Edward C Hsiao

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Stem Cell Res Ther 2:11. 2011
  2. pmc Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Bone Miner Res 25:584-93. 2010
  3. pmc Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice
    Koen Schepers
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Medicine, Division of Hematology Oncology, University of California, San Francisco, USA
    Blood 120:3425-35. 2012
  4. pmc Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance
    Linda W Van Laake
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
    Circ Res 107:340-7. 2010
  5. pmc AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy
    Matthew J Spindler
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    PLoS ONE 8:e62705. 2013
  6. pmc Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor
    Wei Chun Chang
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1317. 2007
  7. pmc Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
    Mol Endocrinol 24:621-31. 2010
  8. pmc Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche
    Koen Schepers
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Division of Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 13:285-99. 2013
  9. pmc Engineering GPCR signaling pathways with RASSLs
    Bruce R Conklin
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Methods 5:673-8. 2008
  10. pmc Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America
    PLoS ONE 3:e2532. 2008

Collaborators

Detail Information

Publications14

  1. pmc Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Stem Cell Res Ther 2:11. 2011
    ....
  2. pmc Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Bone Miner Res 25:584-93. 2010
    ..Finally, our model provides a powerful tool for investigating the effects of continuous G(s)-GPCR signaling on dynamic bone growth and remodeling...
  3. pmc Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice
    Koen Schepers
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Medicine, Division of Hematology Oncology, University of California, San Francisco, USA
    Blood 120:3425-35. 2012
    ..Our findings indicate that long-term activation of G(s) signaling in OBCs leads to contextual changes in the BM niche that adversely affect HSC maintenance and blood homeostasis...
  4. pmc Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance
    Linda W Van Laake
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
    Circ Res 107:340-7. 2010
    ....
  5. pmc AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy
    Matthew J Spindler
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    PLoS ONE 8:e62705. 2013
    ..Additionally, the AKAP13 Rho-GEF and PKD-binding domains mediate cardiomyocyte hypertrophy in cell culture. However, the requirements for the Rho-GEF and PKD-binding domains during development and cardiac hypertrophy are unknown...
  6. pmc Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor
    Wei Chun Chang
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1317. 2007
    ..This G(i)-coupled RASSL, Rs1.3, exhibited no measurable signaling to the G(s) or G(q) pathway. These findings show that the signaling repertoire of Rs1 can be expanded and controlled by receptor engineering and drug selection...
  7. pmc Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
    Mol Endocrinol 24:621-31. 2010
    ..This model provides a powerful tool for investigating the effects of ligand-activated G(s)-GPCR signaling on dynamic bone growth and remodeling...
  8. pmc Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche
    Koen Schepers
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Division of Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 13:285-99. 2013
    ..Targeting this pathological interplay could represent a novel avenue for treatment of MPN-affected patients and prevention of myelofibrosis. ..
  9. pmc Engineering GPCR signaling pathways with RASSLs
    Bruce R Conklin
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Methods 5:673-8. 2008
    ..Currently, RASSLs exist for the three major GPCR signaling pathways (G(s), G(i) and G(q)). We review these advances here to facilitate the use of these powerful and diverse tools...
  10. pmc Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America
    PLoS ONE 3:e2532. 2008
    ..Multiple fluorophores and genetic selection markers exist; however, a system for creating reporter constructs that preserve the regulatory sequences near a gene's native ATG start site has not been widely available...
  11. ncbi request reprint Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling
    Eric K Nakakura
    Department of Surgery, University of California, San Francisco, California 94115, USA
    J Clin Endocrinol Metab 90:4350-6. 2005
    ....
  12. pmc MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
    Kathryn N Ivey
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell Stem Cell 2:219-29. 2008
    ..Our findings indicate that muscle-specific miRNAs reinforce the silencing of nonmuscle genes during cell lineage commitment and suggest that miRNAs may have general utility in regulating cell-fate decisions from pluripotent ES cells...
  13. pmc Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass
    Edward C Hsiao
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:1209-14. 2008
    ..This pathway may represent an important determinant of bone mass and may open future avenues for enhancing bone repair and treating metabolic bone diseases...
  14. pmc Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:10894-9. 2007
    ..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes...