J W Horton

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes
    J W Horton
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Am J Physiol Heart Circ Physiol 280:H1591-601. 2001
  2. ncbi request reprint Burn injury decreases myocardial Na-K-ATPase activity: role of PKC inhibition
    Jureta W Horton
    Dept of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1684-92. 2007
  3. ncbi request reprint Bactericidal/permeability increasing protein attenuates the myocardial inflammation/dysfunction that occurs with burn complicated by subsequent infection
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9136, USA
    J Appl Physiol 103:948-58. 2007
  4. ncbi request reprint A model of myocardial inflammation and dysfunction in burn complicated by sepsis
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9136, USA
    Shock 28:326-33. 2007
  5. ncbi request reprint Left ventricular contractile dysfunction as a complication of thermal injury
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Shock 22:495-507. 2004
  6. ncbi request reprint Reducing susceptibility to bacteremia after experimental burn injury: a role for selective decontamination of the digestive tract
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX 75390, USA
    J Appl Physiol 102:2207-16. 2007
  7. ncbi request reprint Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Toxicology 189:75-88. 2003
  8. ncbi request reprint Effects of burn serum on myocardial inflammation and function
    Jureta W Horton
    Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390 9160, USA
    Shock 22:438-45. 2004
  9. ncbi request reprint Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 286:H202-13. 2004
  10. pmc Myocardial inflammatory responses to sepsis complicated by previous burn injury
    Jureta W Horton
    Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Surg Infect (Larchmt) 4:363-77. 2003

Research Grants

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes
    J W Horton
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Am J Physiol Heart Circ Physiol 280:H1591-601. 2001
    ..These data suggest that HSD mediates cardioprotection after burn trauma, in part, by downregulating cardiomyocyte secretion of inflammatory cytokines...
  2. ncbi request reprint Burn injury decreases myocardial Na-K-ATPase activity: role of PKC inhibition
    Jureta W Horton
    Dept of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1684-92. 2007
    ..Since intracellular Na(+) is one determinant of electrical-mechanical recovery after insults such as burn injury, burn-related inhibition of Na-K-ATPase may be critical in postburn recovery of myocardial contractile function...
  3. ncbi request reprint Bactericidal/permeability increasing protein attenuates the myocardial inflammation/dysfunction that occurs with burn complicated by subsequent infection
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9136, USA
    J Appl Physiol 103:948-58. 2007
    ..rBPI attenuated myocyte cytokine responses to septic challenge and improved contractile function, suggesting that burn-related mobilization of microbial-like products contribute to postburn susceptibility to infection...
  4. ncbi request reprint A model of myocardial inflammation and dysfunction in burn complicated by sepsis
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9136, USA
    Shock 28:326-33. 2007
    ....
  5. ncbi request reprint Left ventricular contractile dysfunction as a complication of thermal injury
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Shock 22:495-507. 2004
  6. ncbi request reprint Reducing susceptibility to bacteremia after experimental burn injury: a role for selective decontamination of the digestive tract
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX 75390, USA
    J Appl Physiol 102:2207-16. 2007
    ..05) than values measured in burn plus sepsis in the absence of SDD. This work confirms that endogenous gut organisms contribute to sensitivity to subsequent infectious challenge...
  7. ncbi request reprint Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Toxicology 189:75-88. 2003
    ....
  8. ncbi request reprint Effects of burn serum on myocardial inflammation and function
    Jureta W Horton
    Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390 9160, USA
    Shock 22:438-45. 2004
    ..Our finding that experimental approaches neutralizing circulating LPS provided cardioprotection suggested that bacterial endotoxin or LPS-like molecules contribute, in part, to burn-related myocardial contractile dysfunction...
  9. ncbi request reprint Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 286:H202-13. 2004
    ..05). Our data confirm gender-related differences in myocardial function and myocardial inflammatory responses to burn injury...
  10. pmc Myocardial inflammatory responses to sepsis complicated by previous burn injury
    Jureta W Horton
    Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Surg Infect (Larchmt) 4:363-77. 2003
    ....
  11. ncbi request reprint The effects of early excision and grafting on myocardial inflammation and function after burn injury
    Jureta W Horton
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    J Trauma 61:1069-77. 2006
    ..This present study determined whether excision and grafting of the burned wound within 30 minutes after injury abrogated myocardial inflammation and contractile defects that occur after burn injury...
  12. ncbi request reprint Selective decontamination of the digestive tract attenuated the myocardial inflammation and dysfunction that occur with burn injury
    Jureta W Horton
    Dept of Surgery, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 287:H2241-51. 2004
    ..Our data suggest that burn-related loss of GI barrier function and translocation of microbial products serve as upstream mediators of postburn myocardial inflammatory signaling and dysfunction...
  13. ncbi request reprint Rho-associated kinase modulates myocardial inflammatory cytokine responses
    Jureta W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Shock 24:53-8. 2005
    ..Our data suggest that the Rho-kinase pathway is one potential upstream regulator of cardiac inflammatory response to burn injury...
  14. pmc Hypertonic saline dextran after burn injury decreases inflammatory cytokine responses to subsequent pneumonia-related sepsis
    Jureta W Horton
    Dept of Surgery, UT Southwestern Medical Center, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 290:H1642-50. 2006
    ....
  15. ncbi request reprint Effect of aspiration pneumonia-induced sepsis on post-burn cardiac inflammation and function in mice
    Jureta Horton
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Surg Infect (Larchmt) 7:123-35. 2006
    ....
  16. ncbi request reprint Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte cytokine secretion
    J W Horton
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 50:397-406; discussion 407-8. 2001
    ....
  17. ncbi request reprint Development of an acute burn model in adult mice for studies of cardiac function and cardiomyocyte cellular function
    J White
    Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390-9160, USA
    Shock 16:122-9. 2001
    ..05). These data confirm that the murine burn model provides a reasonable approach to study the molecular and cell biology of inflammation in organ dysfunction after burn trauma...
  18. ncbi request reprint Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNF-alpha
    C Ballard-Croft
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9160, USA
    Am J Physiol Heart Circ Physiol 280:H1970-81. 2001
    ..These data suggest p38 MAPK activation is one aspect of the signaling cascade that culminates in postburn secretion of TNF-alpha and contributes to postburn cardiac dysfunction...
  19. ncbi request reprint Detecting genetic predisposition for complicated clinical outcomes after burn injury
    R C Barber
    Department of Surgery, Burn Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Burns 32:821-7. 2006
    ..This article will review the few studies of genetic predisposition that have been conducted in the setting of burn injury, then discuss some of the obstacles and potential approaches for the discovery of additional allelic associations...
  20. ncbi request reprint Changes in cardiac contractile function and myocardial
    Z F Xia
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9160, USA
    Am J Physiol Heart Circ Physiol 280:H1916-22. 2001
    ..In conclusion, burn trauma impaired cardiac contractility, and this functional defect was paralleled by a significant rise in [Ca(2+)](i) in the heart...
  21. ncbi request reprint Overexpression of cardiac I-kappaBalpha prevents endotoxin-induced myocardial dysfunction
    S B Haudek
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Physiol Heart Circ Physiol 280:H962-8. 2001
    ..Inhibition of myocyte NF-kappaB activation by overexpression of myocyte I-kappaBalpha is sufficient to block cardiac TNF-alpha production and prevent cardiac dysfunction after LPS challenge...
  22. ncbi request reprint Nitric oxide modulation of TNF-alpha-induced cardiac contractile dysfunction is concentration dependent
    J W Horton
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas 75235 9160, USA
    Am J Physiol Heart Circ Physiol 278:H1955-65. 2000
    ....
  23. ncbi request reprint Time course of myocardial sodium accumulation after burn trauma: a (31)P- and (23)Na-NMR study
    P J Sikes
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9160, USA
    J Appl Physiol 91:2695-702. 2001
    ..Cardiomyocyte Na+ accumulation paralleled cardiac contractile dysfunction, suggesting that myocardial Na+ overload contributes, in part, to the progressive postburn decrease in ventricular performance...
  24. ncbi request reprint Cardiovascular effect of 7.5% sodium chloride-dextran infusion after thermal injury
    J T Murphy
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Arch Surg 134:1091-7. 1999
    ..5% sodium chloride in 6% dextran-70 (hypertonic saline-dextran-70 [HSD]) given as an adjuvant to a standard resuscitation with lactated Ringer (RL) solution following severe thermal injury...
  25. ncbi request reprint A primary burn wound does not slow the contraction rate of an adjacent excisional wound
    M A Carlson
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Ann Plast Surg 46:36-42. 2001
    ..Burn injury appears to have an inconsequential effect on the contraction of an adjacent wound...
  26. pmc TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury
    R C Barber
    The Department of Surgery, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    J Med Genet 41:808-13. 2004
    ..The inability of clinical factors to identify at-risk patients suggests that genetic variation may influence the risk for serious infection and the outcome from severe injury...
  27. ncbi request reprint Characterization of cardiac beta-adrenergic receptors in the guinea pig heart: application to study of beta-adrenergic receptors in shock models
    T M Kaufman
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235 9031
    J Surg Res 55:516-23. 1993
    ..2 +/- 4.7%) compared to sham-burned controls (54 +/- 2%, P < or = 0.023).(ABSTRACT TRUNCATED AT 250 WORDS)..
  28. ncbi request reprint Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma
    Cherry Ballard-Croft
    University of Texas Southwestern Medical Center, Department of Surgery, Dallas 75390 9160, USA
    Shock 18:38-45. 2002
    ..Thus, burn trauma-related sympathetic activity likely activates the stress-responsive cascade, which regulates myocardial TNF-alpha transcription/translation and culminates in cardiac contraction and relaxation defects...
  29. doi request reprint Alterations in the cardiac inflammatory response to burn trauma in mice lacking a functional Toll-like receptor 4 gene
    Brandon Bruns
    Department of Surgery, UT Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    Shock 30:740-6. 2008
    ..These data suggest that burn injury initiates an inflammatory response via Toll/IL-1 signaling in the heart, which contributes to cardiac injury and contractile dysfunction...
  30. ncbi request reprint Burn plasma mediates cardiac myocyte apoptosis via endotoxin
    Deborah L Carlson
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Physiol Heart Circ Physiol 282:H1907-14. 2002
    ....
  31. ncbi request reprint Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses
    Deborah Carlson
    Dept of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 291:H2779-89. 2006
    ....
  32. ncbi request reprint Cardiac mitochondrial damage and loss of ROS defense after burn injury: the beneficial effects of antioxidant therapy
    Qun Zang
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    J Appl Physiol 102:103-12. 2007
    ..These data suggest that burn-mediated mitochondrial dysfunction and loss of reactive oxygen species defense may play a role in postburn cardiac dysfunction...
  33. ncbi request reprint Echocardiography assessment of myocardial function after burn injury
    David L Maass
    Department of Surgery and Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9160, USA
    Shock 25:363-9. 2006
    ....
  34. ncbi request reprint Effects of burn injury on myocardial signaling and cytokine secretion: Possible role of PKC
    Jing Tan
    Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Regul Integr Comp Physiol 292:R887-96. 2007
    ..These data suggest that the PKCepsilon isoform plays a pivotal role in myocardial inflammatory response to injury, altering cardiac function by modulating cardiomyocyte inflammatory cytokine response to injury...
  35. ncbi request reprint Cardiac molecular signaling after burn trauma
    Deborah L Carlson
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Texas 75390 9160, USA
    J Burn Care Res 27:669-75. 2006
    ..These new mediators provide opportunities for therapeutic intervention, but further research is needed to clarify the importance of their mechanisms of action and the complex interactions between these various signaling pathways...
  36. ncbi request reprint Sepsis and burn complicated by sepsis alter cardiac transporter expression
    Cherry Ballard-Croft
    Department of Surgery, University of Kentucky, Lexington, Kentucky, USA
    Burns 33:72-80. 2007
    ..Western blot analysis of rat hearts used antibodies against the sarcoplasmic reticular Ca(2+) ATPase (SERCA), the L-type calcium channel, the Na(+)/Ca(2+) exchanger or the Na(+)/K(+) ATPase...
  37. doi request reprint Increasing percent burn is correlated with increasing inflammation in an adult rodent model
    Robert C Barber
    Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Shock 30:388-93. 2008
    ....
  38. doi request reprint Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury
    Robert C Barber
    Surgery Department, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    J Burn Care Res 29:168-75. 2008
    ..Increasingly sophisticated analytical methods will be required as gene-mapping studies transition from a candidate-gene based approach to genome-wide association scans...
  39. ncbi request reprint American Burn Association consensus conference to define sepsis and infection in burns
    David G Greenhalgh
    Department of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, California 95817, USA
    J Burn Care Res 28:776-90. 2007
    ..Standardized definitions will improve the capability of performing more meaningful multicenter trials among burn centers...
  40. ncbi request reprint Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury
    Deborah L Carlson
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9160, USA
    J Appl Physiol 103:323-30. 2007
    ..The present data suggest that signaling through myocardial caspases plays a pivotal role in burn-related myocyte sodium dyshomeostasis and myocyte inflammation, perhaps contributing to burn-related contractile dysfunction...
  41. ncbi request reprint Cardiac mitochondrial damage and inflammation responses in sepsis
    Qun Zang
    Department of Surgery, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Surg Infect (Larchmt) 8:41-54. 2007
    ..Inflammation responses also were examined...
  42. ncbi request reprint CD14-159 C allele is associated with increased risk of mortality after burn injury
    Robert C Barber
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Shock 27:232-7. 2007
    ....
  43. ncbi request reprint Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis
    Hongchao Zhang
    Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines, Dallas, TX 75390 9068, USA
    Am J Physiol Heart Circ Physiol 292:H2408-16. 2007
    ..These changes were attenuated in the IL-6 KO group but accentuated in the TG group. We conclude myocardial IL-6 mediates cardiac inflammation and contractile dysfunction after burn plus sepsis...
  44. pmc Innate immunity SNPs are associated with risk for severe sepsis after burn injury
    Robert C Barber
    University of Texas Southwestern Medical Center, Department of Surgery, Dallas, TX 75390 9160, USA
    Clin Med Res 4:250-5. 2006
    ..To analyze allelic association with clinical outcome in a cohort of burn patients...
  45. ncbi request reprint Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Circulation 114:1838-46. 2006
    ..Postreceptor signaling events that lead to stress responses and cytokine production are sensitive to redox changes and products of lipid peroxidation...
  46. ncbi request reprint Nitric oxide donors alter cardiomyocyte cytokine secretion and cardiac function
    David L Maass
    Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
    Crit Care Med 33:2794-803. 2005
    ....
  47. ncbi request reprint Murine in vivo myocardial contractile dysfunction after burn injury is exacerbated by pneumonia sepsis
    Weike Tao
    Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9068, USA
    Shock 24:495-9. 2005
    ..Our data indicate that burn complicated by sepsis is associated with more pronounced cardiac contractile dysfunction than burn alone or sepsis alone...
  48. ncbi request reprint Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction
    Patricia A Rothenbach
    Department of Surgery, University of Texas Sourthwestern Medical School and the Vererans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Appl Physiol 96:25-31. 2004
    ..Our findings are consistent with the hypothesis that plasma gelsolin depletion contributes to the pathophysiology of pulmonary microvascular dysfunction during inflammation...
  49. ncbi request reprint Cardiac effects of burn injury complicated by aspiration pneumonia-induced sepsis
    Jean White
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 285:H47-58. 2003
    ..In conclusion, our data suggest that burn injury primes the subject such that a second insult early in the postburn period produces significantly greater cardiac abnormalities than those seen with either burn alone or sepsis alone...
  50. ncbi request reprint I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma
    Deborah L Carlson
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Am J Physiol Heart Circ Physiol 284:H804-14. 2003
    ..These data suggest that NF-kappaB activation and inflammatory cytokine secretion play a significant role in postburn myocardial abnormalities...
  51. ncbi request reprint IL-1beta and IL-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma
    David L Maass
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Shock 18:360-6. 2002
    ..The data confirm that burn trauma upregulates inflammatory cytokine secretion by cardiomyocytes and suggest that these inflammatory cytokines act in concert to produce burn-mediated cardiac contractile dysfunction...
  52. ncbi request reprint Burn-induced impairment of cardiac contractile function is due to gut-derived factors transported in mesenteric lymph
    Justin T Sambol
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103, USA
    Shock 18:272-6. 2002
    ....
  53. ncbi request reprint TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction
    James A Thomas
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Physiol Heart Circ Physiol 283:H1645-55. 2002
    ....
  54. ncbi request reprint IRAK contributes to burn-triggered myocardial contractile dysfunction
    James A Thomas
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Am J Physiol Heart Circ Physiol 283:H829-36. 2002
    ..The findings demonstrate that IRAK and the Toll/interleukin-1 pathways participate in the response to large body surface area burns that leads to impaired cardiac contractility...
  55. ncbi request reprint Sympathoadrenal modulation of stress-activated signaling in burn trauma
    Cherry Ballard-Croft
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9160, USA
    J Burn Care Rehabil 23:172-82. 2002
    ..Burn trauma activated p38 MAPK, JNK, and NF-kappaB, and this stress response was blocked by either prazosin or propranolol. Thus, stimulation of the adrenergic pathway may constitute one upstream activator of stress response in burn...
  56. ncbi request reprint The time course of cardiac NF-kappaB activation and TNF-alpha secretion by cardiac myocytes after burn injury: contribution to burn-related cardiac contractile dysfunction
    David L Maass
    The University of Texas Southwestern Medical Center at Dallas, Department of Surgery, 75390 9160, USA
    Shock 17:293-9. 2002
    ..This inflammatory cascade preceded the appearance of cardiac dysfunction, suggesting that cardiac myocyte derived TNF-alpha contributes, in part, to postburn cardiac contractile deficits...
  57. ncbi request reprint Molecular and pharmacological approaches to inhibiting nitric oxide after burn trauma
    Jean White
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    Am J Physiol Heart Circ Physiol 285:H1616-25. 2003
    ..However, our data indicate a role for NO in cardiac dysfunction after major trauma...
  58. ncbi request reprint IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction
    James A Thomas
    Departments of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Heart Circ Physiol 285:H597-606. 2003
    ..Thus the Toll/IL-1 pathway is active in myocardial tissue and interference with pathway function, through IRAK1 inactivation, may represent a novel strategy to protect against cardiac contractile dysfunction...
  59. ncbi request reprint Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction
    Deborah L Carlson
    Department of Pediatrics, University of Texas Southwestern, Dallas, TX, USA
    Crit Care Med 33:1021-8. 2005
    ....
  60. ncbi request reprint Cardiac myocyte accumulation of calcium in burn injury: cause or effect of myocardial contractile dysfunction
    David L Maass
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    J Burn Care Rehabil 26:252-9. 2005
    ..Our finding that myocyte sodium loading precedes myocyte calcium accumulation suggests a role for the reverse mode function of the sodium/calcium exchanger in burn trauma...
  61. ncbi request reprint Sodium/hydrogen exchange activity in sepsis and in sepsis complicated by previous injury: 31P and 23Na NMR study
    Patricia J Sikes
    UT Southwestern Medical Center Department of Surgery, Dallas, Texas, USA
    Crit Care Med 33:605-15. 2005
    ..This study was directed to examine the role of Na/H exchange activity in myocardial defects after sepsis or after sepsis complicated by a previous burn injury...
  62. ncbi request reprint Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock
    Brian W Binck
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Am J Physiol Heart Circ Physiol 288:H577-83. 2005
    ..However, because inactivation of marrow-derived TLR4 function alone does not protect against endotoxin-triggered contractile dysfunction, TLR4 function in other tissues may also contribute to this response...
  63. ncbi request reprint Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury
    Monte S Willis
    Department of Pediatrics, University of Texas Southwestern, Dallas, Texas 75390 9063, USA
    Am J Physiol Heart Circ Physiol 288:H795-804. 2005
    ..This study is the first to demonstrate that MIF mediates late, prolonged cardiac dysfunction after burn injury and suggests that MIF blockade should be considered a therapeutic target for the treatment of burn injury...
  64. ncbi request reprint Role of cytosolic vs. mitochondrial Ca2+ accumulation in burn injury-related myocardial inflammation and function
    David L Maass
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    Am J Physiol Heart Circ Physiol 288:H744-51. 2005
    ..Our data suggest that a rise in mitochondrial Ca2+ is one modulator of myocardial inflammation and dysfunction in injury states such as sepsis and burn trauma...
  65. ncbi request reprint Protective role of heat stress in burn trauma
    D Jean White
    Departments of Surgery DJW, JWH, Pediatrics DC, and Physiology GAO, UT Southwestern Medical Center at Dallas, TX
    Crit Care Med 32:1338-45. 2004
    ....
  66. ncbi request reprint Burn trauma alters calcium transporter protein expression in the heart
    Cherry Ballard-Croft
    Dept of Surgery, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    J Appl Physiol 97:1470-6. 2004
    ..These data confirm that burn trauma alters calcium transporter expression, likely contributing to cardiomyocyte calcium loading and cardiac contractile dysfunction...
  67. ncbi request reprint Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor
    Leslie B Garner
    Department of Pediatrics, University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Heart Circ Physiol 285:H2500-9. 2003
    ..This study demonstrates that MIF mediates LPS-induced cardiac dysfunction and suggests that MIF should be considered a pharmacological target for the treatment of cardiac dysfunction in sepsis and potentially other cardiac diseases...
  68. ncbi request reprint Cardiomyocyte intracellular calcium and cardiac dysfunction after burn trauma
    D Jean White
    University of Texas Southwestern Medical Center, Department of Surgery, Dallas 75390 9160, USA
    Crit Care Med 30:14-22. 2002
    ..To examine the effects of pharmacologic agents designed to limit burn-mediated calcium overload on cardiomyocyte [Ca2+] and cardiac contractile function...
  69. ncbi request reprint Effect of thermal injury on relative anaplerosis and gluconeogenesis in the rat during infusion of [U-13C] propionate
    Xia Zhaofan
    Department of Burns Surgery, Changhai Hospital, Shanghai, China
    Burns 28:625-30. 2002
    ..Similarly, flux through pyruvate kinase (again relative to citrate synthase) was significantly increased in burn injury...
  70. doi request reprint Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients
    Aman Russom
    Surgical Services and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, MA, USA
    Clin Chem 54:891-900. 2008
    ..Here, we report the clinical validation of a novel microfluidic leukocyte nucleic acid isolation technique for gene expression analysis from critically ill, hospitalized patients that can be readily used on small volumes of blood...

Research Grants9

  1. Training in Trauma, Inflammation, Sepsis and Critical Care
    Fiemu Nwariaku; Fiscal Year: 2007
    ..Thus, the research and training described herein are particularly relevant to public health issues and concerns. ..
  2. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Jureta Horton; Fiscal Year: 2002
    ..Only by understanding the cellular events involved in the postburn inflammatory cascade can adequate prevention and treatment modalities be designed to improve outcome. ..
  3. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..