Ke Qin Hu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma
    Yong Ping Yang
    Center of Therapeutic Research for Liver Cancer, The 302nd Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China
    J Transl Med 11:41. 2013
  2. doi request reprint Barriers to screening for hepatitis B virus infection in Asian Americans
    Ke Qin Hu
    Division of GI Hepatology, University of California, Irvine, 101, The City Drive, Building 56, Rt 81, Rm 231, Orange, CA 92868, USA
    Dig Dis Sci 56:3163-71. 2011
  3. doi request reprint Impact of Hispanic or Asian ethnicity on the treatment outcomes of chronic hepatitis C: results from the WIN-R trial
    Ke Qin Hu
    Division of Gastroenterology and Hepatology, University of California Irvine, Orange, CA 92868, USA
    J Clin Gastroenterol 45:720-6. 2011
  4. ncbi request reprint Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veterans
    Ke Qin Hu
    Loma Linda VA Medical Center, Loma Linda, CA, USA
    Dig Dis Sci 52:570-8. 2007
  5. doi request reprint Histologic evidence of active liver injury in chronic hepatitis B patients with normal range or minimally elevated alanine aminotransferase levels
    Ke Qin Hu
    Division of GI Hepatology, University of California Irvine School of Medicine, Orange, CA 92868, USA
    J Clin Gastroenterol 44:510-6. 2010
  6. ncbi request reprint Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases
    Ke Qin Hu
    Division of Gastroenterology and Hepatology and Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, CA 92868, USA
    Prostaglandins Leukot Essent Fatty Acids 69:329-37. 2003
  7. ncbi request reprint Overweight and obesity, hepatic steatosis, and progression of chronic hepatitis C: a retrospective study on a large cohort of patients in the United States
    Ke Qin Hu
    Division of Gastroenterology Hepatology, University of California Irvine, Orange, CA 92868, USA
    J Hepatol 40:147-54. 2004
  8. doi request reprint The clinical presentation of chronic hepatitis B virus infection in Asian Americans: a single center retrospective study
    Jonathan S Mellen
    Department of Medicine parallel, Chao Comprehensive Digestive Disease Center, Irvine Medical Center, Orange, CA 92868, USA
    J Clin Gastroenterol 44:364-70. 2010
  9. ncbi request reprint In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells
    Wei Cui
    Division of Gastroenterology and Chao Family Comprehensive Cancer Center, University of California, Irvine Medical Center, Orange, California 92868, USA
    Clin Cancer Res 11:8213-21. 2005
  10. ncbi request reprint Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma
    Ke Qin Hu
    Division of Gastroenterology, University of California, Irvine Medical Center, Orange, California 92868, USA
    Am J Gastroenterol 99:860-5. 2004

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma
    Yong Ping Yang
    Center of Therapeutic Research for Liver Cancer, The 302nd Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China
    J Transl Med 11:41. 2013
    ..Metastasis-associated in colon cancer-1 (MACC1) overexpression has been associated with poor prognosis of HCC, but its predictive value to post-cryoablation outcomes remains unknown in patients with BCLC stage C HCC...
  2. doi request reprint Barriers to screening for hepatitis B virus infection in Asian Americans
    Ke Qin Hu
    Division of GI Hepatology, University of California, Irvine, 101, The City Drive, Building 56, Rt 81, Rm 231, Orange, CA 92868, USA
    Dig Dis Sci 56:3163-71. 2011
    ..Although the overall prevalence of HBV infection in the United States is low (<1%), it is high (~10%) in Asian Americans. However, HBV screening rates in this population have been reported to be low...
  3. doi request reprint Impact of Hispanic or Asian ethnicity on the treatment outcomes of chronic hepatitis C: results from the WIN-R trial
    Ke Qin Hu
    Division of Gastroenterology and Hepatology, University of California Irvine, Orange, CA 92868, USA
    J Clin Gastroenterol 45:720-6. 2011
    ..The aim of this subanalysis of the Weight-based Dosing of PegINterferon α-2b and Ribavirin (WIN-R) study was to assess the impact of Asian (n=118), Hispanic (n=289), and white (n=3919) ethnicity on CHC treatment outcomes...
  4. ncbi request reprint Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veterans
    Ke Qin Hu
    Loma Linda VA Medical Center, Loma Linda, CA, USA
    Dig Dis Sci 52:570-8. 2007
    ..We found that steatosis is independently associated with stage III-IV fibrosis. However, only HCV genotype, and not steatosis, obesity, or stage III-IV fibrosis, was associated with SVR to interferon alpha-2b and ribavirin treatment...
  5. doi request reprint Histologic evidence of active liver injury in chronic hepatitis B patients with normal range or minimally elevated alanine aminotransferase levels
    Ke Qin Hu
    Division of GI Hepatology, University of California Irvine School of Medicine, Orange, CA 92868, USA
    J Clin Gastroenterol 44:510-6. 2010
    ..Sub-analysis was performed to determine whether HEALD based upon liver biopsy better correlates with ALT using modified ALT (30 men/19 women) upper limit of normal (ULN) criteria compared with local conventional laboratory...
  6. ncbi request reprint Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases
    Ke Qin Hu
    Division of Gastroenterology and Hepatology and Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, CA 92868, USA
    Prostaglandins Leukot Essent Fatty Acids 69:329-37. 2003
    ..This provided rationale for further testing COX2 inhibitors as clinical agents for HCC chemoprovention. Further studies will be needed to examine how COX2 inhibitors affect pathogenesis of various liver diseases...
  7. ncbi request reprint Overweight and obesity, hepatic steatosis, and progression of chronic hepatitis C: a retrospective study on a large cohort of patients in the United States
    Ke Qin Hu
    Division of Gastroenterology Hepatology, University of California Irvine, Orange, CA 92868, USA
    J Hepatol 40:147-54. 2004
    ..Hepatic steatosis has been associated with chronic hepatitis C (CHC), but its prevalence, risk factors, and clinical significance remain to be determined...
  8. doi request reprint The clinical presentation of chronic hepatitis B virus infection in Asian Americans: a single center retrospective study
    Jonathan S Mellen
    Department of Medicine parallel, Chao Comprehensive Digestive Disease Center, Irvine Medical Center, Orange, CA 92868, USA
    J Clin Gastroenterol 44:364-70. 2010
    ..The clinical course of chronic hepatitis B virus (HBV) infection varies with ethnicity. Little is known about the clinical presentation of chronic HBV infection in Asian Americans...
  9. ncbi request reprint In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells
    Wei Cui
    Division of Gastroenterology and Chao Family Comprehensive Cancer Center, University of California, Irvine Medical Center, Orange, California 92868, USA
    Clin Cancer Res 11:8213-21. 2005
    ..The related mechanisms remain to be determined. The present study was aimed to determine the effect of celecoxib on growth of hepatocellular carcinoma cells and xenografts and the related mechanisms...
  10. ncbi request reprint Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma
    Ke Qin Hu
    Division of Gastroenterology, University of California, Irvine Medical Center, Orange, California 92868, USA
    Am J Gastroenterol 99:860-5. 2004
    ..Although elevated serum alpha-fetoprotein (AFP) is often seen in patients with chronic hepatitis C (CHC), its prevalence, risk factors, and clinical significance remain to be determined...
  11. ncbi request reprint Intraoperative hypokalemia in pediatric liver transplantation: incidence and risk factors
    Victor W Xia
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1778, USA
    Anesth Analg 103:587-93. 2006
    ..These findings support the use of K+ replacement to maintain normokalemia and avoid the potential complications related to hypokalemia in pediatric liver transplantation, especially in children with the risk factors for hypokalemia...
  12. ncbi request reprint Effects and mechanisms of silibinin on human hepatoma cell lines
    John J Lah
    Division of Gastroenterology, University of California, Irvine Medical Center, 101 The City Drive, Building 53, Suite 113, Orange, CA 92868, United States
    World J Gastroenterol 13:5299-305. 2007
    ..To investigate in vitro effects and mechanisms of silibinin on hepatocellular carcinoma (HCC) cell growth...
  13. ncbi request reprint Clinical presentation of chronic hepatitis C in patients with end-stage renal disease and on hemodialysis versus those with normal renal function
    Ke Qin Hu
    Division of Gastroenterology and Hepatology, University of California, Irvine Medical Center, Orange, California 92868, USA
    Am J Gastroenterol 100:2010-8. 2005
    ..The natural history of chronic hepatitis C (CHC) remains to be defined in patients with end-stage renal disease (ESRD)...
  14. ncbi request reprint Charcoal-based hemodiabsorption liver support for episodic type C hepatic encephalopathy
    Kevin Hill
    Department of Internal Medicine, Transplantation Institute, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA
    Am J Gastroenterol 98:2763-70. 2003
    ..We prospectively studied extracorporeal liver support for AHE failing to respond to medical therapy to assess its safety and efficacy and the role of anticoagulation...
  15. doi request reprint In-vivo effects and mechanisms of celecoxib-reduced growth of cyclooxygenase-2 (COX-2)-expressing versus COX-2-deleted human HCC xenografts in nude mice
    Wei Cui
    Division of Gastroenterology and Hepatology, University of California, Irvine Medical Center, Orange, CA, USA
    Anticancer Drugs 19:891-7. 2008
    ..In conclusion, celecoxib suppresses growth of HuH7 xenografts regardless of COX-2 expression, which may be mediated through different signaling...
  16. ncbi request reprint Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor
    Ke Qin Hu
    Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Int J Oncol 22:757-63. 2003
    ..Our findings confirmed an effective inhibitory effect of NS-398 on proliferation of COX-2 expressing human hepatoma cells through a decreased COX-2/PG activity that is associated with altered cell cycle progression and apoptotic rate...
  17. doi request reprint Factors associated with hepatic fibrosis in patients with chronic hepatitis C: a retrospective study of a large cohort of U.S. patients
    Shirley X Hu
    Earl Warren College, University of California, San Diego, CA, USA
    J Clin Gastroenterol 43:758-64. 2009
    ..To determine the risk factors for stage 3 and 4 fibrosis in a large cohort of U.S. patients with chronic hepatitis C (CHC)...
  18. ncbi request reprint Preoperative characteristics and intraoperative transfusion and vasopressor requirements in patients with low vs. high MELD scores
    Victor W Xia
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1778, USA
    Liver Transpl 12:614-20. 2006
    ..In conclusion, these data suggest that pretransplant MELD scores provide important information for perioperative management of patients undergoing liver transplantation...
  19. ncbi request reprint Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors
    Ke Qin Hu
    Transplantation Institute Division of Gastroenterology, Loma Linda University Medical Center, 11234 Anderson Street, Rm 1405, Loma Linda, CA 92354, USA
    J Lab Clin Med 139:234-43. 2002
    ....
  20. ncbi request reprint Occult hepatitis B virus infection and its clinical implications
    Ke Qin Hu
    Transplantation Institute and Division of Gastroenterology, Loma Linda University Medical Center and Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92354, USA
    J Viral Hepat 9:243-57. 2002
    ..Highly sensitive, quantitative, and functional molecular analyses of HBV, combined with a well-designed prospective clinical assessment will provide the best approach for the future study of occult HBV infection...
  21. ncbi request reprint Formal heparin anticoagulation protocol improves safety of charcoal-based liver-assist treatments
    Donald J Hillebrand
    Division of Gastroenterology Hepatology Scripps Clinic, Irvine, CA, USA
    ASAIO J 52:334-42. 2006
    ..3 vs 15.8 units/patient, p = 0.13) and fewer complications (16.7% vs 66.7%, p = 0.15) in group 2. Anticoagulation using ACT monitoring, heparin dose-response curves, and a target ACT of 300 seconds improves the safety of LDU treatments...
  22. ncbi request reprint MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitis
    Wichit Srikureja
    Division of Gastroenterology, Loma Linda University Medical Center, Loma Linda, CA, USA
    J Hepatol 42:700-6. 2005
    ....
  23. ncbi request reprint Nephrogenic fibrosing dermopathy after liver transplantation successfully treated with plasmapheresis
    Pedro W Baron
    Department of Surgery, Loma Linda University Medical Center, 11234 Anderson Street, Room 1405, PO Box 2000, Loma Linda, CA 92354, USA
    Am J Dermatopathol 25:204-9. 2003
    ..Preliminary studies (unpublished data) show that decreasing plasma levels of transforming growth factor-beta1 after plasmapheresis appear to correlate with the amelioration of this clinical condition...
  24. doi request reprint Storage age of transfused red blood cells during liver transplantation and its intraoperative and postoperative effects
    Jun Chen
    Department of Anesthesiology, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 3325, Los Angeles, CA 90095 7430, USA
    World J Surg 36:2436-42. 2012
    ..We studied perioperative effects of RBC storage age in patients undergoing orthotopic liver transplant (OLT)...
  25. pmc Clinical presentation of hepatocellular carcinoma (HCC) in Asian-Americans versus non-Asian-Americans
    Philip Y Wong
    Department of Internal Medicine, University of California Irvine School of Medicine, Irvine, CA, USA
    J Immigr Minor Health 13:842-8. 2011
    ..8%, P = 0.001). Asian-American patients with HCC presented with a higher incidence of history and family history of HBV infection, lower incidence of hepatic decompensation, lower Child and MELD scores, and an early stage HCC disease...
  26. doi request reprint Postliver transplant acute renal injury and failure by the RIFLE criteria in patients with normal pretransplant serum creatinine concentrations: a matched study
    Jie Chen
    Department of Anesthesiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095 7430, USA
    Transplantation 91:348-53. 2011
    ..The aims of this study were to identify the incidence, risk factors, and impact of ARI and ARF in this patient population...
  27. ncbi request reprint Predictors of hyperkalemia in the prereperfusion, early postreperfusion, and late postreperfusion periods during adult liver transplantation
    Victor W Xia
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1778, USA
    Anesth Analg 105:780-5. 2007
    ..Hyperkalemia poses serious hazards to patients undergoing orthotopic liver transplantation (OLT), and its predictors have not been thoroughly examined...
  28. doi request reprint Hepatitis B virus (HBV) infection in Asian and Pacific Islander Americans (APIAs): how can we do better for this special population?
    Ke Qin Hu
    Division of Gastroenterology and Hepatology, University of California, Irvine School of Medicine, Irvine, California, USA
    Am J Gastroenterol 103:1824-33. 2008
    ....
  29. ncbi request reprint Fatal spontaneous gallbladder variceal bleeding in a patient with alcoholic cirrhosis
    Eric C Chu
    Division of Gastroenterology, Loma Linda University Medical Center, Loma Linda, California 92354, USA
    Dig Dis Sci 47:2682-5. 2002
    ..The diagnosis of gallbladder varices eluded conventional imaging and was made only at autopsy. Gallbladder variceal hemorrhage is a rare, but potentially catastrophic complication of cirrhosis...
  30. pmc Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice
    Wei Cui
    Division of Gastroenterology, University of California Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA
    World J Gastroenterol 15:1943-50. 2009
    ..To investigate the in vivo effects and mechanisms of silibinin on the growth of hepatocellular carcinoma (HCC) xenografts in nude mice...
  31. pmc Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells
    Wei Cui
    Division of Gastroenterology and Hepatology, Dept of Medicine, University of California Irvine, CA, USA
    Am J Transl Res 2:95-104. 2010
    ..In the absence of exogenous inflammatory mediators, OA-induced steatosis results in a series of pathophysilogical changes in HepG2 cells, indicating direct pathogenic roles of hepatocytes in NAFLD...
  32. doi request reprint Hepatobiliary manifestations of gastrointestinal and nutritional disorders
    Jason B Samarasena
    Division of Gastroenterology, University of California Irvine Medical Center, 101 The City Drive, City Tower, Suite 400, Zot 4092, Orange, CA 92868, USA
    Clin Liver Dis 15:89-110. 2011
    ....
  33. ncbi request reprint Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection
    Edmund J Bini
    VA New York Harbor Healthcare System and NYU School of Medicine, New York, New York 10010, USA
    Am J Gastroenterol 100:1772-9. 2005
    ..The aims of this study were to determine the proportion of HCV-infected veterans who were eligible for interferon alfa and ribavirin therapy and to evaluate barriers to HCV treatment...
  34. doi request reprint Can we predict the degree of fibrosis in chronic hepatitis C patients using routine blood tests in our daily practice?
    Ramsey C Cheung
    VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    J Clin Gastroenterol 42:827-34. 2008
    ..To determine the validity of fibrosis indexes based on simple laboratory tests in daily practice...
  35. ncbi request reprint Treatment eligibility and outcomes in elderly patients with chronic hepatitis C: results from the VA HCV-001 Study
    Judith I Tsui
    San Francisco VAMC, 4150 Clement St, San Francisco, CA 94121, USA
    Dig Dis Sci 53:809-14. 2008
    ..We undertook this study to determine if treatment candidacy and outcomes were similar between elderly and non-elderly patients...
  36. ncbi request reprint Octreotide/Midodrine therapy significantly improves renal function and 30-day survival in patients with type 1 hepatorenal syndrome
    Eric Esrailian
    Division of Digestive Diseases, David Geffen School of Medicine at UCLA, USA
    Dig Dis Sci 52:742-8. 2007
    ..05). This large retrospective study suggests that octreotide/midodrine treatment appears to improve 30-day survival. A randomized, controlled trial is the next important step toward evaluating this treatment modality...

Research Grants1

  1. Suppression of Hepatoma Cell Growth by Celecoxib
    Ke Qin Hu; Fiscal Year: 2004
    ..abstract_text> ..