Jeffrey M Holzbeierlein

..In addition, to the N-terminal site of Hsp90, the C-terminal site appears to be another target for inhibition of Hsp90. More recently, inhibitors of the C terminus of Hsp90 have been developed and studied in vitro with promising results...

..This article describes the potential complications of ADT and the recommendations for treatment or prevention of these complications. In addition,we examine the role of nontraditional forms of ADT and the potential benefits they offer...

..One hypothesis for this reduction in prostate cancer deaths is due to the difference in soy consumption. The purpose of this paper is to review the effects of soy at the molecular level as well as to review the in-vivo effects...

..As discussed in this article, RPP offers several advantages over the retropubic or laparoscopic approach for certain patients...

..Within the last decade, however, there has been a significant increase in its use. Therefore, it is incumbent upon the physician to be familiar with the side effects associated with this treatment...

..This review focuses on the wide range of side effects associated with androgen ablation as well as preventive and treatment strategies...

..Patients and physicians should be well aware of the potential side effects of androgen-deprivation therapy as well as the preventive and treatment strategies for these side effects in order to improve patients quality of life and health...

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..Looking for improvement on these outcomes, we conducted a phase II clinical trial examining the combination of ketoconazole and docetaxel in the neoadjuvant setting before radical prostatectomy...

..We review our experience with active surveillance in a veteran population...

..There are no published reports to our knowledge comparing the complication rates of the 2 most frequently used ureterointestinal anastomoses. We compared the Bricker method vs the Wallace method in terms of stricture rate...

..In this review we present the arguments for and against a biopsy of the contralateral testicle, review the techniques of biopsy as well as its complications, and discuss the interventions employed to prevent CIS from progressing...

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..We used this adenovirus vector to test the concept that multiantigenic effector T cells could be generated simultaneously following a single immunization...

..This article presents case studies of PET scanning using carbon 11 acetate and discusses intravenously infused ascorbate, a complementary and alternative medicine therapy for prostate cancer...

..We now report the characterization of the novel novobiocin analogue, F-4, which demonstrates improved cytotoxicity in prostate cancer cell lines compared to the N-terminal inhibitor, 17-AAG...

..The decision to use ART should be based on the patient's pathological characteristics, clinical status, side effects, and open communication between the patient and provider...

..CONCLUSIONS: In highly selected patients with invasive bladder cancer, partial cystectomy offers acceptable outcomes. Concomitant CIS and presence of metastases to regional lymph nodes predict advanced recurrence...

..This review summarizes the PCPT, analyzes its controversial results, and describes future prostate cancer chemoprevention studies...

..In patients with metachronous tumors treatment of the contralateral tumor is rarely altered by prior treatment of the initial tumor...