Aaron A Hoskins

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi The spliceosome: a flexible, reversible macromolecular machine
    Aaron A Hoskins
    Department of Biochemistry, University of Wisconsin Madison, WI 53706, USA
    Trends Biochem Sci 37:179-88. 2012
  2. ncbi New insights into the spliceosome by single molecule fluorescence microscopy
    Aaron A Hoskins
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Curr Opin Chem Biol 15:864-70. 2011
  3. ncbi Ordered and dynamic assembly of single spliceosomes
    Aaron A Hoskins
    Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 331:1289-95. 2011
  4. ncbi Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site
    Daniel J Crawford
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605
    Proc Natl Acad Sci U S A 110:6783-8. 2013

Collaborators

Detail Information

Publications4

  1. ncbi The spliceosome: a flexible, reversible macromolecular machine
    Aaron A Hoskins
    Department of Biochemistry, University of Wisconsin Madison, WI 53706, USA
    Trends Biochem Sci 37:179-88. 2012
    ..These experiments are rewriting the textbooks, with a new picture emerging of a dynamic, malleable machine heavily influenced by the identity of its pre-mRNA substrate...
  2. ncbi New insights into the spliceosome by single molecule fluorescence microscopy
    Aaron A Hoskins
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Curr Opin Chem Biol 15:864-70. 2011
    ..These methods complement ensemble measurements of splicing in vivo and in vitro to facilitate kinetic dissection of pre-mRNA splicing...
  3. ncbi Ordered and dynamic assembly of single spliceosomes
    Aaron A Hoskins
    Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 331:1289-95. 2011
    ..This experimental strategy should prove widely useful for mechanistic analysis of other macromolecular machines in environments approaching the complexity of living cells...
  4. ncbi Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site
    Daniel J Crawford
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605
    Proc Natl Acad Sci U S A 110:6783-8. 2013
    ..Separation of the sites of chemistry until very late in the splicing pathway may be crucial for preventing splicing at incorrect sites...