Marybeth Howard

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70
    Marybeth Howard
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, CA 94110, USA
    Thorax 65:346-53. 2010
  2. pmc PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice
    Arnaud Goolaerts
    Department of Anesthesiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    Thorax 66:788-96. 2011
  3. pmc Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice
    Nastasha Bir
    Cardiovascular Research Institute and Institute of Molecular Medicine, Department of Anesthesia, University of California at San Francisco, San Francisco, California, USA
    Am J Respir Cell Mol Biol 45:632-41. 2011
  4. doi Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice
    Michel Carles
    Department of Anesthesia, University of Alabama, Birmingham, AL, USA
    Anesthesiology 113:1134-43. 2010
  5. pmc Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport
    Marybeth Howard
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, California, USA
    Shock 39:189-96. 2013
  6. pmc Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel
    Arnaud Goolaerts
    Department of Anesthesia, Room 3C 38, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Am J Respir Cell Mol Biol 43:99-108. 2010
  7. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
  8. pmc Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability
    Michael T Ganter
    Department of Anesthesia and Surgery, University of California San Francisco, San Francisco, California 94110, USA
    Am J Respir Cell Mol Biol 40:108-18. 2009
  9. pmc Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury
    Michael T Ganter
    Department of Anesthesia, University of California, San Francisco, 94110, USA
    Am J Physiol Lung Cell Mol Physiol 291:L354-61. 2006
  10. pmc Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism
    Jeremie Roux
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:4278-90. 2010

Collaborators

Detail Information

Publications13

  1. pmc Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70
    Marybeth Howard
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, CA 94110, USA
    Thorax 65:346-53. 2010
    ..The activation of the stress protein response (SPR) in alveolar macrophages on iNOS-dependent NO production in response to interferon gamma (IFNgamma), a major cytokine present in the airspace of patients with ALI, was investigated...
  2. pmc PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice
    Arnaud Goolaerts
    Department of Anesthesiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    Thorax 66:788-96. 2011
    ..However, whether PAI-1 plays a pathogenic role in the breakdown of the alveolar-capillary barrier caused by P aeruginosa is unknown...
  3. pmc Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice
    Nastasha Bir
    Cardiovascular Research Institute and Institute of Molecular Medicine, Department of Anesthesia, University of California at San Francisco, San Francisco, California, USA
    Am J Respir Cell Mol Biol 45:632-41. 2011
    ..aeruginosa-induced lung vascular permeability and mortality, suggesting that cytoprotective-selective aPC-5A with diminished bleeding risks could attenuate the lung damage caused by P. aeruginosa in critically ill patients...
  4. doi Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice
    Michel Carles
    Department of Anesthesia, University of Alabama, Birmingham, AL, USA
    Anesthesiology 113:1134-43. 2010
    ..However, whether inhibition of RhoA would significantly attenuate P. aeruginosa-mediated lung injury in mice is unknown...
  5. pmc Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport
    Marybeth Howard
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, California, USA
    Shock 39:189-96. 2013
    ..These studies demonstrate new mechanisms by which the induction of the heat shock response protects the barrier function of the alveolar epithelium in ALI...
  6. pmc Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel
    Arnaud Goolaerts
    Department of Anesthesia, Room 3C 38, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Am J Respir Cell Mol Biol 43:99-108. 2010
    ..Together, these results indicate that 5-HT inhibits the amiloride-sensitive fraction of the alveolar epithelial fluid transport via a direct interaction with ENaC, and thus can be an endogenous inhibitor of this ion channel...
  7. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
    ..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
  8. pmc Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability
    Michael T Ganter
    Department of Anesthesia and Surgery, University of California San Francisco, San Francisco, California 94110, USA
    Am J Respir Cell Mol Biol 40:108-18. 2009
    ..aeruginosa-induced lung vascular permeability. In addition, activation of the stress protein response with pharmacologic inhibitors of Hsp90 may protect lungs against P. aeruginosa-induced permeability changes...
  9. pmc Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury
    Michael T Ganter
    Department of Anesthesia, University of California, San Francisco, 94110, USA
    Am J Physiol Lung Cell Mol Physiol 291:L354-61. 2006
    ..Thus SPR may protect the alveolar epithelium against oxidative stress associated with experimental ALI, and eHsp72 may serve as a marker of SPR activation in the distal air spaces of patients with ALI...
  10. pmc Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism
    Jeremie Roux
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:4278-90. 2010
    ....
  11. pmc Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
    Mitchell J Cohen
    The Department of Surgery, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    Crit Care 13:R174. 2009
    ..However, whether HMGB1 is released early after trauma hemorrhage in humans and is associated with the development of an inflammatory response and coagulopathy is not known and therefore constitutes the aim of the present study...
  12. ncbi Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway
    Melissa H Pespeni
    Laboratory of Surgical Research, Cardiovascular Research Institute, University of California San Francisco, California 94110, USA
    Cancer Res 67:2865-71. 2007
    ..In summary, these results support the novel concept that heat stress inhibits the Akt pathway by dissociating PDK-1 from its chaperone Hsp90, leading to potentiation of TRAIL-induced apoptosis in resistant malignant cells...
  13. ncbi Serum levels of Hsp60 correlate with the development of acute lung injury after trauma
    Melissa Pespeni
    Department of Anesthesia, San Francisco General Hospital, University of California, California 94110, USA
    J Surg Res 126:41-7. 2005
    ..The purpose of this study was to determine whether Hsp60 could be detected in the serum of patients early after severe trauma and whether its serum level might correlate with the development of acute lung injury (ALI) in trauma patients...