Gary W Hoyle

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Mitigation of chlorine lung injury by increasing cyclic AMP levels
    Gary W Hoyle
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Proc Am Thorac Soc 7:284-9. 2010
  2. pmc Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation
    Gary W Hoyle
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Lung Cell Mol Physiol 298:L830-6. 2010
  3. pmc Deviations from Haber's Law for multiple measures of acute lung injury in chlorine-exposed mice
    Gary W Hoyle
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky 40202, USA
    Toxicol Sci 118:696-703. 2010
  4. pmc Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram
    Weiyuan Chang
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA
    Toxicol Appl Pharmacol 263:251-8. 2012
  5. doi Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide
    Jing Chen
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA
    Toxicol Appl Pharmacol 272:408-13. 2013
  6. pmc Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis
    Yiqun Mo
    Dept of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 701 HSC A, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Am J Physiol Lung Cell Mol Physiol 304:L92-102. 2013
  7. pmc Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells
    Weiyuan Chang
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky 40202, USA
    Exp Lung Res 35:324-43. 2009
  8. doi Tumor necrosis factor-α mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter
    Sadiatu Musah
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, United States
    Toxicology 299:125-32. 2012
  9. pmc Repair of tracheal epithelium by basal cells after chlorine-induced injury
    Sadiatu Musah
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 701 HSC A, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Respir Res 13:107. 2012

Research Grants

Collaborators

  • Jing Chen
  • Sadiatu Musah
  • Weiyuan Chang
  • Connie F Schlueter
  • Yiqun Mo
  • Yashwant V Pathak
  • Natasha Dejarnett
  • Roy J Rando

Detail Information

Publications9

  1. pmc Mitigation of chlorine lung injury by increasing cyclic AMP levels
    Gary W Hoyle
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Proc Am Thorac Soc 7:284-9. 2010
    ....
  2. pmc Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation
    Gary W Hoyle
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Lung Cell Mol Physiol 298:L830-6. 2010
    ..The results demonstrate that triptolide exhibits anti-inflammatory activity in cultured lung cells and in an in vivo model of acute lung injury...
  3. pmc Deviations from Haber's Law for multiple measures of acute lung injury in chlorine-exposed mice
    Gary W Hoyle
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky 40202, USA
    Toxicol Sci 118:696-703. 2010
    ....
  4. pmc Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram
    Weiyuan Chang
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA
    Toxicol Appl Pharmacol 263:251-8. 2012
    ..The results of the study suggest that rolipram may be an effective rescue treatment for chlorine-induced lung injury and that both systemic and targeted administration to the respiratory tract were effective routes of delivery...
  5. doi Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide
    Jing Chen
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA
    Toxicol Appl Pharmacol 272:408-13. 2013
    ..The results suggest that mometasone and budesonide may represent potential treatments for chemical-induced lung injury...
  6. pmc Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis
    Yiqun Mo
    Dept of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 701 HSC A, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Am J Physiol Lung Cell Mol Physiol 304:L92-102. 2013
    ..The observed differences in susceptibility to chlorine-induced airway disease provide a model in which mechanisms and treatment of airway fibrosis can be investigated...
  7. pmc Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells
    Weiyuan Chang
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky 40202, USA
    Exp Lung Res 35:324-43. 2009
    ..The results demonstrate a common signaling pathway in primary lung epithelial and endothelial cells, suggesting a generalized mechanism for the induction of proinflammatory gene expression by G(q)-coupled GPCRs following lung injury...
  8. doi Tumor necrosis factor-α mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter
    Sadiatu Musah
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, United States
    Toxicology 299:125-32. 2012
    ..The findings suggest a potential mechanism by which inhaled PM induces inflammation in the lung...
  9. pmc Repair of tracheal epithelium by basal cells after chlorine-induced injury
    Sadiatu Musah
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 701 HSC A, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Respir Res 13:107. 2012
    ..Efficient repair of injured epithelium is necessary to restore normal lung structure and function. The objective of the current study was to characterize repair of the tracheal epithelium after acute chlorine injury...

Research Grants2

  1. Novel Therapies for Chlorine-Induced Lung Injury
    Gary Hoyle; Fiscal Year: 2007
    ..S. civilians could be adversely affected by highly toxic chemicals released intentionally in terrorist attacks or unintentionally in industrial accidents or natural disasters. ..