Research Topics
Species | Peter J HornsbySummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
Adrenarche: a cell biological perspectivePeter J Hornsby
Department of Physiology, and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas TX 78245, USA
J Endocrinol 214:113-9. 2012..It is proposed here that the in vitro differentiation of pluripotent cells, combined with appropriate in vitro and in vivo methods for validating authentic adrenocortical stem cells, is a promising approach to solving these questions...
Aging of the human adrenal cortexPeter J Hornsby
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
Sci Aging Knowledge Environ 2004:re6. 2004..The effect of imperfect repair of damage combined with compensatory overgrowth in the form of nodules leads to an increasingly abnormal tissue architecture...
Telomerase and the aging processPeter J Hornsby
Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
Exp Gerontol 42:575-81. 2007..The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed...- Short telomeres: cause or consequence of aging?Peter J Hornsby
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
Aging Cell 5:577-8. 2006..Questions about mechanisms, about the direction of causality, and about cellular heterogeneity complicate interpretation of claims associating short telomeres with adverse health outcomes... - Senescence as an anticancer mechanismPeter J Hornsby
Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
J Clin Oncol 25:1852-7. 2007..These two processes, oncogene-induced senescence and telomere-based crisis, exert powerful anticancer effects... - Senescence and life spanPeter J Hornsby
Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
Pflugers Arch 459:291-9. 2010..Much more research is needed to address the broader question of the overall impact of senescence on life span... - Mouse and human cells versus oxygenPeter J Hornsby
Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
Sci Aging Knowledge Environ 2003:PE21. 2003..Much more work is needed to understand the basis for these differences and the implications for aging and cancer... - Using cell transplantation to investigate genes involved in agingPeter J Hornsby
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2 200, San Antonio, TX 78245, USA
Mech Ageing Dev 124:79-84. 2003..Using hTERT (telomerase reverse transcriptase) and oncoproteins, we show the potential for investigating gene action in genetically modified tissues created by cell transplantation... - Adrenocortical cell proliferation in a cell transplantation model: the role of SV40 T antigenPeter J Hornsby
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
Endocr Res 28:777-83. 2002.... - Cellular aging and cancerPeter J Hornsby
Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
Crit Rev Oncol Hematol 79:189-95. 2011..In this way the absence of telomerase in human cells, while one cause of cellular aging, also acts as an anti-cancer mechanism... - Aging of the human adrenal cortexPeter J Hornsby
Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2 200, San Antonio, TX 78245, USA
Ageing Res Rev 1:229-42. 2002..This review explores these issues, the underlying basic cell and molecular biology, and the techniques that can address these questions... - Cellular senescence and tissue aging in vivoPeter J Hornsby
Department of Physiology and the Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio 78245, USA
J Gerontol A Biol Sci Med Sci 57:B251-6. 2002.... - Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptaseBeicheng Sun
Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
Cancer Res 64:6144-51. 2004.... - Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)Sitai Liang
Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
Aging Cell 9:626-35. 2010..The unique reaction of NMR cells to oncogene expression may form part of the cancer resistance of this species... - Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisisFurong Yuan
Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
Oncol Rep 23:377-86. 2010..Moreover, we find that tumorigenic human cells retain malignant properties of the cells as they approach and reach crisis... - Telomerase is not required for experimental tumorigenesis of human and bovine adrenocortical cellsMeizhen Chen
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
Endocr Res 30:555-65. 2004.... - The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assayBeicheng Sun
Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
Neoplasia 7:585-93. 2005..The cellular pathways targeted by SV40 large T antigen (p53 and pRb) and those targeted by activated Ras represent a minimal set of genetic alterations required for the conversion of normal human fibroblasts into cancer cells... - Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformationBeicheng Sun
Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78245, USA
Cancer Res 65:6512-5. 2005.... - Stress resistance in the naked mole-rat: the bare essentials - a mini-reviewKaitlyn N Lewis
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78209, USA
Gerontology 58:453-62. 2012.... - Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretionDan Liu
Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
Cancer Res 67:3117-26. 2007..This exposure may increase cancer cell proliferation and result in promotion of preneoplastic cells... - Identification of alpha-enolase as a nuclear DNA-binding protein in the zona fasciculata but not the zona reticularis of the human adrenal cortexWeiye Wang
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
J Endocrinol 184:85-94. 2005..Transfection of an alpha-enolase expression vector into NCI-H295R human adrenocortical cells increased HSD3B2 promoter activity, suggesting a possible functional role for this protein in regulation of HSD3B2 expression... - Fibroblast stimulation of blood vessel development and cancer cell invasion in a subrenal capsule xenograft model: stress-induced premature senescence does not increase effectDan Liu
Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Neoplasia 9:418-26. 2007..Therefore, cancer promotion by the senescence of adjacent stromal cells may be restricted to certain organ and tissue types... - Replicative senescence and cancerPeter J Hornsby
Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
Cancer Treat Res 124:53-73. 2005 - Adrenocortical cell transplantation in scid mice: the role of the host animals' adrenal glandsMichael Thomas
Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive STCBM 2.200, San Antonio, TX 78245, USA
J Steroid Biochem Mol Biol 85:285-90. 2003.... - Telomerization of mammalian cells and transplantation of telomerized cells in immunodeficient micePeter J Hornsby
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio, USA
Methods Mol Biol 240:147-66. 2004 - Improving cell therapy--experiments using transplanted telomerase-immortalized cells in immunodeficient miceQin Huang
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
Mech Ageing Dev 128:25-30. 2007..For both hTERT modification and mesenchymal cell-assisted cell therapy, genomics approaches will be needed to define what genetic modifications are desirable and safe in cells used in cell therapy... - Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularisYasuhiro Nakamura
Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
J Clin Endocrinol Metab 94:2192-8. 2009..The human adrenal gland produces small amounts of testosterone that are increased under pathological conditions. However, the mechanisms through which the adrenal gland produces testosterone are poorly defined... - Generation of induced pluripotent stem cells from newborn marmoset skin fibroblastsYuehong Wu
College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100, China
Stem Cell Res 4:180-8. 2010..These experiments provide proof of principle that iPSC technology can be adapted for use in the marmoset, as a future model of autologous cell therapy... - Neoplastic conversion of human colon smooth muscle cells: No requirement for telomeraseSitai Liang
Department of Physiology, Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78245, USA
Mol Carcinog 47:478-84. 2008..These experiments on human colon smooth muscle cells support the concept that Ras(G12V) and SV40 TAg form a minimal set of genes that can convert normal human cells to cancer cells without a requirement for hTERT... - Bioluminescence measurements in mice using a skin windowQin Huang
University of Texas Health Science Center, Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas 78245, USA
J Biomed Opt 12:054012. 2007..When rapid and accurate measurement of light from internal organs is required, rather than spatial imaging of bioluminescence, the combination of skin/body wall window and fiber optic light measurement will be advantageous... - In vitro osteogenic differentiation of adipose stem cells after lentiviral transduction with green fluorescent proteinQian Wang
Plastic and Reconstructive Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Craniofac Surg 20:2193-9. 2009.... - Nonhuman primate induced pluripotent stem cells in regenerative medicineYuehong Wu
Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245, USA
Stem Cells Int 2012:767195. 2012..The marmoset can serve as a model for the implementation of patient-specific autologous cell therapy in regenerative medicine... - Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumorTina T L Chen
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Pediatr Blood Cancer 53:1040-7. 2009..The scarcity of adequate cell models has limited our understanding of this tumor. Here we describe and characterize a new human liver tumor cell line, Hep293TT, derived from an aggressive childhood hepatoblastoma... - In situ ligation: a decade and a half of experiencePeter J Hornsby
Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Methods Mol Biol 682:49-63. 2011..In the decade and a half since its introduction, ISL has been used in several hundred publications. Here we review the development of the method, its current status, and its uses and limitations... - In situ DNA ligation as a method for labeling apoptotic cells in tissue sections. An overviewPeter J Hornsby
Department of Physiology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Methods Mol Biol 203:133-41. 2002 - Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapySalvatore Alesci
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
Proc Natl Acad Sci U S A 99:7484-9. 2002..At the same time, the high level of transfection in adrenocortical cells might make appropriately modified adenoviral vectors suitable for gene therapy of adrenocortical carcinomas with poor prognosis... - Cooperation of hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cellsMichael Thomas
Huffington Center on Aging, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Neoplasia 4:493-500. 2002..The use of cell transplantation techniques in a cell type that is able to form tissue structures with or without full neoplastic conversion allows the phenotypes produced by individual cooperating oncogenes to be observed... - Intradermal cell transplantation in soluble collagenHao Zhang
Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Cell Transplant 11:139-45. 2002..The ability to grow both types of cells in an easily accessible site allows less invasive monitoring of growth, angiogenesis, and other features of the transplant... - Human adrenocortical cell xenotransplantation: model of cotransplantation of human adrenocortical cells and 3T3 cells in scid mice to form vascularized functional tissue and prevent adrenal insufficiencyMichael Thomas
Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston TX 77030, USA
Xenotransplantation 9:58-67. 2002..This demonstrates that transplanted human endocrine cells can functionally replace a surgically removed endocrine organ in a host animal... - Global gene expression response to telomerase in bovine adrenocortical cellsSteven D Perrault
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada N1G 2W1
Biochem Biophys Res Commun 335:925-36. 2005..As well, we identified alterations in genes associated with development and wound healing that support a model that high telomerase expression induces a highly adaptable, progenitor-like state... - Tumorigenic study on hepatocytes coexpressing SV40 with RasBeicheng Sun
Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
Mol Carcinog 45:213-9. 2006.... - Replicative senescence of human and mouse cells in culture: significance for aging researchPeter J Hornsby
Mech Ageing Dev 124:853-5. 2003 - An interview with Peter J. Hornsby, Ph.D. Interview by Vicki GlaserPeter J Hornsby
J Anti Aging Med 6:77-81. 2003 - Human chorionic gonadotropin does not alter patterns of adrenal androgen secretion in primary human adrenal reticularis and fasciculata cell culturePeter R Casson
Department of OBGYN, University of Vermont, Burlington 05401, USA
Menopause 14:316-9. 2007..We hypothesized that human chorionic gonadotropin (hCG), acting as an luteinizing hormone analog, would thus augment adrenal androgen secretion from primary human adrenocortical zona reticularis and zona fasciculata cell cultures... 
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic neviDebdutta Bandyopadhyay
Department of Dermatology, and Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Aging Cell 6:577-91. 2007..These results provide new insights into the role of the RB pathway in regulating cellular senescence and implicate HDAC1 as a likely mediator of early chromatin remodeling events...
Research Grants
- TYPE II 3BETA HSD GENE--REGULATION OF DHEAS SYNTHESISPeter Hornsby; Fiscal Year: 2007..Cell transplantation offers the possibility of future testing of molecular mechanisms of zonation under controlled in vivo conditions. ..