JOAN HOOPER

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Smoothened translates Hedgehog levels into distinct responses
    Joan E Hooper
    Department of Cell and Structural Biology and Program in Cell and Developmental Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Development 130:3951-63. 2003
  2. ncbi request reprint Communicating with Hedgehogs
    Joan E Hooper
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 East 17th Avenue, Box 8018, Aurora, Colorado 80045, USA
    Nat Rev Mol Cell Biol 6:306-17. 2005
  3. ncbi request reprint Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
    David Kent
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, PO Box 6511, Aurora, CO 80045, USA
    Development 133:2001-10. 2006
  4. ncbi request reprint The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway
    Robert M Gemmill
    Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, Colorado, CO 80262, USA
    Oncogene 21:3507-16. 2002
  5. ncbi request reprint Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5
    Robert M Gemmill
    Division of Medical Oncology, University of Colorado Health Sciences Center, 12801 E 17th Avenue, Aurora, CO 80010, USA
    Oncogene 24:3503-11. 2005
  6. pmc Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen Hall, Hanover, NH 03755, USA
    Curr Biol 13:1998-2003. 2003

Research Grants

  1. Mechanism of Hedgehog signal transduction
    JOAN HOOPER; Fiscal Year: 2007

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Smoothened translates Hedgehog levels into distinct responses
    Joan E Hooper
    Department of Cell and Structural Biology and Program in Cell and Developmental Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Development 130:3951-63. 2003
    ..Thus, two activities of Smoothened translate different levels of Hedgehog into distinct intracellular responses...
  2. ncbi request reprint Communicating with Hedgehogs
    Joan E Hooper
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 East 17th Avenue, Box 8018, Aurora, Colorado 80045, USA
    Nat Rev Mol Cell Biol 6:306-17. 2005
    ..The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution...
  3. ncbi request reprint Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
    David Kent
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, PO Box 6511, Aurora, CO 80045, USA
    Development 133:2001-10. 2006
    ..The existence of human orthologs for Rdx raises the possibility that this novel feedback loop also modulates Hh responses in humans...
  4. ncbi request reprint The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway
    Robert M Gemmill
    Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, Colorado, CO 80262, USA
    Oncogene 21:3507-16. 2002
    ..Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer...
  5. ncbi request reprint Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5
    Robert M Gemmill
    Division of Medical Oncology, University of Colorado Health Sciences Center, 12801 E 17th Avenue, Aurora, CO 80010, USA
    Oncogene 24:3503-11. 2005
    ..While there was no obvious influence on CSN deneddylation activity, the increase in CSN subunits and holocomplex suggests that TRC8 modulates signalosome levels or compartmentalization...
  6. pmc Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen Hall, Hanover, NH 03755, USA
    Curr Biol 13:1998-2003. 2003
    ..This work fills in the last major gap in our understanding of the Hh signal transduction pathway by suggesting that no intermediate signal is required to connect Smo to the HSC...

Research Grants4

  1. Mechanism of Hedgehog signal transduction
    JOAN HOOPER; Fiscal Year: 2007
    ..Their successful completion would significantly advance our understanding of this fundamental signal transduction pathway and may pinpoint therapeutic targets for Hh-based pathologies. ..