Chou Long Huang

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+
    Jason Lee
    Department of Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 126:439-51. 2005
  2. pmc Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
    Jian Xie
    Department of Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Commun 3:1238. 2012
  3. doi request reprint Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease
    Chou Long Huang
    Department of Internal Medicine, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 22:452-8. 2013
  4. doi request reprint Regulation of ion channels by secreted Klotho
    Chou Long Huang
    Department of Medicine, UT Southwestern Medical Center, Dallas, TX, USA
    Adv Exp Med Biol 728:100-6. 2012
  5. ncbi request reprint Mechanism of regulation of renal ion transport by WNK kinases
    Chou Long Huang
    Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 17:519-25. 2008
  6. doi request reprint WNK kinases and essential hypertension
    Chou Long Huang
    Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 17:133-7. 2008
  7. ncbi request reprint Mechanism of hypokalemia in magnesium deficiency
    Chou Long Huang
    UT Southwestern Medical Center, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 18:2649-52. 2007
  8. ncbi request reprint Complex roles of PIP2 in the regulation of ion channels and transporters
    Chou Long Huang
    UT Southwestern Medical Center, Dept of Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 293:F1761-5. 2007
  9. ncbi request reprint Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension
    Chou Long Huang
    Division of Nephrology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    Nat Clin Pract Nephrol 3:623-30. 2007
  10. ncbi request reprint WNKs: protein kinases with a unique kinase domain
    Chou Long Huang
    Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
    Exp Mol Med 39:565-73. 2007

Research Grants

  1. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2009
  2. Regulation of renal calcium transport
    Chou Long Huang; Fiscal Year: 2010
  3. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2009
  4. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2007
  5. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2006
  6. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2005
  7. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2005
  8. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2004
  9. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2004
  10. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2004

Collaborators

Detail Information

Publications56

  1. pmc PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+
    Jason Lee
    Department of Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 126:439-51. 2005
    ..These results provide a novel mechanism for regulation of TRP channels by phospholipase C-activating hormones via alteration of the sensitivity to intracellular Mg2+...
  2. pmc Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
    Jian Xie
    Department of Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Commun 3:1238. 2012
    ..These results provide a new perspective on the pathogenesis of cardiomyopathies and open new avenues for treatment of the disease...
  3. doi request reprint Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease
    Chou Long Huang
    Department of Internal Medicine, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 22:452-8. 2013
    ..The purpose of this review is to clarify the above concepts and discuss the utility of the currently available tests to assess phosphorus disorders...
  4. doi request reprint Regulation of ion channels by secreted Klotho
    Chou Long Huang
    Department of Medicine, UT Southwestern Medical Center, Dallas, TX, USA
    Adv Exp Med Biol 728:100-6. 2012
    ..Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism...
  5. ncbi request reprint Mechanism of regulation of renal ion transport by WNK kinases
    Chou Long Huang
    Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 17:519-25. 2008
    ..This review summarizes recent advances in the understanding of the mechanism of regulation of renal ion transport by WNK kinases...
  6. doi request reprint WNK kinases and essential hypertension
    Chou Long Huang
    Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 17:133-7. 2008
    ..The present review summarizes recent literature and discusses the potential roles of WNKs in the pathogenesis of essential hypertension...
  7. ncbi request reprint Mechanism of hypokalemia in magnesium deficiency
    Chou Long Huang
    UT Southwestern Medical Center, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 18:2649-52. 2007
    ..Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency...
  8. ncbi request reprint Complex roles of PIP2 in the regulation of ion channels and transporters
    Chou Long Huang
    UT Southwestern Medical Center, Dept of Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 293:F1761-5. 2007
    ..Here, I briefly review several past and recent studies to illustrate the complexities and raise outstanding questions for future studies...
  9. ncbi request reprint Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension
    Chou Long Huang
    Division of Nephrology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    Nat Clin Pract Nephrol 3:623-30. 2007
    ..Here, we review the role of dietary K(+) deficiency in the pathogenesis of salt-sensitive hypertension and summarize recent findings indicating that WNK1 might mediate renal Na(+) retention and hypertension in K(+) deficiency...
  10. ncbi request reprint WNKs: protein kinases with a unique kinase domain
    Chou Long Huang
    Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
    Exp Mol Med 39:565-73. 2007
    ..Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development...
  11. doi request reprint Klotho: a novel regulator of calcium and phosphorus homeostasis
    Chou Long Huang
    Department of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Pflugers Arch 462:185-93. 2011
    ..Through its systematic as well as renal actions, Klotho is emerging as a principal calciophosphoregulatory hormone...
  12. ncbi request reprint The transient receptor potential superfamily of ion channels
    Chou Long Huang
    Division of Nephrology, Department of Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Am Soc Nephrol 15:1690-9. 2004
    ..Mutations of TRP proteins produce many renal diseases, including Mg2+ wasting, hypocalcemia, and polycystic kidney diseases. This review focuses on recent advances in the understanding of their functions...
  13. pmc Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
    Ahmed Lazrak
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Proc Natl Acad Sci U S A 103:1615-20. 2006
    ..Thus, KS-WNK1 is a physiological antagonist of long WNK1. Hyperkalemia in PHA II patients with PHA II mutations may be caused, at least partially, by increased expression of long WNK1 with or without decreased expression of KS-WNK1...
  14. pmc WNK1 activates SGK1 to regulate the epithelial sodium channel
    Bing E Xu
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Proc Natl Acad Sci U S A 102:10315-20. 2005
    ..This finding provides compelling evidence that this molecular mechanism contributes to the pathogenesis of hypertension in pseudohypoaldosteronism type II caused by WNK1 and, possibly, in other forms of hypertension...
  15. ncbi request reprint Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles
    Wei Zhong Zeng
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75390 8856, USA
    Am J Physiol Renal Physiol 283:F630-9. 2002
    ..These results provide compelling evidence for endocytosis of ROMK channels via clathrin-coated vesicles...
  16. ncbi request reprint WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism
    Bing E Xu
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 280:34218-23. 2005
    ..Phosphorylation of WNK1 on Thr-58 contributes to SGK1 activation. Finally, we show that WNK1 is required for the activation of SGK1 by insulin-like growth factor 1...
  17. pmc Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1
    Chih Jen Cheng
    Department of Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 22:460-71. 2011
    ..Taken together, these results suggest that PI3K-activating hormones inhibit ROMK by enhancing its endocytosis via a mechanism that involves phosphorylation of WNK1 by Akt1 and SGK1...
  18. pmc Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase
    Zhen Liu
    Department of Medicine Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Biol Chem 284:12198-206. 2009
    ..Thus, KS-WNK1 is an important physiological regulator of renal K(+) excretion, likely through its effects on the ROMK1 channel...
  19. ncbi request reprint Inhibition of ROMK potassium channel by syntaxin 1A
    Tie Jun Sun
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 288:F284-9. 2005
    ..Binding of synaptobrevin 2 to syntaxin 1A during docking and fusion of transport vesicles to the plasma membranes of CCD may lead to activation of these channels...
  20. pmc Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models
    Zhen Liu
    Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Hum Mol Genet 20:855-66. 2011
    ..Thus, KS-WNK1 is a negative regulator of NCC and NKCC2 in vivo and plays an important role in the control of Na(+) homeostasis and blood pressure. These results have important implications to the pathogenesis of PHA2 with WNK1 mutations...
  21. ncbi request reprint Regulation of TRPV5 single-channel activity by intracellular pH
    Seung Kuy Cha
    Division of Nephrology and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    J Membr Biol 220:79-85. 2007
    ..Thus, intracellular acidification directly inhibits TRPV5 by causing a conformational change(s) leading to a decrease of open probability of TRPV5 as well as of the single-channel conductance...
  22. ncbi request reprint Structural determinants and specificities for ROMK1-phosphoinositide interaction
    Wei Zhong Zeng
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Am J Physiol Renal Physiol 282:F826-34. 2002
    ..These results suggest that phosphatidylinositol 4,5-bisphosphate is likely the important phosphoinositide in the regulation of ROMK1 channels in a physiological membrane milieu...
  23. pmc Intersectin links WNK kinases to endocytosis of ROMK1
    Guocheng He
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Clin Invest 117:1078-87. 2007
    ..Disease-causing WNK4 mutations enhanced interactions of WNK4 with ITSN and ROMK1, leading to increased endocytosis of ROMK1. These results provide a molecular mechanism for stimulation of endocytosis of ROMK1 by WNK kinases...
  24. ncbi request reprint Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH
    Byung Il Yeh
    Center for Mineral Metabolism and Clinical Research and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 8856, USA
    J Biol Chem 278:51044-52. 2003
    ..These data suggest that glutamate 522 of the rabbit TRPV5 is a "pH sensor," and extracellular protons inhibit TRPV5 likely by altering conformation of the channel protein...
  25. ncbi request reprint Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5
    Seung Kuy Cha
    Department of Medicine Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Am J Physiol Renal Physiol 294:F1212-21. 2008
    ..Activation of PKC increases cell surface abundance of TRPV5 by inhibiting the endocytosis. This mechanism of regulation by PKC may contribute to the acute stimulation of TRPV5 and renal Ca(2+) reabsorption by PTH...
  26. pmc Association of urinary sodium/potassium ratio with blood pressure: sex and racial differences
    S Susan Hedayati
    Renal Section, Medical Service, Veterans Affairs North Texas Health Care System, Dallas, TX 75216 7167, USA
    Clin J Am Soc Nephrol 7:315-22. 2012
    ..Previous studies reporting an association between high BP and high sodium and low potassium intake or urinary sodium/potassium ratio (U[Na(+)]/[K(+)]) primarily included white men and did not control for cardiovascular risk factors...
  27. pmc WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade
    Jian Xie
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8856, USA
    J Biol Chem 288:8566-74. 2013
    ..These results indicate that WNK1 activation of the OSR1 signaling cascade is an essential pathway that regulates angiogenesis and cardiac formation during mouse embryo development...
  28. ncbi request reprint Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism
    Wei Zhong Zeng
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Biol Chem 278:16852-6. 2003
    ..These results suggest that reduction of membrane PIP(2) content contributes to the inhibition of ROMK1 channels by PKC. This mechanism may underscore the inhibition of K(+) secretion in CCD by hormones that activate PKC...
  29. pmc WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling
    Sung Wan An
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Curr Biol 21:1979-87. 2011
    ..WNK1 protein kinase is known to regulate ion homeostasis and cause hypertension when expression is increased by gene mutations. However, its signaling functions remain largely elusive...
  30. pmc Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho
    Seung Kuy Cha
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Mol Pharmacol 76:38-46. 2009
    ..Intravenous administration of KLe increases the level of Klotho in urine and increases urinary excretion of K(+). These results suggest that Klotho may have a broader function in the regulation of ion transport in the kidney...
  31. ncbi request reprint Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct
    Po Yin Chu
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 285:F1179-87. 2003
    ..This decrease in the abundance of ROMK is likely important for maintaining K+ homeostasis during K+ deficiency...
  32. pmc Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct
    Chih Jen Cheng
    Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Renal Physiol 304:F397-402. 2013
    ..In addition, KS-WNK1 plays a role in regulating Na(+) transport in the CCD...
  33. pmc Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members
    Charles J Heise
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 285:25161-7. 2010
    ..Further evidence for the importance of WNK1 in this process comes from the ability of Nedd4-2 to bind to WNK1 and the finding that endogenous SGK1 has reduced activity if WNK1 is knocked down by small interfering RNA...
  34. pmc WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C
    Seung Kuy Cha
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Biol Chem 285:6604-11. 2010
    ..This interaction between WNK4 and PKC regulation of TRPV5 may be important for physiological regulation of renal Ca(2+) reabsorption by parathyroid hormones or the tissue kallikrein in vivo...
  35. ncbi request reprint Probing the effects of phosphoinositides on ion channels
    Chou Long Huang
    Department of Medicine, UT Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 337:81-7. 2006
    ..Discussed here are several methods for studying regulation of ion channels by phospholipids...
  36. pmc Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis
    Matthias T F Wolf
    Division of Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Kidney Int 84:130-7. 2013
    ..UMOD upregulates TRPV5 by acting from extracellular and by decreasing endocytosis of TRPV5. The stimulation of Ca(2+) reabsorption via TRPV5 by UMOD may contribute to protection against kidney-stone formation. ..
  37. pmc Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    Seung Kuy Cha
    Departments of Medicine and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:9805-10. 2008
    ..This action of Klotho represents a novel mechanism for regulation of the activity of cell-surface glycoproteins and likely contributes to maintenance of calcium balance by Klotho...
  38. pmc Domains of WNK1 kinase in the regulation of ROMK1
    Hao Ran Wang
    Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Am J Physiol Renal Physiol 295:F438-45. 2008
    ..Thus, multiple intra- and/or intermolecular interactions of WNK1 domains are at play for regulation of ROMK1 by WNK1...
  39. pmc Conformational changes of pore helix coupled to gating of TRPV5 by protons
    Byung Il Yeh
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    EMBO J 24:3224-34. 2005
    ..Rotation of pore helix may be a common mechanism for cross-regulation of ion channels by extra- and intracellular signals...
  40. pmc Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization
    Seung Kuy Cha
    Department of Physiology, Institute of Lifestyle Medicine and Nuclear Receptor Research Consortium, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA Electronic address
    Biochim Biophys Acta 1833:3046-53. 2013
    ..Activation of TRPV5 and TRPV6 by fluid flow may play a role in the regulation of flow-stimulated K(+) secretion via maxi-K channels in distal renal tubules and in the mechanism of pathogenesis of thiazide-induced hypocalciuria. ..
  41. pmc Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis
    Chih Jen Cheng
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8859, USA
    Semin Nephrol 33:237-47. 2013
    ..These recent findings are reviewed. ..
  42. ncbi request reprint Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome
    Jian Xie
    Department of Medicine, Room J5 104, MC 8856, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 8856, USA
    Pediatr Nephrol 21:1231-6. 2006
    ..Here, we review the pathogenesis of PHA II based on current understanding of the actions of WNK1 and WNK4 on Na+ and K+ handling in the renal distal tubule...
  43. pmc Mechanism of thyrotoxic periodic paralysis
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, No 325 Section 2 Cheng Kung Road, Taipei, Taiwan, Republic of China
    J Am Soc Nephrol 23:985-8. 2012
    ....
  44. pmc Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1
    Seung Kuy Cha
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:1828-35. 2011
    ..Thus, the CaR decreases cell surface expression of Kir4.1 channels via a mechanism that involves Gα(q) and caveolin. These results provide a novel molecular basis for the inhibition of renal NaCl transport by the CaR...
  45. pmc Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb
    Chih Jen Cheng
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 303:F667-73. 2012
    ..Thus KS-WNK1 inhibits Na(+) reabsorption in cTAL and mediates the inhibition of Na(+) reabsorption in the segment by a high-K diet...
  46. doi request reprint Regulation of ion channels by secreted Klotho: mechanisms and implications
    Chou Long Huang
    Department of Medicine, UT Southwestern Medical Center, Dallas, Texas
    Kidney Int 77:855-60. 2010
    ..This mini-review focuses on the mechanisms of regulation of cell-surface abundance of ion channels by secreted Klotho and the importance of these effects of Klotho in physiology and pathological conditions...
  47. pmc Recent advances in distal tubular potassium handling
    Aylin R Rodan
    Division of Nephrology, Department of Medicine, UT, USA
    Am J Physiol Renal Physiol 300:F821-7. 2011
    ..We also discuss outstanding questions and propose working models for future investigation...
  48. pmc Distal potassium handling based on flow modulation of maxi-K channel activity
    Aylin R Rodan
    Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 18:350-5. 2009
    ..This review considers several human disorders characterized by hypokalemia and hyperkalemia, as well as mouse models of these disorders, and the mechanisms by which ROMK and maxi-K may be dysregulated...
  49. ncbi request reprint The N-terminal extracellular domain is required for polycystin-1-dependent channel activity
    Victor Babich
    Division of Nephrology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 279:25582-9. 2004
    ..These results support the hypothesis that polycystin-1 is a surface membrane receptor that transduces the signal via changes in ionic currents...
  50. pmc Mechanism of urinary calcium regulation by urinary magnesium and pH
    Olivier Bonny
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Am Soc Nephrol 19:1530-7. 2008
    ..In summary, these data are compatible with the hypothesis that urinary magnesium directly inhibits renal calcium absorption, which can be negated by high luminal pH, and that this regulation likely takes place in the distal tubule...
  51. pmc The Drosophila NKCC Ncc69 is required for normal renal tubule function
    Aylin R Rodan
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Physiol Cell Physiol 303:C883-94. 2012
    ..Thus, Ncc69 plays an important role in transepithelial ion and fluid transport in the fly renal tubule and is a target for regulation in antidiuretic states...
  52. pmc Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis
    Chih Jen Cheng
    Department of Medicine, Division of Nephrology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Biol Chem 286:27425-35. 2011
    ..6 predisposes the sarcolemma to hypokalemia-induced paradoxical depolarization during attacks, which in turn leads to Na(+) channel inactivation and inexcitability of muscles...
  53. pmc Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice
    Jian Xie
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Pathol 175:1315-27. 2009
    ....
  54. doi request reprint Acquired hypocalciuric hypercalcemia in a patient with CKD
    Elizabeth Kuo
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX Electronic address
    Am J Kidney Dis 62:1151-4. 2013
    ..A calcimimetic is an effective treatment for the hypercalcemia and elevated PTH levels in acquired hypocalciuric hypercalcemia caused by inhibitory anti-CaSR autoantibodies. ..
  55. doi request reprint The mechanism of hypocalciuria with NaCl cotransporter inhibition
    Robert F Reilly
    Department of Medicine, VA North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, 4500 South Lancaster Road, Dallas, TX 75390 8856, USA
    Nat Rev Nephrol 7:669-74. 2011
    ..In this Perspectives article, we discuss the evidence supporting the hypocalciuric effects of NaCl cotransporter inhibition in the proximal and distal nephron...
  56. ncbi request reprint On the role of pore helix in regulation of TRPV5 by extracellular protons
    Byung Il Yeh
    Department of Biochemistry and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Kangwondo, 220 701, Republic of Korea
    J Membr Biol 212:191-8. 2006
    ..Inhibition of TRPV5 by extracellular protons may contribute to hypercalciuria in diseases associated with high acid load...

Research Grants19

  1. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2009
    ..Abnormality in blood potassium level causes irregular heart beat, muscle weakness, and sudden death. Our studies aim to understand how kidney excretes potassium in physiological and diseased states. ..
  2. Regulation of renal calcium transport
    Chou Long Huang; Fiscal Year: 2010
    ..Increase in urinary calcium excretion is a major cause for kidney stone formation. Our studies will help to understand why calcium stone forms and to design treatment for the disease. ..
  3. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2009
    ..Abnormality in blood potassium level causes irregular heart beat, muscle weakness, and sudden death. Our studies aim to understand how kidney excretes potassium in physiological and diseased states. ..
  4. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2007
    ..Abnormality in blood potassium level causes irregular heart beat, muscle weakness, and sudden death. Our studies aim to understand how kidney excretes potassium in physiological and diseased states. ..
  5. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2006
    ..Biochemical binding assay and patch-clamp recording will be performed to examine this hypothesis. ..
  6. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2005
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  7. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2005
    ..Biochemical binding assay and patch-clamp recording will be performed to examine this hypothesis. ..
  8. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2004
    ..Biochemical binding assay and patch-clamp recording will be performed to examine this hypothesis. ..
  9. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2004
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  10. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2004
    ..Biochemical binding assay and patch-clamp recording will be performed to examine this hypothesis. ..
  11. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2003
    ..Biochemical binding assay and patch-clamp recording will be performed to examine this hypothesis. ..
  12. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2003
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  13. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2002
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  14. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2001
    ..The structural and functional constraints conferred by Bartter's mutation will be examined by screening libraries of ROMK constructed by saturation mutagenesis in a potassium uptake-defective yeast strains. ..
  15. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2000
    ..The structural and functional constraints conferred by Bartter's mutation will be examined by screening libraries of ROMK constructed by saturation mutagenesis in a potassium uptake-defective yeast strains. ..
  16. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 1999
    ..The structural and functional constraints conferred by Bartter's mutation will be examined by screening libraries of ROMK constructed by saturation mutagenesis in a potassium uptake-defective yeast strains. ..
  17. Membrane Trafficking of Renal Potassium Channel
    Chou Long Huang; Fiscal Year: 2010
    ..Abnormality in blood potassium level causes irregular heart beat, muscle weakness, and sudden death. Our studies aim to understand how kidney excretes potassium in physiological and diseased states. ..