Hui Chen Hsu

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 9:166-75. 2008
  2. pmc Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:5692-700. 2002
  3. pmc CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis
    Zhongyu Liu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 112:1332-41. 2003
  4. ncbi request reprint In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin
    Jian Chen
    Department of Medicine, University of Alabama at Birmingham, and Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Hum Gene Ther 17:669-82. 2006
  5. pmc IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16
    Shutao Xie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:2289-96. 2010
  6. pmc IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells
    Yanna Ding
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 191:1614-24. 2013
  7. ncbi request reprint CD8 T-cell immune phenotype of successful aging
    Hui Chen Hsu
    The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology Rheumatology, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mech Ageing Dev 127:231-9. 2006
  8. ncbi request reprint BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model
    William E Grizzle
    Department of Pathology, University of Alabama at Birmingham, AL 35294 0007, USA
    Int J Cancer 101:270-9. 2002
  9. ncbi request reprint Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:1145-58. 2002
  10. pmc Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
    Hui Chen Hsu
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Rheum 63:2038-48. 2011

Detail Information

Publications40

  1. ncbi request reprint Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 9:166-75. 2008
    ..These findings suggest a mechanism by which IL-17 drives autoimmune responses by promoting the formation of spontaneous GCs...
  2. pmc Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:5692-700. 2002
    ....
  3. pmc CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis
    Zhongyu Liu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 112:1332-41. 2003
    ..Our results suggest that CII-DC-AdTRAIL+DOX cell gene therapy is a safe and effective method for inhibiting the development of CIA...
  4. ncbi request reprint In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin
    Jian Chen
    Department of Medicine, University of Alabama at Birmingham, and Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Hum Gene Ther 17:669-82. 2006
    ..These results provide important implications concerning the development of safe and effective Ad vectors for gene therapy and vaccines...
  5. pmc IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16
    Shutao Xie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:2289-96. 2010
    ..These findings identify the signaling pathway regulated by IL-17 to contribute to the development of spontaneous germinal centers in autoimmune BXD2 mice...
  6. pmc IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells
    Yanna Ding
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 191:1614-24. 2013
    ..These data suggest a novel concept that TFH differentiation and its stabilization in the LZ are two separate checkpoints and that IL-21 and IL-17 act at each checkpoint to enable pathogenic GC development. ..
  7. ncbi request reprint CD8 T-cell immune phenotype of successful aging
    Hui Chen Hsu
    The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology Rheumatology, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mech Ageing Dev 127:231-9. 2006
    ..Increased AICD may result in enhanced rejuvenation capacity of T cells and limit the impact of aging on T cell function in nonagenarians...
  8. ncbi request reprint BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model
    William E Grizzle
    Department of Pathology, University of Alabama at Birmingham, AL 35294 0007, USA
    Int J Cancer 101:270-9. 2002
    ..The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains...
  9. ncbi request reprint Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:1145-58. 2002
    ..6 cM, and 18.0 cM, respectively. Our results suggest that several genetic loci regulate the intra-thymic T-cell maturation process and play an important role in determining age-related decline in thymic T-cell development...
  10. pmc Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
    Hui Chen Hsu
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Rheum 63:2038-48. 2011
    ..To determine whether functional suppression of the catalytic domain of activation-induced cytidine deaminase (AID) can suppress the hyperreactive germinal center (GC) responses in BXD2 mice...
  11. ncbi request reprint Novel tumor necrosis factor alpha-regulated genes in rheumatoid arthritis
    Huang Ge Zhang
    The University of Alabama at Birmingham, and the Birmingham Department of Veterans Affairs Medical Center, Birmingham, AL 35294 0007, USA
    Arthritis Rheum 50:420-31. 2004
    ..To determine novel genes regulated by tumor necrosis factor alpha (TNFalpha) signaling in primary rheumatoid arthritis synovial fibroblasts (RASFs)...
  12. ncbi request reprint Tumor necrosis factor ligand-receptor superfamily and arthritis
    Hui Chen Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Dir Autoimmun 9:37-54. 2006
    ....
  13. ncbi request reprint Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j mice
    Huang Ge Zhang
    University of Alabama, Birmingham, AL 35294, USA
    J Immunol 168:4164-72. 2002
    ..These results indicate that the CII-reactive T cells play a crucial role in the development of CII-induced arthritis and that the anti-CII Abs act to enhance the development of CII-induced arthritis...
  14. ncbi request reprint Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells
    Huang Ge Zhan
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Immunol Res 26:235-46. 2002
    ....
  15. pmc Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice
    Hao Li
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:4465-9. 2013
    ..Lack of clearance of apoptotic debris by MZMs drives follicular Ag-transportation by MZ-P B cells to stimulate an autoimmune response...
  16. pmc Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice
    John H Wang
    University of Alabama, Birmingham, AL, USA
    Arthritis Rheum 63:1054-64. 2011
    ..To investigate the role of CD86(high) marginal zone (MZ) precursor B cells in type I interferon (IFN)-induced T cell-dependent responses in autoimmune BXD2 mice...
  17. ncbi request reprint Genetic regulation of thymic involution
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mech Ageing Dev 126:87-97. 2005
    ..Our results suggest the possibility to identify the complex molecular network that can be associated with the regulation of thymic involution in aged mice using a high-dimensional functional genomics approach...
  18. ncbi request reprint IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation
    Lina Li
    Department of Pathology, Veterans Administration Medical Center, Birmingham, AL 35233, USA
    J Immunol 172:2909-16. 2004
    ..Our data strongly support the role of IL-12 as an enhancement cytokine, which acts through its interactions with other cytokines to maintain thymic T cell function and development during aging...
  19. pmc Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession
    Jian Chen
    1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Ther 16:1500-6. 2008
    ....
  20. pmc Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3
    Jian Chen
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mech Ageing Dev 131:29-37. 2010
    ..These results suggest a model in which IGFBP3, leptin and T3 act as non-immune factors to maintain a larger pool of naïve CD8 T cells in healthy nonagenarians...
  21. pmc Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity
    John H Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:442-51. 2010
    ....
  22. ncbi request reprint Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 178:5357-65. 2007
    ..Taken together, our data indicate that AID expression in B cells is a promising therapeutic target for the treatment of autoimmune diseases and that suppression of this gene may be a molecular target of CTLA4-Ig therapy...
  23. ncbi request reprint Principal component analysis of quantitative trait loci for immune response to adenovirus in mice
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0007, USA
    Hereditas 143:189-97. 2006
    ..01 and 31.01 cM) and 15 (29.21, 36.01, and 56.31 cM). These results illustrate the use of principal component analysis in mapping QTLs using multiple correlated traits...
  24. pmc Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:12023-31. 2002
    ..These observations demonstrate the feasibility of producing high-titer AAV containing a 6xHis-tagged AAV VP3 capsid protein and to utilize the 6xHis-tagged VP3 capsid to achieve high-affinity purification of this recombinant AAV...
  25. ncbi request reprint Genetic analysis of the antibody response to AAV2 and factor IX
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mol Ther 11:866-74. 2005
    ..66) for anti-cF.IX. These results indicate that multiple genetic loci independently regulate the isotype-specific antibody response to the AAV2 capsid and the cF.IX transgene...
  26. pmc IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt
    Hao Li
    1 Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA 2 Department Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Commun 5:4259. 2014
    ..These results extend the action of IL-23 beyond its peripheral effects to a unique role in TCR-mediated negative selection including elimination of natural T regulatory cells in the thymus. ..
  27. ncbi request reprint Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis
    Hui Chen Hsu
    University of Alabama at Birmingham, 701 South 19th Street, Birmingham, AL 35294, USA
    Arthritis Rheum 54:343-55. 2006
    ..The goal of this study was to identify the antigenic target proteins and epitopes and to unravel the mechanisms by which the related conditions arise in BXD2 mice...
  28. ncbi request reprint Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis
    Yalei Wu
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Arthritis Rheum 52:3257-68. 2005
    ..This study was undertaken to explore the roles of hyperproliferating synovial fibroblasts and macrophages in abnormal osteoclast formation, using the recently described BXD2 mouse model of RA...
  29. pmc Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease
    John D Mountz
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Discov Med 11:76-85. 2011
    ..This promotes a prolonged stable interaction of B and T cells in the GC that induces high levels of activation-induced cytidine deaminase (AICDA) thereby enabling development of pathogenic autoantibody-producing B cells...
  30. pmc Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model
    Jun Li
    University of Alabama at Birmingham, AL, USA
    Arthritis Rheum 64:1098-109. 2012
    ..To determine the therapeutic efficacy and immunomodulatory effect of an anti-human death receptor 5 (DR5) antibody, TRA-8, in eliminating macrophage subsets in a mouse model of type II collagen-induced arthritis (CIA)...
  31. ncbi request reprint Beneficial influences of systemic cooperation and sociological behavior on longevity
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:963-73. 2002
    ....
  32. ncbi request reprint Impaired apoptosis and immune senescence - cause or effect?
    Hui Chen Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, 35294, USA
    Immunol Rev 205:130-46. 2005
    ..Based on the accumulating evidence, we propose that the emergence of the FasL(lo) AICD-senescent T cells is not only an effect of immune aging but also an important cause of T-cell proliferative senescence in both humans and mice...
  33. ncbi request reprint Origin of late-onset autoimmune disease
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 701 South 19th Street, Lyons Harrison Research Building 473, Birmingham, AL 35294, USA
    Immunol Allergy Clin North Am 23:65-82, vi. 2003
    ..A decreased T-cell activation response that occurs with age leads to several defects that diminish the immune response...
  34. pmc Managing macrophages in rheumatoid arthritis by reform or removal
    Jun Li
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, SHEL Bldg, Suite 337, 1825 University Blvd, Birmingham, AL 35294 2182, USA
    Curr Rheumatol Rep 14:445-54. 2012
    ....
  35. pmc Metabolic syndrome, hormones, and maintenance of T cells during aging
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Opin Immunol 22:541-8. 2010
    ..Therefore, better understanding of metabolic syndrome, T-cell metabolism, hormones, and microbiota may lead to new insights into the maintenance of proper immune responses in old age...
  36. ncbi request reprint Molecular imaging: new applications for biochemistry
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, Center for Nuclear Imaging Research, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Biochem Suppl 39:162-71. 2002
    ..Advances in genomics and proteomics combine with new peptide-chemistry approaches should provide a large number of targets and tracers in the near future to achieve these imaging objectives...
  37. ncbi request reprint Regulation of apoptosis proteins in cancer cells by ubiquitin
    Huang Ge Zhang
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:2009-15. 2004
    ....
  38. ncbi request reprint Nur77 family of nuclear hormone receptors
    Hui Chen Hsu
    The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology and Rheumatology, Birmingham, Alabama 35294, USA
    Curr Drug Targets Inflamm Allergy 3:413-23. 2004
    ....
  39. ncbi request reprint Quantitative trait locus (QTL) mapping in aging systems
    Hui Chen Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 371:321-48. 2007
    ....
  40. pmc Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach
    Qiana L Matthews
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
    Virol J 5:98. 2008
    ..Our study describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology...