Peter J Hornsby

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Nonhuman primate induced pluripotent stem cells in regenerative medicine
    Yuehong Wu
    Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Stem Cells Int 2012:767195. 2012
  2. pmc Improved coinfection with amphotropic pseudotyped retroviral vectors
    Yuehong Wu
    Institute of Biotechnology, Northwest A and F University, Yangling, Shaanxi 712100, China
    J Biomed Biotechnol 2009:901079. 2009
  3. doi request reprint Adrenarche: a cell biological perspective
    Peter J Hornsby
    Department of Physiology, and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas TX 78245, USA
    J Endocrinol 214:113-9. 2012
  4. ncbi request reprint Senescence and life span
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Pflugers Arch 459:291-9. 2010
  5. pmc Telomerase and the aging process
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Exp Gerontol 42:575-81. 2007
  6. ncbi request reprint Senescence as an anticancer mechanism
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    J Clin Oncol 25:1852-7. 2007
  7. ncbi request reprint Aging of the human adrenal cortex
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Sci Aging Knowledge Environ 2004:re6. 2004
  8. ncbi request reprint Short telomeres: cause or consequence of aging?
    Peter J Hornsby
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Aging Cell 5:577-8. 2006
  9. ncbi request reprint Mouse and human cells versus oxygen
    Peter J Hornsby
    Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Sci Aging Knowledge Environ 2003:PE21. 2003
  10. ncbi request reprint Using cell transplantation to investigate genes involved in aging
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2 200, San Antonio, TX 78245, USA
    Mech Ageing Dev 124:79-84. 2003

Research Grants

Collaborators

Detail Information

Publications48

  1. pmc Nonhuman primate induced pluripotent stem cells in regenerative medicine
    Yuehong Wu
    Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Stem Cells Int 2012:767195. 2012
    ..The marmoset can serve as a model for the implementation of patient-specific autologous cell therapy in regenerative medicine...
  2. pmc Improved coinfection with amphotropic pseudotyped retroviral vectors
    Yuehong Wu
    Institute of Biotechnology, Northwest A and F University, Yangling, Shaanxi 712100, China
    J Biomed Biotechnol 2009:901079. 2009
    ..Improved coinfection should be valuable in protocols that require high transduction by combinations of two or more retroviral vectors...
  3. doi request reprint Adrenarche: a cell biological perspective
    Peter J Hornsby
    Department of Physiology, and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas TX 78245, USA
    J Endocrinol 214:113-9. 2012
    ..It is proposed here that the in vitro differentiation of pluripotent cells, combined with appropriate in vitro and in vivo methods for validating authentic adrenocortical stem cells, is a promising approach to solving these questions...
  4. ncbi request reprint Senescence and life span
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Pflugers Arch 459:291-9. 2010
    ..Much more research is needed to address the broader question of the overall impact of senescence on life span...
  5. pmc Telomerase and the aging process
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Exp Gerontol 42:575-81. 2007
    ..The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed...
  6. ncbi request reprint Senescence as an anticancer mechanism
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    J Clin Oncol 25:1852-7. 2007
    ..These two processes, oncogene-induced senescence and telomere-based crisis, exert powerful anticancer effects...
  7. ncbi request reprint Aging of the human adrenal cortex
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Sci Aging Knowledge Environ 2004:re6. 2004
    ..The effect of imperfect repair of damage combined with compensatory overgrowth in the form of nodules leads to an increasingly abnormal tissue architecture...
  8. ncbi request reprint Short telomeres: cause or consequence of aging?
    Peter J Hornsby
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Aging Cell 5:577-8. 2006
    ..Questions about mechanisms, about the direction of causality, and about cellular heterogeneity complicate interpretation of claims associating short telomeres with adverse health outcomes...
  9. ncbi request reprint Mouse and human cells versus oxygen
    Peter J Hornsby
    Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Sci Aging Knowledge Environ 2003:PE21. 2003
    ..Much more work is needed to understand the basis for these differences and the implications for aging and cancer...
  10. ncbi request reprint Using cell transplantation to investigate genes involved in aging
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2 200, San Antonio, TX 78245, USA
    Mech Ageing Dev 124:79-84. 2003
    ..Using hTERT (telomerase reverse transcriptase) and oncoproteins, we show the potential for investigating gene action in genetically modified tissues created by cell transplantation...
  11. ncbi request reprint Adrenocortical cell proliferation in a cell transplantation model: the role of SV40 T antigen
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Endocr Res 28:777-83. 2002
    ....
  12. pmc Cellular aging and cancer
    Peter J Hornsby
    Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Crit Rev Oncol Hematol 79:189-95. 2011
    ..In this way the absence of telomerase in human cells, while one cause of cellular aging, also acts as an anti-cancer mechanism...
  13. ncbi request reprint Cellular senescence and tissue aging in vivo
    Peter J Hornsby
    Department of Physiology and the Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio 78245, USA
    J Gerontol A Biol Sci Med Sci 57:B251-6. 2002
    ....
  14. ncbi request reprint Aging of the human adrenal cortex
    Peter J Hornsby
    Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2 200, San Antonio, TX 78245, USA
    Ageing Res Rev 1:229-42. 2002
    ..This review explores these issues, the underlying basic cell and molecular biology, and the techniques that can address these questions...
  15. ncbi request reprint Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptase
    Beicheng Sun
    Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    Cancer Res 64:6144-51. 2004
    ....
  16. pmc Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)
    Sitai Liang
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Aging Cell 9:626-35. 2010
    ..The unique reaction of NMR cells to oncogene expression may form part of the cancer resistance of this species...
  17. ncbi request reprint Telomerase is not required for experimental tumorigenesis of human and bovine adrenocortical cells
    Meizhen Chen
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Endocr Res 30:555-65. 2004
    ....
  18. pmc Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis
    Furong Yuan
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Oncol Rep 23:377-86. 2010
    ..Moreover, we find that tumorigenic human cells retain malignant properties of the cells as they approach and reach crisis...
  19. pmc The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay
    Beicheng Sun
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Neoplasia 7:585-93. 2005
    ..The cellular pathways targeted by SV40 large T antigen (p53 and pRb) and those targeted by activated Ras represent a minimal set of genetic alterations required for the conversion of normal human fibroblasts into cancer cells...
  20. ncbi request reprint Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation
    Beicheng Sun
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    Cancer Res 65:6512-5. 2005
    ....
  21. ncbi request reprint Stress resistance in the naked mole-rat: the bare essentials - a mini-review
    Kaitlyn N Lewis
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78209, USA
    Gerontology 58:453-62. 2012
    ....
  22. ncbi request reprint Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
    Dan Liu
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 67:3117-26. 2007
    ..This exposure may increase cancer cell proliferation and result in promotion of preneoplastic cells...
  23. ncbi request reprint Adrenocortical cell transplantation in scid mice: the role of the host animals' adrenal glands
    Michael Thomas
    Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2 200, San Antonio, TX 78245, USA
    J Steroid Biochem Mol Biol 85:285-90. 2003
    ....
  24. pmc Directed neural differentiation of induced pluripotent stem cells from non-human primates
    Steven L Farnsworth
    Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Exp Biol Med (Maywood) 238:276-84. 2013
    ..This approach should be generally valuable in the directed differentiation of pluripotent cells for experimental cell therapy...
  25. pmc Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts
    Yuehong Wu
    College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100, China
    Stem Cell Res 4:180-8. 2010
    ..These experiments provide proof of principle that iPSC technology can be adapted for use in the marmoset, as a future model of autologous cell therapy...
  26. ncbi request reprint Telomerization of mammalian cells and transplantation of telomerized cells in immunodeficient mice
    Peter J Hornsby
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio, USA
    Methods Mol Biol 240:147-66. 2004
  27. ncbi request reprint Identification of alpha-enolase as a nuclear DNA-binding protein in the zona fasciculata but not the zona reticularis of the human adrenal cortex
    Weiye Wang
    Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    J Endocrinol 184:85-94. 2005
    ..Transfection of an alpha-enolase expression vector into NCI-H295R human adrenocortical cells increased HSD3B2 promoter activity, suggesting a possible functional role for this protein in regulation of HSD3B2 expression...
  28. ncbi request reprint Replicative senescence and cancer
    Peter J Hornsby
    Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Treat Res 124:53-73. 2005
  29. pmc Fibroblast stimulation of blood vessel development and cancer cell invasion in a subrenal capsule xenograft model: stress-induced premature senescence does not increase effect
    Dan Liu
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
    Neoplasia 9:418-26. 2007
    ..Therefore, cancer promotion by the senescence of adjacent stromal cells may be restricted to certain organ and tissue types...
  30. ncbi request reprint Bioluminescence measurements in mice using a skin window
    Qin Huang
    University of Texas Health Science Center, Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas 78245, USA
    J Biomed Opt 12:054012. 2007
    ..When rapid and accurate measurement of light from internal organs is required, rather than spatial imaging of bioluminescence, the combination of skin/body wall window and fiber optic light measurement will be advantageous...
  31. pmc Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis
    Yasuhiro Nakamura
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Endocrinol Metab 94:2192-8. 2009
    ..The human adrenal gland produces small amounts of testosterone that are increased under pathological conditions. However, the mechanisms through which the adrenal gland produces testosterone are poorly defined...
  32. pmc Improving cell therapy--experiments using transplanted telomerase-immortalized cells in immunodeficient mice
    Qin Huang
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mech Ageing Dev 128:25-30. 2007
    ..For both hTERT modification and mesenchymal cell-assisted cell therapy, genomics approaches will be needed to define what genetic modifications are desirable and safe in cells used in cell therapy...
  33. pmc In vitro osteogenic differentiation of adipose stem cells after lentiviral transduction with green fluorescent protein
    Qian Wang
    Plastic and Reconstructive Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Craniofac Surg 20:2193-9. 2009
    ....
  34. ncbi request reprint Neoplastic conversion of human colon smooth muscle cells: No requirement for telomerase
    Sitai Liang
    Department of Physiology, Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    Mol Carcinog 47:478-84. 2008
    ..These experiments on human colon smooth muscle cells support the concept that Ras(G12V) and SV40 TAg form a minimal set of genes that can convert normal human cells to cancer cells without a requirement for hTERT...
  35. pmc In situ ligation: a decade and a half of experience
    Peter J Hornsby
    Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
    Methods Mol Biol 682:49-63. 2011
    ..In the decade and a half since its introduction, ISL has been used in several hundred publications. Here we review the development of the method, its current status, and its uses and limitations...
  36. doi request reprint Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor
    Tina T L Chen
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Pediatr Blood Cancer 53:1040-7. 2009
    ..The scarcity of adequate cell models has limited our understanding of this tumor. Here we describe and characterize a new human liver tumor cell line, Hep293TT, derived from an aggressive childhood hepatoblastoma...
  37. ncbi request reprint In situ DNA ligation as a method for labeling apoptotic cells in tissue sections. An overview
    Peter J Hornsby
    Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
    Methods Mol Biol 203:133-41. 2002
  38. ncbi request reprint Tumorigenic study on hepatocytes coexpressing SV40 with Ras
    Beicheng Sun
    Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
    Mol Carcinog 45:213-9. 2006
    ....
  39. ncbi request reprint Global gene expression response to telomerase in bovine adrenocortical cells
    Steven D Perrault
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Biochem Biophys Res Commun 335:925-36. 2005
    ..As well, we identified alterations in genes associated with development and wound healing that support a model that high telomerase expression induces a highly adaptable, progenitor-like state...
  40. ncbi request reprint Human adrenocortical cell xenotransplantation: model of cotransplantation of human adrenocortical cells and 3T3 cells in scid mice to form vascularized functional tissue and prevent adrenal insufficiency
    Michael Thomas
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston TX 77030, USA
    Xenotransplantation 9:58-67. 2002
    ..This demonstrates that transplanted human endocrine cells can functionally replace a surgically removed endocrine organ in a host animal...
  41. pmc Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Proc Natl Acad Sci U S A 99:7484-9. 2002
    ..At the same time, the high level of transfection in adrenocortical cells might make appropriately modified adenoviral vectors suitable for gene therapy of adrenocortical carcinomas with poor prognosis...
  42. pmc Cooperation of hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cells
    Michael Thomas
    Huffington Center on Aging, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Neoplasia 4:493-500. 2002
    ..The use of cell transplantation techniques in a cell type that is able to form tissue structures with or without full neoplastic conversion allows the phenotypes produced by individual cooperating oncogenes to be observed...
  43. ncbi request reprint Intradermal cell transplantation in soluble collagen
    Hao Zhang
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Transplant 11:139-45. 2002
    ..The ability to grow both types of cells in an easily accessible site allows less invasive monitoring of growth, angiogenesis, and other features of the transplant...
  44. pmc Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi
    Debdutta Bandyopadhyay
    Department of Dermatology, and Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:577-91. 2007
    ..These results provide new insights into the role of the RB pathway in regulating cellular senescence and implicate HDAC1 as a likely mediator of early chromatin remodeling events...
  45. ncbi request reprint Human chorionic gonadotropin does not alter patterns of adrenal androgen secretion in primary human adrenal reticularis and fasciculata cell culture
    Peter R Casson
    Department of OBGYN, University of Vermont, Burlington 05401, USA
    Menopause 14:316-9. 2007
    ..We hypothesized that human chorionic gonadotropin (hCG), acting as an luteinizing hormone analog, would thus augment adrenal androgen secretion from primary human adrenocortical zona reticularis and zona fasciculata cell cultures...
  46. ncbi request reprint An interview with Peter J. Hornsby, Ph.D. Interview by Vicki Glaser
    Peter J Hornsby
    J Anti Aging Med 6:77-81. 2003
  47. ncbi request reprint Replicative senescence of human and mouse cells in culture: significance for aging research
    Peter J Hornsby
    Mech Ageing Dev 124:853-5. 2003

Research Grants2

  1. TYPE II 3BETA HSD GENE--REGULATION OF DHEAS SYNTHESIS
    Peter Hornsby; Fiscal Year: 2007
    ..Cell transplantation offers the possibility of future testing of molecular mechanisms of zonation under controlled in vivo conditions. ..
  2. TYPE II 3BETA HSD GENE--REGULATION OF DHEAS SYNTHESIS
    Peter Hornsby; Fiscal Year: 2007
    ..Cell transplantation offers the possibility of future testing of molecular mechanisms of zonation under controlled in vivo conditions. ..