Benjamin D Horne

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, Utah 84112, USA
    Genet Epidemiol 26:11-21. 2004
  2. pmc Comparison of linkage analysis methods for genome-wide scanning of extended pedigrees, with application to the TG/HDL-C ratio in the Framingham Heart Study
    Benjamin D Horne
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    BMC Genet 4:S93. 2003
  3. ncbi request reprint Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, UT 84108 1266, USA
    Am Heart J 152:305-11. 2006
  4. ncbi request reprint Evidence for a heritable component in death resulting from aortic and mitral valve diseases
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1266, USA
    Circulation 110:3143-8. 2004
  5. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
  6. ncbi request reprint C-reactive protein predicts death in patients with non-ischemic cardiomyopathy
    Brianna S Ronnow
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 104:196-201. 2005
  7. ncbi request reprint Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing
    John F Carlquist
    Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    J Thromb Thrombolysis 26:1-7. 2008
  8. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
  9. ncbi request reprint Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, University of Utah, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 49:2053-60. 2007
  10. ncbi request reprint Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    Joseph B Muhlestein
    Intermountain Medical Center, Murray, Utah University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 106:764-9. 2010

Detail Information

Publications76

  1. ncbi request reprint Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, Utah 84112, USA
    Genet Epidemiol 26:11-21. 2004
    ..Our findings suggest that PCA may be a powerful tool for establishing an optimal SNP set that maximizes the amount of genetic variation captured for a candidate gene using a minimal number of SNPs...
  2. pmc Comparison of linkage analysis methods for genome-wide scanning of extended pedigrees, with application to the TG/HDL-C ratio in the Framingham Heart Study
    Benjamin D Horne
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    BMC Genet 4:S93. 2003
    ..Results were compared to each other and to those from a previous evaluation using SOLAR for TG/HDL-C ratio on this sample. We also investigated linked pedigrees in each region using by-pedigree analysis...
  3. ncbi request reprint Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, UT 84108 1266, USA
    Am Heart J 152:305-11. 2006
    ..This study evaluated deaths caused by CAD, MI, hypertensive heart disease (HtnHD), and congestive heart failure (CHF) among close and distant relatives...
  4. ncbi request reprint Evidence for a heritable component in death resulting from aortic and mitral valve diseases
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1266, USA
    Circulation 110:3143-8. 2004
    ..This study evaluated the familiality of death resulting from aortic, mitral, and all valvular diseases using a population-based genealogy linked to death records...
  5. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  6. ncbi request reprint C-reactive protein predicts death in patients with non-ischemic cardiomyopathy
    Brianna S Ronnow
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 104:196-201. 2005
    ..0) significantly and independently predicted mortality. Even in the absence of coronary artery disease, patients with left ventricular dysfunction are at increased risk of mortality based on their baseline CRP concentrations...
  7. ncbi request reprint Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing
    John F Carlquist
    Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    J Thromb Thrombolysis 26:1-7. 2008
    ..99. Combined with a method for rapid buccal swab DNA extraction, genotyping results were obtained in a median of 59 min. These methods should facilitate genotype-driven warfarin dosing in "real-time" clinical practice...
  8. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
    ..Mortality is the most definitive clinical endpoint, but medical care is more easily applied to modify morbidity and thereby prevent death. This study tested whether IMRS is associated with clinical morbidity endpoints...
  9. ncbi request reprint Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, University of Utah, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 49:2053-60. 2007
    ....
  10. ncbi request reprint Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    Joseph B Muhlestein
    Intermountain Medical Center, Murray, Utah University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 106:764-9. 2010
    ..In conclusion, elevated baseline PRA is associated with cardiac morbidity and mortality in patients with coronary artery disease but normal left ventricular function and no previous MI or HF...
  11. pmc Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 102:814-819. 2008
    ..In conclusion, not only proscription of tobacco, but also routine periodic fasting was associated with lower risk of CAD...
  12. ncbi request reprint Comparison of effects of simvastatin alone versus fenofibrate alone versus simvastatin plus fenofibrate on lipoprotein subparticle profiles in diabetic patients with mixed dyslipidemia (from the Diabetes and Combined Lipid Therapy Regimen study)
    Heidi T May
    Intermountain Medical Center and LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 101:486-9. 2008
    ..In conclusion, in this trial of mixed dyslipidemic patients with diabetes, combination therapy was more effective in changing a variety of other cardiovascular risk markers...
  13. ncbi request reprint Statin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Circulation 107:258-63. 2003
    ..This study prospectively evaluated the effect of statins on CMV-and CRP-associated death among patients with significant, angiographically defined CAD...
  14. ncbi request reprint Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes
    Matthew J Kolek
    Cardiovascular Department, Division of Cardiology, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 148:1034-40. 2004
    ..We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a decreased risk for CAD and diabetes...
  15. ncbi request reprint The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failure
    Matthew J Kolek
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    J Card Fail 11:677-83. 2005
    ..A common variant of the adenosine monophosphate deaminase (AMPD)-1 gene (C34T) results in enzymatic inactivity and may increase adenosine in cardiac muscle and confer cardioprotection through ischemic preconditioning...
  16. ncbi request reprint Lipoprotein-associated phospholipase A2 independently predicts the angiographic diagnosis of coronary artery disease and coronary death
    Heidi T May
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 152:997-1003. 2006
    ..We evaluated the independent association of lipoprotein-associated phospholipase A2 (Lp-PLA2) to angiographic CAD and CV events adjusting for standard factors, lipids, and CRP...
  17. pmc Soluble CD40 ligand as a predictor of coronary artery disease and long-term clinical outcomes in stable patients undergoing coronary angiography
    Matthew T Rondina
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Cardiology 109:196-201. 2008
    ..We evaluated sCD40L levels and future cardiovascular events in patients not experiencing ACS...
  18. doi request reprint Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 109:1558-62. 2012
    ..A reported fasting association with a lower CAD risk was also validated and fasting associations with lower glucose and BMI were found...
  19. ncbi request reprint The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease
    John F Carlquist
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:1007-14. 2003
    ..We studied CETP Taq1B genotype, plasma HDL, and clinical events among all patients and patients stratified by statin treatment...
  20. ncbi request reprint Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:969-75. 2007
    ..In an independent but demographically similar population, this study tested 6 SNPs that were previously reported to be associated with MI...
  21. ncbi request reprint Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 153:67-73. 2007
    ....
  22. ncbi request reprint Homocysteine levels are associated with increased risk of congestive heart failure in patients with and without coronary artery disease
    Heidi T May
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 107:178-84. 2007
    ..Whether HCY affects development of congestive heart failure (CHF) independent of coronary artery disease (CAD) is uncertain. We evaluated whether increased HCY predicts low ejection fraction or clinical CHF...
  23. ncbi request reprint Less affluent area of residence and lesser-insured status predict an increased risk of death or myocardial infarction after angiographic diagnosis of coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Epidemiol 14:143-50. 2004
    ..Low socioeconomic status (SES) predicts coronary artery disease (CAD) onset, but its value among patients with CAD is uncertain. Geographic measures (e.g., residential neighborhood) may predict risk, but this requires further evaluation...
  24. ncbi request reprint High-resolution characterization of linkage disequilibrium structure and selection of tagging single nucleotide polymorphisms: application to the cholesteryl ester transfer protein gene
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Ann Hum Genet 70:524-34. 2006
    ..This study provides an optimal set of tSNPs for association analyses of CETP. The observed complexity of LD structure highlights the importance of using methods, such as PCA, that allow for multiple dynamics in intragenic LD structure...
  25. ncbi request reprint Relation of serum total cholesterol, C-reactive protein levels, and statin therapy to survival in heart failure
    Heidi T May
    LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 98:653-8. 2006
    ..In conclusion, elevated TC appears to be associated with improved survival. The effect was stronger in patients receiving statin therapy, but the cause of this differential effect is uncertain...
  26. ncbi request reprint Comparison of effects of high (80 mg) versus low (20 mg) dose of simvastatin on C-reactive protein and lipoproteins in patients with angiographic evidence of coronary arterial narrowing
    Kent G Meredith
    Cardiovascular Department, LDS Hospital, Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:149-53. 2007
    ..In conclusion, this randomized trial in patients with chronic stable coronary artery disease showed a strong dose response for simvastatin for total and low-density lipoprotein cholesterol lowering but not for hs-CRP...
  27. ncbi request reprint Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:169-74. 2007
    ..A total CBC score is an important new addition to risk prediction, and it can be easily generated by computer for clinical use at negligible incremental cost...
  28. ncbi request reprint Early effects of statins in patients with coronary artery disease and high C-reactive protein
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 94:1107-12. 2004
    ..This provides further evidence of an anti-inflammatory effect of statins...
  29. ncbi request reprint Surgical revascularization is associated with improved long-term outcomes compared with percutaneous stenting in most subgroups of patients with multivessel coronary artery disease: results from the Intermountain Heart Registry
    Tami L Bair
    Cardiovascular Department, University of Utah, Salt Lake City, USA
    Circulation 116:I226-31. 2007
    ..In this study, we examined the outcomes of major adverse cardiovascular events and death for subgroups of typical "real-world" patients undergoing coronary revascularization in the modern era...
  30. pmc Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  31. ncbi request reprint Effect of fasting glucose levels on mortality rate in patients with and without diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention
    Joseph B Muhlestein
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:351-8. 2003
    ..Diabetes mellitus (DM) is predictive of increased mortality for patients with coronary artery disease (CAD). To what extent this risk extends below the diabetic threshold (fasting glucose level [FG] <126 mg/dL) is uncertain...
  32. doi request reprint The intermountain risk score predicts incremental age-specific long-term survival and life expectancy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah, USA
    Transl Res 158:307-14. 2011
    ..IMRS may be used to stratify age-specific risk of mortality in research, clinical/preventive, and quality improvement applications. A web calculator is located at http://intermountainhealthcare.org/IMRS...
  33. pmc Repeated measurement of the intermountain risk score enhances prognostication for mortality
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    PLoS ONE 8:e69160. 2013
    ..Whether longitudinal repeated measurement of IMRS is useful for prognostication is an important question for its clinical applicability...
  34. ncbi request reprint Which features of the metabolic syndrome predict the prevalence and clinical outcomes of angiographic coronary artery disease?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City, Utah, USA
    Cardiology 101:185-93. 2004
    ..The prevalence of the metabolic syndrome (MS) is growing. The Adult Treatment Panel (ATP) III provided a uniform definition of MS but no information on its predictive ability...
  35. ncbi request reprint Sex- and age-related differences in the prognostic value of C-reactive protein in patients with angiographic coronary artery disease
    Lillian L C Khor
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Am J Med 117:657-64. 2004
    ..To determine whether sex and age affect serum C-reactive protein level and its prognostic value in patients with coronary artery disease...
  36. ncbi request reprint Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Intermountain Healthcare, Salt Lake City, UT, USA
    Circulation 116:2563-70. 2007
    ..Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials...
  37. ncbi request reprint Early postoperative use of unfractionated heparin or enoxaparin is associated with increased surgical re-exploration for bleeding
    Heath U Jones
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    Ann Thorac Surg 80:518-22. 2005
    ..exist for the use of unfractionated heparin (UFH) and enoxaparin (ENOX) in the early postoperative period following open-heart surgery. However, the overall postoperative risk for hemorrhage from the use of UFH and ENOX are not known...
  38. ncbi request reprint Risk of nephropathy is not increased by the administration of larger volume of contrast during coronary angiography
    Troy E Madsen
    Division of Emergency Medicine, University of Utah, Salt Lake City, UT, USA
    Crit Pathw Cardiol 8:167-71. 2009
    ..The apparent inverse relation of risk with volume in the overall population is likely explained by clinical practice bias. If confirmed, these results may have important clinical implications...
  39. ncbi request reprint Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study
    John F Carlquist
    Department of Medicine, Division of Cardiology, University of Utah School of Medicine, Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    J Thromb Thrombolysis 22:191-7. 2006
    ..vitamin K epoxide reductase complex subunit 1-VKORC1). We hypothesized that variants in these two genes explain a substantial proportion of variability in stable warfarin dose and could be used as a basis for improved dosing algorithms...
  40. ncbi request reprint Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?
    James S Zebrack
    Divisions of Cardiology and Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Am Coll Cardiol 42:57-63. 2003
    ..We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI)...
  41. ncbi request reprint Do statins increase the risk of idiopathic polyneuropathy?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Cardiology Division, Intermountain Health Care, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:1097-9. 2005
    ..It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls...
  42. ncbi request reprint A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction
    Yoshikazu Yazaki
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Card Fail 10:316-20. 2004
    ..This variant might lead to ischemic preconditioning by increasing tissue adenosine. We tested whether the survival benefit of C34T occurs preferentially in the setting of ischemic left ventricular dysfunction...
  43. ncbi request reprint Effect of reversible pulmonary hypertension on outcomes after heart transplantation
    Stavros G Drakos
    Utah Transplantation Affiliated Hospitals, Cardiac Transplant Program, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Heart Lung Transplant 26:319-23. 2007
    ..Conflicting data exist regarding the impact of reversible pulmonary hypertension (PHTN) on post-transplant (Tx) outcomes. In this study we sought to determine the influence of reversible PHTN on outcomes after Tx...
  44. doi request reprint Risk factors predictive of right ventricular failure after left ventricular assist device implantation
    Stavros G Drakos
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Cardiol 105:1030-5. 2010
    ....
  45. ncbi request reprint Validation of the Seattle Heart Failure Model in a community-based heart failure population and enhancement by adding B-type natriuretic peptide
    Heidi T May
    LDS Hospital, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 100:697-700. 2007
    ..02). In conclusion, the SHFM predicts survival in patients with HF in a hospital-based population, with areas under the curve similar to those from data on which models were initially fit...
  46. ncbi request reprint Prevalence and risks of allosensitization in HeartMate left ventricular assist device recipients: the impact of leukofiltered cellular blood product transfusions
    Stavros G Drakos
    Utah Transplantation Affiliated Hospitals UTAH Cardiac Transplant Program, Salt Lake City, Utah, USA
    J Thorac Cardiovasc Surg 133:1612-9. 2007
    ..We investigated the pattern of sensitization in left ventricular assist device recipients in relation to cellular blood product transfusions received...
  47. ncbi request reprint Improved long-term survival associated with stent deployment during percutaneous coronary interventions: results from a registry of 3399 patients
    Joseph B Muhlestein
    Division of Cardiology, Department of Cardiovascular Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 150:182-7. 2005
    ..However, few studies have had a sufficient sample size or adequate follow-up to determine whether this advantage results in a positive effect on mortality...
  48. ncbi request reprint Frequency of elevation of C-reactive protein in atrial fibrillation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 94:1255-9. 2004
    ..Increased CRP is a new risk marker for AF propensity, and testing therapies that target inflammation should be considered...
  49. ncbi request reprint Which white blood cell subtypes predict increased cardiovascular risk?
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 45:1638-43. 2005
    ..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
  50. ncbi request reprint Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment
    Jessica L Clarke
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:155-8. 2005
    ..This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank...
  51. ncbi request reprint Multivariate predictors of heart transplantation outcomes in the era of chronic mechanical circulatory support
    Stavros G Drakos
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Thorac Surg 83:62-7. 2007
    ..Determining which pretransplantation (TX) characteristics predict the development of chronic renal dysfunction (CRD) or death after heart TX would enable more accurate risk assessment at the time of candidate evaluation...
  52. ncbi request reprint Beta-blockers reduce the incidence of clinical restenosis: prospective study of 4840 patients undergoing percutaneous coronary revascularization
    Jeffrey D Jackson
    Division of Cardiology, Department of Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 145:875-81. 2003
    ..Although beta-adrenergic receptor blockers (BBs) effectively reduce many cardiac events, no large prospective studies have examined the association of BBs with restenosis...
  53. ncbi request reprint Progress in unraveling the genetics of coronary artery disease and myocardial infarction
    Jeffrey L Anderson
    Department of Cardiology, LDS Hospital, Salt Lake City, UT 84143, USA
    Curr Atheroscler Rep 9:179-86. 2007
    ..Despite the complexity of coronary heart disease genetics, steady progress can be expected...
  54. ncbi request reprint Effect of folic acid fortification of food on homocysteine-related mortality
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah 84143, USA
    Am J Med 116:158-64. 2004
    ..In 1998, the Food and Drug Administration mandated the fortification of food products with folic acid. The effect of this rule on mortality associated with homocysteine levels in patients with coronary artery disease is unknown...
  55. ncbi request reprint Effect of mechanical circulatory support on outcomes after heart transplantation
    Stavros G Drakos
    Utah Transplantation Affiliate Hospitals Cardiac Transplant Program, Salt Lake City, UT, USA
    J Heart Lung Transplant 25:22-8. 2006
    ....
  56. ncbi request reprint The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 48:396-401. 2006
    ..The primary objective was to determine the effect of statin-fibrate combination therapy on inflammatory biomarkers in patients with diabetes...
  57. ncbi request reprint Risk factor analysis of plasma cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay
    Thomas B Martins
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
    Am J Clin Pathol 125:906-13. 2006
    ..017), and CRP (P pound .001). Cytokine profiles may have a role in differentiating patients with CAD with MI from those with chest pain due to other disorders and in deciphering the role of inflammation in the pathogenesis of CAD...
  58. doi request reprint Red cell distribution width is predictive of mortality in trauma patients
    Sarah Majercik
    Divisions of Trauma Services, Intermountain Medical Center, Salt Lake City, UT 84157, USA
    J Trauma Acute Care Surg 74:1021-6. 2013
    ..It is unknown whether RDW predicts outcomes in trauma patients. This study tested whether RDW predicts mortality in a trauma population at a Level I trauma center...
  59. pmc Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah 84107, USA
    Thromb Haemost 107:232-40. 2012
    ..7 mg/week. In conclusion, a pharmacogenetic warfarin dose-refinement algorithm based on clinical, INR, and genetic factors can explain at least 69.1% of therapeutic warfarin dose variability after about one week of therapy...
  60. ncbi request reprint Differential impact on post-transplant outcomes between pulsatile- and continuous-flow left ventricular assist devices
    Pere A Ventura
    Utah Artificial Heart Program, Intermountain Medical Center, Salt Lake City, UT, USA
    Clin Transplant 25:E390-5. 2011
    ..In this study, we compared the post-transplant (PTx) outcomes between XVE and HMII using a large national data registry...
  61. ncbi request reprint C-reactive protein and angiographic coronary artery disease: independent and additive predictors of risk in subjects with angina
    James S Zebrack
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Am Coll Cardiol 39:632-7. 2002
    ..The objective of this study was to determine the prognostic value of C-reactive protein (CRP) independent of coronary angiographic findings...
  62. ncbi request reprint Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients
    Chloe A Allen Maycock
    Cardiology Research, LDS Hospital, 8th Avenue and C Street, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 40:1777-85. 2002
    ..This study evaluated the effect of statin therapy on mortality in individuals with significant coronary artery disease (CAD) stratified by age...
  63. doi request reprint Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
    ..Given the ease of vitamin D measurement and replacement, prospective studies of vitamin D supplementation to prevent and treat CV disease are urgently needed...
  64. ncbi request reprint Effect of implementation of folic acid fortification of food on homocysteine concentrations in subjects with coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah School of Medicine, Salt Lake City, Utah 84143, USA
    Am J Cardiol 90:536-9. 2002
  65. ncbi request reprint Warfarin knowledge in patients with atrial fibrillation: implications for safety, efficacy, and education strategies
    Megan B Smith
    Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, USA
    Cardiology 116:61-9. 2010
    ..Multiple factors influence warfarin metabolism and can significantly affect the risk of adverse events. The extent to which patients understand the modifiable factors that impact on warfarin safety and efficacy is unclear...
  66. ncbi request reprint Characterization of linkage disequilibrium structure, mutation history, and tagging SNPs, and their use in association analyses: ELAC2 and familial early-onset prostate cancer
    Nicola J Camp
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Genet Epidemiol 28:232-43. 2005
    ....
  67. ncbi request reprint Greater pathogen burden but not elevated C-reactive protein increases the risk of clinical restenosis after percutaneous coronary intervention
    Benjamin D Horne
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 144:491-500. 2002
    ....
  68. ncbi request reprint Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigrees
    Nicola J Camp
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1206, USA
    Hypertension 42:322-8. 2003
    ..In conclusion, our results suggest that pulse pressure might be of use for identifying genes involved in blood pressure phenotypes and arterial aging...
  69. ncbi request reprint The power to detect genetic linkage for quantitative traits in the Utah CEPH pedigrees
    Alka Malhotra
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    J Hum Genet 50:69-75. 2005
    ..This investigation delineates parameter conditions under which this unique sample affords adequate power to detect linkage using both PSL and VC methods...
  70. ncbi request reprint Further evidence for the role of genes on chromosome 2 and chromosome 5 in the inheritance of pulmonary function
    Alka Malhotra
    University of Utah, Department of Human Genetics, 15 North 2030 East, Room 2100, Salt Lake City, UT 84112 5330, USA
    Am J Respir Crit Care Med 168:556-61. 2003
    ..In addition, nonparametric variance component linkage analysis showed linkage of FEV1/FVC in both of these regions, providing further support to the results. No nonparametric lod scores over 1.5 were obtained for either FEV1 or FVC...
  71. pmc Analysis of high-density single-nucleotide polymorphism data: three novel methods that control for linkage disequilibrium between markers in a linkage analysis
    Kristina Allen Brady
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, Utah 84108, USA
    BMC Proc 1:S160. 2007
    ..Additional work is required to further understand the effects of LD on linkage results and explore LD control methodology...
  72. ncbi request reprint Analysis of quantitative lipid traits in the genetics of NIDDM (GENNID) study
    Alka Malhotra
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Diabetes 54:3007-14. 2005
    ..1-3q13.31, 11p15.4-11p11.3, and 19p13.2-19q13.42 that may influence traits underlying lipid abnormalities associated with type 2 diabetes...
  73. ncbi request reprint Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans
    Alka Malhotra
    Diabetes and Obesity Research Unit, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Hum Mol Genet 14:3955-62. 2005
    ..0429) for TG. Statistically significant evidence for linkage and low heterogeneity on chromosome 1q therefore suggest that this region may harbor a gene underlying the inheritance of LDL in African Americans...
  74. ncbi request reprint Data mining of RNA expression and DNA genotype data: presentation group 5 contributions to Genetic Analysis Workshop 15
    Catherine T Falk
    Genet Epidemiol 31:S43-50. 2007
    ..The collection of papers and methods offer a starting point for further exploration of complex interactions in human genetic data now readily available...
  75. ncbi request reprint Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Science 297:1333-6. 2002
    ..However, Y1102 may be a useful molecular marker for the prediction of arrhythmia susceptibility in the context of additional acquired risk factors such as the use of certain medications...
  76. ncbi request reprint Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes
    Alka Malhotra
    Diabetes and Obesity Research Unit, Genetic Basis of Human Disease, Translational Genomics Research Institute, 445 N 5th Street, Phoenix, AZ 85004, USA
    Diabetes 56:890-6. 2007
    ....