Troy A Hornberger

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle
    Troy A Hornberger
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Int J Biochem Cell Biol 43:1267-76. 2011
  2. pmc A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Mol Biol Cell 21:3258-68. 2010
  3. pmc Muscle fiber type-dependent differences in the regulation of protein synthesis
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e37890. 2012
  4. pmc Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid
    Jae Sung You
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e47258. 2012
  5. pmc Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome
    Brittany L Jacobs
    T A Hornberger Department of Comparative Biosciences, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 591:4611-20. 2013
  6. pmc The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 589:5485-501. 2011
  7. pmc Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    FASEB J 25:1028-39. 2011
  8. pmc Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706
    Mol Endocrinol 27:1946-57. 2013
  9. pmc Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Cell Signal 23:1896-906. 2011
  10. pmc Measuring protein synthesis with SUnSET: a valid alternative to traditional techniques?
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Exerc Sport Sci Rev 41:107-15. 2013

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle
    Troy A Hornberger
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Int J Biochem Cell Biol 43:1267-76. 2011
    ....
  2. pmc A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Mol Biol Cell 21:3258-68. 2010
    ..The hypertrophic effects of Rheb are driven through a rapamycin-sensitive (RS) mechanism, mTOR is the RS element that confers the hypertrophy, and the kinase activity of mTOR is necessary for this event...
  3. pmc Muscle fiber type-dependent differences in the regulation of protein synthesis
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e37890. 2012
    ..Moreover, these findings demonstrate that changes found at the whole muscle level do not necessarily reflect changes in individual fiber types...
  4. pmc Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid
    Jae Sung You
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e47258. 2012
    ..Furthermore, it appears that a decrease in total 4E-BP1 may be part of the mTOR-dependent mechanism through which mechanical stimuli activate protein synthesis...
  5. pmc Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome
    Brittany L Jacobs
    T A Hornberger Department of Comparative Biosciences, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 591:4611-20. 2013
    ....
  6. pmc The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 589:5485-501. 2011
    ..Overall, these results demonstrate that CML activates several growth regulatory events, but only a few (e.g. hypertrophy) are fully dependent on mTOR signalling within the skeletal muscle cells...
  7. pmc Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    FASEB J 25:1028-39. 2011
    ..Thus, our nonradioactive method allowed us to accurately visualize and quantify PS under various ex vivo and in vivo conditions and revealed novel insights into the regulation of PS in skeletal muscle...
  8. pmc Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706
    Mol Endocrinol 27:1946-57. 2013
    ....
  9. pmc Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Cell Signal 23:1896-906. 2011
    ..AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator-1 α (PGC1α)]. In this review we will attempt to summarize the current knowledge of how these molecules regulate skeletal muscle mass...
  10. pmc Measuring protein synthesis with SUnSET: a valid alternative to traditional techniques?
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Exerc Sport Sci Rev 41:107-15. 2013
    ..Here we provide evidence supporting our hypothesis that the nonisotopic SUnSET technique is a valid and accurate method for the measurement of in vivo changes in protein synthesis at the whole-muscle and single-muscle fiber levels...
  11. pmc A role for Raptor phosphorylation in the mechanical activation of mTOR signaling
    John W Frey
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, 2015 Linden Dr, Madison, WI 53706, USA
    Cell Signal 26:313-22. 2014
    ..Combined, these results suggest that changes in the phosphorylation of Raptor play an important role in the pathway through which mechanical stimuli activate mTOR signaling. ..
  12. pmc The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting
    Brittany L Jacobs
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI, 53706, USA
    J Muscle Res Cell Motil 35:11-21. 2014
    ..Finally, we will summarize the evidence that has implicated the LEL in the regulation of mTOR by various growth regulatory inputs such as amino acids, growth factors and mechanical stimuli. ..
  13. pmc Lipid domain-dependent regulation of single-cell wound repair
    Emily M Vaughan
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706Department of Zoology, University of Wisconsin Madison, Madison, WI 53706
    Mol Biol Cell 25:1867-76. 2014
    ..The results reveal an unexpected diversity in subcellular lipid domains and the importance of such domains for a basic cellular process. ..

Research Grants1

  1. Mechanotransduction and the Regulation of Skeletal Muscle Mass
    Troy A Hornberger; Fiscal Year: 2010
    ..Furthermore, the outcomes could lead to the identification of targets for therapies that mimic the effects of mechanical stimuli and, in-turn, prevent atrophy during periods of disuse such as bedrest, immobilization and aging. ..