Jenny Hsieh

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Orchestrating transcriptional control of adult neurogenesis
    Jenny Hsieh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 26:1010-21. 2012
  2. ncbi request reprint Chromatin remodeling in neural development and plasticity
    Jenny Hsieh
    Department of Molecular Biology and Cecil H and Ida Green Center for Reproductive Biology Sciences, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Curr Opin Cell Biol 17:664-71. 2005
  3. pmc Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind
    Jenny Hsieh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, TX 75390, USA
    Neurobiol Dis 39:73-84. 2010
  4. pmc The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination
    Ying Chen
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 12:1398-406. 2009
  5. pmc Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development
    Rusty L Montgomery
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 106:7876-81. 2009
  6. pmc Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule
    David Petrik
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    FASEB J 26:3148-62. 2012
  7. pmc Neurod1 is essential for the survival and maturation of adult-born neurons
    Zhengliang Gao
    Department of Molecular Biology and Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 12:1090-2. 2009
  8. pmc The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells
    Zhengliang Gao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:9772-86. 2011
  9. pmc Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells
    Jessica L Ables
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:10484-92. 2010
  10. pmc Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression
    Ling Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Differentiation 81:233-42. 2011

Research Grants

  1. Epigenetic regulation of adult neurogenesis
    Jenny Hsieh; Fiscal Year: 2009
  2. Epigenetic regulation of adult neurogenesis
    Jenny Hsieh; Fiscal Year: 2010

Collaborators

Detail Information

Publications22

  1. pmc Orchestrating transcriptional control of adult neurogenesis
    Jenny Hsieh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 26:1010-21. 2012
    ....
  2. ncbi request reprint Chromatin remodeling in neural development and plasticity
    Jenny Hsieh
    Department of Molecular Biology and Cecil H and Ida Green Center for Reproductive Biology Sciences, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Curr Opin Cell Biol 17:664-71. 2005
    ..These epigenetic mechanisms include cell-type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and the activity of retrotransposons...
  3. pmc Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind
    Jenny Hsieh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, TX 75390, USA
    Neurobiol Dis 39:73-84. 2010
    ....
  4. pmc The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination
    Ying Chen
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 12:1398-406. 2009
    ....
  5. pmc Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development
    Rusty L Montgomery
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 106:7876-81. 2009
    ..These results reveal redundant and essential roles for HDAC1 and HDAC2 in the progression of neuronal precursors to mature neurons in vivo...
  6. pmc Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule
    David Petrik
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    FASEB J 26:3148-62. 2012
    ..Thus, Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intrinsic molecular pathway regulating adult neurogenesis...
  7. pmc Neurod1 is essential for the survival and maturation of adult-born neurons
    Zhengliang Gao
    Department of Molecular Biology and Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 12:1090-2. 2009
    ..Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons...
  8. pmc The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells
    Zhengliang Gao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:9772-86. 2011
    ..Our work identifies REST/NRSF as a master negative regulator of adult NSC differentiation and offers a potential molecular target for neuroregenerative approaches...
  9. pmc Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells
    Jessica L Ables
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:10484-92. 2010
    ..These data shed light on the complex relationship between Type-1 NSCs, adult neurogenesis, the neurogenic niche, and environmental stimuli...
  10. pmc Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression
    Ling Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Differentiation 81:233-42. 2011
    ....
  11. doi request reprint On your (methyl) mark, get TET1, go!
    Shradha Mukherjee
    Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell Stem Cell 13:133-4. 2013
    ..In this issue, Zhang et al. (2013) show that Tet1 regulates adult hippocampal neurogenesis by controlling progenitor proliferation, and Tet1 deficiency generates defects in learning and memory. ..
  12. pmc Discovery of a proneurogenic, neuroprotective chemical
    Andrew A Pieper
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9152, USA
    Cell 142:39-51. 2010
    ..Prolonged administration of P7C3 to aged rats also enhanced neurogenesis in the dentate gyrus, impeded neuron death, and preserved cognitive capacity as a function of terminal aging. PAPERCLIP:..
  13. pmc HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
    Feng Ye
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, USA
    Nat Neurosci 12:829-38. 2009
    ..Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation...
  14. pmc Profiling of REST-Dependent microRNAs Reveals Dynamic Modes of Expression
    Zhengliang Gao
    Department of Molecular Biology, UT Southwestern Medical Center Dallas, TX, USA
    Front Neurosci 6:67. 2012
    ..These results suggest that REST functions in a context-dependent manner through its target miRNAs for mediating neuronal production...
  15. ncbi request reprint Small-molecule activation of neuronal cell fate
    Jay W Schneider
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Chem Biol 4:408-10. 2008
    ..These results provide new tools to explore the epigenetic signaling circuitry specifying neuronal cell fate and new leads for neuro-regenerative drugs...
  16. pmc Cardiogenic small molecules that enhance myocardial repair by stem cells
    Hesham Sadek
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:6063-8. 2008
    ..Shz small molecules are promising starting points for drugs to promote myocardial repair/regeneration by activating cardiac differentiation in M-PBMCs...
  17. ncbi request reprint A small modulatory dsRNA specifies the fate of adult neural stem cells
    Tomoko Kuwabara
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:779-93. 2004
    ..The discovery of small modulatory dsRNAs (smRNAs) extends the important contribution of noncoding RNAs as key regulators of cell behavior at both transcriptional and posttranscriptional levels...
  18. ncbi request reprint Epigenetic control of neural stem cell fate
    Jenny Hsieh
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Genet Dev 14:461-9. 2004
    ..Extracellular signaling systems that control the growth and differentiation of neural stem cells act, at least in part, by interfacing with these diverse epigenetic mechanisms...
  19. pmc Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells
    Jenny Hsieh
    Laboratory of Genetics, The Salk Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:16659-64. 2004
    ..These results suggest that VPA promotes neuronal fate and inhibits glial fate simultaneously through the induction of neurogenic transcription factors including NeuroD...
  20. ncbi request reprint Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice
    Liou Y Sun
    Geriatrics Research, Department of Internal Medicine, Southern Illinois University School of Medicine, Room 4389, 801 North Rutledge, Springfield, Illinois 62794 9628, USA
    Endocrinology 146:1138-44. 2005
    ....
  21. ncbi request reprint Epigenetic modulation of seizure-induced neurogenesis and cognitive decline
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:5967-75. 2007
    ..Furthermore, our data indicate that the effectiveness of VPA as an antiepileptic drug may be partially explained by the HDAC-dependent inhibition of aberrant neurogenesis induced by seizure activity within the adult hippocampus...
  22. pmc IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
    Jenny Hsieh
    Laboratory of Genetics, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 164:111-22. 2004
    ..These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage...

Research Grants2

  1. Epigenetic regulation of adult neurogenesis
    Jenny Hsieh; Fiscal Year: 2009
    ..The research proposal will lead to improved understanding of neural stem cell biology, possibly leading to the development of new drugs for repair and regeneration of the nervous system. ..
  2. Epigenetic regulation of adult neurogenesis
    Jenny Hsieh; Fiscal Year: 2010
    ..The research proposal will lead to improved understanding of neural stem cell biology, possibly leading to the development of new drugs for repair and regeneration of the nervous system. ..