Dirk Homann

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection
    Dirk Homann
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:6239-50. 2004
  2. pmc Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center Mail stop B140, P O Box 6511, Aurora, CO 80045, USA
    J Virol 80:270-80. 2006
  3. pmc Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule
    Bumsuk Hahm
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3505-15. 2003
  4. pmc IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory
    Derek C Lenz
    Departments of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:9357-62. 2004
  5. pmc T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies
    Hanna Lewicki
    Division of Virology, Department of Neuropharmacology IMM 6, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3799-808. 2003
  6. ncbi request reprint Detection of low-avidity CD4+ T cells using recombinant artificial APC: following the antiovalbumin immune response
    Valérie I Mallet-Designe
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 170:123-31. 2003
  7. pmc Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity
    Jens Eberlein
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    J Virol 86:1955-70. 2012
  8. pmc Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4357-63. 2002
  9. ncbi request reprint Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice
    Marianne M Martinic
    Immune Regulation Lab DI 3, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Diabetes 56:1059-68. 2007
  10. pmc c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity
    Nathalie Arbour
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:801-10. 2002

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection
    Dirk Homann
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:6239-50. 2004
    ....
  2. pmc Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center Mail stop B140, P O Box 6511, Aurora, CO 80045, USA
    J Virol 80:270-80. 2006
    ..These findings have implications for the physiologic, pathological, and therapeutic regulation of costimulation...
  3. pmc Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule
    Bumsuk Hahm
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3505-15. 2003
    ....
  4. pmc IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory
    Derek C Lenz
    Departments of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:9357-62. 2004
    ..We propose that homeostatic control of antiviral CD4(+) and CD8(+) T cell memory is fundamentally similar and characterized by quantitative, rather than qualitative, differences...
  5. pmc T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies
    Hanna Lewicki
    Division of Virology, Department of Neuropharmacology IMM 6, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3799-808. 2003
    ..However, these CD4 and CD8 T cells are defective in such an effector function(s) as IFN-gamma and TNF-alpha expression or release or lytic activity...
  6. ncbi request reprint Detection of low-avidity CD4+ T cells using recombinant artificial APC: following the antiovalbumin immune response
    Valérie I Mallet-Designe
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 170:123-31. 2003
    ..Artificial APC will allow T cell detection and the dissection of the molecular events of T cell activation and will help us understand the fundamental differences between CD4+ and CD8+ T cells...
  7. pmc Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity
    Jens Eberlein
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    J Virol 86:1955-70. 2012
    ....
  8. pmc Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4357-63. 2002
    ....
  9. ncbi request reprint Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice
    Marianne M Martinic
    Immune Regulation Lab DI 3, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Diabetes 56:1059-68. 2007
    ..Thus, autoreactivity toward de novo-expressed beta-cell autoantigens will not accelerate autoimmunity unless large numbers of antigen-experienced autoreactive T-cells expressing the appropriate chemokine receptors are present...
  10. pmc c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity
    Nathalie Arbour
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:801-10. 2002
    ..JNK1 is involved in survival of activated T cells during immune responses, and JNK2 plays a role in control of CD8(+) T cell expansion in vivo...
  11. pmc Expression and regulation of chemokines in murine and human type 1 diabetes
    Suparna A Sarkar
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:436-46. 2012
    ....
  12. ncbi request reprint Interfacing dendritic and natural killer cells: a tool for targeted tolerance induction?
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Transplantation 76:1657-61. 2003
  13. pmc Comprehensive assessment of chemokine expression profiles by flow cytometry
    Jens Eberlein
    Barbara Davis Center for Childhood Diabetes, Department of Medicine, University of Colorado Denver, Aurora, 80045 0511, USA
    J Clin Invest 120:907-23. 2010
    ..The versatility of this analytical methodology was further demonstrated by its application to selected human chemokines and should greatly facilitate any future investigation into chemokine biology at large...
  14. ncbi request reprint T cells in the central nervous system: the delicate balance between viral clearance and disease
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Infect Dis 186:S145-51. 2002
    ..Understanding the specific constraints imposed by the CNS on local T cell activity has important consequences for the design of therapeutic strategies aimed at preventing or curing CNS infection...
  15. ncbi request reprint Regulatory T cells and type 1 diabetes
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Immunol 112:202-9. 2004
    ..However, in vitro amplification and autologous regulatory T cell therapy might soon become a clinical reality...
  16. ncbi request reprint One, two, or three step: measles virus receptor dance
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey pinesRoad, IMM 6, La Jolla, CA 92037 1092, USA
    Virology 299:162-3. 2002
  17. pmc An immunologic homunculus for type 1 diabetes
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA
    J Clin Invest 116:1212-5. 2006
    ....
  18. ncbi request reprint CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells
    Dirk Homann
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 16:403-15. 2002
    ..Furthermore, protection of prediabetic recipients was autoantigen specific and did not result in generalized immunosuppression. The origin, function, and therapeutic potential of these bitypic NK/DC regulatory cells is discussed...
  19. ncbi request reprint Molecules in medicine mini review: the αβ T cell receptor
    Eric T Clambey
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado School of Medicine, Mail Stop B112, Research Complex 2, 12700 East 19th Avenue, Aurora, CO, 80045, USA
    J Mol Med (Berl) 92:735-41. 2014
    ....
  20. ncbi request reprint Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection
    Rob J de Boer
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    J Immunol 171:3928-35. 2003
    ....
  21. ncbi request reprint Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes
    Matthias von Herrath
    Immune Regulation Laboratory, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Pediatr Diabetes 5:23-8. 2004
    ..The recent development of novel technologies will allow more precise quantification of in vivo destruction and regeneration in order to test these hypotheses...
  22. pmc Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II
    Dirk Homann
    Barbara Davis Center, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora CO, USA
    Virology 363:113-23. 2007
    ..Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction...
  23. ncbi request reprint To help and help not
    Dirk Homann
    Nat Immunol 5:878-80. 2004
  24. pmc Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection
    Mark K Slifka
    Oregon Health and Science University Vaccine and Gene Therapy Institute, Beaverton, Oregon, USA
    J Clin Invest 111:805-10. 2003
    ..These results document that MV infection can suppress both innate and adaptive immune responses and lead to increased susceptibility to bacterial infection...
  25. ncbi request reprint Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells
    Stephanie Hugues
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097, 660 route des Lucioles, 06560 Valbonne, France
    Immunity 16:169-81. 2002
    ..Our results support a model in which apoptosis of pancreatic beta cells induces the development of regulatory cells leading to the tolerization of self-reactive T cells and protection from diabetes...

Research Grants1

  1. Maturation of established antiviral CD8 T cell memory
    Dirk Homann; Fiscal Year: 2006
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