Jonathan Hosler

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi Energy transduction: proton transfer through the respiratory complexes
    Jonathan P Hosler
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Annu Rev Biochem 75:165-87. 2006
  2. ncbi The influence of subunit III of cytochrome c oxidase on the D pathway, the proton exit pathway and mechanism-based inactivation in subunit I
    Jonathan P Hosler
    Department of Biochemistry, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Biochim Biophys Acta 1655:332-9. 2004
  3. ncbi Altering conserved lipid binding sites in cytochrome c oxidase of Rhodobacter sphaeroides perturbs the interaction between subunits I and III and promotes suicide inactivation of the enzyme
    Lakshman Varanasi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216, USA
    Biochemistry 45:14896-907. 2006
  4. ncbi A role for subunit III in proton uptake into the D pathway and a possible proton exit pathway in Rhodobacter sphaeroides cytochrome c oxidase
    Denise A Mills
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 42:7410-7. 2003
  5. ncbi Alternative initial proton acceptors for the D pathway of Rhodobacter sphaeroides cytochrome c oxidase
    Lakshman Varanasi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, United States
    Biochemistry 50:2820-8. 2011
  6. ncbi Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models
    Melyssa Bratton
    Department of Biochemistry, University of Mississippi Medical Center, USA
    Eur J Biochem 270:1222-30. 2003
  7. ncbi Assembly of cytochrome-c oxidase in the absence of assembly protein Surf1p leads to loss of the active site heme
    Daniel Smith
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Biol Chem 280:17652-6. 2005
  8. ncbi Mutagenic analysis of Cox11 of Rhodobacter sphaeroides: insights into the assembly of Cu(B) of cytochrome c oxidase
    Audie K Thompson
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Biochemistry 49:5651-61. 2010
  9. ncbi Evidence for a cytochrome bcc-aa3 interaction in the respiratory chain of Mycobacterium smegmatis
    James A Megehee
    Department of Microbiology, The University of Mississippi Medical Center, Jackson, 2500 North State Street, MS 39216-4505, USA
    Microbiology 152:823-9. 2006
  10. ncbi Detection of transient intermediates in the metal-dependent nonoxidative decarboxylation catalyzed by alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
    Tingfeng Li
    Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Am Chem Soc 129:9278-9. 2007

Research Grants

  1. SUBUNIT III AND CYTOCHROME OXIDASE FUNCTION
    Jonathan Hosler; Fiscal Year: 2002
  2. Role of Subunit III in Cytochrome Oxidase Function
    Jonathan Hosler; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. ncbi Energy transduction: proton transfer through the respiratory complexes
    Jonathan P Hosler
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Annu Rev Biochem 75:165-87. 2006
    ..There is evidence for an important role of subunit III and proton backflow, but the number and nature of gating mechanisms remain elusive, as does the mechanism of physiological control of efficiency...
  2. ncbi The influence of subunit III of cytochrome c oxidase on the D pathway, the proton exit pathway and mechanism-based inactivation in subunit I
    Jonathan P Hosler
    Department of Biochemistry, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Biochim Biophys Acta 1655:332-9. 2004
    ..Analysis of proton pumping by subunit III-depleted oxidase forms leads to the proposal that the trapping of two protons in the D pathway, one on E286 and one on D132, is required for efficient proton pumping...
  3. ncbi Altering conserved lipid binding sites in cytochrome c oxidase of Rhodobacter sphaeroides perturbs the interaction between subunits I and III and promotes suicide inactivation of the enzyme
    Lakshman Varanasi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216, USA
    Biochemistry 45:14896-907. 2006
    ....
  4. ncbi A role for subunit III in proton uptake into the D pathway and a possible proton exit pathway in Rhodobacter sphaeroides cytochrome c oxidase
    Denise A Mills
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 42:7410-7. 2003
    ..Thus, subunit III appears to affect the transfer of protons from both the inner and outer surfaces of cytochrome oxidase, perhaps accounting for the long-observed lower efficiency of proton pumping by the subunit III-depleted oxidase...
  5. ncbi Alternative initial proton acceptors for the D pathway of Rhodobacter sphaeroides cytochrome c oxidase
    Lakshman Varanasi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, United States
    Biochemistry 50:2820-8. 2011
    ..The results show how the environment of the initial proton acceptor for the D pathway in these CcO forms dictates the pH range of CcO activity, with implications for the function of Asp-132, the normal proton acceptor...
  6. ncbi Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models
    Melyssa Bratton
    Department of Biochemistry, University of Mississippi Medical Center, USA
    Eur J Biochem 270:1222-30. 2003
    ..The bacterial system allows detailed biochemical analysis of the effect of the mutations on the function and assembly of the catalytic core of the enzyme...
  7. ncbi Assembly of cytochrome-c oxidase in the absence of assembly protein Surf1p leads to loss of the active site heme
    Daniel Smith
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Biol Chem 280:17652-6. 2005
    ..The results suggest that maturation of the heme a(3)-Cu(B) center is a step that limits the association of subunits I and II in the assembly of mitochondrial cytochrome oxidase...
  8. ncbi Mutagenic analysis of Cox11 of Rhodobacter sphaeroides: insights into the assembly of Cu(B) of cytochrome c oxidase
    Audie K Thompson
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Biochemistry 49:5651-61. 2010
    ..Rather, consideration of the properties of Lys-123 and the apparent specificity of Cox11 suggest that Lys-123 plays a role in the interaction of Cox11 with its target...
  9. ncbi Evidence for a cytochrome bcc-aa3 interaction in the respiratory chain of Mycobacterium smegmatis
    James A Megehee
    Department of Microbiology, The University of Mississippi Medical Center, Jackson, 2500 North State Street, MS 39216-4505, USA
    Microbiology 152:823-9. 2006
    ..The results indicate that hydrophobic interactions are the primary forces maintaining the bcc-aa3 interaction, but ionic interactions may assist in aligning the two complexes for efficient electron transfer...
  10. ncbi Detection of transient intermediates in the metal-dependent nonoxidative decarboxylation catalyzed by alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
    Tingfeng Li
    Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Am Chem Soc 129:9278-9. 2007
  11. ncbi The axial ligand and extent of protein folding determine whether Zn or Cu binds to amicyanin
    John K Ma
    Department of Biochemistry, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, United States
    J Inorg Biochem 102:342-6. 2008
    ..These results suggest that metal incorporation in vivo occurs during protein folding in the periplasm and not to a preformed type 1 site...
  12. ncbi Slow proton transfer through the pathways for pumped protons in cytochrome c oxidase induces suicide inactivation of the enzyme
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48109, USA
    Biochemistry 44:4656-66. 2005
    ..The experiments suggest that increased lifetimes of the heme a(3) oxoferryl intermediates as well as the anionic form of Glu286 of the D pathway cause suicide inactivation in the active site...
  13. ncbi Generation of novel copper sites by mutation of the axial ligand of amicyanin. Atomic resolution structures and spectroscopic properties
    Christopher J Carrell
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 46:1900-12. 2007
    ....

Research Grants10

  1. SUBUNIT III AND CYTOCHROME OXIDASE FUNCTION
    Jonathan Hosler; Fiscal Year: 2002
    ....
  2. Role of Subunit III in Cytochrome Oxidase Function
    Jonathan Hosler; Fiscal Year: 2007
    ..The mechanism of this assembly process is likely to differ from the assembly of other copper centers in proteins since the active site of cytochrome oxidase is buried within subunit I and within the transmembrane region of the protein. ..