Patricia R Houck

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint An intent-to-treat method for enhancing analysis of clinical trials with rescue medication: a mixed-model approach
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Psychopharmacol Bull 37:79-89. 2003
  2. ncbi request reprint Reliability of the self-report version of the panic disorder severity scale
    Patricia R Houck
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 15:183-5. 2002
  3. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
  4. pmc Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
  5. ncbi request reprint Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
  6. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
  7. pmc Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
  8. pmc Protecting sleep, promoting health in later life: a randomized clinical trial
    Charles F Reynolds
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Psychosom Med 72:178-86. 2010
  9. pmc Cognitive performance in suicidal depressed elderly: preliminary report
    Alexandre Y Dombrovski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:109-15. 2008
  10. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006

Detail Information

Publications86

  1. ncbi request reprint An intent-to-treat method for enhancing analysis of clinical trials with rescue medication: a mixed-model approach
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Psychopharmacol Bull 37:79-89. 2003
    ..This analytic approach illustrates the importance of collecting and incorporating data after rescue, including the timing of rescue...
  2. ncbi request reprint Reliability of the self-report version of the panic disorder severity scale
    Patricia R Houck
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 15:183-5. 2002
    ..81) and was sensitive to change with treatment, with a mean decrease of 7.3 (S.D.=5.1). The self-report version of the PDSS is a reliable format, which could be useful in clinical and research settings...
  3. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  4. pmc Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  5. ncbi request reprint Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
    ..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy...
  6. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..Anxiety disorders are common in later life, but little is known about the long-term benefits and risks of pharmacotherapy...
  7. pmc Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
    ..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression...
  8. pmc Protecting sleep, promoting health in later life: a randomized clinical trial
    Charles F Reynolds
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Psychosom Med 72:178-86. 2010
    ..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life...
  9. pmc Cognitive performance in suicidal depressed elderly: preliminary report
    Alexandre Y Dombrovski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:109-15. 2008
    ..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts...
  10. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  11. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  12. ncbi request reprint Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..To explore clinical and treatment-response variability in late-onset vs early-onset non-bipolar, non-psychotic major depression...
  13. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  14. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  15. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..The objective of this study was to describe the correlates of prior antidepressant exposure and its association with response to protocolized treatment in older patients with major depression...
  16. pmc Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
    ..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment...
  17. pmc Treating post-CABG depression with telephone-delivered collaborative care: does patient age affect treatment and outcome?
    Herbert C Schulberg
    Department of Psychiatry, Weill Cornell Medical College, White Plains, New York, USA
    Am J Geriatr Psychiatry 19:871-80. 2011
    ....
  18. pmc A comparison of the frequencies of risk factors for depression in older black and white participants in a study of indicated prevention
    Roy Sriwattanakomen
    University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, PA, USA
    Int Psychogeriatr 22:1240-7. 2010
    ..To compare the frequencies of risk factors, we describe risks for depression as a function of race among consecutively admitted participants in a randomized clinical trial of indicated depression prevention in later life...
  19. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  20. ncbi request reprint Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:550-4. 2006
    ..The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression...
  21. pmc Statistical analysis of longitudinal psychiatric data with dropouts
    Sati Mazumdar
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Psychiatr Res 41:1032-41. 2007
    ....
  22. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  23. pmc Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care management
    Charles F Reynolds
    Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 25:1134-41. 2010
    ....
  24. ncbi request reprint Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
    ..No significant treatment differences were found. We conclude that attention to the missing-data mechanism should be an integral part in analysis of clinical trial data...
  25. ncbi request reprint Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The purpose of this study was to determine whether comorbid GAD or PD was associated with poorer long-term outcomes of late-life MDD, in terms of symptoms, functional disability, and cognitive status...
  26. ncbi request reprint Impact of cluster C personality disorders on outcomes of acute and maintenance treatment in late-life depression
    Jennifer Q Morse
    Personality Studies, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:808-14. 2005
    ..Personality disorders (PDs) have been associated with poor treatment outcomes in acute treatments for late-life depression and with persistent functional impairment after recovery from an episode of depression...
  27. ncbi request reprint Relationship of variability in residual symptoms with recurrence of major depressive disorder during maintenance treatment
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1877-84. 2004
    ....
  28. pmc Telephone-delivered collaborative care for treating post-CABG depression: a randomized controlled trial
    Bruce L Rollman
    Division of General Internal Medicine, Center for Research on Health Care, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    JAMA 302:2095-103. 2009
    ..Depressive symptoms commonly follow coronary artery bypass graft (CABG) surgery and are associated with less positive clinical outcomes...
  29. pmc A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive function
    Kristen Carreira
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 23:1110-3. 2008
    ..To evaluate the effect of maintenance Interpersonal Psychotherapy (IPT) on recurrence rates and time to recurrence of major depression in elderly patients with varying levels of cognitive function...
  30. pmc Sex differences in correlates of suicide attempt lethality in late life
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 16:905-13. 2008
    ..To understand this sex difference, the authors assessed correlates of suicide attempt lethality in older men and women...
  31. ncbi request reprint Indirect self-destructive behavior and overt suicidality in patients with complicated grief
    Katalin Szanto
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 67:233-9. 2006
    ..Therefore, we examined suicidal behavior and its correlates in 149 patients who signed informed consent statements to participate in a National Institute of Mental Health-funded treatment study of complicated grief...
  32. pmc Adolescent substance use in the multimodal treatment study of attention-deficit/hyperactivity disorder (ADHD) (MTA) as a function of childhood ADHD, random assignment to childhood treatments, and subsequent medication
    Brooke S G Molina
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 52:250-63. 2013
    ....
  33. pmc Coping with health stresses and remission from late-life depression in primary care: a two-year prospective study
    Meredith L Wallace
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 27:178-86. 2012
    ..Conversely, disengagement strategies involve the withdrawal of these resources from obsolete or unattainable health goals, combined with goal restructuring...
  34. ncbi request reprint Treating complicated grief: effects on sleep quality
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 4:152-63. 2006
    ..Given that sleep disturbance is a risk factor for poor health outcomes, adjunctive sleep interventions may be necessary to enhance CGT outcomes...
  35. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  36. pmc Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and older
    Henry C Driscoll
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 16:74-82. 2008
    ....
  37. ncbi request reprint Trajectories of treatment response in late-life depression: psychosocial and clinical correlates
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S8-13. 2005
    ..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies...
  38. pmc Efficacy of brief behavioral treatment for chronic insomnia in older adults
    Daniel J Buysse
    Sleep Medicine Institute, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Arch Intern Med 171:887-95. 2011
    ..Cognitive behavioral treatments are efficacious but not widely available. The aim of this study was to test the efficacy of brief behavioral treatment for insomnia (BBTI) vs an information control (IC) condition...
  39. pmc Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:51-60. 2011
    ..Cognitive impairment in late-life depression is a core feature of the illness...
  40. pmc Disability in late-life major depression: patterns of self-reported task abilities, task habits, and observed task performance
    Joan C Rogers
    Department of Occupational Therapy, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, USA
    Psychiatry Res 178:475-9. 2010
    ..The findings led us to conclude that when performance testing is not feasible, self-reports of functional status that focus on habits may be more accurate than those that focus on abilities...
  41. pmc Factors associated with pain interference in an epidemiologic sample of adults with bipolar I disorder
    Benjamin I Goldstein
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    J Affect Disord 117:151-6. 2009
    ..Epidemiologic studies have found that major depressive disorder (MDD) and anxiety disorders are associated with pain. However, little is known regarding the prevalence and correlates of pain in bipolar I disorder (BD)...
  42. pmc Social emotion recognition, social functioning, and attempted suicide in late-life depression
    Katalin Szanto
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Am J Geriatr Psychiatry 20:257-65. 2012
    ..This study assessed the relationship between social emotion recognition, problem solving, social functioning, and attempted suicide in late-life depression...
  43. pmc Optimism, response to treatment of depression, and rehospitalization after coronary artery bypass graft surgery
    Hilary Tindle
    Department of Medicine, University of Pittsburgh, 230 McKee Pl, Suite 600, Pittsburgh, PA 15213, USA
    Psychosom Med 74:200-7. 2012
    ..Optimism has been associated with a lower risk of rehospitalization after coronary artery bypass graft (CABG) surgery, but little is known about how optimism affects treatment of depression in post-CABG patients...
  44. pmc Empirically derived decision trees for the treatment of late-life depression
    Carmen Andreescu
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:855-62. 2008
    ..The aim of this analysis was to develop a clinically useful algorithm that would allow clinicians to predict which patients will likely respond to treatment and thereby guide clinical decision making...
  45. pmc The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
    ..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years...
  46. pmc Family-based treatment of severe pediatric obesity: randomized, controlled trial
    Melissa A Kalarchian
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 124:1060-8. 2009
    ..We evaluated the efficacy of family-based, behavioral weight control in the management of severe pediatric obesity...
  47. pmc Brief interpersonal psychotherapy for depressed mothers whose children are receiving psychiatric treatment
    Holly A Swartz
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:1155-62. 2008
    ....
  48. ncbi request reprint Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age
    Katalin Szanto
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania 15213, United States
    J Affect Disord 98:153-61. 2007
    ..To determine the rate and clinical correlates of emergent, persistent, and resolved suicidal ideation during treatment of major depression in the elderly...
  49. ncbi request reprint Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  50. pmc The impact of pain and depression on recovery after coronary artery bypass grafting
    Natalia E Morone
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychosom Med 72:620-5. 2010
    ..To describe the relationship between pain and depression on recovery after coronary artery bypass grafting (CABG)...
  51. pmc Does age at onset have clinical significance in older adults with bipolar disorder?
    David Chu
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 25:1266-71. 2010
    ....
  52. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  53. ncbi request reprint 2002 Robert Ader New Investigator award. Relationship of cardiovascular reactivity, stressful life events, and multiple sclerosis disease activity
    Kurt D Ackerman
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 17:141-51. 2003
    ..These results are consistent with the hypothesis that stress is a potential trigger of MS disease activity and suggest that autonomic tone and stress reactivity may play a role in the development of stress-related exacerbations...
  54. pmc Weight concerns, mood, and postpartum smoking relapse
    Michele D Levine
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Prev Med 39:345-51. 2010
    ..Evidence suggests that changes in depressive symptoms, perceived stress, and concerns about weight may relate to postpartum smoking relapse...
  55. pmc Comparisons of methods for multiple hypothesis testing in neuropsychological research
    Richard E Blakesley
    Department of Biostatistics, University of Pittsburgh, PA, USA
    Neuropsychology 23:255-64. 2009
    ..The authors note caveats regarding the implementation of these methods using available software...
  56. pmc Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:382-90. 2009
    ..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder...
  57. ncbi request reprint Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
    ..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
  58. pmc Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Int Clin Psychopharmacol 25:37-45. 2010
    ..Our findings of intolerance of a second-generation antipsychotics and persistence of psychosis in patients with low-expression alleles needs to be replicated...
  59. pmc The association of public and private religious involvement with severity of depression and hopelessness in older adults treated for major depression
    Mario Cruz
    Western Psychiatric Institute and Clinic, Advanced Center for Intervention and Services Research for Late life Mood and Anxiety Disorders, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:503-7. 2009
    ..The authors assessed the association between public and private religious participation and depression as well as hopelessness in older depressed, adults treated in mental health settings...
  60. ncbi request reprint Relationship of general medical burden, duration of illness and age in patients with bipolar I disorder
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    J Psychiatr Res 42:956-61. 2008
    ..This study was aimed at evaluating general medical burden in a group of 111 patients with bipolar I disorder...
  61. pmc Self-reported sleep quality predicts poor cognitive performance in healthy older adults
    Robert D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Gerontol B Psychol Sci Soc Sci 64:180-7. 2009
    ..Sleep problems may contribute to performance variability between elderly individuals but only in certain cognitive domains...
  62. ncbi request reprint Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late Life and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate...
  63. ncbi request reprint Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine
    Robert D Nebes
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychiatr Res 37:99-108. 2003
    ..The present results suggest that cognitive dysfunction persists in older depressed patients even after their mood disorder has responded to antidepressant medications...
  64. pmc Use of OSWALD for analyzing longitudinal data with informative dropout
    Amy E Begley
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Comput Methods Programs Biomed 85:109-14. 2007
    ..This report illustrates the usage of OSWALD for analyzing longitudinal data with dropouts and how to draw appropriate conclusions based on the analytic results under different assumptions regarding the dropout mechanism...
  65. pmc When the solution is part of the problem: problem solving in elderly suicide attempters
    Lawrence M Gibbs
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:1396-404. 2009
    ..Thus, those with perceived deficits in problem-solving ability may be predisposed to suicidal behavior. To test this hypothesis, we investigated whether elderly suicide attempters perceived their problem solving as deficient...
  66. ncbi request reprint The daily life of complicated grief patients--what gets missed,what gets added?
    Timothy H Monk
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Room E 1123, 3811 O Hara Street, Pittsburgh, Pennsylvania, 15213, USA
    Death Stud 30:77-85. 2006
    ..Patients were significantly more likely than controls to miss contact with another person, breakfast, lunch, dinner, starting work, and going outside, and to add a nap and evening snack...
  67. ncbi request reprint Somatic symptoms in late-life anxiety: treatment issues
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 18:89-96. 2005
    ..However, additional treatment and integrated approaches are likely to be necessary for many such individuals...
  68. ncbi request reprint Prevalence of obesity and weight change during treatment in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:528-33. 2002
    ..Individuals with bipolar disorder tend to be overweight, and their treatment may exacerbate obesity and increase the risk of concurrent medical disease in this population...
  69. pmc Bupropion and cognitive behavioral therapy for weight-concerned women smokers
    Michele D Levine
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Arch Intern Med 170:543-50. 2010
    ..However, the efficacy of combining CONCERNS with cessation medication is unknown. We sought to determine if the combination of CONCERNS and bupropion therapy would enhance abstinence for weight-concerned women smokers...
  70. ncbi request reprint Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 160:1636-42. 2003
    ..Utilizing data from a previously characterized registry of subjects with bipolar illness, the authors examined age at onset of the first illness episode in cohorts of subjects born from 1900 through 1939 and from 1940 through 1959...
  71. pmc The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study
    Brooke S G Molina
    University of Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 48:484-500. 2009
    ....
  72. ncbi request reprint Symptom reports in severe chronic insomnia
    Douglas E Moul
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Sleep 25:553-63. 2002
    ..To describe patterns and severities of the daytime and nighttime symptoms of chronic insomnia patients...
  73. ncbi request reprint Obesity as a correlate of outcome in patients with bipolar I disorder
    Andrea Fagiolini
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 160:112-7. 2003
    ....
  74. ncbi request reprint The value of maintenance interpersonal psychotherapy (IPT) in older adults with different IPT foci
    Mark D Miller
    Intervention Research Center for Late Life Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 11:97-102. 2003
    ....
  75. ncbi request reprint Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  76. ncbi request reprint African-American participants in a bipolar disorder registry: clinical and treatment characteristics
    David J Kupfer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:82-8. 2005
    ..The goal of this paper was to compare clinical characteristics and treatment history of African-American and Caucasian participants in a bipolar disorder registry...
  77. ncbi request reprint Treatment of complicated grief: a randomized controlled trial
    Katherine Shear
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    JAMA 293:2601-8. 2005
    ..Complicated grief is a debilitating disorder associated with important negative health consequences, but the results of existing treatments for it have been disappointing...
  78. ncbi request reprint Demographic and clinical characteristics of individuals in a bipolar disorder case registry
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:120-5. 2002
    ....
  79. ncbi request reprint A randomized trial to improve the quality of treatment for panic and generalized anxiety disorders in primary care
    Bruce L Rollman
    Division of General Internal Medicine, Center for Research on Health Care, Department of Psychiatry, University of Pittsburgh School of Medicine, 230 McKee Place, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1332-41. 2005
    ..Panic disorder and generalized anxiety disorder are prevalent in primary care, associated with poor functional outcomes, and are often unrecognized and ineffectively treated by primary care physicians...
  80. ncbi request reprint Long-term changes in blood pressure in extremely obese patients who have undergone bariatric surgery
    John D Fernstrom
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Surg 141:276-83. 2006
    ..Systolic and diastolic pressure and the incidence of hypertension in very obese patients decline after bariatric surgery and do not rebound...
  81. ncbi request reprint Using trajectories from a bivariate growth curve as predictors in a Cox regression model
    Qianyu Dang
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Stat Med 26:800-11. 2007
    ..An illustrative example is provided with data from a maintenance treatment trial for major depression in an elderly population. Visual Fortran 90 programs were developed to implement the algorithm...
  82. ncbi request reprint The relation of white matter hyperintensities to cognitive performance in the normal old: education matters
    Robert D Nebes
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006
    ..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies...
  83. ncbi request reprint Serum anticholinergic activity and motor performance in elderly persons
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:83-5. 2007
    ..Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons...
  84. ncbi request reprint Characteristics of depression in hemodialysis patients: symptoms, quality of life and mortality risk
    Rebecca A Drayer
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Gen Hosp Psychiatry 28:306-12. 2006
    ..We interviewed outpatients at an urban dialysis facility using a criterion-based case-finding instrument to assess the rates, clinical correlates and outcomes of depression...
  85. pmc Sample size and power calculations based on generalized linear mixed models with correlated binary outcomes
    Qianyu Dang
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Comput Methods Programs Biomed 91:122-7. 2008
    ..A simulation study was used to compare the results. We also provide a Web link to the SAS macro that we developed to compute power and sample sizes for correlated binary outcomes...
  86. ncbi request reprint Effects of nortriptyline and paroxetine on postural sway in depressed elderly patients
    David C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 10:199-205. 2002
    ..Further studies with other SSRIs are needed...