John A Hossack

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Quantitative 3-d diagnostic ultrasound imaging using a modified transducer array and an automated image tracking technique
    John A Hossack
    Department of Biomedical Engineering, University of Virginia, Charlottesville 22903, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1029-38. 2002
  2. ncbi request reprint Free-hand ultrasound scanning approaches for volume quantification of the mouse heart Left ventricle
    Christopher D Garson
    University of Virginia, Department of Biomedical Engineering, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:966-77. 2007
  3. ncbi request reprint Reducing inter-element acoustic crosstalk in capacitive micromachined ultrasound transducers
    Shiwei Zhou
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22901, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1217-28. 2007
  4. ncbi request reprint Determination of an optimal image frame interval for frame-to-frame ultrasound image motion tracking
    Jun S Ha
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:386-96. 2005
  5. pmc Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling
    Prasad R Konkalmatt
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    J Gene Med 14:609-20. 2012
  6. doi request reprint Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force
    Joseph P Kilroy
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 59:2156-66. 2012
  7. pmc Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report
    Linsey C Phillips
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 31:2853-5. 2011
  8. pmc High frequency ultrasound imaging detects cardiac dyssynchrony in noninfarcted regions of the murine left ventricle late after reperfused myocardial infarction
    Yinbo Li
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    Ultrasound Med Biol 34:1063-75. 2008
  9. pmc Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles
    Jose L Tlaxca
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Ultrasound Med Biol 36:1907-18. 2010
  10. pmc Guiding automated left ventricular chamber segmentation in cardiac imaging using the concept of conserved myocardial volume
    Christopher D Garson
    University of Virginia, Charlottesville, VA 22908, USA
    Comput Med Imaging Graph 32:321-30. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Quantitative 3-d diagnostic ultrasound imaging using a modified transducer array and an automated image tracking technique
    John A Hossack
    Department of Biomedical Engineering, University of Virginia, Charlottesville 22903, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1029-38. 2002
    ..The average time for performing a screening test for carotid stenosis was reduced from an average of 45 minutes using 2-D duplex Doppler to 12 minutes using the new 3-D scanning approach...
  2. ncbi request reprint Free-hand ultrasound scanning approaches for volume quantification of the mouse heart Left ventricle
    Christopher D Garson
    University of Virginia, Department of Biomedical Engineering, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:966-77. 2007
    ..2% and 2.60% for eight scans conducted on each of two mice using the articulated arm, and a mean error of 13.6%, 6.53%, and 12.58% for eight scans conducted on each of three mice using the E-beam...
  3. ncbi request reprint Reducing inter-element acoustic crosstalk in capacitive micromachined ultrasound transducers
    Shiwei Zhou
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22901, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1217-28. 2007
    ..5 dB was achieved. This method also can be combined with other structure-modification based crosstalk reduction approaches...
  4. ncbi request reprint Determination of an optimal image frame interval for frame-to-frame ultrasound image motion tracking
    Jun S Ha
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:386-96. 2005
    ..In practical experiments, we found that the optimal step size generally required using every available image frame rather than 'skipping' any intermediate frames...
  5. pmc Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling
    Prasad R Konkalmatt
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    J Gene Med 14:609-20. 2012
    ..The present study evaluated the therapeutic potential of post-myocardial infarction gene delivery using intravenous AAV9...
  6. doi request reprint Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force
    Joseph P Kilroy
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 59:2156-66. 2012
    ..A sustained increase of 31 dB in average video intensity was measured following insonation with the ARFIVUS, indicating microbubble accumulation resulting from the application of acoustic radiation force...
  7. pmc Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report
    Linsey C Phillips
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 31:2853-5. 2011
    ....
  8. pmc High frequency ultrasound imaging detects cardiac dyssynchrony in noninfarcted regions of the murine left ventricle late after reperfused myocardial infarction
    Yinbo Li
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    Ultrasound Med Biol 34:1063-75. 2008
    ....
  9. pmc Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles
    Jose L Tlaxca
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Ultrasound Med Biol 36:1907-18. 2010
    ..Moreover, direct conjugation of plasmid to the microbubble did not appear to significantly enhance transfection efficiency under the examined conditions, although this strategy may be important for targeted transfection in vivo...
  10. pmc Guiding automated left ventricular chamber segmentation in cardiac imaging using the concept of conserved myocardial volume
    Christopher D Garson
    University of Virginia, Charlottesville, VA 22908, USA
    Comput Med Imaging Graph 32:321-30. 2008
    ..The metric was most useful when applied to the gradient vector field weighting and temporal step-size parameters, but less effective in guiding an optimal choice of the active surface tension and rigidity parameters...
  11. pmc Fabrication and evaluation of fully-sampled, two-dimensional transducer array for "Sonic Window" imaging system
    Matthew D C Eames
    Department of Biomedical Engineering, The University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA
    Ultrasonics 48:376-83. 2008
    ..We are currently working to fabricate a custom PCB material to address this concern, and may also consider using a pre-compensated transmit waveform or matched digital filter approach to further reduce the effects of such reverberations...
  12. pmc Serial ultrasound evaluation of intramyocardial strain after reperfused myocardial infarction reveals that remote zone dyssynchrony develops in concert with left ventricular remodeling
    Yinbo Li
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Ultrasound Med Biol 37:1073-86. 2011
    ..It was discovered that the form of LV dyssynchrony that develops in the remote zone late after MI does so in concert with the progression of LV remodeling (R = 0.70, p < 0.05)...
  13. ncbi request reprint Finite-element analysis of material and parameter effects in laser-based thermoelastic ultrasound generation
    Shiwei Zhou
    University of Virginia, Department of Biomedical Engineering, Charlottesville, VA 22908 0759, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:1178-86. 2004
    ..The FEA approach was verified first against experimental data. Thereafter, we explored the impact of various design variables, including laser spot size and laser penetration depth...
  14. ncbi request reprint Novel transmit protection scheme for ultrasound systems
    Michael I Fuller
    University of Virginia, Department of Biomedical Engineering, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:79-86. 2007
    ..The scheme was also incorporated into a prototype 1024-channel, low-cost, ultrasound system successfully used to form pulse echo images...
  15. doi request reprint Improved elevational and azimuthal motion tracking using sector scans
    Kevin Owen
    University of Virginia, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 60:671-84. 2013
    ..2 mm, compared with 2.43 mm for conventional methods. These data indicate that the new algorithm is capable of improved tracking performance for sector scan systems, enabling effective freehand 3-D scanning...
  16. pmc Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results
    Abhay V Patil
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Mol Imaging 10:238-47. 2011
    ....
  17. pmc Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery
    Linsey C Phillips
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Ultrasound Med Biol 36:1470-80. 2010
    ..We demonstrated that we can locally deliver DNA to vascular smooth muscle cells in vitro using microbubble carriers and focused ultrasound...
  18. pmc A non-linear three-dimensional model for quantifying microbubble dynamics
    Abhay V Patil
    Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Room 2127, Charlottesville, Virginia 22908, USA
    J Acoust Soc Am 127:EL80-6. 2010
    ..Appl. Phys. Lett. 90, 114103 (2007)]. The adherent microbubble oscillated asymmetrically in the plan view and symmetrically in the elevation view, consistent with the previous experimental results...
  19. pmc Quantification and MRI validation of regional contractile dysfunction in mice post myocardial infarction using high resolution ultrasound
    Yinbo Li
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    Ultrasound Med Biol 33:894-904. 2007
    ..85 for radial and circumferential strain, respectively). Therefore, ultrasound imaging, followed by 2D image tracking, provides an effective, low cost, mobile method to quantify murine cardiac function accurately and reliably...
  20. pmc Enhanced intracellular delivery of a model drug using microbubbles produced by a microfluidic device
    Adam J Dixon
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Ultrasound Med Biol 39:1267-76. 2013
    ..These results demonstrate the potential of transiently stable microbubbles produced in real time and in close proximity to the intended therapeutic site for enhancing localized drug delivery...
  21. pmc Intravascular near-infrared fluorescence catheter with ultrasound guidance and blood attenuation correction
    Adam J Dixon
    University of Virginia, Department of Biomedical Engineering, Charlottesville, VA 22908, USA
    J Biomed Opt 18:56009. 2013
    ..24 to 0.69, p < 0.01, n = 6). This work demonstrates that catheter-to-vessel wall distances, measured from IVUS images, can be employed to compensate for inaccuracies caused by variable intravascular NIRF sensing distances...
  22. pmc Real-time targeted molecular imaging using singular value spectra properties to isolate the adherent microbubble signal
    F William Mauldin
    Department of Biomedical Engineering, University of Virginia, MR5 415 Lane Rd, Charlottesville, VA 22908, USA
    Phys Med Biol 57:5275-93. 2012
    ..001, n = 4) and a larger area under the receiver operating characteristic curve (P < 0.05, n = 4)...
  23. doi request reprint The effects of transducer geometry on artifacts common to diagnostic bone imaging with conventional medical ultrasound
    F William Mauldin
    School of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 59:1101-14. 2012
    ..e., bone or bone-like) objects. Transducer geometries with reduced sensitivity to off-axis surface reflections, such as a piston transducer geometry, yield significant reductions in image artifact...
  24. pmc The singular value filter: a general filter design strategy for PCA-based signal separation in medical ultrasound imaging
    F William Mauldin
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    IEEE Trans Med Imaging 30:1951-64. 2011
    ....
  25. ncbi request reprint Speckle reducing anisotropic diffusion for 3D ultrasound images
    Qingling Sun
    Department of Computer Science, University of Virginia, Charlottesville, VA 22904 4743, USA
    Comput Med Imaging Graph 28:461-70. 2004
    ....
  26. ncbi request reprint Direct sampled I/Q beamforming for compact and very low-cost ultrasound imaging
    Karthik Ranganathan
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:1082-94. 2004
    ..We also describe implementation of the DSIQ beamformer in an inexpensive hand-held ultrasound system being developed in our laboratory...
  27. pmc Shear forces from flow are responsible for a distinct statistical signature of adherent microbubbles in large vessels
    Shiying Wang
    Department of Biomedical Engineering and Electrical and Computer Engineering, University of Virginia, Charlottesville, VA, USA
    Mol Imaging 12:396-408. 2013
    ..These findings confirm the hypothesis that the statistical signature of adherent microbubbles is derived from frame-to-frame decorrelation, which is induced by flow shear forces...
  28. pmc Synthesis and Characterization of Transiently Stable Albumin-Coated Microbubbles via a Flow-Focusing Microfluidic Device
    Johnny L Chen
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Ultrasound Med Biol 40:400-9. 2014
    ..In addition, successful microbubble production with blood plasma suggests the potential to use blood as a stabilizing shell. ..
  29. pmc Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue
    Ji Song
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Invest Radiol 43:322-9. 2008
    ..To measure how ultrasound attenuation by contrast agent microbubbles (MBs) in superficial tissue affects petechiae creation in underlying deep tissue...
  30. pmc Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation
    Linsey C Phillips
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    J Control Release 154:42-9. 2011
    ..The anti-proliferative effect was also localized within a 6mm wide zone by focusing the ultrasound beam...
  31. pmc Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles
    Linsey C Phillips
    Biomedical Engineering, Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Vasc Res 47:270-4. 2010
    ..Microbubble contrast agents have been shown to increase gene transfection in vivo in the presence of ultrasound...
  32. pmc Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels
    Abhay V Patil
    Biomedical Engineering, Charlottesville, VA 22908, USA
    Ultrasound Med Biol 35:2021-30. 2009
    ..The proposed dual frequency sequence may enable the application of radiation force for optimizing the effect of targeted imaging and modulating drug delivery in large blood vessels with high flow velocities...
  33. pmc Binding dynamics of targeted microbubbles in response to modulated acoustic radiation force
    Shiying Wang
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Phys Med Biol 59:465-84. 2014
    ..01). These findings suggest the possibility of enhanced detection of specifically bound microbubbles in real-time, using relatively short imaging protocols (approximately 3 min), without waiting for free microbubble clearance...
  34. ncbi request reprint 3D perfusion mapping in post-infarct mice using myocardial contrast echocardiography
    Brent A French
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    Ultrasound Med Biol 32:805-15. 2006
    ....
  35. ncbi request reprint Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification
    Joshua J Rychak
    University of Virginia, Charlottesville, VA 22904, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:421-33. 2005
    ..Microbubble adhesion increased with the square of acoustic pressure between 25 and 122 kPa, and decreased substantially at higher pressures...
  36. ncbi request reprint Detection of lesions using differential rates of speckle decorrelation
    Jun S Ha
    Biomedical Engineering Department, University of Virginia, Room 2121, MR 5 Building, 415 Lane Rd, Charlottesville, VA 22908 0759, USA
    Ultrason Imaging 25:226-44. 2003
    ..This approach is simple and requires only a short period of time for each scan. It has practically no theoretical incremental cost...
  37. ncbi request reprint Dynamic-transmit focusing using time-dependent focal zone and center frequency
    Shiwei Zhou
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 50:142-52. 2003
    ..A discussion of implementation considerations and limitations is presented...
  38. doi request reprint Experimental system prototype of a portable, low-cost, C-scan ultrasound imaging device
    Michael I Fuller
    PocketSonics, Inc, Charlottesville, VA 22901, USA
    IEEE Trans Biomed Eng 55:519-30. 2008
    ..Pulse-echo images obtained with the prototype are presented. Results from this prototype support the feasibility of a low-cost, pocket-sized, C-scan imaging device...
  39. doi request reprint Synthetic axial acquisition-full resolution, low-cost C-scan ultrasonic imaging
    Yinbo Li
    IEEE Trans Ultrason Ferroelectr Freq Control 55:236-9. 2008
    ..The impact of electronic noise on SAA also is considered...
  40. ncbi request reprint Carotid disease: automated analysis with cardiac-gated three-dimensional US technique and preliminary results
    Sandy Napel
    Department of Radiology, Stanford University School of Medicine, Lucas Magnetic Resonance Imaging and Spectroscopy MRS Center P 287, Stanford, CA 94305 5488, USA
    Radiology 222:560-3. 2002
    ..Data for all healthy volunteers (n = 8) and patients with complete occlusions (n = 3) were correctly classified. Data for two of the 12 patients with mild to severe (but not occlusive) disease were misclassified by one category...
  41. ncbi request reprint Enhanced targeting of ultrasound contrast agents using acoustic radiation force
    Joshua J Rychak
    University of Virginia Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Ultrasound Med Biol 33:1132-9. 2007
    ..These results suggest acoustic treatment as a mechanism for enabling ultrasound-based molecular imaging in blood vessels with hemodynamic and anatomical conditions otherwise adversarial for UCA retention...