William T Hu

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Survival profiles of patients with frontotemporal dementia and motor neuron disease
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Arch Neurol 66:1359-64. 2009
  2. ncbi request reprint TDP-43 and frontotemporal dementia
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19106, USA
    Curr Neurol Neurosci Rep 9:353-8. 2009
  3. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
  4. pmc CSF biomarkers cutoffs: the importance of coincident neuropathological diseases
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 124:23-35. 2012
  5. pmc Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease
    William T Hu
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol 120:385-99. 2010
  6. pmc Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 25:1246-52. 2010
  7. doi request reprint Alzheimer's disease and corticobasal degeneration presenting as corticobasal syndrome
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Mov Disord 24:1375-9. 2009
  8. pmc Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol 116:215-20. 2008
  9. ncbi request reprint Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia
    William T Hu
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Alzheimer Dis Assoc Disord 21:S39-43. 2007
  10. pmc Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease
    Alice S Chen-Plotkin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 69:655-63. 2011

Detail Information

Publications17

  1. pmc Survival profiles of patients with frontotemporal dementia and motor neuron disease
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Arch Neurol 66:1359-64. 2009
    ..Frontotemporal dementia and amyotrophic lateral sclerosis are neurodegenerative diseases associated with TAR DNA-binding protein 43- and ubiquitin-immunoreactive pathologic lesions...
  2. ncbi request reprint TDP-43 and frontotemporal dementia
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19106, USA
    Curr Neurol Neurosci Rep 9:353-8. 2009
    ....
  3. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
    ..Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI)...
  4. pmc CSF biomarkers cutoffs: the importance of coincident neuropathological diseases
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 124:23-35. 2012
    ....
  5. pmc Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease
    William T Hu
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol 120:385-99. 2010
    ....
  6. pmc Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 25:1246-52. 2010
    ..In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology...
  7. doi request reprint Alzheimer's disease and corticobasal degeneration presenting as corticobasal syndrome
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Mov Disord 24:1375-9. 2009
    ..AD patients with clinical CBS have similar characteristics to CBD patients. Functional brain imaging may have greater utility than the clinical and neuropsychological features in differentiating AD presenting as CBS from CBD...
  8. pmc Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol 116:215-20. 2008
    ..The distribution of the lesions in this cross-sectional analysis may suggest a progression of TDP-43 pathology in AD, with limbic structures in the medial temporal lobe affected first, followed by higher order association cortices...
  9. ncbi request reprint Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia
    William T Hu
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Alzheimer Dis Assoc Disord 21:S39-43. 2007
    ..In summary, survival in 4R tauopathies seemed independent of the presenting clinical phenotype, and there may be subtle clinical differences between bv-FTD patients with 3R and 4R tauopathies...
  10. pmc Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease
    Alice S Chen-Plotkin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 69:655-63. 2011
    ..Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD...
  11. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  12. ncbi request reprint Clinical features of pathologic subtypes of behavioral--variant frontotemporal dementia
    William T Hu
    Department of Neurology, Mayo Clinic College of Medicine, Rochester MN, USA
    Arch Neurol 64:1611-6. 2007
    ..To identify clinical features in behavioral-variant frontotemporal dementia that may help predict tau-positive pathology...
  13. pmc Biomarkers in frontotemporal lobar degenerations--progress and challenges
    William T Hu
    Department of Neurology, Center for Neurodegenerative Diseases, Emory University, Atlanta, GA 30322, USA
    Prog Neurobiol 95:636-48. 2011
    ..Given the pathologic overlap of FTLD with ALS and PSP, collaboration with specialists in those fields will be essential in the translation of promising FTLD biomarkers into clinical practice...
  14. pmc Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis
    Ryan Vass
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 121:373-80. 2011
    ..These findings implicate the FTLD-TDP risk gene TMEM106B in the development of cognitive impairment in ALS...
  15. doi request reprint From frontotemporal lobar degeneration pathology to frontotemporal lobar degeneration biomarkers
    Chadwick M Hales
    Department of Neurology, Emory Alzheimer s Disease Research Center and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA
    Int Rev Psychiatry 25:210-20. 2013
    ..Finally we will highlight future directions in the FTD field. More research is needed to elucidate the cellular mechanisms of neurodegeneration in FTLD and improve clinical diagnostic capabilities...
  16. ncbi request reprint Cognitive impairment and celiac disease
    William T Hu
    Departments of Neurology, Internal Medicine, Psychology, and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Neurol 63:1440-6. 2006
    ..To characterize the clinical, radiological, and electrophysiological laboratory profiles and histological features of patients who developed cognitive impairment temporally associated with celiac disease...
  17. ncbi request reprint MRI correlates of alien leg-like phenomenon in corticobasal degeneration
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 20:870-3. 2005
    ..The MRI brain scan in both had unique focal abnormalities in the corresponding leg area of the homunculus that may be the substrate for the alien limb features...