LORA HOOPER

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint Interactions between the microbiota and the immune system
    Lora V Hooper
    The Howard Hughes Medical Institute and Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Science 336:1268-73. 2012
  2. pmc Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Heather L Cash
    Center for Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1126-30. 2006
  3. ncbi request reprint Laser microdissection: exploring host-bacterial encounters at the front lines
    Lora V Hooper
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Curr Opin Microbiol 7:290-5. 2004
  4. ncbi request reprint Bacterial contributions to mammalian gut development
    Lora V Hooper
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Trends Microbiol 12:129-34. 2004
  5. doi request reprint Do symbiotic bacteria subvert host immunity?
    Lora V Hooper
    Department of Immunology, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Rev Microbiol 7:367-74. 2009
  6. doi request reprint Immune adaptations that maintain homeostasis with the intestinal microbiota
    Lora V Hooper
    The Howard Hughes Medical Institute and The Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Nat Rev Immunol 10:159-69. 2010
  7. ncbi request reprint You AhR what you eat: linking diet and immunity
    Lora V Hooper
    The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 147:489-91. 2011
  8. pmc Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment
    Sohini Mukherjee
    Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 284:4881-8. 2009
  9. pmc Molecular basis for peptidoglycan recognition by a bactericidal lectin
    Rebecca E Lehotzky
    Departments of Immunology, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7722-7. 2010
  10. pmc Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli
    Heather L Cash
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Protein Expr Purif 48:151-9. 2006

Research Grants

Collaborators

  • Andrew J Macpherson
  • Dan R Littman
  • CHARLES BEVINS
  • L Eckmann
  • Felix Yarovinsky
  • Jeffrey I Gordon
  • Ting Wang
  • Shipra Vaishnava
  • Cassie L Behrendt
  • Anisa S Ismail
  • Heather L Cash
  • Rebecca E Lehotzky
  • Sohini Mukherjee
  • Cecilia V Whitham
  • Thaddeus S Stappenbeck
  • Carrie L Partch
  • Kevin H Gardner
  • Alicia Benson
  • Breck A Duerkop
  • Fredrik Backhed
  • Jian Xu
  • William E Goldman
  • Reed Pifer
  • Hiutung Chu
  • Clay F Semenkovich
  • Andras Nagy
  • Gou Young Koh
  • Hao Ding
  • Magnus K Bjursell
  • Jason Himrod
  • Su Deng
  • Herbert C Chiang
  • Lynn K Carmichael
  • Melissa H Wong
  • Jill K Manchester

Detail Information

Publications24

  1. doi request reprint Interactions between the microbiota and the immune system
    Lora V Hooper
    The Howard Hughes Medical Institute and Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Science 336:1268-73. 2012
    ..Here, we review advances in our understanding of the interactions between resident microbes and the immune system and the implications of these findings for human health...
  2. pmc Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Heather L Cash
    Center for Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1126-30. 2006
    ..We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships...
  3. ncbi request reprint Laser microdissection: exploring host-bacterial encounters at the front lines
    Lora V Hooper
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Curr Opin Microbiol 7:290-5. 2004
    ..This approach has already yielded key insights into the nature of mucosal responses to commensal, as well as pathogenic bacteria, and promises to be an important addition to the cellular microbiologist's toolkit...
  4. ncbi request reprint Bacterial contributions to mammalian gut development
    Lora V Hooper
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Trends Microbiol 12:129-34. 2004
  5. doi request reprint Do symbiotic bacteria subvert host immunity?
    Lora V Hooper
    Department of Immunology, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Rev Microbiol 7:367-74. 2009
    ..In light of the varied ways in which pathogenic bacteria manipulate host immunity, this Opinion article explores the role of immune suppression, subversion and evasion in the establishment of symbiotic host-bacterial associations...
  6. doi request reprint Immune adaptations that maintain homeostasis with the intestinal microbiota
    Lora V Hooper
    The Howard Hughes Medical Institute and The Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Nat Rev Immunol 10:159-69. 2010
    ..In this Review, we discuss the unique adaptations of the intestinal immune system that maintain homeostatic interactions with a diverse resident microbiota...
  7. ncbi request reprint You AhR what you eat: linking diet and immunity
    Lora V Hooper
    The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 147:489-91. 2011
    ..Li et al. (2011) now show that specific dietary compounds present in cruciferous vegetables act through the AhR to promote intestinal immune function, revealing AhR as a critical link between diet and immunity...
  8. pmc Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment
    Sohini Mukherjee
    Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 284:4881-8. 2009
    ..These findings reveal a novel regulatory mechanism governing C-type lectin biological function and yield new insight into the control of intestinal innate immunity...
  9. pmc Molecular basis for peptidoglycan recognition by a bactericidal lectin
    Rebecca E Lehotzky
    Departments of Immunology, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7722-7. 2010
    ..We propose that dynamic recognition of highly clustered carbohydrate epitopes in native peptidoglycan is an essential mechanism governing high-affinity interactions between HIP/PAP and the bacterial cell wall...
  10. pmc Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli
    Heather L Cash
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Protein Expr Purif 48:151-9. 2006
    ..These studies thus provide an essential foundation for further analyses of human and mouse RegIII protein function...
  11. doi request reprint Innate immune responses to commensal bacteria in the gut epithelium
    Shipra Vaishnava
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Pediatr Gastroenterol Nutr 46:E10-1. 2008
  12. doi request reprint Immune responses to the microbiota at the intestinal mucosal surface
    Breck A Duerkop
    Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Immunity 31:368-76. 2009
    ..These findings are also yielding a better understanding of how symbiotic host-microbial relationships can break down in inflammatory bowel disease...
  13. pmc Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injury
    Anisa S Ismail
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:3047-54. 2009
    ..Taken together, these findings disclose a reciprocal relationship between gammadelta T cells and intestinal microbiota that promotes beneficial host-microbial relationships in the intestine...
  14. pmc Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    Shipra Vaishnava
    The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:20858-63. 2008
    ..Our findings establish that gut epithelia actively sense enteric bacteria and play an essential role in maintaining host-microbial homeostasis at the mucosal interface...
  15. ncbi request reprint Alkaline phosphatase: keeping the peace at the gut epithelial surface
    Shipra Vaishnava
    Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell Host Microbe 2:365-7. 2007
    ....
  16. ncbi request reprint Epithelial cells and their neighbors. IV. Bacterial contributions to intestinal epithelial barrier integrity
    Anisa S Ismail
    Center for Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Am J Physiol Gastrointest Liver Physiol 289:G779-84. 2005
    ..By modulating epithelial inflammatory responses, antimicrobial protein expression, and tissue repair functions, indigenous microbial populations are essential for the maintenance of healthy mucosal surfaces...
  17. pmc Gut commensal bacteria direct a protective immune response against Toxoplasma gondii
    Alicia Benson
    Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell Host Microbe 6:187-96. 2009
    ..Thus, our results reveal that gut commensal bacteria can serve as molecular adjuvants during parasitic infection, providing indirect immunostimulation that protects against T. gondii in the absence of TLR11...
  18. ncbi request reprint Laser capture microdissection of mouse intestine: characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations
    Thaddeus S Stappenbeck
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Methods Enzymol 356:167-96. 2002
  19. pmc Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
    Thaddeus S Stappenbeck
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:15451-5. 2002
    ....
  20. ncbi request reprint Angiogenins: a new class of microbicidal proteins involved in innate immunity
    Lora V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 4:269-73. 2003
    ..These results establish angiogenins as a family of endogenous antimicrobial proteins...
  21. ncbi request reprint A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
    Jian Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 299:2074-6. 2003
    ..These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine...
  22. ncbi request reprint Response from Jeffrey I. Gordon et al.: Commensal bacteria make a difference
    Jeffrey I Gordon
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Microbiol 11:150-1. 2003
    ....
  23. ncbi request reprint How host-microbial interactions shape the nutrient environment of the mammalian intestine
    Lora V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Nutr 22:283-307. 2002
    ..These and other studies underscore the importance of understanding precisely how nutrient metabolism serves to establish and sustain symbiotic relationships between mammals and their bacterial partners...
  24. pmc The gut microbiota as an environmental factor that regulates fat storage
    Fredrik Backhed
    Center for Genome Sciences and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:15718-23. 2004
    ..Data deposition: The sequences reported in this paper have been deposited in the GenBank database (accession nos. AY 667702--AY 668946)...

Research Grants6

  1. Bacterial regulation of intestinal antimicrobial defense
    Lora V Hooper; Fiscal Year: 2010
    ..The results from these studies should yield new strategies for designing novel antimicrobial therapeutics, and could lead to new approaches to treating inflammatory bowel disease. ..
  2. Bacterial regulation of intestinal antimicrobial defense
    LORA HOOPER; Fiscal Year: 2009
    ..Furthermore, this work will aid in designing novel strategies for strengthening the role of the microflora in enhancing the mucosal barrier. ..