Xiaotang Hu

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells
    Xiaotang Hu
    Interdisciplinary Oncology Program, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33161, USA
    Cytokine 37:155-62. 2007
  2. ncbi request reprint Characterization of a unique factor-independent variant derived from human factor-dependent TF-1 cells: a transformed event
    X Hu
    Department of Internal Medicine, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa 33612, USA
    Leuk Res 22:817-26. 1998
  3. ncbi request reprint Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795
    X Hu
    Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center, and Research Institute, Tampa 33612, USA
    Exp Hematol 27:605-14. 1999
  4. ncbi request reprint TNF-alpha-induced growth suppression of CD34+ myeloid leukemic cell lines signals through TNF receptor type I and is associated with NF-kappa B activation
    X Hu
    Division of Medical Oncology and Hematology, Department of Internal Medicine, University South Florida, Tampa 33612, USA
    J Immunol 163:3106-15. 1999
  5. ncbi request reprint Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line
    X Hu
    Department of Internal Medicine, University of South Florida and H Lee Moffitt Cancer Center and Research Institute, Tampa 33612, USA
    Cell Growth Differ 11:191-200. 2000
  6. ncbi request reprint Cell cycle and transcriptional control of human myeloid leukemic cells by transforming growth factor beta
    X Hu
    Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center and Research Institute, Tampa 33612, USA
    Leuk Lymphoma 38:235-46. 2000
  7. ncbi request reprint Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest
    Xiaotang Hu
    Interdisciplinary Oncology Program, Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 277:16528-37. 2002
  8. ncbi request reprint Proteolytic signaling by TNFalpha: caspase activation and IkappaB degradation
    Xiaotang Hu
    Department of Interdisciplinary Oncology, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cytokine 21:286-94. 2003

Detail Information

Publications8

  1. ncbi request reprint TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells
    Xiaotang Hu
    Interdisciplinary Oncology Program, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33161, USA
    Cytokine 37:155-62. 2007
    ..The transient activation of cdc2 and cdc25c and subsequent inhibition of cdc2, cyclin B1, and cdc25c could amplify TGFbeta-induced G1 arrest and growth inhibition...
  2. ncbi request reprint Characterization of a unique factor-independent variant derived from human factor-dependent TF-1 cells: a transformed event
    X Hu
    Department of Internal Medicine, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa 33612, USA
    Leuk Res 22:817-26. 1998
    ..The variant appears to be an excellent model for studying the process of progressive malignant transformation of myeloid cells and for studying signal pathways involved in the spontaneous and factor-induced growth of the cells...
  3. ncbi request reprint Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795
    X Hu
    Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center, and Research Institute, Tampa 33612, USA
    Exp Hematol 27:605-14. 1999
    ....
  4. ncbi request reprint TNF-alpha-induced growth suppression of CD34+ myeloid leukemic cell lines signals through TNF receptor type I and is associated with NF-kappa B activation
    X Hu
    Division of Medical Oncology and Hematology, Department of Internal Medicine, University South Florida, Tampa 33612, USA
    J Immunol 163:3106-15. 1999
    ..Our data also show that TNF-alpha is incapable of inducing activation of the mitogen-activated protein kinase pathway in these leukemic cell lines...
  5. ncbi request reprint Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line
    X Hu
    Department of Internal Medicine, University of South Florida and H Lee Moffitt Cancer Center and Research Institute, Tampa 33612, USA
    Cell Growth Differ 11:191-200. 2000
    ....
  6. ncbi request reprint Cell cycle and transcriptional control of human myeloid leukemic cells by transforming growth factor beta
    X Hu
    Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center and Research Institute, Tampa 33612, USA
    Leuk Lymphoma 38:235-46. 2000
    ..In summary, TGFbeta1 inhibits growth of human myeloid leukemic cells through multiple pathways, whereas the "cdk inhibitor" p27 is both a positive and negative regulator...
  7. ncbi request reprint Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest
    Xiaotang Hu
    Interdisciplinary Oncology Program, Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 277:16528-37. 2002
    ..Additional support for this conclusion was obtained from experiments showing an increase of proteasome activity in TNF-treated cells and in vitro degradation of cyclin D3 by 26 S proteasome...
  8. ncbi request reprint Proteolytic signaling by TNFalpha: caspase activation and IkappaB degradation
    Xiaotang Hu
    Department of Interdisciplinary Oncology, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cytokine 21:286-94. 2003
    ..Both processes involve in proteolysis. This crosstalk may be important for maintaining the balance between the two pathways and for determining whether a cell should live or die...