Research Topics
| Jonathan C HortonSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Ocular integration in the human visual cortexJonathan C Horton
Beckman Vision Center, University of California, San Francisco 94143 0730, USA
Can J Ophthalmol 41:584-93. 2006..Although the function of ocular dominance columns is unknown, their metabolism is altered in strabismus, suggesting a role in visual suppression...
Orientation tuning of cytochrome oxidase patches in macaque primary visual cortexJohn R Economides
Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA
Nat Neurosci 14:1574-80. 2011..This global difference in neuronal responsiveness, rather than an absence of orientation tuning, may account for the rich mitochondrial enzyme activity that defines patches...- Preserving information in neural transmissionLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, California 94143, USA
J Neurosci 29:6207-16. 2009.... - Complete pattern of ocular dominance columns in human primary visual cortexDaniel L Adams
Beckman Vision Center, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 27:10391-403. 2007..In one subject, monocular visual loss began at age 4 months, causing shrinkage of ocular dominance columns. In V2, which had a larger surface area than V1, CO stripes were present but could not be classified as thick or thin... - Resolving single cone inputs to visual receptive fieldsLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA
Nat Neurosci 12:967-9. 2009..Parvocellular LGN neurons mapped in this manner responded with high reliability to stimulation of single cones... - The representation of retinal blood vessels in primate striate cortexDaniel L Adams
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 23:5984-97. 2003..The representations of retinal blood vessels separated by only 0.65 degrees were resolvable in the cortex, yielding an upper limit on cortical resolution of 340 microm in layer 4C... - V1 interpatch projections to v2 thick stripes and pale stripesLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 30:6963-74. 2010.... - Ocular dominance columns in strabismusDaniel L Adams
Beckman Vision Center, University of California San Francisco, San Francisco, California 94143, USA
Vis Neurosci 23:795-805. 2006..In addition, in strabismic monkeys, as in normal animals, patches were not aligned with ocular dominance columns... - Transmission of spike trains at the retinogeniculate synapseLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 27:2683-92. 2007..Hence, the timing of EPSPs arising from the primary retinal driver governs synaptic efficacy and provides the basis for successful retinogeniculate transmission... - Bypassing V1: a direct geniculate input to area MTLawrence C Sincich
Beckman Vision Center, University of California, 10 Koret Way, San Francisco, California 94143, USA
Nat Neurosci 7:1123-8. 2004.... - Ocular motor behavior in macaques with surgical exotropiaJohn R Economides
Beckman Vision Center, University of California, San Francisco, CA 94143 0730, USA
J Neurophysiol 98:3411-22. 2007..These animals will be valuable for probing the cortical mechanisms that underlie visual suppression in strabismus... - A precise retinotopic map of primate striate cortex generated from the representation of angioscotomasDaniel L Adams
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 23:3771-89. 2003..We conclude that, in monkey striate cortex, more tissue is allocated per ganglion cell for the analysis of information emanating from the macula as compared with the peripheral retina... - Monocular cells without ocular dominance columnsDaniel L Adams
Beckman Vision Center, 10 Koret Way, University of California, San Francisco, San Francisco, CA 94143 0730, USA
J Neurophysiol 96:2253-64. 2006..Thus even when ocular dominance columns occur in the squirrel monkey, they do not transform the functional architecture to resemble that of the macaque... - Shadows cast by retinal blood vessels mapped in primary visual cortexDaniel L Adams
Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143 0730, USA
Science 298:572-6. 2002..This process illustrates vividly that local imbalances in neuronal activity can influence column formation during normal development... - Capricious expression of cortical columns in the primate brainDaniel L Adams
Beckman Vision Center, University of California at San Francisco, 10 Kirkham Street, San Francisco, California 94143-0730, USA
Nat Neurosci 6:113-4. 2003 - Independent projection streams from macaque striate cortex to the second visual area and middle temporal areaLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 23:5684-92. 2003..The results demonstrate that primary sensory cortices can use multiple projection strategies to distribute signals to higher areas, and suggest that feedforward projections may route signals with more specificity than feedback pathways... - A watertight acrylic-free titanium recording chamber for electrophysiology in behaving monkeysDaniel L Adams
Program in Neuroscience, University of California, San Francisco, California 94143 0730, USA
J Neurophysiol 106:1581-90. 2011..Refinement of appliances and techniques used for recordings in awake monkeys promises to increase the pace of scientific discovery and to benefit animal welfare... - Perception via the deviated eye in strabismusJohn R Economides
Beckman Vision Center, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 32:10286-95. 2012..This plasticity in the coding of visual direction allows accurate localization of objects everywhere in the visual scene, despite the presence of strabismus... - Complete flatmounting of the macaque cerebral cortexLawrence C Sincich
Beckman Vision Center, University of California-San Francisco, San Francisco 94143-0730, USA
Vis Neurosci 20:663-86. 2003..Flatmounting the cerebral cortex is a simple, efficient method that can be used routinely for mapping areas and connections in the macaque brain, the most widely used primate model of the human brain... - The cortical column: a structure without a functionJonathan C Horton
Beckman Vision Center, 10 Koret Way, University of California, San Francisco, CA 94143-0730, USA
Philos Trans R Soc Lond B Biol Sci 360:837-62. 2005..Unravelling the organization of the cerebral cortex will require a painstaking description of the circuits, projections and response properties peculiar to cells in each of its various areas... - Pale cytochrome oxidase stripes in V2 receive the richest projection from macaque striate cortexLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
J Comp Neurol 447:18-33. 2002..Therefore, V2 receives interleaved projections from V1 and the pulvinar. Because these projections favor different stripe types, they may target separate populations of neurons... - An albino-like decussation error in the optic chiasm revealed by anomalous ocular dominance columnsLawrence C Sincich
Beckman Vision Center, University of California San Francisco, San Francisco 94143 0730, USA
Vis Neurosci 19:541-5. 2002.... - Neurons in V1 patch columns project to V2 thin stripesLawrence C Sincich
Beckman Vision Center, University of California San Francisco, San Francisco, CA 94143 0730, USA
Cereb Cortex 17:935-41. 2007..However, multiple V1 layers innervate V2 thin stripes, and the projection from layer 5/6 does not respect the patch/interpatch dichotomy... - Input to V2 thin stripes arises from V1 cytochrome oxidase patchesLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, California 94143, USA
J Neurosci 25:10087-93. 2005..This finding means that different signals are likely conveyed by patches and interpatches to V2... 
Extraocular muscle dynamics in diplopia from enophthalmosMichael K Yoon
Beckman Vision Center, Department of Ophthalmology, University of California San Francisco, USA
Strabismus 19:142-6. 2011..This case underscores the value of careful orbital wall reconstruction after orbitotomy and suggests a mechanism for diplopia produced by postoperative enophthalmos...- The circuitry of V1 and V2: integration of color, form, and motionLawrence C Sincich
Beckman Vision Center, University of California San Francisco, San Francisco, CA 94143, USA
Annu Rev Neurosci 28:303-26. 2005..Each stream is composed of a mixture of magno, parvo, and konio geniculate signals. Further studies are required to elucidate how the patches and interpatches differ in the output they convey to extrastriate cortex... - Labeling of cytochrome oxidase patches in intact flatmounts of striate cortexJohn R Economides
Beckman Vision Center, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USA
J Neurosci Methods 149:1-6. 2005..In vitro labeling of CO patches in the intact striate cortex may prove useful for directing injections of anatomical tracers such as Lucifer Yellow or DiI into identified patch and interpatch compartments... - A biocompatible titanium headpost for stabilizing behaving monkeysDaniel L Adams
Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurophysiol 98:993-1001. 2007..The headpost is simpler to implant, more securely anchored, easier to maintain, and less obtrusive than devices attached with acrylic... - Divided by cytochrome oxidase: a map of the projections from V1 to V2 in macaquesLawrence C Sincich
Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143 0730, USA
Science 295:1734-7. 2002..Projection of interpatches to common V2 stripe types (pale and thick) merges parvo and magno inputs, making it likely that these functional channels are distributed strongly to both dorsal and ventral streams... - Eye movement abnormalities in stiff person syndromeJohn R Economides
Beckman Vision Center, University of California, San Francisco, CA 94143-0730, USA
Neurology 65:1462-4. 2005..There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA... - Optic nerve sheath meningioma: visual improvement during radiation treatmentM Reza Vagefi
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
Am J Ophthalmol 142:343-4. 2006..In such patients, it may be possible to customize the radiation dose by assessing of visual function during the course of therapy... - Thalamic filtering of retinal spike trains by postsynaptic summationMatteo Carandini
Smith Kettlewell Eye Research Institute, San Francisco, CA, USA
J Vis 7:20.1-11. 2007..This simple form of integration explains the response differences between a geniculate neuron and its main retinal driver, and thereby determines the flow of visual information to cortex... - Recurrent visual loss in Leber hereditary optic neuropathyDavid E Newman-Toker
MEEI Ninth Floor, 243 Charles St, Boston, MA 02114, USA
Arch Ophthalmol 121:288-91. 2003 - Intracranial pressure returns to normal about a month after stopping tetracycline antibioticsBryan J Winn
Arch Ophthalmol 125:1137-8. 2007