Hailiang Hu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc ATM is down-regulated by N-Myc-regulated microRNA-421
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:1506-11. 2010
  2. pmc MicroRNAs: new players in the DNA damage response
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Mol Cell Biol 3:151-8. 2011
  3. pmc ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response
    Nathan T Martin
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Genet 9:e1003505. 2013
  4. pmc A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene
    Liutao Du
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Ther 21:1653-60. 2013
  5. ncbi request reprint SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs
    Peiyee Lee
    Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, California 90095, USA
    Nat Commun 4:1824. 2013
  6. ncbi request reprint Synthesis and evaluation of compounds that induce readthrough of premature termination codons
    Michael E Jung
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA 90095, United States
    Bioorg Med Chem Lett 21:5842-8. 2011
  7. pmc Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum
    Liutao Du
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Hum Mol Genet 20:3151-60. 2011
  8. pmc Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration
    Hailiang Hu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Cell Biol 28:1573-83. 2008
  9. pmc Nonaminoglycoside compounds induce readthrough of nonsense mutations
    Liutao Du
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Exp Med 206:2285-97. 2009
  10. ncbi request reprint Common copy number variations in fifty radiosensitive cell lines
    Xinmin Li
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Genomics 99:96-100. 2012

Collaborators

Detail Information

Publications13

  1. pmc ATM is down-regulated by N-Myc-regulated microRNA-421
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:1506-11. 2010
    ..Taken together, our findings implicate a previously undescribed regulatory mechanism for ATM expression and ATM-dependent DNA damage response and provide several potential targets for treating neuroblastoma and perhaps A-T...
  2. pmc MicroRNAs: new players in the DNA damage response
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Mol Cell Biol 3:151-8. 2011
    ....
  3. pmc ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response
    Nathan T Martin
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Genet 9:e1003505. 2013
    ..Taken together, these findings strongly suggest that an ATM-dependent CREB-miR-335-CtIP axis influences the selection of HRR for repair of certain DSB lesions...
  4. pmc A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene
    Liutao Du
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Ther 21:1653-60. 2013
    ..We also identified another two active RTCs in the primary screen, RTC204 and RTC219, which share a key structural feature with GJ072 and its analogs...
  5. ncbi request reprint SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs
    Peiyee Lee
    Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, California 90095, USA
    Nat Commun 4:1824. 2013
    ..This platform allows for efficient screening of novel compounds, identification of target and off-target effects, and preclinical testing on relevant cell types for the pathogenic dissection and treatment of ataxia telangiectasia...
  6. ncbi request reprint Synthesis and evaluation of compounds that induce readthrough of premature termination codons
    Michael E Jung
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA 90095, United States
    Bioorg Med Chem Lett 21:5842-8. 2011
    ..In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity...
  7. pmc Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum
    Liutao Du
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Hum Mol Genet 20:3151-60. 2011
    ..Taken together, these results highlight the therapeutic potential of (RXRRBR)(2)XB-AMOs in A-T and other neurogenetic disorders...
  8. pmc Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration
    Hailiang Hu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Cell Biol 28:1573-83. 2008
    ..These findings shed new light on the basis for distinct interpretations of TGF-beta signaling by normal versus transformed cells...
  9. pmc Nonaminoglycoside compounds induce readthrough of nonsense mutations
    Liutao Du
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Exp Med 206:2285-97. 2009
    ..The two compounds also demonstrated readthrough activity in mdx mouse myotube cells carrying a nonsense mutation and induced significant amounts of dystrophin protein...
  10. ncbi request reprint Common copy number variations in fifty radiosensitive cell lines
    Xinmin Li
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Genomics 99:96-100. 2012
    ..The dominance of the chromosomal gains over losses is inconsistent with the traditional concept of molecular basis of RS and suggests more complex genetic mechanisms for RS...
  11. ncbi request reprint Defective DNA double-strand break repair in pediatric systemic lupus erythematosus
    Robert C Davies
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Arthritis Rheum 64:568-78. 2012
    ..We undertook this study to assess the integrity of DSB recognition, signaling, and repair mechanisms in B lymphoblastoid cell lines derived from patients with pediatric SLE...
  12. pmc RIN1 is a breast tumor suppressor gene
    Marc Milstein
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cancer Res 67:11510-6. 2007
    ....
  13. pmc New approaches to treatment of primary immunodeficiencies: fixing mutations with chemicals
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1732, USA
    Curr Opin Allergy Clin Immunol 8:540-6. 2008
    ..This review is to highlight the most current mutation-targeted therapeutic approaches and provide insights into new developments for treating primary immunodeficiencies...