JeanMarie Houghton

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Helicobacter species methods and protocols. Introduction
    Jean Marie Houghton
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School Worcester, Worcester, MA, USA
    Methods Mol Biol 921:1-5. 2012
  2. pmc Mutations in bone marrow-derived stromal stem cells unmask latent malignancy
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts 01635, USA
    Stem Cells Dev 19:1153-66. 2010
  3. ncbi request reprint Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Gastroenterology 128:1567-78. 2005
  4. ncbi request reprint Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
  5. ncbi request reprint Stem cells and cancer
    JeanMarie Houghton
    Department of Medicine, GI Division, University of Massachusetts Medical School, LRB Second Floor, Room 209, 364 Plantation Street, Worcester, MA 01605 2324, United States
    Semin Cancer Biol 17:191-203. 2007
  6. ncbi request reprint Bone-marrow-derived cells and cancer--an opportunity for improved therapy
    JeanMarie Houghton
    Division of Gastroenterology, Department of Cancer Biology, University of Massachusetts Medical School, LRB 209, 364 Plantation Street, Worcester, MA 01605, USA
    Nat Clin Pract Oncol 4:2-3. 2007
  7. ncbi request reprint Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility
    Hanchen Li
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, LRB Second Floor, Room 209, 364 Plantation Street, Worcester MA 01605, USA
    Curr Gastroenterol Rep 5:459-67. 2003
  8. ncbi request reprint Gastric cancer: laboratory bench to clinic
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical Center, NRB Second Floor, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Gastroenterol Hepatol 17:495-502. 2002
  9. pmc T-bet knockout prevents Helicobacter felis-induced gastric cancer
    Calin Stoicov
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01635, USA
    J Immunol 183:642-9. 2009
  10. ncbi request reprint Carcinogenesis of Helicobacter pylori
    Pelayo Correa
    Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 133:659-72. 2007

Research Grants

  1. Role of Fas/NF kB in H.pylori induced gastric carcinoma
    JeanMarie Houghton; Fiscal Year: 2003
  2. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2010
  3. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2009
  4. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2009
  5. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2007
  6. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2007
  7. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2006
  8. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2006
  9. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Helicobacter species methods and protocols. Introduction
    Jean Marie Houghton
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School Worcester, Worcester, MA, USA
    Methods Mol Biol 921:1-5. 2012
    ..The following chapters will describe the clinical aspects of infection and touch on the important techniques for optimal investigation of this infection...
  2. pmc Mutations in bone marrow-derived stromal stem cells unmask latent malignancy
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts 01635, USA
    Stem Cells Dev 19:1153-66. 2010
    ..The significant synergy between host immunity and mesenchymal cells identified here may restructure treatments to restore an anticancer microenvironment...
  3. ncbi request reprint Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Gastroenterology 128:1567-78. 2005
    ..It is likely that this new BMDC paradigm of epithelial cancer will prove useful in future investigations of gastrointestinal metaplasia and gastrointestinal cancers associated with chronic inflammation...
  4. ncbi request reprint Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  5. ncbi request reprint Stem cells and cancer
    JeanMarie Houghton
    Department of Medicine, GI Division, University of Massachusetts Medical School, LRB Second Floor, Room 209, 364 Plantation Street, Worcester, MA 01605 2324, United States
    Semin Cancer Biol 17:191-203. 2007
    ....
  6. ncbi request reprint Bone-marrow-derived cells and cancer--an opportunity for improved therapy
    JeanMarie Houghton
    Division of Gastroenterology, Department of Cancer Biology, University of Massachusetts Medical School, LRB 209, 364 Plantation Street, Worcester, MA 01605, USA
    Nat Clin Pract Oncol 4:2-3. 2007
  7. ncbi request reprint Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility
    Hanchen Li
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, LRB Second Floor, Room 209, 364 Plantation Street, Worcester MA 01605, USA
    Curr Gastroenterol Rep 5:459-67. 2003
    ....
  8. ncbi request reprint Gastric cancer: laboratory bench to clinic
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical Center, NRB Second Floor, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Gastroenterol Hepatol 17:495-502. 2002
    ..Identifying potentially removable factors (in addition to H. pylori infection) in the acquisition and progression of neoplastic disease may provide targets for early intervention and prevention strategies...
  9. pmc T-bet knockout prevents Helicobacter felis-induced gastric cancer
    Calin Stoicov
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01635, USA
    J Immunol 183:642-9. 2009
    ....
  10. ncbi request reprint Carcinogenesis of Helicobacter pylori
    Pelayo Correa
    Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 133:659-72. 2007
    ....
  11. ncbi request reprint Gastrin-induced apoptosis contributes to carcinogenesis in the stomach
    Guanglin Cui
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Lab Invest 86:1037-51. 2006
    ..These results indicate that gastrin can induce apoptosis in gastric epithelial cells and contribute to the development of gastric carcinogenesis...
  12. pmc Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation
    Calin Stoicov
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, Worcester, 01615, USA
    Infect Immun 73:6311-21. 2005
    ..Depolymerization of actin with cytochalasin D allows receptors to aggregate and restores Fas sensitivity. These findings offer one mechanism by which gastric mucosal cells acquire Fas resistance...
  13. pmc Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building Rm 226, Worcester, MA 01605, USA
    Infect Immun 75:471-80. 2007
    ..Our studies suggest that TFF2 not only controls gastrointestinal repair but also regulates mononuclear cell inflammatory responses...
  14. pmc Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver
    Hanchen Li
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01635, USA
    Gastroenterology 137:934-44, 944.e1-4. 2009
    ..However, direct causality between these alterations and clinical disease progression has not been shown...
  15. ncbi request reprint Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 128:1965-83. 2005
    ..We used this model to examine the role of cholecystokinin 2 (CCK2)/gastrin receptor and histamine H2-receptor signaling in the development of gastric atrophy and cancer...
  16. ncbi request reprint Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice
    Xun Cai
    Division of Gastroenterology, Department of Internal Medicine, University of Massachusetts Medical School, Worcester 01605 2324, USA
    Gastroenterology 128:1937-52. 2005
    ..This study examined the effects of eradication therapy on inflammation, atrophy, metaplasia, dysplasia, and cancer progression...
  17. ncbi request reprint Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in mice
    Xun Cai
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Cancer Res 65:10912-20. 2005
    ..This earlier onset and more aggressive histology strongly argues that Fas-apoptosis resistance is an early and important feature of gastric cancer formation...
  18. pmc Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation
    Calin Stoicov
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01635, USA
    Dig Dis Sci 58:2466-77. 2013
    ..CXCR4/SDF-1 axis is used by MSC in trafficking, homing, and engraftment at chronic inflammation sites, and plays an important role in tumorigenesis...
  19. doi request reprint Helicobacter-based mouse models of digestive system carcinogenesis
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Mol Biol 511:267-95. 2009
    ....
  20. ncbi request reprint Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells
    Hanchen Li
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Physiol Gastrointest Liver Physiol 294:G263-75. 2008
    ....
  21. ncbi request reprint Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling
    Calin Stoicov
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building Room, 2nd Floor, Room 209, Worcester, MA 01605, USA
    Gene 341:1-17. 2004
    ..Modulation of the pivotal balance between cell growth and cell death leads to the formation of gastric adenocarcinoma...
  22. ncbi request reprint Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice
    Hanchen Li
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Cancer Res 67:10889-98. 2007
    ..These data suggest that MSCs may play a key role in age-related tumors, and fusion with host cells restores a nonmalignant phenotype, thereby providing a mechanism for regulating tumor cell activity...
  23. pmc Green tea inhibits Helicobacter growth in vivo and in vitro
    Calin Stoicov
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Int J Antimicrob Agents 33:473-8. 2009
    ..Components within natural remedies such as green tea could be further used for prevention and treatment of Helicobacter-induced gastritis in humans...
  24. ncbi request reprint Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections
    Calin Stoicov
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3329-36. 2004
    ..These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease...
  25. ncbi request reprint Bone marrow cells as the origin of stomach cancer
    Calin Stoicov
    University of Massachusetts Medical School, Department of Medicine, Division of Gasteroenterology, Department of Cancer Biology, Worcester MA 01605, USA
    Future Oncol 1:851-62. 2005
    ..Identifying the cell responsible for initiating a tumor offers the exciting possibility of specifically targeting unique aspects of these cells and altering signaling properties for more effective therapeutic approaches...
  26. ncbi request reprint Role of therapy or monitoring in preventing progression to gastric cancer
    Jaroslav Zivny
    Gastroenterology Division and Department of Medicine, University of Massachusetts School of Medicine, Lazare Research Building, Room 209, 364 Plantation Street, Worcester, MA 01605 2324, U S A
    J Clin Gastroenterol 36:S50-60; discussion S61-2. 2003
    ....
  27. pmc Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant
    Lloyd Hutchinson
    Department of Pathology, UMass Memorial Health Care, Worcester, MA, USA
    Stem Cells Dev 20:11-7. 2011
    ..These findings demonstrate that BMDCs can generate cancer-associated fibroblasts as well as contribute directly to epithelial cells in cancer of the esophagus...
  28. pmc NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer
    Justin Maykel
    Division of Colorectal Surgery, Department of Surgery, UMass Memorial Health Care System, Worcester, MA, USA
    Dig Dis Sci 59:1169-79. 2014
    ..In contrast, severely immunodeficient NOD-scid and NOD-Rag1 (null) strains carrying the IL2rg (null) mutation (NSG and NRG) support the growth of many types of human primary tumors...
  29. ncbi request reprint Tumor microenvironment: the role of the tumor stroma in cancer
    Hanchen Li
    Division of Gastroenterology, Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biochem 101:805-15. 2007
    ..Additionally, we will emphasize the role of the bone marrow-derived cell in providing cells for the stroma...
  30. pmc Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4
    Leisa Mandell
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01605, USA
    Infect Immun 72:6446-54. 2004
    ..Our studies suggest that TLR2 may be the dominant innate immune receptor for recognition of gastrointestinal Helicobacter species...
  31. pmc Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers
    Han chen Li
    Department of Medicine, University of Massachusetts Medical School, LRB Second Floor, Room 209, 364 Plantation Street, Worcester, MA 01605 2324, United States
    World J Gastroenterol 12:363-71. 2006
    ..Here we review the recent advances in our understanding of the contributions of circulating bone marrow-derived stem cells to the formation of tumors in animal models as well as in human beings...
  32. ncbi request reprint Glycine-extended gastrin promotes the growth of lung cancer
    Theodore J Koh
    Gastroenterology Division and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Cancer Res 64:196-201. 2004
    ..Taken together, these results suggest that glycine-extended gastrin may play a role in the growth and progression of some human lung cancers...
  33. pmc Slow-cycling therapy-resistant cancer cells
    Nathan Moore
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stem Cells Dev 21:1822-30. 2012
    ..Further, we demonstrate the innovative application of CFSE to live sort slow-cycling tumor cells and validate their chemoresistance and tumorigenic potential...
  34. ncbi request reprint Human plasma is directly bacteriocidal against Helicobacter pylori in vitro, potentially explaining the decreased detection of Helicobacter pylori during acute upper GI bleeding
    JeanMarie Houghton
    Department of Medicine, The Division of Gastroenterology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Gastrointest Endosc 55:11-6. 2002
    ..It has been suggested that false-negative results occur, resulting from buffering effects of blood. The direct effect of blood was evaluated on H pylori growth in ex vivo and in vitro systems...
  35. ncbi request reprint Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders
    Jan Cerny
    Department of Medicine, Division of Hematology and Oncology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hematology 14:187-97. 2009
    ..Rituximab based therapy induces MR in high number of patients, which can be further improved by ASCT and patients have an excellent outcome. PCR positive harvest represents a high risk of relapse after ASCT...

Research Grants11

  1. Role of Fas/NF kB in H.pylori induced gastric carcinoma
    JeanMarie Houghton; Fiscal Year: 2003
    ..Defining the regulation of these pathways will help define the complex relationship helicobacter shares with its host. ..
  2. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2010
    ..We have identified a role for bone marrow stem cells in cancer formation. This grant will mechanistically address how these cells cause cancer, and may shed light on new approaches to treat epithelial cancers. ..
  3. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2009
    ..These studies will provide critical insight into novel preventive, and anti-cancer strategies aimed at restoring Fas sensitivity within tumor cells and provide a new direction for cancer treatment. ..
  4. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2009
    ..We have identified a role for bone marrow stem cells in cancer formation. This grant will mechanistically address how these cells cause cancer, and may shed light on new approaches to treat epithelial cancers. ..
  5. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2007
    ..These studies will provide critical insight into novel preventive, and anti-cancer strategies aimed at restoring Fas sensitivity within tumor cells and provide a new direction for cancer treatment. ..
  6. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2007
    ..We have identified a role for bone marrow stem cells in cancer formation. This grant will mechanistically address how these cells cause cancer, and may shed light on new approaches to treat epithelial cancers. ..
  7. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2006
    ..abstract_text> ..
  8. Stem Cells and Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2006
    ..We have identified a role for bone marrow stem cells in cancer formation. This grant will mechanistically address how these cells cause cancer, and may shed light on new approaches to treat epithelial cancers. ..
  9. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2010
    ..These studies will provide critical insight into novel preventive, and anti-cancer strategies aimed at restoring Fas sensitivity within tumor cells and provide a new direction for cancer treatment. ..