Jonathan C Horton

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Orientation tuning of cytochrome oxidase patches in macaque primary visual cortex
    John R Economides
    Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 14:1574-80. 2011
  2. ncbi request reprint Ocular integration in the human visual cortex
    Jonathan C Horton
    Beckman Vision Center, University of California, San Francisco 94143 0730, USA
    Can J Ophthalmol 41:584-93. 2006
  3. ncbi request reprint Transmission of spike trains at the retinogeniculate synapse
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2683-92. 2007
  4. pmc Cortical metabolic activity matches the pattern of visual suppression in strabismus
    Daniel L Adams
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:3752-9. 2013
  5. pmc Preserving information in neural transmission
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, California 94143, USA
    J Neurosci 29:6207-16. 2009
  6. ncbi request reprint Complete pattern of ocular dominance columns in human primary visual cortex
    Daniel L Adams
    Beckman Vision Center, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 27:10391-403. 2007
  7. pmc Resolving single cone inputs to visual receptive fields
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 12:967-9. 2009
  8. ncbi request reprint The representation of retinal blood vessels in primate striate cortex
    Daniel L Adams
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 23:5984-97. 2003
  9. pmc V1 interpatch projections to v2 thick stripes and pale stripes
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 30:6963-74. 2010
  10. ncbi request reprint Monocular cells without ocular dominance columns
    Daniel L Adams
    Beckman Vision Center, 10 Koret Way, University of California, San Francisco, San Francisco, CA 94143 0730, USA
    J Neurophysiol 96:2253-64. 2006

Collaborators

Detail Information

Publications36

  1. pmc Orientation tuning of cytochrome oxidase patches in macaque primary visual cortex
    John R Economides
    Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 14:1574-80. 2011
    ..This global difference in neuronal responsiveness, rather than an absence of orientation tuning, may account for the rich mitochondrial enzyme activity that defines patches...
  2. ncbi request reprint Ocular integration in the human visual cortex
    Jonathan C Horton
    Beckman Vision Center, University of California, San Francisco 94143 0730, USA
    Can J Ophthalmol 41:584-93. 2006
    ..Although the function of ocular dominance columns is unknown, their metabolism is altered in strabismus, suggesting a role in visual suppression...
  3. ncbi request reprint Transmission of spike trains at the retinogeniculate synapse
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2683-92. 2007
    ..Hence, the timing of EPSPs arising from the primary retinal driver governs synaptic efficacy and provides the basis for successful retinogeniculate transmission...
  4. pmc Cortical metabolic activity matches the pattern of visual suppression in strabismus
    Daniel L Adams
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:3752-9. 2013
    ....
  5. pmc Preserving information in neural transmission
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, California 94143, USA
    J Neurosci 29:6207-16. 2009
    ....
  6. ncbi request reprint Complete pattern of ocular dominance columns in human primary visual cortex
    Daniel L Adams
    Beckman Vision Center, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 27:10391-403. 2007
    ..In one subject, monocular visual loss began at age 4 months, causing shrinkage of ocular dominance columns. In V2, which had a larger surface area than V1, CO stripes were present but could not be classified as thick or thin...
  7. pmc Resolving single cone inputs to visual receptive fields
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 12:967-9. 2009
    ..Parvocellular LGN neurons mapped in this manner responded with high reliability to stimulation of single cones...
  8. ncbi request reprint The representation of retinal blood vessels in primate striate cortex
    Daniel L Adams
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 23:5984-97. 2003
    ..The representations of retinal blood vessels separated by only 0.65 degrees were resolvable in the cortex, yielding an upper limit on cortical resolution of 340 microm in layer 4C...
  9. pmc V1 interpatch projections to v2 thick stripes and pale stripes
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 30:6963-74. 2010
    ....
  10. ncbi request reprint Monocular cells without ocular dominance columns
    Daniel L Adams
    Beckman Vision Center, 10 Koret Way, University of California, San Francisco, San Francisco, CA 94143 0730, USA
    J Neurophysiol 96:2253-64. 2006
    ..Thus even when ocular dominance columns occur in the squirrel monkey, they do not transform the functional architecture to resemble that of the macaque...
  11. pmc Shadows cast by retinal blood vessels mapped in primary visual cortex
    Daniel L Adams
    Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143 0730, USA
    Science 298:572-6. 2002
    ..This process illustrates vividly that local imbalances in neuronal activity can influence column formation during normal development...
  12. ncbi request reprint Ocular dominance columns in strabismus
    Daniel L Adams
    Beckman Vision Center, University of California San Francisco, San Francisco, California 94143, USA
    Vis Neurosci 23:795-805. 2006
    ..In addition, in strabismic monkeys, as in normal animals, patches were not aligned with ocular dominance columns...
  13. ncbi request reprint Bypassing V1: a direct geniculate input to area MT
    Lawrence C Sincich
    Beckman Vision Center, University of California, 10 Koret Way, San Francisco, California 94143, USA
    Nat Neurosci 7:1123-8. 2004
    ....
  14. ncbi request reprint Ocular motor behavior in macaques with surgical exotropia
    John R Economides
    Beckman Vision Center, University of California, San Francisco, CA 94143 0730, USA
    J Neurophysiol 98:3411-22. 2007
    ..These animals will be valuable for probing the cortical mechanisms that underlie visual suppression in strabismus...
  15. ncbi request reprint A precise retinotopic map of primate striate cortex generated from the representation of angioscotomas
    Daniel L Adams
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 23:3771-89. 2003
    ..We conclude that, in monkey striate cortex, more tissue is allocated per ganglion cell for the analysis of information emanating from the macula as compared with the peripheral retina...
  16. ncbi request reprint Pale cytochrome oxidase stripes in V2 receive the richest projection from macaque striate cortex
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 447:18-33. 2002
    ..Therefore, V2 receives interleaved projections from V1 and the pulvinar. Because these projections favor different stripe types, they may target separate populations of neurons...
  17. pmc Thalamic filtering of retinal spike trains by postsynaptic summation
    Matteo Carandini
    Smith Kettlewell Eye Research Institute, San Francisco, CA, USA
    J Vis 7:20.1-11. 2007
    ..This simple form of integration explains the response differences between a geniculate neuron and its main retinal driver, and thereby determines the flow of visual information to cortex...
  18. ncbi request reprint Capricious expression of cortical columns in the primate brain
    Daniel L Adams
    Beckman Vision Center, University of California at San Francisco, 10 Kirkham Street, San Francisco, California 94143 0730, USA
    Nat Neurosci 6:113-4. 2003
  19. ncbi request reprint Independent projection streams from macaque striate cortex to the second visual area and middle temporal area
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 23:5684-92. 2003
    ..The results demonstrate that primary sensory cortices can use multiple projection strategies to distribute signals to higher areas, and suggest that feedforward projections may route signals with more specificity than feedback pathways...
  20. pmc A watertight acrylic-free titanium recording chamber for electrophysiology in behaving monkeys
    Daniel L Adams
    Program in Neuroscience, University of California, San Francisco, California 94143 0730, USA
    J Neurophysiol 106:1581-90. 2011
    ..Refinement of appliances and techniques used for recordings in awake monkeys promises to increase the pace of scientific discovery and to benefit animal welfare...
  21. pmc Perception via the deviated eye in strabismus
    John R Economides
    Beckman Vision Center, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 32:10286-95. 2012
    ..This plasticity in the coding of visual direction allows accurate localization of objects everywhere in the visual scene, despite the presence of strabismus...
  22. pmc The cortical column: a structure without a function
    Jonathan C Horton
    Beckman Vision Center, 10 Koret Way, University of California, San Francisco, CA 94143 0730, USA
    Philos Trans R Soc Lond B Biol Sci 360:837-62. 2005
    ..Unravelling the organization of the cerebral cortex will require a painstaking description of the circuits, projections and response properties peculiar to cells in each of its various areas...
  23. ncbi request reprint Complete flatmounting of the macaque cerebral cortex
    Lawrence C Sincich
    Beckman Vision Center, University of California San Francisco, San Francisco 94143 0730, USA
    Vis Neurosci 20:663-86. 2003
    ..Flatmounting the cerebral cortex is a simple, efficient method that can be used routinely for mapping areas and connections in the macaque brain, the most widely used primate model of the human brain...
  24. ncbi request reprint Labeling of cytochrome oxidase patches in intact flatmounts of striate cortex
    John R Economides
    Beckman Vision Center, University of California, 10 Koret Way, San Francisco, CA 94143 0730, USA
    J Neurosci Methods 149:1-6. 2005
    ..In vitro labeling of CO patches in the intact striate cortex may prove useful for directing injections of anatomical tracers such as Lucifer Yellow or DiI into identified patch and interpatch compartments...
  25. doi request reprint Extraocular muscle dynamics in diplopia from enophthalmos
    Michael K Yoon
    Beckman Vision Center, Department of Ophthalmology, University of California San Francisco, USA
    Strabismus 19:142-6. 2011
    ..This case underscores the value of careful orbital wall reconstruction after orbitotomy and suggests a mechanism for diplopia produced by postoperative enophthalmos...
  26. ncbi request reprint Neurons in V1 patch columns project to V2 thin stripes
    Lawrence C Sincich
    Beckman Vision Center, University of California San Francisco, San Francisco, CA 94143 0730, USA
    Cereb Cortex 17:935-41. 2007
    ..However, multiple V1 layers innervate V2 thin stripes, and the projection from layer 5/6 does not respect the patch/interpatch dichotomy...
  27. ncbi request reprint An albino-like decussation error in the optic chiasm revealed by anomalous ocular dominance columns
    Lawrence C Sincich
    Beckman Vision Center, University of California San Francisco, San Francisco 94143 0730, USA
    Vis Neurosci 19:541-5. 2002
    ....
  28. ncbi request reprint Input to V2 thin stripes arises from V1 cytochrome oxidase patches
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, California 94143, USA
    J Neurosci 25:10087-93. 2005
    ..This finding means that different signals are likely conveyed by patches and interpatches to V2...
  29. ncbi request reprint Divided by cytochrome oxidase: a map of the projections from V1 to V2 in macaques
    Lawrence C Sincich
    Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143 0730, USA
    Science 295:1734-7. 2002
    ..Projection of interpatches to common V2 stripe types (pale and thick) merges parvo and magno inputs, making it likely that these functional channels are distributed strongly to both dorsal and ventral streams...
  30. ncbi request reprint The circuitry of V1 and V2: integration of color, form, and motion
    Lawrence C Sincich
    Beckman Vision Center, University of California San Francisco, San Francisco, CA 94143, USA
    Annu Rev Neurosci 28:303-26. 2005
    ..Each stream is composed of a mixture of magno, parvo, and konio geniculate signals. Further studies are required to elucidate how the patches and interpatches differ in the output they convey to extrastriate cortex...
  31. ncbi request reprint A biocompatible titanium headpost for stabilizing behaving monkeys
    Daniel L Adams
    Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurophysiol 98:993-1001. 2007
    ..The headpost is simpler to implant, more securely anchored, easier to maintain, and less obtrusive than devices attached with acrylic...
  32. ncbi request reprint Eye movement abnormalities in stiff person syndrome
    John R Economides
    Beckman Vision Center, University of California, San Francisco, CA 94143 0730, USA
    Neurology 65:1462-4. 2005
    ..There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA...
  33. doi request reprint Sunken eyes, sagging brain syndrome: bilateral enophthalmos from chronic intracranial hypotension
    Thomas N Hwang
    Department of Ophthalmology, The Permanente Medical Group, Kaiser Permanente, Redwood City, California, USA
    Ophthalmology 118:2286-95. 2011
    ..To explain the mechanism for acquired enophthalmos after ventriculoperitoneal shunting (VPS)...
  34. ncbi request reprint Optic nerve sheath meningioma: visual improvement during radiation treatment
    M Reza Vagefi
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    Am J Ophthalmol 142:343-4. 2006
    ..To describe four patients with optic nerve sheath meningioma in whom visual improvement began to occur even before completion of a standard course of radiation therapy...
  35. ncbi request reprint Intracranial pressure returns to normal about a month after stopping tetracycline antibiotics
    Bryan J Winn
    Arch Ophthalmol 125:1137-8. 2007
  36. ncbi request reprint Recurrent visual loss in Leber hereditary optic neuropathy
    David E Newman-Toker
    MEEI Ninth Floor, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 121:288-91. 2003