Howard Hu

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Personal characteristics related to the risk of adolescent internet addiction: a survey in Shanghai, China
    Jian Xu
    Xinhua Hospital, MOE Shanghai Key Laboratory of Children s Environmental Health, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    BMC Public Health 12:1106. 2012
  2. pmc Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study
    Hector Lamadrid-Figueroa
    Division of Program Evaluation and Biostatistics, Center for Research in Evaluation and Surveys, National Institute of Public Health, Cuernavaca, Mexico
    BMC Pregnancy Childbirth 7:22. 2007
  3. pmc The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:455-62. 2007
  4. pmc Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1730-5. 2006
  5. pmc The challenge posed to children's health by mixtures of toxic waste: the Tar Creek superfund site as a case-study
    Howard Hu
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Room 1518, Vaughan Building SPH I, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Pediatr Clin North Am 54:155-75, x. 2007
  6. pmc HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health 9:43. 2010
  7. pmc Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 50:1053-61. 2008
  8. pmc Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline
    Florence T Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:1210-5. 2007
  9. pmc Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 166:1400-8. 2007
  10. pmc Association between prenatal lead exposure and blood pressure in children
    Aimin Zhang
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 120:445-50. 2012

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Personal characteristics related to the risk of adolescent internet addiction: a survey in Shanghai, China
    Jian Xu
    Xinhua Hospital, MOE Shanghai Key Laboratory of Children s Environmental Health, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    BMC Public Health 12:1106. 2012
    ..This study aims to explore the prevalence of AIA and associated symptoms in a large population-based sample in Shanghai and identify potential predictors related to personal characteristics...
  2. pmc Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study
    Hector Lamadrid-Figueroa
    Division of Program Evaluation and Biostatistics, Center for Research in Evaluation and Surveys, National Institute of Public Health, Cuernavaca, Mexico
    BMC Pregnancy Childbirth 7:22. 2007
    ..Women with a tendency to have a higher plasma/whole blood Pb ratio could tend towards an elevated risk of miscarriage due to a higher plasma Pb for a given whole blood Pb and would consequently have a history of spontaneous abortion...
  3. pmc The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:455-62. 2007
    ..In addition, we also discuss methodologic challenges that arise in studies of occupationally and environmentally exposed subjects and those concerning race/ethnicity and socioeconomic status and other important covariates...
  4. pmc Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1730-5. 2006
    ..The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure...
  5. pmc The challenge posed to children's health by mixtures of toxic waste: the Tar Creek superfund site as a case-study
    Howard Hu
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Room 1518, Vaughan Building SPH I, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Pediatr Clin North Am 54:155-75, x. 2007
    ..This article discusses the issue of toxic mixtures and children's health by focusing on the specific example of mining waste at the Tar Creek Superfund Site in Northeast Oklahoma...
  6. pmc HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health 9:43. 2010
    ..Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight...
  7. pmc Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 50:1053-61. 2008
    ..We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men...
  8. pmc Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline
    Florence T Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:1210-5. 2007
    ..As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship...
  9. pmc Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 166:1400-8. 2007
    ..004). These results augment evidence of a deleterious association between lead and psychiatric symptoms...
  10. pmc Association between prenatal lead exposure and blood pressure in children
    Aimin Zhang
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 120:445-50. 2012
    ..Altered prenatal nutrition is associated with subsequent risks of adult hypertension, but little is known about whether prenatal exposure to toxicants, such as lead, may also confer such risks...
  11. pmc Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City
    J Richard Pilsner
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Am J Clin Nutr 92:226-34. 2010
    ..The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations...
  12. pmc Bone lead level prediction models and their application to examine the relationship of lead exposure and hypertension in the Third National Health and Nutrition Examination Survey
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    J Occup Environ Med 51:1422-36. 2009
    ..We developed prediction models for bone lead using blood lead levels and other standard covariates in a community-based cohort of older men...
  13. pmc Variants in iron metabolism genes predict higher blood lead levels in young children
    Marianne R Hopkins
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 116:1261-6. 2008
    ..Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children...
  14. pmc Critical windows of fetal lead exposure: adverse impacts on length of gestation and risk of premature delivery
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory Street, Ann Arbor, MI 48109, USA
    J Occup Environ Med 52:1106-11. 2010
    ..We assessed the trimester-specific effect of prenatal lead exposure on gestational age and risk of premature delivery...
  15. pmc Lead exposure and rate of change in cognitive function in older women
    Melinda C Power
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA Department of Environmental Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA Electronic address
    Environ Res 129:69-75. 2014
    ..Higher long-term cumulative lead exposure predicts faster cognitive decline in older men, but evidence of an association in women is lacking...
  16. pmc Cumulative lead exposure in community-dwelling adults and fine motor function: comparing standard and novel tasks in the VA normative aging study
    Rachel Grashow
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 35:154-61. 2013
    ....
  17. pmc Associations of early childhood manganese and lead coexposure with neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 120:126-31. 2012
    ..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
  18. pmc Early postnatal blood manganese levels and children's neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:433-9. 2010
    ..Previous studies have addressed the effects of prenatal exposure, but little is known about developmental effects of early postnatal exposure...
  19. pmc Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function
    Ki Do Eum
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 39:65-71. 2013
    ..We investigated whether the GSTP1 Val105 and GSTM1 deletion polymorphisms modify the lead-cognitive function association...
  20. ncbi Influence of maternal bone lead burden and calcium intake on levels of lead in breast milk over the course of lactation
    Adrienne S Ettinger
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 163:48-56. 2006
    ....
  21. pmc Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study
    Junenette L Peters
    Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:361-6. 2012
    ..However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between lead and multiple biomarkers of CVD...
  22. pmc HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study
    Aimin Zhang
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 118:1261-6. 2010
    ..Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulative lead exposure on measures of adult cognition and cardiac function...
  23. pmc Effect of breast milk lead on infant blood lead levels at 1 month of age
    Adrienne S Ettinger
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, Boston, MA 02215, USA
    Environ Health Perspect 112:1381-5. 2004
    ..However, because human milk is the best and most complete nutritional source for young infants, breast-feeding should be encouraged because the absolute values of the effects are small within this range of lead concentrations...
  24. pmc Air pollution and heart rate variability: effect modification by chronic lead exposure
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Epidemiology 19:111-20. 2008
    ..Outdoor air pollution and lead exposure can disturb cardiac autonomic function, but the effects of both these exposures together have not been studied...
  25. pmc Windows of lead exposure sensitivity, attained height, and body mass index at 48 months
    Myriam Afeiche
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Pediatr 160:1044-9. 2012
    ..To examine longitudinal associations of prenatal, infancy, and early childhood lead exposure during sensitive periods with height and body mass index (BMI)...
  26. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
    ..Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism...
  27. pmc Maternal self-esteem, exposure to lead, and child neurodevelopment
    Pamela J Surkan
    Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 29:278-85. 2008
    ..Moreover, there was evidence that maternal self-esteem attenuated the negative effects of lead exposure, although the interaction fell short of conventional levels of statistical significance...
  28. ncbi Cumulative lead exposure and cognitive performance among elderly men
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Epidemiology 18:59-66. 2007
    ..Recent evidence suggests that cumulative lead exposure among adults in nonoccupational settings can adversely affect cognitive function. Which cognitive domains are affected has not been explored in detail...
  29. pmc Prospective cohort study of lead exposure and electrocardiographic conduction disturbances in the Department of Veterans Affairs Normative Aging Study
    Ki Do Eum
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:940-4. 2011
    ....
  30. pmc Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 112:746-50. 2004
    ..Among elderly men, subjects with HFE variants had lower patella lead levels. These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores...
  31. pmc Stress as a potential modifier of the impact of lead levels on blood pressure: the normative aging study
    Junenette L Peters
    Department of Environmental Health, Harvard Shool of Public Health, Boston, MA 02215, USA
    Environ Health Perspect 115:1154-9. 2007
    ..Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated...
  32. pmc Longitudinal changes in bone lead levels: the VA Normative Aging Study
    Elissa Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Occup Environ Med 53:850-5. 2011
    ..We examined repeated measures of bone lead over 11 years to characterize long-term changes and identify predictors of tibia and patella lead stores in an elderly male population...
  33. ncbi Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
    Am J Epidemiol 160:1184-93. 2004
    ..The data suggest that higher patella bone lead levels, a marker of mobilizable accumulated lead burden, are associated with a steeper decline over time in performance on the MMSE test among nonoccupationally exposed elderly men...
  34. pmc Lead, diabetes, hypertension, and renal function: the normative aging study
    Shirng Wern Tsaih
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1178-82. 2004
    ....
  35. pmc Assessing windows of susceptibility to lead-induced cognitive deficits in Mexican children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 33:1040-7. 2012
    ..The identification of susceptible periods to Pb-induced decrements in childhood cognitive abilities remains elusive...
  36. pmc Cumulative lead exposure and age-related hearing loss: the VA Normative Aging Study
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Hear Res 269:48-55. 2010
    ..Our results suggest that chronic low-level lead exposure may be an important risk factor for age-related hearing loss and reduction of lead exposure could help prevent or delay development of age-related hearing loss...
  37. pmc Association of cumulative lead exposure with Parkinson's disease
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:1609-13. 2010
    ....
  38. ncbi HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 114:2798-805. 2006
    ..Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system...
  39. pmc Biomarkers of lead exposure and DNA methylation within retrotransposons
    Robert O Wright
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:790-5. 2010
    ..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead...
  40. pmc Relation of cumulative low-level lead exposure to depressive and phobic anxiety symptom scores in middle-age and elderly women
    Ki Do Eum
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 120:817-23. 2012
    ..Different lines of evidence suggest that low-level lead exposure could be a modifiable risk factor for adverse psychological symptoms, but little work has explored this relation...
  41. pmc Prenatal lead exposure and weight of 0- to 5-year-old children in Mexico city
    Myriam Afeiche
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1436-41. 2011
    ..Cumulative prenatal lead exposure, as measured by maternal bone lead burden, has been associated with smaller weight of offspring at birth and 1 month of age, but no study has examined whether this effect persists into early childhood...
  42. pmc Cumulative community-level lead exposure and pulse pressure: the normative aging study
    Todd Perlstein
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Environ Health Perspect 115:1696-700. 2007
    ..Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease...
  43. pmc Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Am J Epidemiol 167:1171-81. 2008
    ..3, -0.9) for the WRAVMA. Fish consumption of < or =2 servings/week was not associated with a benefit. Dietary recommendations for pregnant women should incorporate the nutritional benefits as well as the risks of fish intake...
  44. pmc Traffic-related particles are associated with elevated homocysteine: the VA normative aging study
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory Street, SPH II M6240, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 178:283-9. 2008
    ..Particulate air pollution has been related to cardiovascular death and hospital admission, but the underlying mechanisms are not fully elucidated...
  45. pmc Interaction of stress, lead burden, and age on cognition in older men: the VA Normative Aging Study
    Junenette L Peters
    Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:505-10. 2010
    ..However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined...
  46. pmc Iron metabolism genes, low-level lead exposure, and QT interval
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 117:80-5. 2009
    ....
  47. pmc Bone lead and endogenous exposure in an environmentally exposed elderly population: the normative aging study
    Huiling Nie
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 51:848-57. 2009
    ..The objective of this study is to investigate the mobilization of lead from bone to blood (endogenous exposure) in a large epidemiologic population...
  48. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009
    ..Epigenetic fetal programming via DNA methylation may provide a pathway by which environmental lead exposure can influence disease susceptibility...
  49. ncbi Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico
    Gamola Z Fortenberry
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Environ Res 132:342-9. 2014
    ..27 points higher (95% CI (0.002, 4.53) for maternal PON1192QQ in comparison to PON1192QR+RR. Because maternal PON1 polymorphisms were associated with child ADHD-LP, this may be a viable biomarker of susceptibility for ADHD-LP...
  50. pmc Maternal dietary intake of polyunsaturated fatty acids modifies the relationship between lead levels in bone and breast milk
    Manish Arora
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 138:73-9. 2008
    ..Monounsaturated fatty acids did not modify the relationship between lead levels in patella and breast milk. In conclusion, higher maternal dietary intake of PUFA may limit the transfer of lead from bone to breast milk...
  51. pmc Black-white blood pressure disparities: depressive symptoms and differential vulnerability to blood lead
    Margaret T Hicken
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 121:205-9. 2013
    ..Differential vulnerability, through which stress alters vulnerability to the effects of environmental hazards, is an emergent notion in environmental health that may contribute to these disparities...
  52. pmc Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics
    Kelly M Bakulski
    University of Michigan, School of Public Health, Department of Environmental Health Sciences, MI, USA
    Curr Alzheimer Res 9:563-73. 2012
    ..Future studies that use a cohort design to measure both Pb exposure and validated epigenetic biomarkers of LOAD will be useful to clarify this important relationship...
  53. pmc Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study
    Junenette L Peters
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Am J Epidemiol 174:1345-53. 2011
    ..Results demonstrate an interrelated role of lead burden and SES over the life course in relation to psychological functioning in older age...
  54. pmc Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health 9:62. 2010
    ....
  55. pmc Fruit, vegetable, and fish consumption and heart rate variability: the Veterans Administration Normative Aging Study
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 South Observatory Street, Ann Arbor, MI 48109, USA
    Am J Clin Nutr 89:778-86. 2009
    ..Higher intakes of fruit, vegetables, and dark fish may prevent sudden cardiac death and arrhythmias, but the exact mechanisms are not fully understood...
  56. pmc Cumulative exposure to lead in relation to cognitive function in older women
    Jennifer Weuve
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:574-80. 2009
    ..Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women...
  57. ncbi Predictors of blood lead in children in Chennai, India (2005-2006)
    Ananya Roy
    University of Michigan School of Public Health 109 Observatory St, 1700 SPH i, Ann Arbor, MI 48109 2029, USA
    Int J Occup Environ Health 15:351-9. 2009
    ..Industrial activity, water storage vessels, and lower socio-economic status are predictors of elevated blood lead in this population, but additional work is required to better define preventable risk factors...
  58. ncbi Dietary calcium as a potential modifier of the relationship of lead burden to blood pressure
    Sahar F Elmarsafawy
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 17:531-7. 2006
    ..There is evidence of an interaction between these factors. We tested the hypothesis that dietary calcium intake modifies the relationship between lead burden and hypertension...
  59. ncbi Season modifies the relationship between bone and blood lead levels: the Normative Aging Study
    Steve Oliveira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Environ Health 57:466-72. 2002
    ....
  60. pmc Lead levels and ischemic heart disease in a prospective study of middle-aged and elderly men: the VA Normative Aging Study
    Nitin B Jain
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 115:871-5. 2007
    ..Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes...
  61. pmc Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites
    Jennifer Weuve
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1424-31. 2006
    ....
  62. pmc Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one month postpartum
    Adrienne S Ettinger
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Landmark East 3 110A, Boston, MA 02215, USA
    Environ Health Perspect 112:926-31. 2004
    ....
  63. pmc Environmental cadmium and lead exposures and hearing loss in U.S. adults: the National Health and Nutrition Examination Survey, 1999 to 2004
    Yoon Hyeong Choi
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 120:1544-50. 2012
    ..Although cadmium and lead are known risk factors for hearing loss in animal models, few epidemiologic studies have been conducted on their associations with hearing ability in the general population...
  64. pmc A novel look at racial health disparities: the interaction between social disadvantage and environmental health
    Margaret T Hicken
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Public Health 102:2344-51. 2012
    ..Specifically, we examined (1) whether race modifies the association between blood lead and blood pressure and (2) whether socioeconomic status (SES) plays a role in this modifying effect...
  65. pmc Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
    Environ Health Perspect 115:519-23. 2007
    ..Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans...
  66. pmc Urinary phthalate metabolites in relation to preterm birth in Mexico city
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 117:1587-92. 2009
    ..Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role...
  67. pmc Lead exposure and behavior among young children in Chennai, India
    Ananya Roy
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 117:1607-11. 2009
    ..Lead exposure has long been associated with deficits in IQ among children. However, few studies have assessed the impact of lead on specific domains of behavior and cognition...
  68. ncbi Apolipoprotein E genotype predicts 24-month bayley scales infant development score
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusett 02115, USA
    Pediatr Res 54:819-25. 2003
    ..These results suggest that subjects with the E4 isoform of APOE may have advantages over those with the E2 or E3 isoforms with respect to early life neuronal/brain development...
  69. pmc Low-level lead exposure, metabolic syndrome, and heart rate variability: the VA Normative Aging Study
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1718-24. 2006
    ..Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure...
  70. pmc Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey
    Mi Sun Lee
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Res 111:171-6. 2011
    ..We examined the associations of cadmium exposure with cardiovascular disease in nationally representative general Korean adults...
  71. pmc A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Circulation 120:1056-64. 2009
    ..The association between bone lead levels and mortality has not been explored...
  72. pmc Maternal blood manganese levels and infant birth weight
    Ami R Zota
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:367-73. 2009
    ..High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies have examined the effects of human fetal manganese exposure...
  73. pmc Effect of calcium supplementation on blood lead levels in pregnancy: a randomized placebo-controlled trial
    Adrienne S Ettinger
    Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:26-31. 2009
    ..Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of maternal bone lead and/or intestinal absorption of ingested lead...
  74. ncbi Relationship of bone and blood lead levels to psychiatric symptoms: the normative aging study
    Daniel Rhodes
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Occup Environ Med 45:1144-51. 2003
    ..05 level. Tibia and blood lead had similar associations. We conclude that cumulative lead exposure, which bone lead levels reflect, could be a risk factor for psychiatric symptoms even at modest levels of exposure...
  75. ncbi Correlates of bone and blood lead levels among middle-aged and elderly women
    Susan A Korrick
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 156:335-43. 2002
    ....
  76. pmc A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study
    Ming Tsang Wu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 111:335-41. 2003
    ..Additional research is needed to ascertain whether this constitutes a true gene-environment interaction and, if so, its clinical impact...
  77. pmc Cumulative lead exposure and tooth loss in men: the normative aging study
    Manish Arora
    Environmental and Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:1531-4. 2009
    ..Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor for tooth loss...
  78. ncbi Maternal lead exposure and the secondary sex ratio
    John F Jarrell
    Harvard School of Public Health, Harvard University, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hum Reprod 21:1901-6. 2006
    ..A reduction in the secondary sex ratio may be associated with exposure to environmental toxicants. Little data exists relating this outcome to lead exposure, a well-known reproductive toxicant...
  79. ncbi A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India
    David C Bellinger
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Int J Occup Environ Health 11:138-43. 2005
    ..0+/-22.5, respectively. Behavior ratings were not associated with blood lead level. Lead exposure is a significant problem among Indian children, with many having blood lead levels associated with increased neurodevelopmental risk...
  80. doi Bone lead levels and blood pressure endpoints: a meta-analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Epidemiology 19:496-504. 2008
    ..We performed a meta-analysis of the association of bone lead levels with systolic blood pressure, diastolic blood pressure, and hypertension using published data...
  81. pmc Maternal arsenic exposure and impaired glucose tolerance during pregnancy
    Adrienne S Ettinger
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1059-64. 2009
    ..Accumulating evidence has shown an increased risk of type 2 diabetes in general populations exposed to arsenic, but little is known about exposures during pregnancy and the association with gestational diabetes (GD)...
  82. ncbi Lead exposure biomarkers and mini-mental status exam scores in older men
    Robert O Wright
    Division of Emergency Medicine, Department of Pediatrics, Boston Children s Hospital, Boston, MA, USA
    Epidemiology 14:713-8. 2003
    ..We studied whether lead exposure biomarkers are associated with cognitive test scores, as well as the modifying effects of age on the lead-cognition relationship...
  83. ncbi Occupational determinants of bone and blood lead levels in middle aged and elderly men from the general community: the Normative Aging Study
    Sahar F Elmarsafawy
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Ind Med 42:38-49. 2002
    ..Few studies of the general population have investigated risk factors for elevated levels of lead in bone in relation to occupation...
  84. pmc Impacts of climate change on public health in India: future research directions
    Kathleen F Bush
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 119:765-70. 2011
    ..More research is needed, particularly in developing countries, to accurately predict the anticipated impacts and inform effective interventions...
  85. pmc Statistical methods to study timing of vulnerability with sparsely sampled data on environmental toxicants
    Brisa Ney Sánchez
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Environ Health Perspect 119:409-15. 2011
    ..Identifying windows of vulnerability to environmental toxicants is an important area in children's health research...
  86. ncbi Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study
    Ahmed Gomaa
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Pediatrics 110:110-8. 2002
    ..Our objective was to compare lead levels in umbilical cord blood and maternal bone as independent predictors of infant mental development using a prospective design...
  87. ncbi Accumulated lead exposure and risk of age-related cataract in men
    Debra A Schaumberg
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Mass 02215 1204, USA
    JAMA 292:2750-4. 2004
    ..Several studies have documented the presence of lead in lenses with cataract. The intrusion of lead into the lens may alter lens redox status and cause protein conformational changes that decrease lens transparency...
  88. pmc Childhood correlates of blood lead levels in Mumbai and Delhi
    Nitin B Jain
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 114:466-70. 2006
    ..In India, it has been reported that nearly half of the children have elevated blood lead levels (BLLs). However, little is known about risk factors for these elevated BLLs...
  89. doi A combined ecological and epidemiologic investigation of metal exposures amongst Indigenous peoples near the Marlin Mine in Western Guatemala
    Niladri Basu
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States
    Sci Total Environ 409:70-7. 2010
    ....
  90. ncbi Invited commentary: lead, bones, women, and pregnancy--the poison within?
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 156:1088-91. 2002
  91. pmc Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
    Environ Health Perspect 112:620-5. 2004
    ..Nevertheless, the results point to the potential utility of MRS in determining mechanisms of neurotoxicity not only for lead but also for other neurotoxicants as well...
  92. ncbi Lead exposure in Mexican radiator repair workers
    Ronald Dykeman
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Ind Med 41:179-87. 2002
    ..RRWs were employed at 4 radiator repair shops in Mexico City and 27 shops in Cuernavaca and surrounding areas...
  93. pmc Cadmium exposure and nephropathy in a 28-year-old female metals worker
    Richard Wittman
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 110:1261-6. 2002
    ....
  94. ncbi Risk factors for multisymptom illness in US Army veterans of the Gulf War
    Jessica Wolfe
    Women s Health Sciences Division, National Center for PTSD, Boston Environmental Hazards Center, 150 South Huntington Avenue, Boston, MA, USA
    J Occup Environ Med 44:271-81. 2002
    ..Analyses in which subjects were stratified by level of psychological symptoms revealed different sets of GW-service environmental exposures and suggest that subgroups of GW veterans may have different sets of risk factors...
  95. ncbi Lead exposure and amyotrophic lateral sclerosis
    Freya Kamel
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Epidemiology 13:311-9. 2002
    ..Previous interview-based studies have suggested that exposure to neurotoxicants including metals might be related to ALS...
  96. pmc The relationship between lead in plasma and whole blood in women
    Donald Smith
    Environmental Toxicology, University of California, Santa Cruz, CA 95604, USA
    Environ Health Perspect 110:263-8. 2002
    ..g., brain, kidney, skeleton), the routine assessment of plasma Pb may provide a more meaningful measure of toxicologically available Pb...
  97. doi The faroes statement: human health effects of developmental exposure to chemicals in our environment
    Philippe Grandjean
    Basic Clin Pharmacol Toxicol 102:73-5. 2008
  98. ncbi Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City
    Martha M Téllez-Rojo
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Pediatrics 118:e323-30. 2006
    ..Using data from a prospective study conducted in Mexico City, Mexico, we evaluated the dose-effect relationship between blood lead levels and neurodevelopment at 12 and 24 months of age...
  99. ncbi Biological markers of fetal lead exposure at each stage of pregnancy
    Hector Lamadrid-Figueroa
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    J Toxicol Environ Health A 69:1781-96. 2006
    ..Collectively, these data suggest that at elevated maternal blood Pb levels the developing fetus may be at greater risk of Pb exposure from increased maternal plasma Pb than otherwise predicted from whole-blood Pb levels...
  100. pmc Recommendations for medical management of adult lead exposure
    Michael J Kosnett
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80202, USA
    Environ Health Perspect 115:463-71. 2007
    ..Chelation may have an adjunctive role in the medical management of highly exposed adults with symptomatic lead intoxication but is not recommended for asymptomatic individuals with low blood lead concentrations...
  101. pmc Relationship of blood and bone lead to menopause and bone mineral density among middle-age women in Mexico City
    Francisco Garrido Latorre
    Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Environ Health Perspect 111:631-6. 2003
    ..These results support the hypothesis that release of bone lead stores increases during menopause and constitutes an internal source of exposure possibly associated with health effects in women in menopause transition...

Research Grants35

  1. LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMES
    Howard Hu; Fiscal Year: 2001
    ....
  2. GENE-METAL INTERACTIONS AND PARKINSON'S DISEASE
    Howard Hu; Fiscal Year: 2002
    ..abstract_text> ..
  3. LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMES
    Howard Hu; Fiscal Year: 2002
    ....
  4. GENE-METAL INTERACTIONS AND PARKINSON'S DISEASE
    Howard Hu; Fiscal Year: 2003
    ..abstract_text> ..
  5. GENE-METAL INTERACTIONS AND PARKINSON'S DISEASE
    Howard Hu; Fiscal Year: 2004
    ..abstract_text> ..
  6. LEAD-GENE INTERACTIONS AND CONGNITION
    Howard Hu; Fiscal Year: 2003
    ..Results of this research promise to shed further light on lead's potential impact on society and may also give rise to tools for identifying susceptible individuals as well as early brain effects. ..
  7. LEAD-GENE INTERACTIONS AND CONGNITION
    Howard Hu; Fiscal Year: 2004
    ..Results of this research promise to shed further light on lead's potential impact on society and may also give rise to tools for identifying susceptible individuals as well as early brain effects. ..
  8. GENE-METAL INTERACTIONS AND PARKINSON'S DISEASE
    Howard Hu; Fiscal Year: 2005
    ..abstract_text> ..
  9. LEAD-GENE INTERACTIONS AND CONGNITION
    Howard Hu; Fiscal Year: 2005
    ..Results of this research promise to shed further light on lead's potential impact on society and may also give rise to tools for identifying susceptible individuals as well as early brain effects. ..
  10. GENE-METAL INTERACTIONS AND PARKINSON'S DISEASE
    Howard Hu; Fiscal Year: 2006
    ..abstract_text> ..
  11. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2007
    ..This research promises to provide key insights into mechanisms of neurotoxicity, individual susceptibility, and both behavior and cognition as toxic endpoints. ..
  12. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2006
    ..This research promises to provide key insights into mechanisms of neurotoxicity, individual susceptibility, and both behavior and cognition as toxic endpoints. ..
  13. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2008
    ..This research promises to provide key insights into mechanisms of neurotoxicity, individual susceptibility, and both behavior and cognition as toxic endpoints. ..
  14. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2009
    ..This research promises to provide key insights into mechanisms of neurotoxicity, individual susceptibility, and both behavior and cognition as toxic endpoints. ..
  15. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2008
    ..This research promises to provide key insights into mechanisms of neurotoxicity, individual susceptibility, and both behavior and cognition as toxic endpoints. ..
  16. LEAD BIOMARKERS AGING AND CHRONIC DISEASE
    Howard Hu; Fiscal Year: 2001
    ..If the second mechanism dominates, it would then be important to examine factors that influence bone lead, with important implications for the development of possible strategies for secondary prevention of toxicity from bone lead. ..
  17. LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMES
    Howard Hu; Fiscal Year: 2000
    ....
  18. LEAD BIOMARKERS AGING AND CHRONIC DISEASE
    Howard Hu; Fiscal Year: 2000
    ..If the second mechanism dominates, it would then be important to examine factors that influence bone lead, with important implications for the development of possible strategies for secondary prevention of toxicity from bone lead. ..
  19. LEAD BIOMARKERS AGING AND CHRONIC DISEASE
    Howard Hu; Fiscal Year: 1999
    ..If the second mechanism dominates, it would then be important to examine factors that influence bone lead, with important implications for the development of possible strategies for secondary prevention of toxicity from bone lead. ..
  20. EPIDEMIOLOGY OF LEAD, DIET AND BLOOD PRESSURE
    Howard Hu; Fiscal Year: 1991
    ..Finally, we outline our strategy for analysis of the data including specific approaches for the blood lead-blood pressure data at multiple points in time...
  21. EPIDEMIOLOGY OF LEAD, DIET AND BLOOD PRESSURE
    Howard Hu; Fiscal Year: 1992
    ..Finally, we outline our strategy for analysis of the data including specific approaches for the blood lead-blood pressure data at multiple points in time...
  22. EPIDEMIOLOGY OF LEAD, DIET AND BLOOD PRESSURE
    Howard Hu; Fiscal Year: 1993
    ..Finally, we outline our strategy for analysis of the data including specific approaches for the blood lead-blood pressure data at multiple points in time...
  23. LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMES
    Howard Hu; Fiscal Year: 1999
    ....
  24. LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMES
    Howard Hu; Fiscal Year: 1999
    ....
  25. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2010
    ..This research promises to provide key insights into mechanisms of neurotoxicity, individual susceptibility, and both behavior and cognition as toxic endpoints. ..