Research Topics
Species | Zhiyuan HuSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assayLaurent Perreard
The ARUP Institute for Clinical and Experimental Pathology, SLC, Utah, USA
Breast Cancer Res 8:R23. 2006..The proliferation meta-gene offers an objective and quantitative measurement for grade and adds significant prognostic information to the biological subtypes...- The molecular portraits of breast tumors are conserved across microarray platformsZhiyuan Hu
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
BMC Genomics 7:96. 2006..To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list... - A compact VEGF signature associated with distant metastases and poor outcomesZhiyuan Hu
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
BMC Med 7:9. 2009..Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies... 
Estrogen-regulated genes predict survival in hormone receptor-positive breast cancersDaniel S Oh
Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
J Clin Oncol 24:1656-64. 2006..CONCLUSION: This study provides new biologic information concerning differences within hormone receptor-positive breast cancers and a means of predicting long-term outcomes in tamoxifen-treated patients...- Molecular characterization of human breast tumor vascular cellsRajendra Bhati
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Pathol 172:1381-90. 2008..Therefore, these genetic markers may serve as potential targets for the development of angiogenesis inhibitors... - Quality assurance of RNA expression profiling in clinical laboratoriesWeihua Tang
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599 7525, USA
J Mol Diagn 14:1-11. 2012..Careful attention to the well-honed principles of laboratory medicine, along with guidance from government and professional groups on strategies to preserve RNA and manage large data sets, promotes clinical-grade assay performance... - Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumorsJason I Herschkowitz
Lineberger Comprehensive Cancer Center
Genome Biol 8:R76. 2007..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors... - Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samplesFathi Elloumi
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
BMC Med Genomics 4:54. 2011..This "normal" tissue could represent a source of non-random error or systematic bias in genomic classification... - Supervised risk predictor of breast cancer based on intrinsic subtypesJoel S Parker
Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Clin Oncol 27:1160-7. 2009..The prognostic properties of the continuous risk score will be of value for the management of node-negative breast cancers. The subtypes and risk score can also be used to assess the likelihood of efficacy from neoadjuvant chemotherapy... - High reproducibility using sodium hydroxide-stripped long oligonucleotide DNA microarraysZhiyuan Hu
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
Biotechniques 38:121-4. 2005..90-0.98, which is comparable to the ICC of two virgin arrays hybridized with the same sample. Using this method, once-stripped oligonucleotide microarrays are usable, reliable, and help to reduce costs...