Research Topics
Genomes and Genes
| J D HortonSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Regulation of sterol regulatory element binding proteins in livers of fasted and refed miceJ D Horton
Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Room L5 238, Dallas, TX 75235 9046, USA
Proc Natl Acad Sci U S A 95:5987-92. 1998..We conclude that SREBPs are regulated by food consumption in the mouse liver and that the decline in nuclear SREBP-1c upon fasting may explain in part the decrease in mRNAs encoding enzymes of the fatty acid biosynthetic pathway...- Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesisJ D Horton
Department of Molecular Genetics, University of Texas Southwestern Medical Centre, Dallas 75235, USA
Curr Opin Lipidol 10:143-50. 1999..In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes... - Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 geneH Shimano
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Clin Invest 100:2115-24. 1997.... - Decreased lipid synthesis in livers of mice with disrupted Site-1 protease geneJ Yang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 98:13607-12. 2001..These data raise the possibility that S1P inhibitors may be effective lipid-lowering agents, but they suggest that nearly complete inhibition will be required... - Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsI Shimomura
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Clin Invest 99:838-45. 1997..2-fold), and the 1c transcript remained virtually undetectable. We conclude that the SREBP-1a and 1c transcripts are controlled independently by regulatory regions that respond differentially to organ-specific and metabolic factors... - Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitusI Shimomura
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
J Biol Chem 274:30028-32. 1999..These studies suggest that increased levels of nuclear SREBP-1c contribute to the elevated rates of hepatic fatty acid synthesis that leads to steatosis in diabetic mice... - SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationM Matsuda
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
Genes Dev 15:1206-16. 2001..These data provide in vivo evidence that SCAP and the SREBPs are required for hepatic lipid synthesis under basal and adaptive conditions... - Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aH Shimano
Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Clin Invest 98:1575-84. 1996..The amount of white adipose tissue decreased progressively as the liver enlarged. These studies indicate that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver... - SREBPs: transcriptional mediators of lipid homeostasisJ D Horton
Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cold Spring Harb Symp Quant Biol 67:491-8. 2002 - Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteinsY A Moon
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 276:45358-66. 2001..The current studies suggest that mouse LCE expression is increased by SREBPs and that the enzyme is a component of the elusive mammalian elongation system that converts palmitic to stearic acid... - Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feedingJ J Repa
Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 275:39685-92. 2000..These studies confirm the importance of CYP27 in bile acid synthesis and they reveal an unexpected function of the enzyme in triacylglycerol metabolism... - Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genesJ Zhang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA
Proc Natl Acad Sci U S A 98:3756-61. 2001..Sustained repression of IRS-2, as occurs in chronic hyperinsulinemia, contributes to hepatic insulin resistance and accelerates the development of the diabetic state...