V Y Hook

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells
    Jean C Lee
    The Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 42:6938-46. 2003
  2. pmc Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Dept of Neurosciences, Univ of Calif, San Diego, USA
    Biochim Biophys Acta 1824:89-104. 2012
  3. pmc Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites
    Jill L Wegrzyn
    Computational Science Research Center, San Diego State University, San Diego, USA
    BMC Bioinformatics 9:232. 2008
  4. ncbi request reprint Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease
    Vivian Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Biol Chem 386:931-40. 2005
  5. ncbi request reprint Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease
    Vivian Y H Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Medicine, University of California at San Diego, La Jolla, 92093 0744, USA
    Biol Chem 387:1429-39. 2006
  6. ncbi request reprint Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093 0744, USA
    Biol Chem 388:247-52. 2007
  7. pmc Proteases for processing proneuropeptides into peptide neurotransmitters and hormones
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, and Department of Neuroscience, Pharmacology, and Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0744, USA
    Annu Rev Pharmacol Toxicol 48:393-423. 2008
  8. doi request reprint Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
    Vivian Y H Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7745-53. 2008
  9. ncbi request reprint Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones
    Vivian Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    Biol Chem 385:473-80. 2004
  10. pmc Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0744, La Jolla, CA 92093 0744, USA
    Neuropeptides 42:503-11. 2008

Research Grants

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells
    Jean C Lee
    The Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 42:6938-46. 2003
    ..These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release...
  2. pmc Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Dept of Neurosciences, Univ of Calif, San Diego, USA
    Biochim Biophys Acta 1824:89-104. 2012
    ..This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome...
  3. pmc Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites
    Jill L Wegrzyn
    Computational Science Research Center, San Diego State University, San Diego, USA
    BMC Bioinformatics 9:232. 2008
    ..This study has investigated 5'-UTR regions of mRNAs to define consensus sequence properties and structural features that allow identification of alternative initiation sites for protein translation...
  4. ncbi request reprint Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease
    Vivian Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Biol Chem 386:931-40. 2005
    ..These findings implicate cathepsin B as beta-secretase in the regulated secretory pathway of brain neurons, suggesting that inhibitors of cathepsin B may be considered as therapeutic agents to reduce A beta in AD...
  5. ncbi request reprint Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease
    Vivian Y H Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Medicine, University of California at San Diego, La Jolla, 92093 0744, USA
    Biol Chem 387:1429-39. 2006
    ..These results demonstrate newly identified roles for cathepsins L and B in neurosecretory vesicles in the production of biologically active peptides...
  6. ncbi request reprint Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093 0744, USA
    Biol Chem 388:247-52. 2007
    ..These results, showing highly effective in vivo decreases in brain Abeta levels by these cysteine protease inhibitors, indicate the feasibility of using related compounds for lowering Abeta in AD...
  7. pmc Proteases for processing proneuropeptides into peptide neurotransmitters and hormones
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, and Department of Neuroscience, Pharmacology, and Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0744, USA
    Annu Rev Pharmacol Toxicol 48:393-423. 2008
    ..Pharmacological applications for neuropeptide research may provide valuable therapeutics in health and disease...
  8. doi request reprint Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
    Vivian Y H Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7745-53. 2008
    ....
  9. ncbi request reprint Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones
    Vivian Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    Biol Chem 385:473-80. 2004
    ..These two proteolytic pathways demonstrate the increasing complexity of regulatory mechanisms for the production of peptide neurotransmitters and hormones...
  10. pmc Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0744, La Jolla, CA 92093 0744, USA
    Neuropeptides 42:503-11. 2008
    ..The selective activation of neuropeptide production by forskolin and PMA demonstrates that PKA and PKC pathways are involved in the differential regulation of neuropeptide production...
  11. pmc Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093 0744, USA
    Endocrine 35:429-37. 2009
    ..These findings suggest that human pituitary may utilize the cathepsin L and prohormone convertase pathways for producing POMC-derived peptide hormones...
  12. pmc Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein
    Vivian Y H Hook
    Depts of Neurosciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0744, USA
    Biochem Biophys Res Commun 386:284-8. 2009
    ..Since most AD patients express hAPPwt, these data validate cathepsin B as a target for development of inhibitors to lower Abeta in AD...
  13. doi request reprint Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Biol Chem 391:861-72. 2010
    ..Cathepsin B and BACE1 could participate jointly as beta-secretases. Significantly, the majority of AD patients express WT APP and, therefore, inhibitors of cathepsin B represent candidate drugs for AD...
  14. pmc Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease
    Vivian Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Biol Chem 389:993-1006. 2008
    ..Furthermore, cyclization of N-terminal Glu by glutaminyl cyclase generates highly amyloidogenic pGluAbeta(3-40/42). These presentations suggest cathepsin B and glutaminyl cyclase as potential new AD therapeutic targets...
  15. ncbi request reprint Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells
    V Y Hook
    Department of Medicine, University of California San Diego, La Jolla 92093 0822, USA
    Endocrinology 140:3744-54. 1999
    ..Calcium-dependent secretion is a well known property of regulated secretory vesicle exocytosis. Overall, these results are consistent with the localization of PTP to functional, regulated secretory vesicles that contain (Met)enkephalin...
  16. ncbi request reprint The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles
    V Y Hook
    Department of Medicine and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0822, USA
    J Biol Chem 274:3165-72. 1999
    ..In addition, these results are the first to identify an endogenous protease target of KPI/APP, which is developmentally regulated in aging and Alzheimer's disease...
  17. pmc Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication
    Vivian Hook
    University of California, San Diego, La Jolla, 92093 0744, USA
    AAPS J 12:635-45. 2010
    ..Knowledge of the entire repertoire of neuropeptides that regulate physiological systems will provide novel insight into regulatory mechanisms in health, disease, and therapeutics...
  18. ncbi request reprint High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing
    V Y Hook
    Department of Medicine, University of California, San Diego, La Jolla 92093 0822, USA
    Protein Expr Purif 10:80-8. 1997
    ..However, PC1/3 and PC2 prefer POMC as substrate. Demonstration of selectivity of processing enzymes for prohormone substrates illustrates the importance of expressing recombinant prohormones for in vitro processing studies...
  19. ncbi request reprint Protease pathways in peptide neurotransmission and neurodegenerative diseases
    Vivian Y H Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0744, La Jolla, CA 92093 0324, USA
    Cell Mol Neurobiol 26:449-69. 2006
    ....
  20. ncbi request reprint Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1
    S R Hwang
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0822, USA
    J Biol Chem 274:34164-73. 1999
    ..These results suggest a role for the novel serpin, endopin 1, in regulating basic residue-cleaving proteases within neurosecretory vesicles of chromaffin cells...
  21. ncbi request reprint Proteolysis of ProPTHrP(1-141) by "prohormone thiol protease" at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells
    V Y Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Biochem Biophys Res Commun 285:932-8. 2001
    ..The presence of PTP immunoreactivity in PTHrP-containing lung cancer cells suggests PTP as a candidate processing enzyme for the PTHrP precursor...
  22. ncbi request reprint Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues
    L J Deftos
    Dept of Medicine, San Diego VA Medical Center, University of California, La Jolla 92093 0822, USA
    Endocrine 15:217-24. 2001
    ..These results support the importance of these processing enzymes in their hypothesized roles in prohormone processing...
  23. ncbi request reprint Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2
    S R Hwang
    Department of Medicine, University of California, San Diego, La Jolla, USA
    DNA Cell Biol 19:409-19. 2000
    ..These results establish the defined structural domains of bovine PC1 and PC2 that are known to be essential for the activities of these enzymes in various species...
  24. ncbi request reprint Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver
    S R Hwang
    Department of Medicine and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0822, USA
    J Biol Chem 274:1821-7. 1999
    ..The determined reactive site loop domain of hippocampus ACT will allow prediction of potential target proteases inhibited by ACT in AD...
  25. ncbi request reprint Expression and mutagenesis of the novel serpin endopin 2 demonstrates a requirement for cysteine-374 for dithiothreitol-sensitive inhibition of elastase
    S R Hwang
    Departments of Medicine and Neuroscience, University of California, San Diego, La Jolla, California 92093, USA
    Biochemistry 39:8944-52. 2000
    ..These findings demonstrate the importance of Cys-374 for DTT-sensitive inhibition of elastase by endopin 2...
  26. ncbi request reprint Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum
    L M Mende-Mueller
    Departments of Medicine and Neuroscience, University of California, San Diego, San Diego, California 92093, USA
    J Neurosci 21:1830-7. 2001
    ..Thus, regulated tissue-specific proteolysis and ubiquitination of htt occur in human HD brains. These results suggest that the role of huntingtin proteolysis should be explored in the pathogenic mechanisms of HD...
  27. ncbi request reprint Agonist-stimulated neuropeptide and catecholamine release from bovine adrenal chromaffin cells
    R A Bundey
    The Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 971:338-40. 2002
  28. ncbi request reprint Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Neurosci Res 74:393-405. 2003
    ..These results indicate that inhibition of multiple proteases may be needed to decrease Abeta production as a therapeutic strategy for Alzheimer's disease...
  29. ncbi request reprint Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 81:237-56. 2002
    ..These findings suggest that drug inhibition of several proteases may be required for reducing Abeta levels as a potential therapeutic approach for AD...
  30. ncbi request reprint Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics
    Gregory Hook
    American Life Science Pharmaceuticals Inc, San Diego, CA 92121, USA
    Biol Chem 388:979-83. 2007
    ..The results suggest that cysteine protease inhibitors generally, and reversible cysteine protease inhibitors specifically, have potential for development as AD therapeutics...
  31. ncbi request reprint Unique reactive site domains of neuroendocrine isoforms of alpha 1-antichymotrypsin from bovine adrenal medulla and pituitary revealed by molecular cloning
    S R Hwang
    Department of Medicine, UCSD Medical Center 92103 8227, USA
    FEBS Lett 368:471-6. 1995
    ..Furthermore, RT-PCR indicated tissue-specific expression of AM and Pit ACT mRNAs. The AM and Pit isoforms of ACT may regulate novel target proteases involved in neuroendocrine function...
  32. ncbi request reprint The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition
    Shin Rong Hwang
    Department of Pharmacology, Medicine, and Neurosciences, University of California, San Diego, La Jolla, CA 92093 0324, USA
    Biochemistry 44:7757-67. 2005
    ..These findings demonstrate endopin 2C as a novel serpin that possesses cross-class inhibition with selectivity for inhibition of cathepsin L...
  33. ncbi request reprint The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells
    Shin Rong Hwang
    Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 41:10397-405. 2002
    ..These findings demonstrate that endopin 2 inhibitory functions may occur in the regulated secretory pathway...
  34. ncbi request reprint Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research
    Vivian Y H Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA
    BioDrugs 20:105-19. 2006
    ..Moreover, inhibition of cathepsin B reduces Abeta peptide levels in brain. These neuroproteases potentially represent new drug targets that should be explored in future pharmaceutical research endeavors for drug discovery...
  35. ncbi request reprint Heredity and the autonomic nervous system in human hypertension
    D T O'Connor
    Departments of Medicine and Pharmacology and Center for Molecular Genetics, University of California, San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Curr Hypertens Rep 2:16-22. 2000
    ..Such biochemical, physiologic, or pharmacologic autonomic traits may be especially valuable as phenotypic anchor points in linkage or association studies probing the genetic basis of human hypertension...
  36. pmc Multiple domains of endopin 2A for serpin cross-class inhibition of papain
    Shin Rong Hwang
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0744, USA
    Arch Biochem Biophys 461:219-24. 2007
    ..These findings indicate that the NH(2)-domain and the RSL region both participate in endopin 2A inhibition of papain...
  37. ncbi request reprint Regulation of cellular alpha-MSH and beta-endorphin during stimulated secretion from intermediate pituitary cells: involvement of aspartyl and cysteine proteases in the control of cellular levels of alpha-MSH and beta-endorphin
    Catherine Sei
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Peptides 23:1409-18. 2002
    ..These findings demonstrate the parallel regulation of cellular levels of alpha-MSH and beta-endorphin during their cosecretion, which may involve aspartyl and cysteine proteases in the metabolism of these peptide hormones...
  38. ncbi request reprint Novel secretory vesicle serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    Biol Chem 383:1067-74. 2002
    ..It will be of interest in future studies to define the endogenous protease targets of these two novel secretory vesicle serpins...
  39. ncbi request reprint Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH
    Catherine Sei
    Department of Neurosciences and Medicine, University of California, San Diego, La Jolla, CA, USA
    Peptides 24:717-25. 2003
    ..Thus, aspartyl and cysteine proteases may be involved in the cellular metabolism of ACTH...
  40. ncbi request reprint Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2
    Shin Rong Hwang
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA
    Biochem Biophys Res Commun 327:837-44. 2005
    ..Significantly, further analyses of mammalian genomes based on GTG as an alternative initiation codon may predict new candidate gene products expressed by mammalian and human genomes...
  41. ncbi request reprint Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice
    Ruthellen Miller
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 86:556-63. 2003
    ..Overall, these studies demonstrated that the PC2 processing enzyme is critical for the in vivo production of alpha-MSH in pituitary and brain...
  42. ncbi request reprint Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice
    Ruthellen Miller
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA, USA
    Neuropeptides 37:140-8. 2003
    ..These results demonstrate the selective role of PC2 in neuropeptide production that provides active peptide neurotransmitter or hormones for biological functions in brain and neuroendocrine systems...
  43. ncbi request reprint Novel chromaffin granule serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 971:426-44. 2002
    ..These findings indicate the presence of endogenous endopin 1 and endopin 2 in secretory vesicle function...

Research Grants38

  1. SERPIN PROTEASE INHIBITORS IN OPIOID NEUROPEPTIDE PRODUC
    Vivian Hook; Fiscal Year: 2002
    ..Evaluation of an endopin-interacting clone for enhanced POMC processing, regulated secretion, and inhibition by endopin(s), will lead to consideration of the clone as an endopin target protease for POMC processing. ..
  2. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  3. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  4. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  5. POMC Processing and Beta-Endorphin-Related Opioid Peptides
    Vivian Hook; Fiscal Year: 2007
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  6. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2007
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
  7. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  8. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2002
    ..These studies may lead to novel therapeutics that modify the endogenous opioid system through precursor processing enzymes. ..
  9. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..