Richard Holubkov

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study
    Richard Holubkov
    Division of Critical Care, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA
    Pediatr Crit Care Med 14:374-83. 2013
  2. pmc Is "rescue" therapy ethical in randomized controlled trials?
    Richard Holubkov
    Department of Pediatrics, Pediatric Critical Care, University of Utah, Salt Lake City, UT, USA
    Pediatr Crit Care Med 10:431-8. 2009
  3. doi request reprint Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children
    Sabrina M Heidemann
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI, USA
    Pediatr Crit Care Med 14:e202-6. 2013
  4. pmc Collaborative pediatric critical care research network: looking back and moving forward
    Douglas F Willson
    Department of Pediatrics, University of Virginia Children s Hospital, Charlottesville, VA, USA
    Pediatr Crit Care Med 11:1-6. 2010
  5. pmc Revision surgeries are associated with significant increased risk of subsequent cerebrospinal fluid shunt infection
    Tamara D Simon
    Department of Pediatrics, University of Washington Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Infect Dis J 31:551-6. 2012
  6. pmc The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in pediatric critical care medicine
    Jeri S Burr
    University of Utah JSB, Salt Lake City, UT, USA
    Pediatr Crit Care Med 12:387-92. 2011
  7. pmc Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing
    Robert A Berg
    1Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 2Department of Pediatrics, University of Utah, Salt Lake City, UT 3Division of Critical Care Medicine, Department of Pediatrics, National Institute of Child Health and Human Development, Bethesda, MD 4Division of Critical Care Medicine, Department of Pediatrics, University of California at Los Angeles, Los Angeles, CA 5Division of Critical Care Medicine, Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 6Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children s Hospital Los Angeles, Los Angeles, CA 7Division of Critical Care Medicine, Department of Pediatrics, University of Michigan and Mott Children s Hospital, Ann Arbor, MI 8Division of Critical Care Medicine, Department of Pediatrics, Phoenix Children s Hospital, Phoenix, AZ 9Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 10Division of Critical Care Medicine, Department of Pediatrics, Children s National Medical Center, Washington, DC 11Department of Critical Care Medicine, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA
    Crit Care Med 41:2292-7. 2013
  8. pmc Critical pertussis illness in children: a multicenter prospective cohort study
    John T Berger
    Department of Pediatrics, Children s National Medical Center Washington, DC, USA
    Pediatr Crit Care Med 14:356-65. 2013
  9. pmc Critical care for pediatric asthma: wide care variability and challenges for study
    Susan L Bratton
    Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
    Pediatr Crit Care Med 13:407-14. 2012
  10. pmc Center effect and other factors influencing temporization and shunting of cerebrospinal fluid in preterm infants with intraventricular hemorrhage
    Jay Riva-Cambrin
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Primary Children s Hospital, Salt Lake City, UT, USA
    J Neurosurg Pediatr 9:473-81. 2012

Detail Information

Publications37

  1. pmc The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study
    Richard Holubkov
    Division of Critical Care, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA
    Pediatr Crit Care Med 14:374-83. 2013
    ..Researchers must incorporate Data and Safety Monitoring Board oversight into the design, monitoring, and reporting of randomized trials...
  2. pmc Is "rescue" therapy ethical in randomized controlled trials?
    Richard Holubkov
    Department of Pediatrics, Pediatric Critical Care, University of Utah, Salt Lake City, UT, USA
    Pediatr Crit Care Med 10:431-8. 2009
    ..The ethical, conceptual, and analytic challenges related to rescue therapy in randomized trials can be misrepresented...
  3. doi request reprint Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children
    Sabrina M Heidemann
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI, USA
    Pediatr Crit Care Med 14:e202-6. 2013
    ..To describe serum concentrations of zinc, selenium, and prolactin in critically ill children within 72 hours of PICU admission, and to investigate relationships between these immunomodulators and lymphopenia...
  4. pmc Collaborative pediatric critical care research network: looking back and moving forward
    Douglas F Willson
    Department of Pediatrics, University of Virginia Children s Hospital, Charlottesville, VA, USA
    Pediatr Crit Care Med 11:1-6. 2010
    ..To update the pediatric critical care community on the progress of the Collaborative Pediatric Critical Care Research Network and plans for the future...
  5. pmc Revision surgeries are associated with significant increased risk of subsequent cerebrospinal fluid shunt infection
    Tamara D Simon
    Department of Pediatrics, University of Washington Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Infect Dis J 31:551-6. 2012
    ..The object of this study was to determine whether cerebrospinal fluid (CSF) shunt revision(s) are associated with increased risk of CSF shunt infection, after adjusting for baseline factors that contribute to infection risk...
  6. pmc The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in pediatric critical care medicine
    Jeri S Burr
    University of Utah JSB, Salt Lake City, UT, USA
    Pediatr Crit Care Med 12:387-92. 2011
    ..To provide an updated overview of critical pertussis to the pediatric critical care community and describe a study of critical pertussis recently undertaken...
  7. pmc Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing
    Robert A Berg
    1Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 2Department of Pediatrics, University of Utah, Salt Lake City, UT 3Division of Critical Care Medicine, Department of Pediatrics, National Institute of Child Health and Human Development, Bethesda, MD 4Division of Critical Care Medicine, Department of Pediatrics, University of California at Los Angeles, Los Angeles, CA 5Division of Critical Care Medicine, Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 6Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children s Hospital Los Angeles, Los Angeles, CA 7Division of Critical Care Medicine, Department of Pediatrics, University of Michigan and Mott Children s Hospital, Ann Arbor, MI 8Division of Critical Care Medicine, Department of Pediatrics, Phoenix Children s Hospital, Phoenix, AZ 9Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 10Division of Critical Care Medicine, Department of Pediatrics, Children s National Medical Center, Washington, DC 11Department of Critical Care Medicine, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA
    Crit Care Med 41:2292-7. 2013
    ..We hypothesized that the proportion of pediatric cardiopulmonary resuscitation provided in ICUs versus general wards has increased over the past decade, and this shift is associated with improved resuscitation outcomes...
  8. pmc Critical pertussis illness in children: a multicenter prospective cohort study
    John T Berger
    Department of Pediatrics, Children s National Medical Center Washington, DC, USA
    Pediatr Crit Care Med 14:356-65. 2013
    ..This report characterizes the presentation and acute course of critical pertussis by quantifying demographic data, laboratory findings, clinical complications, and critical care therapies among children requiring admission to the PICU...
  9. pmc Critical care for pediatric asthma: wide care variability and challenges for study
    Susan L Bratton
    Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
    Pediatr Crit Care Med 13:407-14. 2012
    ..To describe pediatric severe asthma care, complications, and outcomes to plan for future prospective studies by the Collaborative Pediatric Critical Care Research Network...
  10. pmc Center effect and other factors influencing temporization and shunting of cerebrospinal fluid in preterm infants with intraventricular hemorrhage
    Jay Riva-Cambrin
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Primary Children s Hospital, Salt Lake City, UT, USA
    J Neurosurg Pediatr 9:473-81. 2012
    ....
  11. pmc Opioid analgesia in mechanically ventilated children: results from the multicenter Measuring Opioid Tolerance Induced by Fentanyl study
    Kanwaljeet J S Anand
    Department of Pediatrics, Le Bonheur Children s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA
    Pediatr Crit Care Med 14:27-36. 2013
    ..To examine the clinical factors associated with increased opioid dose among mechanically ventilated children in the pediatric intensive care unit...
  12. doi request reprint Rationale, timeline, study design, and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials
    Frank W Moler
    1Department of Pediatrics, University of Michigan, Ann Arbor, MI 2Department of Pediatrics, Wayne State University, Detroit, MI 3Department of Pediatrics, University of Utah, Salt Lake City, UT 4Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 5Department of Pediatric Rehabilitation Medicine, Kennedy Krieger Institute, Baltimore, MD
    Pediatr Crit Care Med 14:e304-15. 2013
    ..To describe the rationale, timeline, study design, and protocol overview of the Therapeutic Hypothermia after Pediatric Cardiac Arrest trials...
  13. pmc A standardized protocol to reduce cerebrospinal fluid shunt infection: the Hydrocephalus Clinical Research Network Quality Improvement Initiative
    John R W Kestle
    Primary Children s Medical Center, University of Utah, Salt Lake City, Utah, USA
    J Neurosurg Pediatr 8:22-9. 2011
    ..In an effort to reduce the ventriculoperitoneal shunt infection rate, a standardized protocol was developed and implemented at 4 centers of the Hydrocephalus Clinical Research Network (HCRN)...
  14. doi request reprint Clinical performance of decellularized cryopreserved valved allografts compared with standard allografts in the right ventricular outflow tract
    Phillip T Burch
    Division of Cardiothoracic Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah, USA
    Ann Thorac Surg 90:1301-5; discussion 1306. 2010
    ..To assess functional results and durability, we studied a group of patients with DCAs implanted between 2000 and 2005 and compared them with a similar group with SCAs...
  15. pmc Expected changes in clinical measures of adiposity during puberty
    Nicole L Mihalopoulos
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84158, USA
    J Adolesc Health 47:360-6. 2010
    ..Abnormal increases in fat during puberty may reflect an increased risk of developing cardiovascular disease. Therefore, it is important to establish the normal patterns of change in clinically relevant measures of adiposity...
  16. doi request reprint Coarctation repair in neonates and young infants: is small size or low weight still a risk factor?
    Phillip T Burch
    Division of Cardiothoracic Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah, USA
    J Thorac Cardiovasc Surg 138:547-52. 2009
    ..This study assesses the effect of patient size on reintervention and survival in neonates and infants undergoing repair of simple aortic coarctation...
  17. pmc Infection rates following initial cerebrospinal fluid shunt placement across pediatric hospitals in the United States. Clinical article
    Tamara D Simon
    Divisions of Inpatient Medicine, University of Utah, Salt Lake City, Utah, USA
    J Neurosurg Pediatr 4:156-65. 2009
    ..The authors hypothesized that infection rates between hospitals would vary widely even after adjustment for patient, hospital, and surgeon factors...
  18. ncbi request reprint Risk reduction behaviors and provider communication following genetic counseling and BRCA1 mutation testing in an African American kindred
    Anita Yeomans Kinney
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Genet Couns 15:293-305. 2006
    ..Surveillance for breast cancer was preferred to prophylactic surgery and chemoprevention as a way to reduce risk for these cancers. Our data indicate that patient-provider communication about BRCA1 test results is suboptimal...
  19. ncbi request reprint Thyroid disease associated with exposure to the Nevada nuclear weapons test site radiation: a reevaluation based on corrected dosimetry and examination data
    Joseph L Lyon
    Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Epidemiology 17:604-14. 2006
    ..In 1993, we reported that among those examined in 1985 to 1986 (Phase II) there was an association between radiation from the Nevada Test Site and thyroid neoplasms...
  20. pmc Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer
    Maureen A Murtaugh
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 18:153-63. 2007
    ..Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer...
  21. ncbi request reprint Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury
    Kimberly D Statler
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Brain Res 1076:216-24. 2006
    ..e., when discontinued with recovery to tail pinch immediately before injury). Investigators using isoflurane must consider its beneficial effects in the design and interpretation of experimental TBI research...
  22. ncbi request reprint The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation
    Anita Yeomans Kinney
    Cancer Control and Population Sciences Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer 104:2508-16. 2005
    ....
  23. ncbi request reprint Intermediate-term results of repair for aortic, neoaortic, and truncal valve insufficiency in children
    John A Hawkins
    Division of Cardiothoracic Surgery, Department of Surgery, Primary Children s Medical Center, and the University of Utah, Salt Lake City, Utah 84113, USA
    J Thorac Cardiovasc Surg 133:1311-7. 2007
    ..This study evaluates the intermediate-term results of repair of the systemic semilunar valve, including the native aortic valve, neoaortic valve (anatomic pulmonary), and truncal valve...
  24. ncbi request reprint Quality of life of children with neurological impairment who receive a fundoplication for gastroesophageal reflux disease
    Rajendu Srivastava
    University of Utah Health Sciences Center, Salt Lake City, Utah 84113, USA
    J Hosp Med 2:165-73. 2007
    ..Children with neurological impairment (NI) commonly have gastroesophageal reflux disease (GERD) treated with a fundoplication. The impact of this procedure on quality of life is poorly understood...
  25. ncbi request reprint p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry
    Karen Curtin
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Appl Immunohistochem Mol Morphol 12:380-6. 2004
    ..Advantages gained by sequencing are its ability to examine specific mutations and the improved ability to discriminate between cases with p 53 mutation and wild type when evaluating associations...
  26. doi request reprint US estimates of hospitalized pediatric patients with ulcerative colitis: implications for multicenter clinical studies
    Stephen L Guthery
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Inflamm Bowel Dis 14:1253-8. 2008
    ..We analyzed the Kids' Inpatient Database (KID, 2003), to estimate the distribution of hospitalized children with UC and estimate sample sizes available for clinical research...
  27. doi request reprint Impact of fundoplication versus gastrojejunal feeding tubes on mortality and in preventing aspiration pneumonia in young children with neurologic impairment who have gastroesophageal reflux disease
    Rajendu Srivastava
    University of Utah Health Sciences Center, Division of Inpatient Medicine, Salt Lake City, UT 84113, USA
    Pediatrics 123:338-45. 2009
    ..The objective of this study was to compare outcomes for children with neurologic impairment and gastroesophageal reflux disease after either a first fundoplication or a first gastrojejunal feeding tube...
  28. doi request reprint Developing a diagnosis-based severity classification system for use in emergency medical services for children
    Evaline A Alessandrini
    Department of Pediatrics, University of Cincinnati College of Medicine, James M Anderson Center for Health Systems Excellence and Division of Emergency Medicine, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH, USA
    Acad Emerg Med 19:70-8. 2012
    ....
  29. doi request reprint Modeling motor vehicle crashes for street racers using zero-inflated models
    Zhuo Li
    Department of Family and Preventive Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Accid Anal Prev 40:835-9. 2008
    ..However, drivers with increased numbers of non-street-racing citations experience crash risks approaching those of the cited street racers...
  30. pmc Association of intraventricular hemorrhage secondary to prematurity with cerebrospinal fluid shunt surgery in the first year following initial shunt placement
    Tamara D Simon
    Department of Pediatrics, University of Washington Seattle Children s Hospital, Seattle, Washington, USA
    J Neurosurg Pediatr 9:54-63. 2012
    ..The object of this study was to identify baseline factors at the time of initial CSF shunt placement that are independently associated with subsequent surgery...
  31. doi request reprint Spinal muscular atrophy type 1: are proactive respiratory interventions associated with longer survival?
    Tara J Lemoine
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA
    Pediatr Crit Care Med 13:e161-5. 2012
    ..Spinal muscular atrophy type 1, an autosomal recessive motor neuron disease, is a leading genetic cause of death in infancy and early childhood...
  32. doi request reprint Bronchiolitis: clinical characteristics associated with hospitalization and length of stay
    Howard M Corneli
    University of Utah and Primary Children s Medical Center, Salt Lake City, UT, USA
    Pediatr Emerg Care 28:99-103. 2012
    ..3 days. We sought to identify the initial clinical characteristics of bronchiolitis associated with admission and with longer LOS in a large multicenter clinical trial...
  33. pmc FL-41 tint improves blink frequency, light sensitivity, and functional limitations in patients with benign essential blepharospasm
    Marcus K Blackburn
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah Health Sciences Center, 65 Mario Capecchi Drive, Salt Lake City, UT 94132, USA
    Ophthalmology 116:997-1001. 2009
    ..The objective of these 2 studies was to assess the efficacy of FL-41-tinted lenses in the treatment of benign essential blepharospasm (BEB)...
  34. ncbi request reprint A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis
    Howard M Corneli
    University of Utah, Salt Lake City, USA
    N Engl J Med 357:331-9. 2007
    ..Corticosteroids are commonly used to treat bronchiolitis, but evidence of their effectiveness is limited...
  35. ncbi request reprint Transnasal endoscopy vs. fluoroscopy for the placement of nasoenteric feeding tubes in critically ill patients
    John C Fang
    Department of Gastroenterology and Hepatology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132 2410, USA
    Gastrointest Endosc 62:661-6. 2005
    ..The object of this prospective study was to compare the efficacy of NET placement by using ultrathin transnasal endoscopy vs. fluoroscopic placement...
  36. ncbi request reprint In vivo evaluation of argon plasma coagulation in a porcine model
    Christopher J Goulet
    GI Division, University of Utah Health Sciences Center, 30 N 1900 E, Salt Lake City, UT 84132, USA
    Gastrointest Endosc 65:457-62. 2007
    ..One purported advantage of APC includes a limit to the depth of injury. It is unclear from previous studies whether the depth of injury is limited to superficial tissue layers with the settings used in clinical practice...
  37. ncbi request reprint Identification, evaluation, and management of obesity in an academic primary care center
    Sarah Harvey O'Brien
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 114:e154-9. 2004
    ..While the medical community struggles to develop effective strategies for the treatment of this epidemic, timely identification of obesity by pediatric health care providers remains the crucial initial step in the management of obesity...