Nobuo Horikoshi

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
    Nobuo Horikoshi
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genome Integr 4:3. 2013
  2. pmc T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice
    Arun Gupta
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75229, USA
    Mutagenesis 28:263-70. 2013
  3. ncbi request reprint Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice
    Arun Gupta
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Radiat Res 181:1-8. 2014
  4. ncbi request reprint MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
    Arun Gupta
    Deparment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Rep 8:177-89. 2014
  5. doi request reprint Histone modifications and DNA double-strand break repair after exposure to ionizing radiations
    Clayton R Hunt
    University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 179:383-92. 2013
  6. pmc Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
    Mayank Singh
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 33:1210-22. 2013
  7. pmc Chromatin modifications and the DNA damage response to ionizing radiation
    Rakesh Kumar
    Department of Radiation Oncology, University of Texas Southwestern Medical Center Dallas, TX, USA
    Front Oncol 2:214. 2012
  8. doi request reprint Does PTEN loss impair DNA double-strand break repair by homologous recombination?
    Clayton R Hunt
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Cancer Res 18:920-2. 2012

Collaborators

Detail Information

Publications8

  1. pmc Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
    Nobuo Horikoshi
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genome Integr 4:3. 2013
    ..However, in mammalian cells, H4K16ac is not associated with dosage compensation and the genomic distribution of H4K16ac is not precisely known. Therefore, we have mapped the genome-wide H4K16ac distribution in human cells...
  2. pmc T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice
    Arun Gupta
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75229, USA
    Mutagenesis 28:263-70. 2013
    ..As a result, these mice have a shorter lifespan and reduced survival after irradiation...
  3. ncbi request reprint Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice
    Arun Gupta
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Radiat Res 181:1-8. 2014
    ..In this review, we have summarized recent advances in understanding the role of 53BP1 in regulating DNA DSBs repair pathway choice, variable diversity joining [V(D)J] recombination and class-switch recombination (CSR). ..
  4. ncbi request reprint MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
    Arun Gupta
    Deparment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Rep 8:177-89. 2014
    ....
  5. doi request reprint Histone modifications and DNA double-strand break repair after exposure to ionizing radiations
    Clayton R Hunt
    University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 179:383-92. 2013
    ..In this review, we summarize histone modifications that occur during DNA DSB repair processes...
  6. pmc Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
    Mayank Singh
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 33:1210-22. 2013
    ..We propose that lamin A/C is required for maintaining genomic stability following replication fork stalling, induced by either ICL damage or replicative stress, in order to facilitate fork regression prior to DNA damage repair...
  7. pmc Chromatin modifications and the DNA damage response to ionizing radiation
    Rakesh Kumar
    Department of Radiation Oncology, University of Texas Southwestern Medical Center Dallas, TX, USA
    Front Oncol 2:214. 2012
    ..In this review, we will summarize chromatin modifications by the respective chromatin modifying factors that occur during the DNA damage response...
  8. doi request reprint Does PTEN loss impair DNA double-strand break repair by homologous recombination?
    Clayton R Hunt
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Cancer Res 18:920-2. 2012
    ..However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity...