Ming Chang Hu

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint Klotho connects intermedin1-53 to suppression of vascular calcification in chronic kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA Electronic address
    Kidney Int 89:534-7. 2016
  2. doi request reprint Renal Production, Uptake, and Handling of Circulating αKlotho
    Ming Chang Hu
    Departments of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas
    J Am Soc Nephrol 27:79-90. 2016
  3. pmc Klotho and phosphate are modulators of pathologic uremic cardiac remodeling
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Departments of Internal Medicine
    J Am Soc Nephrol 26:1290-302. 2015
  4. pmc The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection
    Ming Chang Hu
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8885, USA
    Kidney Int 84:468-81. 2013
  5. pmc Klotho as a potential biomarker and therapy for acute kidney injury
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Nat Rev Nephrol 8:423-9. 2012
  6. pmc The emerging role of Klotho in clinical nephrology
    Ming Chang Hu
    Nephrol Dial Transplant 27:2650-7. 2012
  7. pmc Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 78:1240-51. 2010
  8. pmc Klotho and kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 7390 8855, USA
    J Nephrol 23:S136-44. 2010
  9. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
  10. pmc Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    FASEB J 24:3438-50. 2010

Collaborators

Detail Information

Publications25

  1. doi request reprint Klotho connects intermedin1-53 to suppression of vascular calcification in chronic kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA Electronic address
    Kidney Int 89:534-7. 2016
    ..Intermedin1-53 may be a novel therapeutic agent for CKD. ..
  2. doi request reprint Renal Production, Uptake, and Handling of Circulating αKlotho
    Ming Chang Hu
    Departments of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas
    J Am Soc Nephrol 27:79-90. 2016
    ..Thus, we conclude that the kidney has dual roles in αKlotho homeostasis, producing and releasing αKlotho into the circulation and clearing αKlotho from the blood into the urinary lumen. ..
  3. pmc Klotho and phosphate are modulators of pathologic uremic cardiac remodeling
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Departments of Internal Medicine
    J Am Soc Nephrol 26:1290-302. 2015
    ....
  4. pmc The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection
    Ming Chang Hu
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8885, USA
    Kidney Int 84:468-81. 2013
    ..Thus in the kidney, EpoR and its activity are downstream effectors of Klotho enabling it to function as a cytoprotective protein against oxidative injury. ..
  5. pmc Klotho as a potential biomarker and therapy for acute kidney injury
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Nat Rev Nephrol 8:423-9. 2012
    ..Although data are still emerging, in this Perspectives article we discuss why this renal-derived protein is a highly promising candidate as both an early biomarker and therapeutic agent for AKI...
  6. pmc The emerging role of Klotho in clinical nephrology
    Ming Chang Hu
    Nephrol Dial Transplant 27:2650-7. 2012
    ..Klotho can possibly emerge on the horizon as a candidate for an unprecedented sole biomarker and intervention. Nephrologists should monitor the progress of the preclinical studies and the imminently emerging human database...
  7. pmc Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 78:1240-51. 2010
    ..Thus, endogenous Klotho not only serves as an early biomarker for AKI but also functions as a renoprotective factor with therapeutic potential...
  8. pmc Klotho and kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 7390 8855, USA
    J Nephrol 23:S136-44. 2010
    ..In summary, Klotho is a critical molecule in a wide variety of renal diseases and bears great potential as a diagnostic and prognostic biomarker as well as for therapeutic replacement therapy...
  9. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
    ..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD...
  10. pmc Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    FASEB J 24:3438-50. 2010
    ....
  11. pmc Klotho and chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Contrib Nephrol 180:47-63. 2013
    ..Therefore, Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease...
  12. pmc Secreted klotho and chronic kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Adv Exp Med Biol 728:126-57. 2012
    ..Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease...
  13. pmc α-Klotho protects against oxidative damage in pulmonary epithelia
    Priya Ravikumar
    Departments of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas
    Am J Physiol Lung Cell Mol Physiol 307:L566-75. 2014
    ..Cytoprotection by α-Klotho may play an important role in degenerative diseases of the lung...
  14. pmc Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms
    Ming Chang Hu
    Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Am J Physiol Renal Physiol 304:F1169-80. 2013
    ..In summary, chronic DA inhibits NHE3 with mechanisms distinct from its acute action and involves decreased NHE3 translation and increased NHE3 degradation, which are novel mechanisms for NHE3 regulation...
  15. pmc Klotho has dual protective effects on cisplatin-induced acute kidney injury
    Monica C Panesso
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 85:855-70. 2014
    ..Klotho may be a useful agent to prevent and treat cisplatin-induced nephrotoxicity. ..
  16. pmc Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Annu Rev Physiol 75:503-33. 2013
    ....
  17. pmc Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: role of protein phosphatase 2A
    I Alexandru Bobulescu
    Dept of Internal Medicine, Div of Nephrology, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 298:F1205-13. 2010
    ..These studies demonstrate that PP2A is an integral and critical participant in the signal transduction pathway between dopamine receptor activation and NHE3 inhibition...
  18. pmc Regulation of fibroblast growth factor-23 signaling by klotho
    Hiroshi Kurosu
    Department of Pathology, Pediatrics, and Internal Medicine and Applied Genomics, Genzyme Corporation, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:6120-3. 2006
    ..Thus, Klotho functions as a cofactor essential for activation of FGF signaling by FGF23...
  19. pmc Renal and extrarenal actions of Klotho
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Semin Nephrol 33:118-29. 2013
    ....
  20. pmc The reduction of Na/H exchanger-3 protein and transcript expression in acute ischemia-reperfusion injury is mediated by extractable tissue factor(s)
    Francesca Di Sole
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 80:822-31. 2011
    ..Thus, transferable factor(s) mediate the ischemia-reperfusion injury-induced decrease in NHE3 of the kidney...
  21. pmc Adiponectin promotes functional recovery after podocyte ablation
    Joseph M Rutkowski
    Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Am Soc Nephrol 24:268-82. 2013
    ..Furthermore, the POD-ATTAC mouse provides a platform for further studies, allowing precise timing of podocyte injury and regeneration...
  22. doi request reprint Fibroblast growth factor 23 and acute kidney injury
    Javier A Neyra
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 885, USA
    Pediatr Nephrol 30:1909-18. 2015
    ..More importantly, the biologic effect of increased FGF23 in AKI needs to be defined. ..
  23. pmc αKlotho and vascular calcification: an evolving paradigm
    Ming Chang Hu
    aDepartment of Internal Medicine bThe Charles and Jane Pak Center of Mineral Metabolism and Clinical Research cDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA dCenter for Molecular Medicine, Jichi Medical University Tochigi, Japan eDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Nephrol Hypertens 23:331-9. 2014
    ..Although the molecular mechanism of action of αKlotho is not well understood, the downstream targets and biologic functions of αKlotho are astonishingly pleiotropic. An emerging body of literature links αKlotho to uremic vasculopathy...
  24. pmc Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho
    Seung Kuy Cha
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Mol Pharmacol 76:38-46. 2009
    ..Intravenous administration of KLe increases the level of Klotho in urine and increases urinary excretion of K(+). These results suggest that Klotho may have a broader function in the regulation of ion transport in the kidney...
  25. doi request reprint Klotho, stem cells, and aging
    Ao Bian
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People s Republic of China
    Clin Interv Aging 10:1233-43. 2015
    ..The klotho protein may be a promising therapeutic agent for aging and aging-related disorders. ..