David Hoyt

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Trauma systems
    David B Hoyt
    Department of Surgery, University of California, Irvine School of Medicine, City Tower, 333 City Boulevard West, 700, Orange, CA 92868, USA
    Surg Clin North Am 87:21-35, v-vi. 2007
  2. doi request reprint Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice
    David B Hoyt
    Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
    J Trauma 65:755-64; discussion 764-5. 2008
  3. doi request reprint Acute care surgery: a new training and practice model in the United States
    David B Hoyt
    Department of Surgery, Division of Trauma, University of California, Irvine, 333 City Blvd West, Suite 700, Orange, CA 92868, USA
    World J Surg 32:1630-5. 2008
  4. ncbi request reprint Utility of thoracic computed tomography after blunt trauma: when is chest radiograph enough?
    Cristobal Barrios
    University of California, Irvine Medical Center, Orange, CA, USA
    Am Surg 75:966-9. 2009
  5. doi request reprint Implementation of a cost-saving algorithm for pelvic radiographs in blunt trauma patients
    Andrew Barleben
    Division of Trauma, Burns, Critical Care, and Acute Care Surgery, Department of Surgery, University of California, Irvine, Orange, California 92868, USA
    J Trauma 71:582-4. 2011
  6. ncbi request reprint The clinical significance of occult thoracic injury in blunt trauma patients
    Meghann Kaiser
    Department of Surgery, University of California Irvine, Orange, California, USA
    Am Surg 76:1063-6. 2010
  7. ncbi request reprint Early predictors of the need for emergent surgery to control hemorrhage in hypotensive trauma patients
    Meghann Kaiser
    Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
    Am Surg 75:986-90. 2009
  8. doi request reprint The U.S. trauma surgeon's current scope of practice: can we deliver acute care surgery?
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, Colorado, USA
    J Trauma 64:955-65; discussion 965-8. 2008
  9. ncbi request reprint Minimally invasive esophagectomy without the use of postoperative nasogastric tube decompression
    Ninh T Nguyen
    Department of Surgery, University of California Irvine Medical Center, Orange, California, USA
    Am Surg 75:929-31. 2009
  10. doi request reprint Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, USA
    J Am Coll Surg 208:1-13. 2009

Research Grants

Detail Information

Publications86

  1. ncbi request reprint Trauma systems
    David B Hoyt
    Department of Surgery, University of California, Irvine School of Medicine, City Tower, 333 City Boulevard West, 700, Orange, CA 92868, USA
    Surg Clin North Am 87:21-35, v-vi. 2007
    ..Disaster preparedness also is an important function of trauma systems, and using an established trauma system network facilitates the care of victims of natural disasters or terrorist attacks...
  2. doi request reprint Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice
    David B Hoyt
    Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
    J Trauma 65:755-64; discussion 764-5. 2008
    ..Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly...
  3. doi request reprint Acute care surgery: a new training and practice model in the United States
    David B Hoyt
    Department of Surgery, Division of Trauma, University of California, Irvine, 333 City Blvd West, Suite 700, Orange, CA 92868, USA
    World J Surg 32:1630-5. 2008
    ..This article reviews the evolution of a new specialty and identifies some of the challenges and opportunities associated with the implementation of this model...
  4. ncbi request reprint Utility of thoracic computed tomography after blunt trauma: when is chest radiograph enough?
    Cristobal Barrios
    University of California, Irvine Medical Center, Orange, CA, USA
    Am Surg 75:966-9. 2009
    ..A diagnostic strategy of obtaining TCT only in patients with abnormal CXR or high-risk mechanism of injury can result in significant cost savings without adversely affecting patient outcomes...
  5. doi request reprint Implementation of a cost-saving algorithm for pelvic radiographs in blunt trauma patients
    Andrew Barleben
    Division of Trauma, Burns, Critical Care, and Acute Care Surgery, Department of Surgery, University of California, Irvine, Orange, California 92868, USA
    J Trauma 71:582-4. 2011
    ..The purpose of this study was to prospectively validate an algorithm defining indications for PXR in blunt trauma patients in the emergency department...
  6. ncbi request reprint The clinical significance of occult thoracic injury in blunt trauma patients
    Meghann Kaiser
    Department of Surgery, University of California Irvine, Orange, California, USA
    Am Surg 76:1063-6. 2010
    ..No patient with isolated occult thoracic injury required intubation or tube thoracostomy. Occult injuries, diagnosed by TCT only, have minimal clinical consequences but attract increased hospital resources...
  7. ncbi request reprint Early predictors of the need for emergent surgery to control hemorrhage in hypotensive trauma patients
    Meghann Kaiser
    Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
    Am Surg 75:986-90. 2009
    ..1, all P < 0.05). We concluded that hypotensive trauma patients without head injuries who require prolonged extrication, intubation, central venous access, and blood transfusion in the ED are more likely to need emergent surgery...
  8. doi request reprint The U.S. trauma surgeon's current scope of practice: can we deliver acute care surgery?
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, Colorado, USA
    J Trauma 64:955-65; discussion 965-8. 2008
    ..The purpose of this study is to determine the practice patterns of trauma surgeons at major trauma centers throughout the United States...
  9. ncbi request reprint Minimally invasive esophagectomy without the use of postoperative nasogastric tube decompression
    Ninh T Nguyen
    Department of Surgery, University of California Irvine Medical Center, Orange, California, USA
    Am Surg 75:929-31. 2009
    ..7%, respectively). In conclusion, the use of NGT decompression during minimally invasive esophagectomy can be safely omitted. In cases with postoperative gastric conduit distention, an NGT can be safely placed under fluoroscopic guidance...
  10. doi request reprint Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, USA
    J Am Coll Surg 208:1-13. 2009
    ..This multicenter phase III trial was the first US study to assess survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injury...
  11. doi request reprint Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death
    Darren J Malinoski
    Division of Trauma and Critical Care Surgery, UCI Medical Center, 333 City Boulevard West, Suite 705, Orange, CA 92868, USA
    J Trauma 67:445-9. 2009
    ..We hypothesized that serum amylase and lipase would be significantly elevated in patients presenting in hemorrhagic shock and in those who develop organ failure...
  12. doi request reprint Pancreatic duct: A suitable route to oxygenate tissue during pancreas hypothermic preservation?
    M Reza Mirbolooki
    Division of Surgical Research, Department of Surgery, University of California, Irvine, United States
    Transpl Immunol 22:191-4. 2010
    ..14.2+/-2.4, p<0.03) and improved intracellular energy charge (0.36+/-0.05 vs. 0.22+/-0.03, p<0.001) as compared to HBSS group. The findings indicate that the pancreatic duct might be a suitable route for pancreatic oxygenation...
  13. ncbi request reprint A twelve-year analysis of disease and provider complications on an organized level I trauma service: as good as it gets?
    David B Hoyt
    Division of Trauma, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 54:26-36; discussion 36-7. 2003
    ..The annual incidence of complications in a trauma population has been previously reported but the frequency change over time in a single institution is not well studied...
  14. doi request reprint Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients
    Darren Malinoski
    Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
    J Trauma 68:874-80. 2010
    ..We hypothesized that low Anti-Xa levels would be found in critically ill trauma and surgical patients and that low levels would be associated with higher rates of DVT...
  15. doi request reprint Improved bariatric surgery outcomes for Medicare beneficiaries after implementation of the medicare national coverage determination
    Ninh T Nguyen
    Department of Surgery, University of California, Irvine Medical Center, Orange, 92868, USA
    Arch Surg 145:72-8. 2010
    ..To compare the outcomes of Medicare beneficiaries who underwent bariatric surgery within 18 months before and after implementation of the national coverage determination (NCD) for bariatric surgery...
  16. ncbi request reprint Patient factors and operating room resuscitation predict mortality in traumatic abdominal aortic injury: a 20-year analysis
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego, San Diego, CA, USA
    J Vasc Surg 45:493-7. 2007
    ..The purposes of this study were to identify primary predictors of mortality and to examine the impact of a well-established operating room resuscitation protocol on survival in patients with traumatic aortic injury...
  17. doi request reprint Air medical response to traumatic brain injury: a computer learning algorithm analysis
    Daniel P Davis
    Divisions of Trauma, University of California, San Diego, California, USA
    J Trauma 64:889-97. 2008
    ..Learning algorithms, such as artificial neural networks (ANN), support vector machines (SVM), and decision trees, can identify relationships between data set variables but are not empirically useful for hypothesis testing...
  18. ncbi request reprint The impact of safety belt use on liver injuries in motor vehicle crashes: the importance of motor vehicle safety systems
    Troy Lisa Holbrook
    Division of Trauma, Department of Surgery, University of California, San Diego, California 92103 8896, USA
    J Trauma 63:300-6. 2007
    ..In the unstable patient, early detection of LI based on clinical suspicion will improve acute trauma care and outcomes. The specific objectives of this analysis are to identify crash scene and occupant risk factors for LI from MVC...
  19. ncbi request reprint Urgent and emergent thoracotomy for penetrating chest trauma
    Riyad Karmy-Jones
    Department of Surgery, Box 359796, 325 Ninth Avenue, Harborview Medical Center, Seattle, WA 98104, USA
    J Trauma 56:664-8; discussion 668-9. 2004
    ..Although the major factor in outcome is presenting physiology, the site of the TCY may influence survival, with the operating room offering a superior environment to the emergency room...
  20. ncbi request reprint Effect of the Uniform Accident and Sickness Policy Provision Law on alcohol screening and intervention in trauma centers
    Larry M Gentilello
    Department of Surgery, The University of Texas Southwestern Medical School, Dallas, Texas 75390 9158, USA
    J Trauma 59:624-31. 2005
    ....
  21. ncbi request reprint Are we the problem? Overcoming obstacles to implementing intervention programs
    David B Hoyt
    Department of Surgery, Division of Trauma, University of California, San Diego, CA 92103 8896, USA
    J Trauma 59:S135-6; discussion S146-66. 2005
    ..Although many obstacles have inhibited progress and made implementing preventive interventions a difficult task, economic constraints are among the biggest challenges to implementing intervention programs as part of routine trauma care...
  22. ncbi request reprint Acute cholecystitis with a hemocholecyst as an unusual presentation of gallbladder cancer: report of a case
    Joseph Ku
    Division of Trauma, Department of Surgery, University of California San Diego, School of Medicine, 200 West Arbor Drive, San Diego, CA 92103 8896, USA
    Surg Today 34:973-6. 2004
    ..The diagnostic approaches and characteristics of a hemocholecyst associated with carcinoma of the gallbladder are discussed...
  23. ncbi request reprint Successful management of occult pneumothorax without tube thoracostomy despite positive pressure ventilation
    Cristobal Barrios
    University of California, Irvine, Department of Surgery, Division of Trauma Critical Care, Burns and Acute Care Surgery, Orange, California, USA
    Am Surg 74:958-61. 2008
    ..31). This study demonstrates that a subset of patients with blunt occult pneumothorax requiring positive pressure ventilation may be safely managed without tube thoracostomy...
  24. doi request reprint Minimally invasive esophagectomy: lessons learned from 104 operations
    Ninh T Nguyen
    Department of Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA
    Ann Surg 248:1081-91. 2008
    ..To review the outcomes of 104 consecutive minimally invasive esophagectomy (MIE) procedures for the treatment of benign and malignant esophageal disease...
  25. ncbi request reprint Trauma in adolescents causes long-term marked deficits in quality of life: adolescent children do not recover preinjury quality of life or function up to two years postinjury compared to national norms
    Troy Lisa Holbrook
    Division of Trauma, Department of Surgery, University of California, CA, USA
    J Trauma 62:577-83; discussion 583. 2007
    ..The objectives of the present report are to describe long-term QoL outcomes and compare posttrauma QoL to national norms for QoL in uninjured adolescents from the National Health Interview Survey (NHIS)...
  26. ncbi request reprint Surgical resident and attending physician attitudes toward glucose control in the surgical patient
    Todd W Costantini
    Department of Surgery, University of California, San Diego Medical Center, San Diego, California, USA
    Am Surg 74:993-6. 2008
    ..This study reveals an important knowledge deficit among surgical resident and attending physicians. Focused education on glycemic control in the perioperative patient should be a mandatory component of surgical training...
  27. ncbi request reprint Fluid resuscitation: the target from an analysis of trauma systems and patient survival
    David B Hoyt
    Department of Surgery, University of California, San Diego, Medical Center, 92103 8896, USA
    J Trauma 54:S31-5. 2003
    ..By agreeing on the form of resuscitation trials in the future, we will increase our ability to see clinically significant differences in outcome as we move from animal data to clinical efficacy...
  28. doi request reprint Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine
    Hubert D Kim
    Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
    J Trauma 68:1078-83. 2010
    ..The objective of this study was to determine whether enteroclysis with NM would improve the clinical outcomes in swine after hemorrhagic shock and intestinal hypoperfusion...
  29. pmc Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    JAMA 304:1455-64. 2010
    ..Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI)...
  30. ncbi request reprint Reversal of anticoagulation in trauma: a North-American survey on clinical practices among trauma surgeons
    Raul Coimbra
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, CA 92103 8896, USA
    J Trauma 59:375-82. 2005
    ..Recent studies addressing reversal of anticoagulation in trauma have reported conflicting results. We hypothesized that current clinical practice is variable throughout North America...
  31. ncbi request reprint The impact of prehospital endotracheal intubation on outcome in moderate to severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, School of Medicine, University of California, San Diego, 92103 8676, USA
    J Trauma 58:933-9. 2005
    ..Although early intubation to prevent the mortality that accompanies hypoxia is considered the standard of care for severe traumatic brain injury (TBI), the efficacy of this approach remains unproven...
  32. ncbi request reprint Female gender does not protect blunt trauma patients from complications and mortality
    Joseph F Rappold
    Department of Surgery, Division of Trauma, Critical Care, and Burns, University of California San Diego, 92103, USA
    J Trauma 53:436-41; discussion 441. 2002
    ....
  33. ncbi request reprint The epidemiology of serious and fatal injury in San Diego County over an 11-year period
    Bruce M Potenza
    Department of Surgery, University of California, San Diego, 92103 8896, USA
    J Trauma 56:68-75. 2004
    ..Analysis of the mechanism and severity of injury over time may permit a more focused planning of acute care and trauma prevention programs...
  34. ncbi request reprint National survey of trauma surgeons' use of alcohol screening and brief intervention
    Carol R Schermer
    Department of Surgery, 1 University of New Mexico, Albuquerque, NM 817131, USA
    J Trauma 55:849-56. 2003
    ....
  35. ncbi request reprint Working Group on Trauma Research Program summary report: National Heart Lung Blood Institute (NHLBI), National Institute of General Medical Sciences (NIGMS), and National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of
    David B Hoyt
    University of California, San Diego, San Diego, California, USA
    J Trauma 57:410-5. 2004
  36. ncbi request reprint What's new in general surgery: trauma and critical care
    David B Hoyt
    University of California, San Diego, USA
    J Am Coll Surg 194:335-51. 2002
  37. ncbi request reprint The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial
    Anne C Mosenthal
    Department of Surgery, New Jersey Trauma Center, University of Medicine and Dentistry of New Jersey New Jersey, Medical School, Newark, New Jersey, USA
    J Trauma 56:1042-8. 2004
    ..We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization...
  38. ncbi request reprint Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage
    David A Z Frankel
    University of California, San Diego, California, USA
    J Surg Res 143:276-80. 2007
    ..Our hypothesis was that rapid bleeding followed by slower bleeding using a fixed total volume would result in a greater physiologic insult...
  39. ncbi request reprint Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation
    Jessica Deree
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California School of Medicine, CA, USA
    J Trauma 62:818-27; discussion 827-8. 2007
    ....
  40. ncbi request reprint From "leaky buckets" to vascular injuries: understanding models of uncontrolled hemorrhage
    Asher Hirshberg
    Department of Surgery, Kings County Hospital Center and SUNY Downstate College of Medicine, Brooklyn, NY 11203, USA
    J Am Coll Surg 204:665-72. 2007
  41. ncbi request reprint Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego, School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 56:442-9. 2004
  42. ncbi request reprint Fatal positional asphyxia associated with rollover crashes
    Carol Conroy
    Department of Surgery, University of California, San Diego, California, USA
    Am J Forensic Med Pathol 28:330-2. 2007
    ..Although this is a rare cause of motor vehicle related death, our results suggest that these are potentially preventable deaths...
  43. doi request reprint Hypertonic resuscitation: design and implementation of a prehospital intervention trial
    Karen J Brasel
    Department of Surgery, Division of Trauma Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Coll Surg 206:220-32. 2008
    ..Trauma is the leading cause of death among North Americans between the ages of 1 and 44 years. Resuscitation with hypertonic saline (7.5%) solutions can reduce mortality in hypotensive and brain-injured patients...
  44. ncbi request reprint Blunt abdominal trauma: clinical value of negative screening US scans
    Claude B Sirlin
    Department of Radiology, University of California, San Diego Medical Center, 200 W Arbor Dr, MC 8756, San Diego, CA 92103 8756, USA
    Radiology 230:661-8. 2004
    ..To assess clinical and surgical outcomes in patients with blunt abdominal trauma and negative screening ultrasonographic (US) scans...
  45. ncbi request reprint A clinical review of bleeding dilemmas in trauma
    David B Hoyt
    Department of Surgery, University of California, San Diego, USA
    Semin Hematol 41:40-3. 2004
    ..This paper reviews recent developments and controversies in trauma care, and, in particular, the potential role of procoagulant therapy using recombinant factor VIIa in the prevention of mortality due to bleeding...
  46. ncbi request reprint Does sexual dimorphism influence outcome of traumatic brain injury patients? The answer is no!
    Raul Coimbra
    Department of Surgery, University of California San Diego, USA
    J Trauma 54:689-700. 2003
    ....
  47. doi request reprint Injury patterns in frontal crashes: the association between knee-thigh-hip (KTH) and serious intra-abdominal injury
    Jeanne Lee
    Department of Surgery, School of Medicine, University of California at San Diego, San Diego, CA, USA
    Accid Anal Prev 42:50-5. 2010
    ..These results may be useful to motor vehicle manufacturers and others who design and test motor vehicle safety systems...
  48. ncbi request reprint Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
    J Trauma 55:713-9. 2003
    ....
  49. doi request reprint Severe traumatic injury: regional variation in incidence and outcome
    Joseph P Minei
    Division of Burn, Trauma and Critical Care, Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390 9158, USA
    Ann Surg 252:149-57. 2010
    ..The objective of this study was to determine whether the incidence and outcome associated with severe traumatic injury differs across geographic regions of North America...
  50. ncbi request reprint Gender differences in long-term posttraumatic stress disorder outcomes after major trauma: women are at higher risk of adverse outcomes than men
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, 92103, USA
    J Trauma 53:882-8. 2002
    ....
  51. ncbi request reprint The use of quantitative end-tidal capnometry to avoid inadvertent severe hyperventilation in patients with head injury after paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, CA 92103 8676, USA
    J Trauma 56:808-14. 2004
    ..This study aimed to determine whether field end-tidal carbon dioxide CO2 (ETCO2) monitoring decreases inadvertent severe hyperventilation after paramedic rapid sequence intubation...
  52. ncbi request reprint Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California School of Medicine, San Diego, CA, USA
    J Trauma 62:104-11. 2007
    ..Because the neutrophil plays a major role in postshock inflammation, we hypothesized that HSPTX reduces pulmonary inflammation after resuscitation in comparison to RL...
  53. ncbi request reprint The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
    J Trauma 57:1-8; discussion 8-10. 2004
    ..An increase in mortality has been documented in association with paramedic rapid sequence intubation (RSI) of severely head-injured patients. This analysis explores the impact of hypoxia and hyperventilation on outcome...
  54. ncbi request reprint Metastatic meningioma to the liver successfully treated with a wedge resection and radiation therapy: report of a case
    Joseph K Ku
    Division of Trauma, Department of Surgery, 8896, University of California San Diego School of Medicine, 200 West Arbor Drive, San Diego, CA 92103 8896, USA
    Surg Today 35:82-5. 2005
    ..Less than 100 cases of extracranial metastatic meningiomas have been reported in the literature. An unusual case of metastatic meningioma to the liver successfully treated by a surgical resection and radiation therapy is presented...
  55. ncbi request reprint High rates of acute stress disorder impact quality-of-life outcomes in injured adolescents: mechanism and gender predict acute stress disorder risk
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California 92103 8896, USA
    J Trauma 59:1126-30. 2005
    ..The specific objectives of the present report are to examine ASD rates and the association of ASD with QoL outcomes in injured adolescents...
  56. ncbi request reprint Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, CA 92103 8896, USA
    J Trauma 59:257-64; discussion 264-5. 2005
    ....
  57. ncbi request reprint HSPTX protects against hemorrhagic shock resuscitation-induced tissue injury: an attractive alternative to Ringer's lactate
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, 200 W Arbor Drive, San Diego, CA 92103, USA
    J Trauma 60:41-51. 2006
    ..Herein, we hypothesized that HSPTX decreases end-organ injury when compared with RL in an animal model of hemorrhagic shock...
  58. ncbi request reprint Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 59:575-82. 2005
    ..In addition, we investigated the effects of PTX on nuclear factor (NK)-kappaB activation using lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs) as a model...
  59. ncbi request reprint Nonoperative management reduces the overall mortality of grades 3 and 4 blunt liver injuries
    Raul Coimbra
    Division of Trauma, Critical Care, and Burns, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    Int Surg 91:251-7. 2006
    ..Six patients failed NON-OP management (22.2%). The mortality rate in the NON-OP group was 0%. NON-OP was associated with a 23.5% reduction in mortality. Unnecessary OP management of grades 3 and 4 liver injuries should be discouraged...
  60. ncbi request reprint Long-term posttraumatic stress disorder persists after major trauma in adolescents: new data on risk factors and functional outcome
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California, USA
    J Trauma 58:764-9; discussion 769-71. 2005
    ..The specific objectives of the present report are to describe long-term PTSD and to identify risk factors for long-term PTSD and the impact of PTSD on QoL...
  61. ncbi request reprint An assessment of the potential for reducing future combat deaths through medical technologies and training
    Christopher G Blood
    Naval Health Research Center, San Diego, CA 92186 5122, USA
    J Trauma 53:1160-5. 2002
    ....
  62. ncbi request reprint The safety and efficacy of prehospital needle and tube thoracostomy by aeromedical personnel
    Daniel P Davis
    Department of Emergency Medicine, UCSD, San Diego, CA 92103, USA
    Prehosp Emerg Care 9:191-7. 2005
    ..Aeromedical crews routinely use needle thoracostomy (NT) and tube thoracostomy (TT) to treat major trauma victims (MTVs) with potential tension pneumothorax; however, the efficacy of prehospital NT and TT is unclear...
  63. ncbi request reprint The predictive value of field versus arrival Glasgow Coma Scale score and TRISS calculations in moderate-to-severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, California 92103 8676, USA
    J Trauma 60:985-90. 2006
    ..This study explores the predictive value of field GCS (fGCS) and arrival GCS (aGCS) as well as TRISS calculations using field (fTRISS) and arrival (aTRISS) data in patients with moderate-to-severe traumatic brain injury (TBI)...
  64. doi request reprint The coagulopathy of trauma: a review of mechanisms
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 65:748-54. 2008
    ..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
  65. ncbi request reprint The Combitube as a salvage airway device for paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, CA 92103 8676, USA
    Ann Emerg Med 42:697-704. 2003
    ..Here we describe our experience with the Combitube (esophageal-tracheal twin-lumen airway device) as a salvage airway device for paramedic rapid sequence intubation...
  66. ncbi request reprint The impact of aeromedical response to patients with moderate to severe traumatic brain injury
    Daniel P Davis
    The UC San Diego Emergency Medicine, San Diego, CA 92103 8676, USA
    Ann Emerg Med 46:115-22. 2005
    ..Here we explore the impact of aeromedical response in patients with moderate to severe traumatic brain injury...
  67. ncbi request reprint The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, UC San Diego, CA 92103 8676, USA
    J Trauma 54:444-53. 2003
    ..To evaluate the effect of paramedic rapid sequence intubation (RSI) on outcome in patients with severe traumatic brain injury...
  68. ncbi request reprint Early ventilation and outcome in patients with moderate to severe traumatic brain injury
    Daniel P Davis
    UC San Diego, Department of Emergency Medicine, USA
    Crit Care Med 34:1202-8. 2006
    ..This analysis explores the impact of early ventilation on outcome in moderate to severe traumatic brain injury...
  69. ncbi request reprint Lessons learned during the San Diego paramedic RSI Trial
    Mel Ochs
    J Emerg Med 24:343-4. 2003
  70. ncbi request reprint National inventory of hospital trauma centers
    Ellen J MacKenzie
    Johns Hopkins Bloomberg School of Public Health, Center for Injury Research and Policy, Baltimore, MD 21205, USA
    JAMA 289:1515-22. 2003
    ..The last full accounting of the number and distribution of trauma centers identified 471 trauma centers in the United States in 1991...
  71. ncbi request reprint Ventilation patterns in patients with severe traumatic brain injury following paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, CA, USA
    Neurocrit Care 2:165-71. 2005
    ..This analysis explores ventilation patterns in a cohort of trial patients undergoing end-tidal CO2 (ETCO2) monitoring...
  72. ncbi request reprint The association between field Glasgow Coma Scale score and outcome in patients undergoing paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego UCSD, San Diego, California 92103 8676, USA
    J Emerg Med 29:391-7. 2005
    ..Other factors should be considered to screen TBI patients for prehospital RSI...
  73. ncbi request reprint Incidence of transient hypoxia and pulse rate reactivity during paramedic rapid sequence intubation
    James V Dunford
    Department of Emergency Medicine, University of California San Diego, USA
    Ann Emerg Med 42:721-8. 2003
    ..We determine the incidence of desaturation and pulse rate reactivity during paramedic rapid sequence intubation of patients with severe head injuries (Glasgow Coma Scale score <or=8)...
  74. ncbi request reprint Air medical transport of severely head-injured patients undergoing paramedic rapid sequence intubation
    Jennifer C Poste
    Air Med J 23:36-40. 2004
    ..This analysis explores the impact of air medical transport of trial patients on outcome...
  75. ncbi request reprint Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients
    Naoyuki Hashiguchi
    University of California San Diego School of Medicine, San Diego, California 92103 8236, USA
    J Trauma 62:299-306. 2007
    ..Hypertonic saline (HS) resuscitation prevents PMN activation in vitro and in animal models. Here, we studied how clinical parameters and timing requirements influence the efficacy of HS in suppressing PMN activation...
  76. ncbi request reprint Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  77. ncbi request reprint Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma
    John R Hess
    Transfusion 46:685-6. 2006
  78. ncbi request reprint Acute care surgery: Eraritjaritjaka
    Ernest E Moore
    J Am Coll Surg 202:698-701. 2006
  79. ncbi request reprint Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock
    Jay J Doucet
    Department of Surgery University of California San Diego 92103 8899, USA
    J Trauma 56:501-10; discussion 510-1. 2004
    ..The objective of this study was to determine the effect of nafamostat mesilate given by enteroclysis on enteric serine protease activity, neutrophil activation, and transfusion requirements during hemorrhagic shock...
  80. ncbi request reprint The ability of paramedics to predict aspiration in patients undergoing prehospital rapid sequence intubation
    Tyler F Vadeboncoeur
    Department of Emergency Medicine, University of California San Diego UCSD Medical Center, San Diego, California 92103 8676, USA
    J Emerg Med 30:131-6. 2006
    ..The vast majority of aspiration events seem to occur before the arrival of prehospital personnel. Alteration in consciousness from TBI may carry a higher risk of aspiration than with other causes, such as alcohol intoxication...
  81. ncbi request reprint Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    J Trauma Stress 20:923-32. 2007
    ..Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury...
  82. ncbi request reprint When will it be clear?
    David B Hoyt
    Crit Care Med 32:1608-9. 2004
  83. ncbi request reprint Head-injured patients who "talk and die": the San Diego perspective
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, CA 92103 8676, USA
    J Trauma 62:277-81. 2007
    ..This study uses a large, comprehensive database to explore risk factors for head-injured patients who deteriorate after their initial presentation...
  84. ncbi request reprint The impact of major trauma: quality-of-life outcomes are worse in women than in men, independent of mechanism and injury severity
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 56:284-90. 2004
    ....
  85. doi request reprint Traumatic coagulopathy: where are the good experimental models?
    Michael J Parr
    Intensive Care Unit, Liverpool Hospital, University of New South Wales, Sydney, Australia
    J Trauma 65:766-71. 2008
    ..This systematic review assessed the primary question "What are relevant experimental models with which to study early traumatic coagulopathy?" and secondary questions on mechanisms...
  86. ncbi request reprint Guidelines for withholding or termination of resuscitation in prehospital traumatic cardiopulmonary arrest
    Laura R Hopson
    Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, USA
    J Am Coll Surg 196:475-81. 2003

Research Grants5

  1. Hemorrhagic Shock and Pancreatic Enzyme Products
    David Hoyt; Fiscal Year: 2007
    ..The results of this research provide not only an approach to examine the different enzymatic and inflammatory processes in hemorrhagic shock but also to directly serve as the basis for possible intervention in patients. ..