Research Topics
Genomes and GenesSpecies | C J HopferSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Common genetic and environmental vulnerability for alcohol and tobacco use in a volunteer sample of older female twinsC J Hopfer
University of Colorado Health Sciences Center, Denver 80262, USA
J Stud Alcohol 62:717-23. 2001..We report patterns of genetic and environmental correlations for alcohol and tobacco use in a volunteer sample of older, white, female twins using three different levels of severity for alcohol use and smoking...
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9Christian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
Drug Alcohol Depend 89:34-41. 2007..Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci...- Club drug use among youths in treatment for substance abuseChristian Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Addict 15:94-9. 2006..01). Youths reported using club drugs frequently outside of rave settings. Club drug use is common among youths in treatment for substance abuse and has spread beyond the rave culture... - Genetic influences on quantity of alcohol consumed by adolescents and young adultsChristian J Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C 268 35, Denver, CO 80262, USA
Drug Alcohol Depend 78:187-93. 2005..To examine genetic and environmental influences on drinking in a nationally representative study of genetically informative adolescents followed into young adulthood... - Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescentsChristian J Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis... - Review of twin and adoption studies of adolescent substance useChristian J Hopfer
Division of Substance Dependence, Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
J Am Acad Child Adolesc Psychiatry 42:710-9. 2003..To review studies of adolescent substance use and abuse with genetically informative designs... - Family transmission of marijuana use, abuse, and dependenceChristian J Hopfer
University of Colorado Health Sciences Center, Denver 80262, USA
J Am Acad Child Adolesc Psychiatry 42:834-41. 2003..To examine the familial aggregation of marijuana use, abuse, and dependence... - Treating adolescent heroin useChristian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, UC Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 42:609-11. 2003 - Adolescent heroin use: a review of the descriptive and treatment literatureChristian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
J Subst Abuse Treat 23:231-37. 2002..Length of time in treatment, regardless of modality, was the best predictor of outcome. The rise of heroin use among adolescents and young adults calls for descriptive studies as well as controlled treatment studies... - The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibitionIsabel R Schlaepfer
Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Addict Biol 12:200-9. 2007..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples... - Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescentsChristie A Hartman
School of Medicine at the University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 47:165-73. 2008..different levels of severity of substance involvement, to what degree do each of the 11 abuse and dependence criteria assess adolescent cannabis problems, and do the DSM-IV items function similarly across different adolescent populations?.. - Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problemsJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
Drug Alcohol Depend 88:130-7. 2007.... - Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sampleJoseph T Sakai
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver CO 80262, USA
Psychiatr Genet 17:207-14. 2007..Using a large general population sample, we sought to test for an association between 5HTTLPR and conduct problems, and to explore for a possible 5HTTLPR by maltreatment interaction... - Mate similarity for substance dependence and antisocial personality disorder symptoms among parents of patients and controlsJ T Sakai
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, 4200 E Ninth Avenue, C268 35, Denver, CO 80262, USA
Drug Alcohol Depend 75:165-75. 2004..Substance dependence (SD) and antisocial personality disorder (ASPD) are highly comorbid and aggregate in families. Mating assortment may be an important process contributing to this familial aggregation... - The family transmission of adolescent alcohol abuse and dependenceChristie A Hartman
University of Colorado Health Sciences Center, Division of Substance Dependence, 4200 East 9th Avenue, Box C 268 35, Denver, Colorado 80262, USA
J Stud Alcohol 67:657-64. 2006..This study examines the familial transmission of alcohol abuse and dependence to adolescents... - Lesbian, gay, and bisexual homeless youth: an eight-city public health perspectiveJames M Van Leeuwen
Urban Peak, Denver, CO, USA
Child Welfare 85:151-70. 2006.... - The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adultsIsabel R Schlaepfer
Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Biol Psychiatry 63:1039-46. 2008..Significant results were then replicated in a separate adult population-representative sample... - The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobaccoJoanna S Zeiger
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Hum Mol Genet 17:724-34. 2008..These results indicate that early subjective response to nicotine may be a valuable endophenotype for genetic studies aimed at uncovering genes contributing to nicotine use and addiction... - Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatmentBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
Am J Med Genet B Neuropsychiatr Genet 135:59-64. 2005..There was, however, a non-significant trend in the predicted direction. Additional studies will be needed before firm conclusions can be drawn about this hypothesized genotype-environment interaction... - Relationship between adolescent marijuana use and young adult illicit drug useJeffrey M Lessem
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
Behav Genet 36:498-506. 2006..Shared environmental factors mediated much of the relationship between adolescent marijuana use and young adult drug use. The association remained, however, even when controlling for familial environmental and other measured factors... - Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adultsBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
J Stud Alcohol Drugs 68:362-70. 2007..The mixed results of association between the DRD2 TaqIA polymorphism and alcohol-use disorders may be the result of differences in sample size, phenotype definition, heterogeneity of the samples, and genetic admixture... - Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotineMarissa A Ehringer
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol... - Association of candidate genes with antisocial drug dependence in adolescentsRobin P Corley
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
Drug Alcohol Depend 96:90-8. 2008..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes... - College attendance and its effect on drinking behaviors in a longitudinal study of adolescentsDavid S Timberlake
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
Alcohol Clin Exp Res 31:1020-30. 2007..We first tested for changes in alcohol consumption in adolescents who did and did not subsequently attend college, and then tested for variation of the genetic and environmental determinants of drinking in these 2 groups... - Genes, time to first cigarette and nicotine dependence in a general population sample of young adultsBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Addiction 102:655-65. 2007..To examine variation in nicotine dependence scores and covariation between different dependence symptoms... - Progression from marijuana use to daily smoking and nicotine dependence in a national sample of U.S. adolescentsDavid S Timberlake
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80303, USA
Drug Alcohol Depend 88:272-81. 2007....