C D Howell

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Peginterferon alfa-2a and ribavirin for chronic hepatitis C genotype 1 infections in black patients: safety, tolerability and impact on sustained virologic response
    C D Howell
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Viral Hepat 13:371-6. 2006
  2. pmc Peginterferon pharmacokinetics in African American and Caucasian American patients with hepatitis C virus genotype 1 infection
    Charles D Howell
    University of Maryland Baltimore School of Medicine, Baltimore, Maryland 21201, USA
    Clin Gastroenterol Hepatol 6:575-83. 2008
  3. ncbi request reprint Role of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 during nonsuppurative destructive cholangitis in a mouse graft-versus-host disease model
    C D Howell
    The University of Maryland at Baltimore, School of Medicine, Baltimore, MD, USA
    Hepatology 29:766-76. 1999
  4. ncbi request reprint Animal models of autoimmunity
    Charles D Howell
    Division of Hepatology, University of Maryland at Baltimore, 22 S Greene Street N, Baltimore, MD 21201, USA
    Clin Liver Dis 6:775-83. 2002
  5. pmc End-stage renal disease and African American race are independent predictors of mild liver fibrosis in patients with chronic hepatitis C infection
    F M Aslinia
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Viral Hepat 19:371-6. 2012
  6. ncbi request reprint Interferon-stimulated gene expression in black and white hepatitis C patients during peginterferon alfa-2a combination therapy
    Shengyuan Luo
    University of Maryland School of Medicine, USA
    Clin Gastroenterol Hepatol 3:499-506. 2005
  7. ncbi request reprint Biased liver T cell receptor V beta repertoire in a murine graft-versus-host disease model
    C D Howell
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    J Immunol 155:2350-8. 1995
  8. ncbi request reprint Peripheral blood gene expression profile associated with sustained virologic response after peginterferon plus ribavirin therapy for chronic hepatitis-C genotype 1
    Chao Huang
    Department of Medicine, Baltimore, MD, USA
    J Natl Med Assoc 100:1425-33. 2008
  9. ncbi request reprint Delayed granuloma formation in a patient with vanishing bile duct syndrome 7 years post-liver transplantation
    F A Anania
    Department of Medicine, The University of Maryland Medical Center and School of Medicine, Baltimore, MD 21201 1595, USA
    Liver Transpl 7:999-1001. 2001
  10. pmc Fibrosis progression in African Americans and Caucasian Americans with chronic hepatitis C
    Norah A Terrault
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    Clin Gastroenterol Hepatol 6:1403-11. 2008

Research Grants

  1. Baltimore VIRAHEP-C Clinical Center
    Charles Howell; Fiscal Year: 2005
  2. Ribavirin Pharmacokinetics, Race and HCV Treatment
    Charles Howell; Fiscal Year: 2007
  3. Racial Disparities in Liver Diseases
    Charles Howell; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Peginterferon alfa-2a and ribavirin for chronic hepatitis C genotype 1 infections in black patients: safety, tolerability and impact on sustained virologic response
    C D Howell
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Viral Hepat 13:371-6. 2006
    ..Adherence to at least >60% of the planned peginterferon alfa-2a and ribavirin doses for 48 weeks was associated with a greater SVR in black patients with HCV genotype 1 infections...
  2. pmc Peginterferon pharmacokinetics in African American and Caucasian American patients with hepatitis C virus genotype 1 infection
    Charles D Howell
    University of Maryland Baltimore School of Medicine, Baltimore, Maryland 21201, USA
    Clin Gastroenterol Hepatol 6:575-83. 2008
    ....
  3. ncbi request reprint Role of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 during nonsuppurative destructive cholangitis in a mouse graft-versus-host disease model
    C D Howell
    The University of Maryland at Baltimore, School of Medicine, Baltimore, MD, USA
    Hepatology 29:766-76. 1999
    ..01), but had no effect on IL-4, IL-10, and interferon gamma. Neither anti-ICAM-1 nor anti-LFA-1 prevented lymphocytes from homing to the liver. These results indicate that both ICAM-1 and LFA-1 are important to the pathogenesis of NSDC...
  4. ncbi request reprint Animal models of autoimmunity
    Charles D Howell
    Division of Hepatology, University of Maryland at Baltimore, 22 S Greene Street N, Baltimore, MD 21201, USA
    Clin Liver Dis 6:775-83. 2002
    ..Lastly, all models require more detailed characterization of the antigen specificity of infiltrating liver T cells and the pathogenesis of liver cell injury...
  5. pmc End-stage renal disease and African American race are independent predictors of mild liver fibrosis in patients with chronic hepatitis C infection
    F M Aslinia
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Viral Hepat 19:371-6. 2012
    ..Thus, HCV patients with ESRD had a lower degree of hepatic inflammation and fibrosis compared to those without renal disease, independent of race...
  6. ncbi request reprint Interferon-stimulated gene expression in black and white hepatitis C patients during peginterferon alfa-2a combination therapy
    Shengyuan Luo
    University of Maryland School of Medicine, USA
    Clin Gastroenterol Hepatol 3:499-506. 2005
    ..We hypothesized that racial differences in IFN-stimulated antiviral gene induction during treatment might be responsible...
  7. ncbi request reprint Biased liver T cell receptor V beta repertoire in a murine graft-versus-host disease model
    C D Howell
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    J Immunol 155:2350-8. 1995
    ..Alloantigens recognized by V beta 2+ CD4 cells appear to be selective for the liver. Expansion of V beta 3+ CD4 cells may reflect recognition of the host Mls-3 superantigen...
  8. ncbi request reprint Peripheral blood gene expression profile associated with sustained virologic response after peginterferon plus ribavirin therapy for chronic hepatitis-C genotype 1
    Chao Huang
    Department of Medicine, Baltimore, MD, USA
    J Natl Med Assoc 100:1425-33. 2008
    ..01). Many of the genes have been implicated in control of HCV lifecycle and thus may play important roles in HCV clearance during peginterferon and ribavirin therapy...
  9. ncbi request reprint Delayed granuloma formation in a patient with vanishing bile duct syndrome 7 years post-liver transplantation
    F A Anania
    Department of Medicine, The University of Maryland Medical Center and School of Medicine, Baltimore, MD 21201 1595, USA
    Liver Transpl 7:999-1001. 2001
    ..We are not aware of another case of granulomata associated with recurrent PSC or vanishing bile duct syndrome 7 years after liver transplantation...
  10. pmc Fibrosis progression in African Americans and Caucasian Americans with chronic hepatitis C
    Norah A Terrault
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    Clin Gastroenterol Hepatol 6:1403-11. 2008
    ..Prior studies suggest the rate of liver fibrosis progression is slower in African Americans (AAs) than Caucasian Americans (CAs) with chronic HCV infection...
  11. ncbi request reprint Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy
    James R Burton
    University of Colorado Denver, School of Medicine, Division Gastroenterology and Hepatology, Hepatitis C Research Center, Aurora, CO 80045, USA
    J Hepatol 49:329-38. 2008
    ..The role of HCV-specific CD4(+) T cells and regulatory T cells in influencing the outcome of antiviral therapy is incompletely defined...
  12. ncbi request reprint Racial differences in liver inflammation and fibrosis related to chronic hepatitis C
    Kester Crosse
    Department of Medicine, The University of Maryland Baltimore School of Medicine, USA
    Clin Gastroenterol Hepatol 2:463-8. 2004
    ..Hepatitis C virus (HCV) infection is more prevalent in black compared with white Americans. However, the natural course of HCV in black patients has not been defined...
  13. doi request reprint Prospective analysis of depression during peginterferon and ribavirin therapy of chronic hepatitis C: results of the Virahep-C study
    Donna M Evon
    Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 104:2949-58. 2009
    ..The objectives of this study were to determine the association between patient characteristics and depression before and during treatment and to evaluate the relationship between depression and treatment outcomes...
  14. pmc Simultaneous liver-kidney versus liver transplantation alone in patients with end-stage liver disease and kidney dysfunction not on dialysis
    A L Mindikoglu
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplant Proc 43:2669-77. 2011
    ..However, predictors and survival benefit of SLKT compared to liver transplantation alone (LTA) are not well defined...
  15. ncbi request reprint Distinctive clinical features of portopulmonary hypertension
    P C Kuo
    Department of Surgery, University of Maryland Medical System, Baltimore, USA
    Chest 112:980-6. 1997
    ..To differentiate the cardiopulmonary profile of portopulmonary hypertension (PPHTN) from that of primary pulmonary hypertension and chronic liver disease...
  16. ncbi request reprint Risk factors for primary hepatocellular carcinoma in black and white Americans in 2000
    Lei Yu
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Gastroenterol Hepatol 4:355-60. 2006
    ..The incidence of primary hepatocellular carcinoma (HCC) is greater in black Americans compared with white Americans. The aim of this study was to better define racial disparity in HCC patients in the United States...
  17. pmc Survival prediction and gene identification with penalized global AUC maximization
    Zhenqiu Liu
    Division of Biostatistics, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    J Comput Biol 16:1661-70. 2009
    ..Software is available upon request from the first author...
  18. ncbi request reprint Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1
    Hari S Conjeevaram
    Division of Gastroenterology, The University of Michigan, Ann Arbor, Michigan 48109 0362, USA
    Gastroenterology 131:470-7. 2006
    ..Compared with Caucasian Americans (CA), African Americans (AA) with chronic hepatitis C are less likely to respond to interferon-based antiviral therapy...
  19. ncbi request reprint Association of interferon-alpha-induced depression and improved treatment response in patients with hepatitis C
    Jennifer M Loftis
    Portland VA Medical Center, Behavioral Health and Clinical Neurosciences Division, OR, USA
    Neurosci Lett 365:87-91. 2004
    ..In conclusion, our findings suggest that IFN-alpha-induced MDD may be a predictor of a positive response to IFN-alpha therapy, or an indication of optimal dosing...
  20. ncbi request reprint Peginterferon alfa-2a (40 kd) and ribavirin for black American patients with chronic HCV genotype 1
    Lennox J Jeffers
    Miami Veterans Affairs Medical Center, Miami, FL, USA
    Hepatology 39:1702-8. 2004
    ....
  21. pmc A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection
    Ying Huang
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:985-90. 2007
    ....

Research Grants3

  1. Baltimore VIRAHEP-C Clinical Center
    Charles Howell; Fiscal Year: 2005
    ..These studies may provide important new insights into the pathogenesis of HCV and lead to novel therapies for chronic HCV. ..
  2. Ribavirin Pharmacokinetics, Race and HCV Treatment
    Charles Howell; Fiscal Year: 2007
    ..More effective treatments are necessary to reduce the disparities between African Americans and Caucasian Americans in sickness and deaths related to HCV liver disease. ..
  3. Racial Disparities in Liver Diseases
    Charles Howell; Fiscal Year: 2007
    ..abstract_text> ..