Zhiyuan Hu

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay
    Laurent Perreard
    The ARUP Institute for Clinical and Experimental Pathology, SLC, Utah, USA
    Breast Cancer Res 8:R23. 2006
  2. pmc The molecular portraits of breast tumors are conserved across microarray platforms
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genomics 7:96. 2006
  3. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
  4. ncbi request reprint Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers
    Daniel S Oh
    Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Clin Oncol 24:1656-64. 2006
  5. pmc Molecular characterization of human breast tumor vascular cells
    Rajendra Bhati
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Pathol 172:1381-90. 2008
  6. pmc Quality assurance of RNA expression profiling in clinical laboratories
    Weihua Tang
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599 7525, USA
    J Mol Diagn 14:1-11. 2012
  7. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
  8. pmc Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples
    Fathi Elloumi
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med Genomics 4:54. 2011
  9. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
  10. ncbi request reprint High reproducibility using sodium hydroxide-stripped long oligonucleotide DNA microarrays
    Zhiyuan Hu
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Biotechniques 38:121-4. 2005

Collaborators

Detail Information

Publications10

  1. pmc Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay
    Laurent Perreard
    The ARUP Institute for Clinical and Experimental Pathology, SLC, Utah, USA
    Breast Cancer Res 8:R23. 2006
    ..In the current article, we use microarray analysis and a real-time quantitative reverse-transcription (qRT)-PCR assay to risk-stratify breast cancers based on biological 'intrinsic' subtypes and proliferation...
  2. pmc The molecular portraits of breast tumors are conserved across microarray platforms
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genomics 7:96. 2006
    ..To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list...
  3. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
    ..Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies...
  4. ncbi request reprint Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers
    Daniel S Oh
    Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Clin Oncol 24:1656-64. 2006
    ..Therefore, we developed a gene expression-based outcome predictor for ER+ and/or PR+ (ie, luminal) breast cancer patients using biologic differences among these tumors...
  5. pmc Molecular characterization of human breast tumor vascular cells
    Rajendra Bhati
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Pathol 172:1381-90. 2008
    ..Therefore, these genetic markers may serve as potential targets for the development of angiogenesis inhibitors...
  6. pmc Quality assurance of RNA expression profiling in clinical laboratories
    Weihua Tang
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599 7525, USA
    J Mol Diagn 14:1-11. 2012
    ..Careful attention to the well-honed principles of laboratory medicine, along with guidance from government and professional groups on strategies to preserve RNA and manage large data sets, promotes clinical-grade assay performance...
  7. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  8. pmc Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples
    Fathi Elloumi
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med Genomics 4:54. 2011
    ..This "normal" tissue could represent a source of non-random error or systematic bias in genomic classification...
  9. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
    ..Test sets from 761 patients (no systemic therapy) were evaluated for prognosis, and 133 patients were evaluated for prediction of pathologic complete response (pCR) to a taxane and anthracycline regimen...
  10. ncbi request reprint High reproducibility using sodium hydroxide-stripped long oligonucleotide DNA microarrays
    Zhiyuan Hu
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Biotechniques 38:121-4. 2005
    ..90-0.98, which is comparable to the ICC of two virgin arrays hybridized with the same sample. Using this method, once-stripped oligonucleotide microarrays are usable, reliable, and help to reduce costs...