Research Topics
Genomes and Genes | Edward C HsiaoSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and miceEdward C Hsiao
Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
Stem Cell Res Ther 2:11. 2011....- Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formationEdward C Hsiao
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
J Bone Miner Res 25:584-93. 2010..Finally, our model provides a powerful tool for investigating the effects of continuous G(s)-GPCR signaling on dynamic bone growth and remodeling... - Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in miceKoen Schepers
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Medicine, Division of Hematology Oncology, University of California, San Francisco, USA
Blood 120:3425-35. 2012..Our findings indicate that long-term activation of G(s) signaling in OBCs leads to contextual changes in the BM niche that adversely affect HSC maintenance and blood homeostasis... - Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression varianceLinda W Van Laake
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
Circ Res 107:340-7. 2010.... - Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptorWei Chun Chang
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
PLoS ONE 2:e1317. 2007..This G(i)-coupled RASSL, Rs1.3, exhibited no measurable signaling to the G(s) or G(q) pathway. These findings show that the signaling repertoire of Rs1 can be expanded and controlled by receptor engineering and drug selection... - Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formationEdward C Hsiao
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
Mol Endocrinol 24:621-31. 2010..This model provides a powerful tool for investigating the effects of ligand-activated G(s)-GPCR signaling on dynamic bone growth and remodeling... - AKAP13 Rho-GEF and PKD-Binding Domain Deficient Mice Develop Normally but Have an Abnormal Response to β-Adrenergic-Induced Cardiac HypertrophyMatthew J Spindler
Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 8:e62705. 2013..However, these domains regulate aspects of β-adrenergic-induced cardiac hypertrophy... - Engineering GPCR signaling pathways with RASSLsBruce R Conklin
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
Nat Methods 5:673-8. 2008..Currently, RASSLs exist for the three major GPCR signaling pathways (G(s), G(i) and G(q)). We review these advances here to facilitate the use of these powerful and diverse tools... - Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporterEdward C Hsiao
Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America
PLoS ONE 3:e2532. 2008..Multiple fluorophores and genetic selection markers exist; however, a system for creating reporter constructs that preserve the regulatory sequences near a gene's native ATG start site has not been widely available... 
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signalingEric K Nakakura
Department of Surgery, University of California, San Francisco, California 94115, USA
J Clin Endocrinol Metab 90:4350-6. 2005....- MicroRNA regulation of cell lineages in mouse and human embryonic stem cellsKathryn N Ivey
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Cell Stem Cell 2:219-29. 2008..Our findings indicate that muscle-specific miRNAs reinforce the silencing of nonmuscle genes during cell lineage commitment and suggest that miRNAs may have general utility in regulating cell-fate decisions from pluripotent ES cells... - Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone massEdward C Hsiao
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 105:1209-14. 2008..This pathway may represent an important determinant of bone mass and may open future avenues for enhancing bone repair and treating metabolic bone diseases... - Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitorsChulan Kwon
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:10894-9. 2007..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes...