James Howe

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients
    Daniel Calva
    Department of Surgery, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, 52242 1086 IA, USA
    Nucleic Acids Res 39:5369-78. 2011
  2. pmc BMPR1A mutations in juvenile polyposis affect cellular localization
    James R Howe
    Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa Electronic address
    J Surg Res 184:739-45. 2013
  3. pmc A family with two consecutive nonsense mutations in BMPR1A causing juvenile polyposis
    James R Howe
    Department of Surgery, University of Iowa Carver College of Medicine, 4644 JCP, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1086, USA
    Cancer Genet Cytogenet 181:52-4. 2008
  4. pmc A gene for familial juvenile polyposis maps to chromosome 18q21.1
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242 1086, USA
    Am J Hum Genet 62:1129-36. 1998
  5. pmc The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
    J Med Genet 41:484-91. 2004
  6. pmc Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot
    James R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
    Am J Hum Genet 70:1357-62. 2002
  7. ncbi request reprint Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Nat Genet 28:184-7. 2001
  8. ncbi request reprint Minimally invasive parathyroid surgery
    J R Howe
    Department of Surgery, University of Iowa Health Care, Iowa City 52242, USA
    Surg Clin North Am 80:1399-426. 2000
  9. ncbi request reprint Small bowel sarcoma: analysis of survival from the National Cancer Data Base
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City 52242, USA
    Ann Surg Oncol 8:496-508. 2001
  10. ncbi request reprint Mutations in the SMAD4/DPC4 gene in juvenile polyposis
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 280:1086-8. 1998

Collaborators

Detail Information

Publications28

  1. pmc Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients
    Daniel Calva
    Department of Surgery, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, 52242 1086 IA, USA
    Nucleic Acids Res 39:5369-78. 2011
    ..The elucidation of these promoters and identification of TFBS has important implications for future studies in sporadic tumors from multiple sites, and in JP patients...
  2. pmc BMPR1A mutations in juvenile polyposis affect cellular localization
    James R Howe
    Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa Electronic address
    J Surg Res 184:739-45. 2013
    ..Mutations in the bone morphogenetic protein receptor type 1A (BMPR1A) are known to predispose to JP. We set out to study the effect of such missense mutations on BMPR1A cellular localization...
  3. pmc A family with two consecutive nonsense mutations in BMPR1A causing juvenile polyposis
    James R Howe
    Department of Surgery, University of Iowa Carver College of Medicine, 4644 JCP, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1086, USA
    Cancer Genet Cytogenet 181:52-4. 2008
    ..This mutation caused protein truncation, and represents a novel case of consecutive nonsense mutations in human disease...
  4. pmc A gene for familial juvenile polyposis maps to chromosome 18q21.1
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242 1086, USA
    Am J Hum Genet 62:1129-36. 1998
    ..These data demonstrate localization of a gene for FJP to chromosome 18q21.1 by linkage, and they raise the possibility that either DCC or DPC4 could be responsible for FJP...
  5. pmc The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
    J Med Genet 41:484-91. 2004
    ..This study determined the prevalence of mutations in MADH4 and BMPR1A, as well as three other BMP/activin pathway candidate genes in a large number of JP patients...
  6. pmc Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot
    James R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
    Am J Hum Genet 70:1357-62. 2002
    ....
  7. ncbi request reprint Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Nat Genet 28:184-7. 2001
    ..These findings indicate involvement of an additional gene in the transforming growth factor-beta (TGF-beta) superfamily in the genesis of JP, and document an unanticipated function for BMP in colonic epithelial growth control...
  8. ncbi request reprint Minimally invasive parathyroid surgery
    J R Howe
    Department of Surgery, University of Iowa Health Care, Iowa City 52242, USA
    Surg Clin North Am 80:1399-426. 2000
    ..Results of minimally invasive techniques, including radio-guided parathyroidectomy, endoscopic parathyroidectomy, and outpatient parathyroidectomy, also are presented...
  9. ncbi request reprint Small bowel sarcoma: analysis of survival from the National Cancer Data Base
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City 52242, USA
    Ann Surg Oncol 8:496-508. 2001
    ..The objective of this study was to examine patient and tumor factors in SBS and to determine prognostic factors for disease-specific survival (DSS) using the National Cancer Data Base...
  10. ncbi request reprint Mutations in the SMAD4/DPC4 gene in juvenile polyposis
    J R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 280:1086-8. 1998
    ..The mutant SMAD4 proteins are predicted to be truncated at the carboxyl-terminus and lack sequences required for normal function. These results confirm an important role for SMAD4 in the development of gastrointestinal tumors...
  11. ncbi request reprint Differences in the pattern of presentation and treatment of proximal and distal gastric cancer: results of the 2001 gastric patient care evaluation
    Neal W Wilkinson
    Division of Surgical Oncology, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Ann Surg Oncol 15:1644-50. 2008
    ..The purpose of this analysis was to highlight key differences between proximal and distal gastric cancer as they relate to presentation and treatment...
  12. ncbi request reprint Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior
    Thomas M O'Dorisio
    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pancreas 39:611-6. 2010
    ..Existing pancreastatin assays, which depend on antibodies that cross-react in varying percents with the larger prohormone, may lack sensitivity and specificity to detect small changes in neuroendocrine tumor volume...
  13. ncbi request reprint ECM1 expression in thyroid tumors--a comparison of real-time RT-PCR and IHC
    Geeta Lal
    Department of Surgery, Section of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Surg Res 149:62-8. 2008
    ..The purpose of the current study is to evaluate and compare ECM1 expression by real-time RT-PCR with immunohistochemistry (IHC) as diagnostic aids in thyroid neoplasms...
  14. ncbi request reprint Determinants of survival in patients with calciphylaxis: a multivariate analysis
    Geeta Lal
    Department of Surgery, University of Iowa Hospitals, Iowa City, IA 52242, USA
    Surgery 146:1028-34. 2009
    ..Our study aims to assess the factors affecting survival in patients with calciphylaxis...
  15. doi request reprint PET-CT scans in recurrent or persistent differentiated thyroid cancer: is there added utility beyond conventional imaging?
    Geeta Lal
    Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Surgery 148:1082-9; discussion 1089-90. 2010
    ..Integrated positron emission tomography (PET)-computed tomography (CT) may have advantages over conventional imaging in localizing recurrent or persistent differentiated thyroid cancer...
  16. ncbi request reprint Genetic conditions associated with intestinal juvenile polyps
    Anders Merg
    Surgical Oncology and Endocrine Surgery, Department of Surgery, Roy J and Lucille A Carver Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Med Genet C Semin Med Genet 129:44-55. 2004
    ..Mutations of the tumor suppressor gene PTEN have been found in the germline of both CS and BRRS patients. Despite different underlying genetic mechanisms, these and other syndromes share the same phenotypic feature of juvenile polyps...
  17. doi request reprint When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation?
    Daniel Calva
    Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, University of Iowa College of Medicine, Iowa City, IA, USA
    Ann Surg Oncol 16:2237-44. 2009
    ..We report a three-generation family with C609Y RET mutation where members having prophylactic or therapeutic thyroidectomy call the current recommendations for age at thyroidectomy into question...
  18. ncbi request reprint Minimally invasive parathyroidectomy and preoperative MIBI scans: correlation of gland weight and preoperative PTH
    Daniel Calva-Cerqueira
    Department of Surgery, University of Iowa Carver College of Medicine, IA, USA
    J Am Coll Surg 205:S38-44. 2007
    ..This strategy depends on preoperative localization tests, of which the MIBI scan is the most commonly used. This study details one surgeon's MIP experience and examines factors that correlate with the results of sestamibi (MIBI) scans...
  19. doi request reprint Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis?
    Ottar M Bergmann
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Lab Invest 88:1349-57. 2008
    ..However, there are complex alterations in DMT1 and ferroportin expression in cirrhotic liver, including decreases in ferroportin and DMT1 at the protein level that may play a role in aberrant regulation of iron metabolism in cirrhosis...
  20. ncbi request reprint RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
    Geeta Lal
    Department of Surgery, Division of Surgical Oncology, University of Iowa, Iowa City, Iowa, USA
    Cancer 107:2752-9. 2006
    ..RIZ1 expression is lost in a variety of tumors, primarily by means of epigenetic mechanisms that involve promoter hypermethylation...
  21. ncbi request reprint Role for limited neck exploration in young adults with apparently sporadic primary hyperparathyroidism
    Laura A Adam
    Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    World J Surg 32:1518-24. 2008
    ..We hypothesized that young adults (ages 16-40 years) without familial PHPT have a disease process similar to that in older patients...
  22. ncbi request reprint Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases
    Denis M McCarthy
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 16:272-8. 2003
    ..Although ampullary and pancreatic adenocarcinomas share histologic and molecular features, ampullary carcinomas are less likely to show loss of Dpc4 expression or K-ras gene mutations...
  23. pmc Hamartomatous polyposis syndromes
    Daniel Calva
    University of Iowa, Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 2600, USA
    Surg Clin North Am 88:779-817, vii. 2008
    ..Although the incidence of these syndromes is low, it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients, and to perform presymptomatic testing in patients at risk...
  24. pmc A new way to rapidly create functional, fluorescent fusion proteins: random insertion of GFP with an in vitro transposition reaction
    Douglas L Sheridan
    Department of Cellular and Molecular Physiology, Yale University Medical School, 330 Cedar St, New Haven, CT 06520, USA
    BMC Neurosci 3:7. 2002
    ..Finding permissive sites for insertion, however, can be difficult. Here we describe a transposon-based approach for rapidly creating libraries of GFP fusion proteins...
  25. ncbi request reprint Hereditary colorectal cancer-part II
    Anders Merg
    Roswell Park Cancer Institute, Buffalo, New York, USA
    Curr Probl Surg 42:267-333. 2005
  26. ncbi request reprint Hereditary colon cancer--part I
    Anders Merg
    Roswell Park Cancer Center, Buffalo, New York, USA
    Curr Probl Surg 42:195-256. 2005
  27. ncbi request reprint Challenging colonic polyposis pedigrees: differential diagnosis, surveillance, and management concerns
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 148:104-17. 2004
    ....
  28. ncbi request reprint Desensitization at the interface
    James R Howe
    Department of Pharmacology, Yale University School of Medicine, SHM B 251, 333 Cedar Street, New Haven, Connecticut 06520, USA
    ACS Chem Biol 1:623-6. 2006
    ..Recent structural data have begun to provide important insights into the molecular mechanisms that underlie channel activation and desensitization...

Research Grants5

  1. Molecular Basis of Juvenile Polyposis
    James Howe; Fiscal Year: 2003
    ..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
  2. The Molecular Basis of Juvenile Polyposis
    James Howe; Fiscal Year: 2004
    ..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
  3. The Molecular Basis of Juvenile Polyposis
    James Howe; Fiscal Year: 2005
    ..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
  4. Regulation of SMAD4 and BMPR1A Expression in Juvenile Polyposis
    James Howe; Fiscal Year: 2009
    ..abstract_text> ..
  5. Regulation of SMAD4 and BMPR1A Expression in Juvenile Polyposis
    James R Howe; Fiscal Year: 2010
    ..abstract_text> ..