Karen Honey

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Lysosomal cysteine proteases regulate antigen presentation
    Karen Honey
    Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Rev Immunol 3:472-82. 2003
  2. ncbi Thymocyte expression of cathepsin L is essential for NKT cell development
    Karen Honey
    Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Nat Immunol 3:1069-74. 2002
  3. ncbi Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M
    Karen Honey
    Department of Immunology and Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 172:4142-50. 2004
  4. ncbi Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages
    Courtney Beers
    Department of Immunology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Exp Med 197:169-79. 2003
  5. ncbi Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands
    Karen Honey
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 195:1349-58. 2002
  6. ncbi A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation
    Chyi Song Hsieh
    Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA
    J Immunol 168:2618-25. 2002
  7. ncbi Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:34827-32. 2004

Collaborators

Detail Information

Publications7

  1. ncbi Lysosomal cysteine proteases regulate antigen presentation
    Karen Honey
    Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Rev Immunol 3:472-82. 2003
    ..Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules...
  2. ncbi Thymocyte expression of cathepsin L is essential for NKT cell development
    Karen Honey
    Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Nat Immunol 3:1069-74. 2002
    ..1(+) T cell selection. These data implicate lysosomal proteases as key regulators of not only classical major histocompatibility complex class II antigen presentation but also nonclassical CD1d presentation...
  3. ncbi Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M
    Karen Honey
    Department of Immunology and Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 172:4142-50. 2004
    ..Thus, we show clearly, in vivo, the critical chaperone function of H-2M, which preserves MHC class II molecules for high affinity peptide binding upon dissociation of Ii degradation intermediates...
  4. ncbi Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages
    Courtney Beers
    Department of Immunology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Exp Med 197:169-79. 2003
    ....
  5. ncbi Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands
    Karen Honey
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 195:1349-58. 2002
    ..Thus, we propose a novel role for cathepsin L in regulating positive selection by generating the major histocompatibility complex class II bound peptide ligands presented by cortical thymic epithelial cells...
  6. ncbi A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation
    Chyi Song Hsieh
    Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USA
    J Immunol 168:2618-25. 2002
    ..This result suggests that these cysteinal proteases participate in Ag processing and generate qualitative and quantitative differences in the peptide repertoires displayed by MHC class II molecules...
  7. ncbi Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:34827-32. 2004
    ..In summary, these data establish that podocyte foot process effacement is a migratory event involving a novel interplay between cathepsin L and alpha(3) integrin...