Research Topics
Genomes and GenesSpecies | L Elliot HongSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibitionL Elliot Hong
Department of Psychiatry, Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
Biol Psychiatry 63:17-23. 2008..A widely used surrogate measure of psychosis in animal models, PPI is considered a schizophrenia endophenotype. We hypothesized that if NRG1 influences PPI in rodents, then it should have a similar effect on PPI in humans...- Mismatch negativity and low frequency oscillations in schizophrenia familiesL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA
Clin Neurophysiol 123:1980-8. 2012..We aimed to test the hypothesis that theta-alpha activities may contribute to MMN in schizophrenia patients and their family members... - A shared low-frequency oscillatory rhythm abnormality in resting and sensory gating in schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21247, USA
Clin Neurophysiol 123:285-92. 2012..We hypothesized that an oscillatory abnormality that is consistently observed across various testing paradigms may index an elementary neuronal abnormality marking schizophrenia risk... 
Components of the smooth pursuit function in deficit and nondeficit schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
Schizophr Res 63:39-48. 2003..These findings suggest that predictive smooth pursuit abnormality is associated with positive symptoms in schizophrenia, and that initiation abnormalities may be associated with the deficit syndrome...- Refining the predictive pursuit endophenotype in schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Lions Vision Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21228, USA
Biol Psychiatry 63:458-64. 2008..Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e., invisible) moving object in schizophrenia. However, the overt awareness of target removal can confound the measurement... - Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patientsL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 33:2167-74. 2008..002). In conclusion, the findings confirmed that nicotine transiently improves acoustic PPI in schizophrenia patients. Additionally, schizophrenia patients with more clinical symptoms may have benefited more from nicotinic effect on PPI... - Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humansL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Psychophysiology 45:197-204. 2008..The results suggested that beta oscillation indexed a neural process associated with the strength of sensory gating... - Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimateL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Arch Gen Psychiatry 65:1008-16. 2008..Frequency-specific sensory gating may be less complex than the P50 response, and therefore closer to the direct genetic effects, and thus a more valid endophenotype... - Is motion perception deficit in schizophrenia a consequence of eye-tracking abnormality?L Elliot Hong
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Biol Psychiatry 65:1079-85. 2009..However, eye movement closely interacts with motion perception. The known eye-tracking difficulties in schizophrenia patients may interact with their motion perception... - Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuitsL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Arch Gen Psychiatry 66:431-41. 2009..Imaging studies showed that nicotine challenges almost always involve the cingulate cortex, suggesting that this locus may be a key region associated with nicotine addiction and its treatment... - Nicotine enhances but does not normalize visual sustained attention and the associated brain network in schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Schizophr Bull 37:416-25. 2011..These findings provide guidance for developing new treatment strategies for the sustained attention deficit in schizophrenia... - Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamineL Elliot Hong
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 35:632-40. 2010..These electrical oscillatory indexes of subanesthetic ketamine can be potentially used to cross-examine glutamatergic pharmacological effects in translational animal and human studies... - A genetically modulated, intrinsic cingulate circuit supports human nicotine addictionL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Proc Natl Acad Sci U S A 107:13509-14. 2010..Identifying where and how brain circuits link genes to smoking provides practical neural circuitry targets for new treatment development... - A CHRNA5 allele related to nicotine addiction and schizophreniaL E Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Genes Brain Behav 10:530-5. 2011.... - Effects of moderate-dose treatment with varenicline on neurobiological and cognitive biomarkers in smokers and nonsmokers with schizophrenia or schizoaffective disorderL Elliot Hong
Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Arch Gen Psychiatry 68:1195-206. 2011..It is not yet clear which nicotinic acetylcholine receptor (nAChR) subtype or subtypes are responsible for these seemingly pervasive nicotinic effects in schizophrenia and schizoaffective disorder... - Independent domains of inhibitory gating in schizophrenia and the effect of stimulus intervalL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
Am J Psychiatry 164:61-5. 2007..The authors hypothesized that the relationship of the two measures may vary as a function of interstimulus intervals of stimulus presentations... - Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophreniaL Elliot Hong
Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA
Am J Med Genet B Neuropsychiatr Genet 136:8-11. 2005..2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia... - Evoked gamma band synchronization and the liability for schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
Schizophr Res 70:293-302. 2004.... - Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patientsL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
Arch Gen Psychiatry 63:259-64. 2006..Recent studies have suggested that deficit in predictive pursuit, a specific component of the SPEMs, marks schizophrenia susceptibility... - Gamma/beta oscillation and sensory gating deficit in schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University of Maryland, PO Box 21247, Baltimore, MD 21228, USA
Neuroreport 15:155-9. 2004..The results of the present study showed that post-SI beta frequency response was inversely correlated to the S2 P50 response in patients with schizophrenia... - Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched functional magnetic resonance imaging studyL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA
Biol Psychiatry 57:726-32. 2005.... - Reliability of a portable head-mounted eye tracking instrument for schizophrenia researchL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA
Behav Res Methods 37:133-8. 2005..96). This result suggests that the portable device is comparable with a lab-based system, which makes possible the collection of eye movement data in community-based and multicenter familial studies of schizophrenia... - Response to unexpected target changes during sustained visual tracking in schizophrenic patientsL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
Exp Brain Res 165:125-31. 2005..Data suggest that at-risk individuals for schizophrenia depend less on extraretinal and more on retinal motion signals to maintain pursuit than healthy individuals... - Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophreniaIkwunga Wonodi
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21228, USA
Am J Med Genet B Neuropsychiatr Genet 150:282-9. 2009..05), but higher expression in schizophrenia donors. Findings suggest regulatory effects of another gene(s) or etiological factor in schizophrenia, which modulate DAT1 gene function... - Insular and anterior cingulate circuits in smokers with schizophreniaLauren V Moran
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Schizophr Res 142:223-9. 2012..Decreased insula-dACC rsFC may index overlapping circuitry associated with smoking and SZ... - Tardive dyskinesia in children treated with atypical antipsychotic medicationsIkwunga Wonodi
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Mov Disord 22:1777-82. 2007..Ethnicity might also be a risk factor for dyskinesia in children. Side-effect profile of the atypical antipsychotic drugs in children may be much different than that in adults... - High vs low frequency neural oscillations in schizophreniaLauren V Moran
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Schizophr Bull 37:659-63. 2011..The review concludes that studying the full spectrum and the interaction of gamma and low frequency oscillations may be critical for deciphering the complex electrophysiological abnormalities observed in schizophrenia patients... 
Dipyridamole monotherapy in schizophrenia: pilot of a novel treatment approach by modulation of purinergic signalingIkwunga Wonodi
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
Psychopharmacology (Berl) 218:341-5. 2011..One previous clinical trial showed superiority of adjunctive dipyridamole, an adenosine reuptake inhibitor, compared to placebo in ameliorating positive symptoms in schizophrenia patients...- Catechol O-methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary reportGunvant K Thaker
MPRC, PO Box 21247, Baltimore, MD 21228, USA
Am J Psychiatry 161:2320-2. 2004..This study examined associations between functional polymorphism (Val(108/158) Met) in the catechol O-methyltransferase (COMT) gene and eye tracking measures in schizophrenia... - Naltrexone treatment of tardive dyskinesia in patients with schizophreniaIkwunga Wonodi
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
J Clin Psychopharmacol 24:441-5. 2004..CONCLUSION: These findings suggest effectiveness of a strategy of combining a GABA(gamma aminobutyric acid)mimetic drug with an enkephalin antagonist to treat dyskinesia... - Factor structure of the Brief Negative Symptom ScaleGregory P Strauss
University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Schizophr Res 142:96-8. 2012..These findings provide further support for the construct validity of the BNSS, and for the existence of these two negative symptom factors... - Role of anticipation in schizophrenia-related pursuit initiation deficitsMatthew T Avila
Maryland Psychiatric Research Ctr, PO Box 21247, Baltimore, MD 21228, USA
J Neurophysiol 95:593-601. 2006.... - Deficits on the Continuous Performance Test within the schizophrenia spectrum and the mediating effects of family history of schizophreniaMatthew T Avila
Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
J Abnorm Psychol 115:771-8. 2006..Results suggest that SSPD in the absence of a family history of psychosis may be a phenocopy... - Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypesIkwunga Wonodi
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228
Arch Gen Psychiatry 68:665-74. 2011..The proximal cause may be an impairment of kynurenine 3-monooxygenase (KMO), a rate-limiting enzyme at the branching point of the kynurenine pathway... - Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortexXiaochu Zhang
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21228, USA
Biol Psychiatry 68:674-7. 2010..We sought to determine whether smoking and schizophrenia are associated with similar white matter abnormalities that could be biomarkers for the high risk of smoking in schizophrenia... - Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neurolepticsIkwunga Wonodi
Maryland Psychiatric Research Center, Motor Disorders Clinic, University of Maryland School of Medicine, Baltimore, Maryland, USA
Adv Neurol 96:336-49. 2005..No effective treatments for TD are available. This lack of effective therapy is problematic, especially in the few patients in whom the disorder causes functional impairment and other complications, and in whom it may be irreversible... - No evidence of exogenous origin for the abnormal glutathione redox state in schizophreniaAlejandro Ballesteros
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, 55 Wade Avenue, 21228 Catonsville, MD, USA Hospital Clínico de Salamanca, Department of Psychiatry, Calle de San Vicente 182, 37007 Salamanca, Spain
Schizophr Res 146:184-9. 2013..In conclusion, none of the exogenous sources played a major role in explaining abnormalities in the glutathione pathway in patients. The state of abnormal glutathione redox may therefore be a part of schizophrenia pathophysiology... - Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphismXiaochu Zhang
Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
Neuroimage 69:62-9. 2013.... - Schizophrenia, VII: defining the neurobiology of risk factorsL Elliot Hong
Am J Psychiatry 160:1929. 2003 - Association between polymorphism of the SNAP29 gene promoter region and schizophreniaIkwunga Wonodi
Schizophr Res 78:339-41. 2005
Research Grants
- Liability Markers for Deficit Schizophrenia?L Hong; Fiscal Year: 2004..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
- fMRI of Eye Movement Phenotype in SchizophreniaL Hong; Fiscal Year: 2007....
- Identifying molecular path of behavioural phenotype in schizophreniaL Hong; Fiscal Year: 2007..This project aims to identify genes and gene products associated with one of these core deficits called eyetracking abnormality in schizophrenia so that drugs can be developed to treat these core physiological and cognitive deficits. ..
- Shared Neural Circuitry in Comorbid Schizophrenia and Nicotine AddictionL Elliot Hong; Fiscal Year: 2010....
- Neural Oscillatory Biomarkers for Genetics and Animal Models of SchizophreniaL Elliot Hong; Fiscal Year: 2010....