data establish numerous reference markers within the proteome map of murine skin and provide an important framework for future efforts aimed at characterization of the epidermal and subepidermal responses to environmental changes...
  13. pmc Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo
    Teruaki Nakatsuji
    Department of Medicine, Division of Dermatology, University of California, San Diego, CA, USA
    Proteomics 8:3406-15. 2008
    ..The bioengineered acne model thus provides an in vivo microenvironment to study the interaction of host with P. acnes and offers a unique set-up for screening novel anti-acne drugs and vaccines...
  14. pmc Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
    J Invest Dermatol 130:985-94. 2010
    ..acnes and enhance the skin's innate antibacterial defense by inducing the expression of hBD-2 in sebocytes as well...
  15. pmc Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis
    Pei Feng Liu
    Department of Medicine, Division of Dermatology, University of California, San Diego, CA 92161, USA
    Vaccine 28:3496-505. 2010
    ..nucleatum co-opts P. gingivalis to exacerbate gum infections. FomA is highlighted as a potential target for development of new therapeutics against periodontal infection and halitosis in humans...
  16. pmc A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, VH 501, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Proteomics 5:1013-23. 2005
    ..These proteins may provide a vital link between early-stage tumor suppression and immune response of skin patch vaccination...
  17. pmc The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes
    Darren Yang
    Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 30:6035-40. 2009
    ..acnes associated diseases...
  18. pmc Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, USA
    PLoS ONE 3:e1551. 2008
    ..Despite substantial research into potential new therapies for this common disease, vaccines against acne vulgaris are not yet available...
  19. ncbi request reprint Identification of Bacillus anthracis proteins associated with germination and early outgrowth by proteomic profiling of anthrax spores
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, 35294 0019, USA
    Proteomics 4:2653-61. 2004
    ..The 31 new proteins identified in this study also complement an emerging proteomic database of B. anthracis...
  20. pmc The response of human skin commensal bacteria as a reflection of UV radiation: UV-B decreases porphyrin production
    Yanhan Wang
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 7:e47798. 2012
    ....
  21. pmc Staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting β-hemolysin and CAMP factor
    Chih Wei Lo
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92121, USA
    J Invest Dermatol 131:401-9. 2011
    ..acnes and S. aureus. These observations suggest a previously unreported immunotherapy targeting the interaction of S. aureus with a skin commensal...
  22. pmc Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 6:e14797. 2011
    ..In the progression of acne vulgaris, the disruption of follicular epithelia by an over-growth of Propionibacterium acnes (P. acnes) permits the bacteria to spread and become in contact with various skin and immune cells...
  23. ncbi request reprint Vaccine therapy for P. acnes-associated diseases
    Teruaki Nakatsuji
    Department of Medicine, Division of Dermatology, University of California, San Diego, CA 92161, USA
    Infect Disord Drug Targets 8:160-5. 2008
    ..acnes challenge and decreases P. acnes-induced elevation of cytokine production. This review highlights the potential functions of killed P. acnes- and sialidase-based vaccines as novel treatments for P. acnes-associated diseases...
  24. pmc Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, California 92161, USA
    J Invest Dermatol 128:2451-7. 2008
    ..These observations highlight the concept that development of vaccines targeting microbial products may represent an alternative strategy to conventional antibiotic therapy...
  25. ncbi request reprint In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, VH 566A, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    J Chromatogr A 1109:144-51. 2006
    ..Also, the technique represents a powerful method for the identification of in vivo secreted proteins and has potential application for in the detection of biomarkers for human diseases...
  26. pmc Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris
    Pei Feng Liu
    Department of Medicine, Division of Dermatology, University of California, San Diego, San Diego, CA 92121, USA
    Vaccine 29:3230-8. 2011
    ..acnes-associated diseases and highlight the concept of neutralizing P. acnes virulence without disturbing the bacterial commensalism in human microbiome...
  27. pmc Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus
    Muya Shu
    Division of Dermatology, Department of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS ONE 8:e55380. 2013
    ..This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health...
  28. ncbi request reprint In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Proteomics 6:5805-14. 2006
    ..The technique of using CUF probes linked to mass spectrometric proteomics represents a powerful method to identify in vivo secreted proteins, and may be applicable for identification of proteins relevant in various human diseases...
  29. ncbi request reprint Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Alabama, USA
    Genomics Proteomics Bioinformatics 2:143-51. 2004
    ....
  30. pmc The essentiality of alpha-2-macroglobulin in human salivary innate immunity against new H1N1 swine origin influenza A virus
    Chao Hsuan Chen
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92121, USA
    Proteomics 10:2396-401. 2010
    ..We emphasize that endogenous A2M in human innate immunity functions as a natural inhibitor against S-OIV...
  31. ncbi request reprint An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine
    Chao Hsuan Chen
    Division of Dermatology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0671, USA
    J Microbiol Biotechnol 21:391-9. 2011
    ..In conclusion, our results suggest a promising therapeutic approach against MRSA through boosting the bacteriocidal activities of native FFAs, which may have been co-evolved during the interactions between microbes and their hosts...
  32. pmc Histone H4 is a major component of the antimicrobial action of human sebocytes
    Dong Youn Lee
    Division of Dermatology, University of California San Diego and VA San Diego Healthcare Center, San Diego, California, USA
    J Invest Dermatol 129:2489-96. 2009
    ..Taken together, these results indicate that the release of histone H4 by holocrine secretion from the sebaceous gland may play an important role in innate immunity...
  33. pmc Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris
    Yanhan Wang
    Division of Dermatology, Department of Medicine, University of California, San Diego, 3525 John Hopkins Court, Rm276, San Diego, CA, 92121, USA
    Appl Microbiol Biotechnol 98:411-24. 2014
    ..In addition, it will open up an entirely new area of study for the biological function of the skin microbiome in promoting human health. ..
  34. ncbi request reprint Proteomic characterization of skin and epidermis in response to environmental agents
    Chun Ming Huang
    Department of Dermatology, Skin Diseases Research Center, University of Alabama, Birmingham, AL 35294 0019, USA
    Expert Rev Proteomics 2:809-20. 2005
    ....
  35. ncbi request reprint Prospective highlights of functional skin proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mass Spectrom Rev 24:647-60. 2005
    ..This type of research into functional skin proteomics will provide a critical step toward understanding disease and developing successful therapeutic strategies...
  36. ncbi request reprint Use of nanoparticles as therapy for methicillin-resistant Staphylococcus aureus infections
    Pei Feng Liu
    Department of Medicine, University of California, San Diego, 92161, USA
    Curr Drug Metab 10:875-84. 2009
    ..This review emphasized the potential of nanoparticles in the targeted antibiotics for therapy of staphylococcal infections...
  37. pmc Proteomics integrated with Escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes
    Cheng Po Huang
    Moores Cancer Center, University of California, San Diego, CA, USA Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taiwan
    Proteomics Clin Appl 2:1234-45. 2008
    ..In addition, the novel immunogenic SLP potentially serves as an antigen candidate for the development of vaccines targeting P. acnes-associated diseases...
  38. pmc A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis
    Pei Feng Liu
    Department of Medicine, Division of Dermatology, University of California, San Diego, CA 92161, USA
    Vaccine 27:1589-95. 2009
    ..nucleatum. The novel vaccine inducing protective immunity provides an alternative option to conventional antibiotic treatments for chronic halitosis associated with abscesses...
  39. pmc A novel immunogenic spore coat-associated protein in Bacillus anthracis: characterization via proteomics approaches and a vector-based vaccine system
    Yu Tsueng Liu
    Moores Cancer Center, University of California, San Diego, CA, USA
    Protein Expr Purif 57:72-80. 2008
    ..More importantly, the immunogenic SCAP may potentially be a new candidate for the development of anthrax vaccines...
  40. pmc Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity
    Nabiha Yusuf
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 182:675-83. 2009
    ..The results suggest that HSPs form a link between adaptive and innate immunity during the early stages of contact hypersensitivity...
  41. pmc Stimuli-responsive liposome fusion mediated by gold nanoparticles
    Dissaya Pornpattananangkul
    Department of NanoEngineering, University of California at San Diego, La Jolla, California 92093, USA
    ACS Nano 4:1935-42. 2010
    ....
  42. pmc Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA
    J Invest Dermatol 129:2480-8. 2009
    ..acnes-induced ear swelling and granulomatous inflammation. The obtained data highlight the potential of using lauric acid as an alternative treatment for antibiotic therapy of acne vulgaris...
  43. pmc In vivo treatment of Propionibacterium acnes infection with liposomal lauric acids
    Dissaya Pornpattananangkul
    Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA
    Adv Healthc Mater 2:1322-8. 2013
    ..These results suggest that LipoLA hold a high therapeutic potential for the treatment of acne infection and other P. acnes related diseases. ..
  44. ncbi request reprint Recent advances in protein profiling of tissues and tissue fluids
    Shi Yang
    The Burnham Institute for Medical Research, Proteomics Facility, La Jolla, CA 92037, USA
    Expert Rev Proteomics 4:515-29. 2007
    ..Advances in quantitative proteomics will significantly improve protein profiling of tissue and tissue fluid samples collected by CUF probes...
  45. ncbi request reprint In vivo sampling of extracellular beta-thymosin by ultrafiltration probes
    Yu Tsueng Liu
    Moores Cancer Center, University of California, San Diego, CA 92161, USA
    Ann N Y Acad Sci 1112:104-13. 2007
    ..The fabrication and biological application of CUF probes are also described. Data from CUF probe-captured beta-thymosin may guide future exploration of extracellular beta-thymosin...
  46. pmc Mass spectrometry-based label-free quantitative proteomics
    Wenhong Zhu
    Center on Proteolytic Pathways, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biomed Biotechnol 2010:840518. 2010
    ..In this paper, we will discuss the technologies of these label-free quantitative methods, statistics, available computational software, and their applications in complex proteomics studies...
  47. pmc Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
    Yuping Lai
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Nat Med 15:1377-82. 2009
    ..To our knowledge, these findings show for the first time that the skin epithelium requires TLR3 for normal inflammation after wounding and that the microflora can modulate specific cutaneous inflammatory responses...
  48. pmc Vaccines and photodynamic therapies for oral microbial-related diseases
    Pei Feng Liu
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA
    Curr Drug Metab 10:90-4. 2009
    ..The purpose of this article is to highlight the advantages of vaccine therapy and photodynamic therapy for oral microbial-related diseases compared to treatments with antimicrobial agents and traditional periodontal surgery...
  49. doi request reprint Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination
    Woan Ruoh Lee
    Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
    J Control Release 128:200-8. 2008
    ..To reveal the mechanisms underlying these changes, a proteomic technique combined with mass spectrometry was used. This is, to our knowledge, the first report of a laser being used to immunize intact animals...
  50. ncbi request reprint Comparative proteomic analysis of human whole saliva
    Chun Ming Huang
    Center for Neuroscience, National Sun Yat Sen University, Kaohsiung, Taiwan
    Arch Oral Biol 49:951-62. 2004
    ..The proteomic approach identifies candidates from human whole saliva that may prove to be of diagnostic and therapeutic significance...
  51. ncbi request reprint Decreasing systemic toxicity via transdermal delivery of anticancer drugs
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Curr Drug Metab 9:592-7. 2008
    ..The use of a erbium:YAG (Er:YAG) laser for transdermal delivery of anticancer drugs is specifically highlighted in this review...
  52. pmc Breast tumor microenvironment: proteomics highlights the treatments targeting secretome
    Shui Tein Chen
    Institute of Biological Chemistry and the Genomics Research Center, Academia Sinica, Taipei, Taiwan
    J Proteome Res 7:1379-87. 2008
    ..Such in vivo profiling of breast cancer secretomes may facilitate the development of novel drugs specifically targeting secretome...
  53. ncbi request reprint A new N-acetylgalactosamine containing peptide as a targeting vehicle for mammalian hepatocytes via asialoglycoprotein receptor endocytosis
    Ying Ta Wu
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Curr Drug Deliv 1:119-27. 2004
    ....
  54. ncbi request reprint Proteomics reveals protein profile changes in doxorubicin--treated MCF-7 human breast cancer cells
    Shui Tein Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Lett 181:95-107. 2002
    ..Modulation of HSP27 levels may be a clinically useful potential target for design of antitumor drugs and controlling breast tumor growth...
  55. ncbi request reprint Proteomic analysis of lipopolysaccharide-induced apoptosis in PC12 cells
    Ya Hui Huang
    Center for Neuroscience, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    Proteomics 2:1220-8. 2002
    ..Their identification therefore provides an impetus for further delineation of the cellular and molecular basis of apoptotic cell death and sepsis based on proteomic profiling of PC12 cells...

Research Grants10

  1. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    ..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
  2. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
  3. Secretomes captured in vivo via ultrafiltration probes
    Chun Ming Huang; Fiscal Year: 2007
    ..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. ..
  4. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2007
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..