R Holubkov

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint MIDCAB characteristics and results: the CardioThoracic Systems (CTS) registry
    R Holubkov
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Eur J Cardiothorac Surg 14:S25-30. 1998
  2. ncbi request reprint Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic Registry
    Richard Holubkov
    Department of Epidemiology, Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am Heart J 144:826-33. 2002
  3. ncbi request reprint Trends in coronary revascularization 1989 to 1997: the Bypass Angioplasty Revascularization Investigation (BARI) survey of procedures
    R Holubkov
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 84:157-61. 1999
  4. ncbi request reprint Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease. Results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) study
    S E Reis
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Coll Cardiol 33:1469-75. 1999
  5. ncbi request reprint The effect of previous coronary-artery bypass surgery on the prognosis of patients with diabetes who have acute myocardial infarction. Bypass Angioplasty Revascularization Investigation Investigators
    K M Detre
    Bypass Angioplasty Revascularization Investigation Coordinating Center, University of Pittsburgh, Graduate School of Public Health, PA 15261, USA
    N Engl J Med 342:989-97. 2000
  6. ncbi request reprint Measurement variation of aortic pulse wave velocity in the elderly
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Hypertens 14:463-8. 2001
  7. ncbi request reprint Estrogen acutely abolishes abnormal cold-induced coronary constriction in men
    S E Reis
    Division of Cardiology, University of Pittsburgh, PA, USA
    Chest 114:1556-61. 1998
  8. ncbi request reprint Usefulness of electron beam tomography to detect progression of coronary and aortic calcium in middle-aged women
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, The Cardiovascular Institute Preventive Heart Care Center, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 87:560-4. 2001
  9. ncbi request reprint Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study
    S E Reis
    Cardiovascular Institute and Department of Epidemiology, University of Pittsburgh, PA, USA
    Am Heart J 141:735-41. 2001
  10. pmc Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 72:13-22. 2003

Detail Information

Publications37

  1. ncbi request reprint MIDCAB characteristics and results: the CardioThoracic Systems (CTS) registry
    R Holubkov
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Eur J Cardiothorac Surg 14:S25-30. 1998
    ....
  2. ncbi request reprint Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic Registry
    Richard Holubkov
    Department of Epidemiology, Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am Heart J 144:826-33. 2002
    ..As percutaneous coronary intervention (PCI) is most commonly performed for relief of angina, it is important to identify factors associated with recurrence of anginal symptoms...
  3. ncbi request reprint Trends in coronary revascularization 1989 to 1997: the Bypass Angioplasty Revascularization Investigation (BARI) survey of procedures
    R Holubkov
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 84:157-61. 1999
    ..These trends are likely due to the proliferation of new devices, especially intracoronary stents, since the mid 1990s...
  4. ncbi request reprint Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease. Results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) study
    S E Reis
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Coll Cardiol 33:1469-75. 1999
    ..e., coronary velocity reserve)...
  5. ncbi request reprint The effect of previous coronary-artery bypass surgery on the prognosis of patients with diabetes who have acute myocardial infarction. Bypass Angioplasty Revascularization Investigation Investigators
    K M Detre
    Bypass Angioplasty Revascularization Investigation Coordinating Center, University of Pittsburgh, Graduate School of Public Health, PA 15261, USA
    N Engl J Med 342:989-97. 2000
    ..We studied whether previous revascularization by coronary-artery bypass grafting (CABG), as compared with percutaneous transluminal coronary angioplasty (PTCA), influences the prognosis in such patients...
  6. ncbi request reprint Measurement variation of aortic pulse wave velocity in the elderly
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Hypertens 14:463-8. 2001
    ..4 to 94.0 cm/sec and 88.7 to 112.8 cm/sec for sonographers and readers, respectively. These results indicate that the mean PWV measure is reproducible even when sonographers and readers are newly trained...
  7. ncbi request reprint Estrogen acutely abolishes abnormal cold-induced coronary constriction in men
    S E Reis
    Division of Cardiology, University of Pittsburgh, PA, USA
    Chest 114:1556-61. 1998
    ..The purpose of this study is to determine whether estrogen acutely abolishes abnormal coronary responses to cold exposure in men...
  8. ncbi request reprint Usefulness of electron beam tomography to detect progression of coronary and aortic calcium in middle-aged women
    K Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, The Cardiovascular Institute Preventive Heart Care Center, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 87:560-4. 2001
    ..Both coronary and aortic calcium were significantly associated with premenopausal cardiovascular risk factors. Thus, progression of coronary and aortic calcium using EBT can be observed over a short time in healthy middle- aged women...
  9. ncbi request reprint Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study
    S E Reis
    Cardiovascular Institute and Department of Epidemiology, University of Pittsburgh, PA, USA
    Am Heart J 141:735-41. 2001
    ..However, the prevalence and determinants of microvascular dysfunction in these women are uncertain...
  10. pmc Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 72:13-22. 2003
    ..26-10.68; P=.017) for PON2 codon 311 Cys/Cys. Our data indicate that the severity of CAD, in terms of the number of diseased vessels, may be affected by common genetic variation in the PON gene cluster, on chromosome 7...
  11. ncbi request reprint Enhanced external counterpulsation as treatment for chronic angina in patients with left ventricular dysfunction: a report from the International EECP Patient Registry (IEPR)
    Ozlem Soran
    Cardiovascular Institute, UPMC Health System, Pittsburgh, PA, USA
    Congest Heart Fail 8:297-302. 2002
    ..Patients with LV dysfunction achieved a less robust reduction in angina than did those without LV dysfunction. For the majority of the patients in the registry, this reduction was maintained at 6 months...
  12. ncbi request reprint The role of PCI and CABG in the management of coronary artery disease in patients with diabetes
    Robert L Frye
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Diab Rep 2:16-20. 2002
    ..Outcomes following PCI and CABG are worse in patients with DM compared to those without DM. This calls for randomized trials and other studies focused on patients with DM...
  13. ncbi request reprint Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, University of Pittsburgh, PA 15261, USA
    Circulation 107:3146-51. 2003
    ..We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population...
  14. ncbi request reprint APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 169:159-67. 2003
    ..These data support the hypothesis that the APOE*4 allele is an independent risk factor not only for the presence of CAD and hyperlipidemia, but also for the angiographic severity of CAD in white women with a family history of disease...
  15. ncbi request reprint Impact of age on procedural and 1-year outcome in percutaneous transluminal coronary angioplasty: a report from the NHLBI Dynamic Registry
    Howard A Cohen
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am Heart J 146:513-9. 2003
    ..As PCI technology evolves and the US population becomes proportionally older, assessment of PCI in older age groups is essential...
  16. ncbi request reprint Hormone therapy, lipoprotein subclasses, and coronary calcification: the Healthy Women Study
    Rachel H Mackey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Arch Intern Med 165:510-5. 2005
    ..To test this hypothesis, we evaluated differences in coronary calcification, lipids, and lipoprotein subclasses among HT users and nonusers in a longitudinal study of the menopause...
  17. ncbi request reprint Lipoprotein subclasses and coronary artery calcium in postmenopausal women from the healthy women study
    Rachel H Mackey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Cardiol 90:71i-76i. 2002
    ..These results suggest that the measurement of lipoprotein subclasses may improve the prediction of CAD in postmenopausal women beyond that provided by the conventional lipid panel and CAD risk factors...
  18. ncbi request reprint Coronary revascularization on balance: Robert L. Frye lecture
    Katherine M Detre
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Mayo Clin Proc 77:72-82. 2002
    ..Thus, they should be regarded as the basic science of medical therapeutics and population health...
  19. ncbi request reprint Subclinical atherosclerosis in multiple vascular beds: an index of atherosclerotic burden evaluated in postmenopausal women
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 160:407-16. 2002
    ..Women with lower premenopausal risk factors did not develop high levels of subclinical atherosclerosis, suggesting that atherosclerosis is a preventable disease in women...
  20. ncbi request reprint Comparison of patients undergoing enhanced external counterpulsation and percutaneous coronary intervention for stable angina pectoris
    Richard Holubkov
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 89:1182-6. 2002
    ..Although PCI was associated with substantially lower rates of 1-year symptoms, EECP may be a safe treatment option for selected patients with obstructive coronary disease...
  21. ncbi request reprint Mild renal insufficiency is associated with angiographic coronary artery disease in women
    Steven E Reis
    Cardiovascular Institute, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 105:2826-9. 2002
    ..9, 95%CI=1.1 to 3.5). After controlling for homocysteine in 509 women, mild renal insufficiency remained predictive of CAD (OR=3.2, 95%CI=1.4 to 7.2)...
  22. ncbi request reprint Large brachial artery diameter is associated with angiographic coronary artery disease in women
    Richard Holubkov
    Department of Epidemiology and the Cardiovascular Institute, University of Pittsburgh, PA 15213, USA
    Am Heart J 143:802-7. 2002
    ....
  23. ncbi request reprint Quality of life of children with neurological impairment who receive a fundoplication for gastroesophageal reflux disease
    Rajendu Srivastava
    University of Utah Health Sciences Center, Salt Lake City, Utah 84113, USA
    J Hosp Med 2:165-73. 2007
    ..Children with neurological impairment (NI) commonly have gastroesophageal reflux disease (GERD) treated with a fundoplication. The impact of this procedure on quality of life is poorly understood...
  24. pmc Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer
    Maureen A Murtaugh
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 18:153-63. 2007
    ..Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer...
  25. ncbi request reprint Risk reduction behaviors and provider communication following genetic counseling and BRCA1 mutation testing in an African American kindred
    Anita Yeomans Kinney
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Genet Couns 15:293-305. 2006
    ..Surveillance for breast cancer was preferred to prophylactic surgery and chemoprevention as a way to reduce risk for these cancers. Our data indicate that patient-provider communication about BRCA1 test results is suboptimal...
  26. ncbi request reprint Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury
    Kimberly D Statler
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Brain Res 1076:216-24. 2006
    ..e., when discontinued with recovery to tail pinch immediately before injury). Investigators using isoflurane must consider its beneficial effects in the design and interpretation of experimental TBI research...
  27. ncbi request reprint Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    Dennis M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 44:2019-26. 2004
    ..We evaluated the interaction of angiotensin-converting enzyme (ACE) inhibitor therapy with the effect of the ACE D/I polymorphism on heart failure survival...
  28. ncbi request reprint Prevalence and severity of paravalvular regurgitation in the Artificial Valve Endocarditis Reduction Trial (AVERT) echocardiography study
    Victor G Davila-Roman
    AVERT Echocardiography Core Laboratory and the Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Coll Cardiol 44:1467-72. 2004
    ..The purpose of this study was to determine the prevalence and severity of paravalvular regurgitation (PVR) in the Artificial Valve Endocarditis Reduction Trial (AVERT) cohort...
  29. ncbi request reprint Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejection
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 23:696-700. 2004
    ..We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients...
  30. ncbi request reprint Identification, evaluation, and management of obesity in an academic primary care center
    Sarah Harvey O'Brien
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 114:e154-9. 2004
    ..While the medical community struggles to develop effective strategies for the treatment of this epidemic, timely identification of obesity by pediatric health care providers remains the crucial initial step in the management of obesity...
  31. ncbi request reprint Analysis of baseline factors associated with reduction in chest pain in patients with angina pectoris treated by enhanced external counterpulsation
    William E Lawson
    State University of New York at Stony Brook, Stony Brook, New York 11740, USA
    Am J Cardiol 92:439-43. 2003
    ....
  32. ncbi request reprint Paravalvular leak and other events in silzone-coated mechanical heart valves: a report from AVERT
    Hartzell V Schaff
    Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 73:785-92. 2002
    ..The present analysis determined late event rates that might be used in the management of approximately 36,000 patients who have received the Silzone prosthesis...
  33. ncbi request reprint Electrocardiogram abnormalities predict angiographic coronary artery disease in women with chest pain: results from the NHLBI WISE Study
    Richard Holubkov
    Epidemiology Data Center, Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania 15213, USA
    Clin Cardiol 25:553-8. 2002
    ..Based on recent reports that gender-specific exercise electrocardiogram (ECG) parameters predict CAD, we evaluated the independent predictive value of the resting ECG for angiographic CAD in women with chest pain...
  34. ncbi request reprint Heterogeneity of microvascular dysfunction in women with chest pain not attributable to coronary artery disease: implications for clinical practice
    Oscar C Marroquin
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Am Heart J 145:628-35. 2003
    ..Therefore, diagnostic accuracy is dependent on homogeneity of microvascular dysfunction in the myocardium...
  35. ncbi request reprint Modeling and risk prediction in the current era of interventional cardiology: a report from the National Heart, Lung, and Blood Institute Dynamic Registry
    David R Holmes
    Mayo Clinic, 200 First Street SW, Rochester, Minn 55905, USA
    Circulation 107:1871-6. 2003
    ..Validation of in-hospital mortality models after percutaneous coronary interventions using multicenter data remains limited...
  36. ncbi request reprint Relation of the pattern of diastolic augmentation during a course of enhanced external counterpulsation (EECP) to clinical benefit (from the International EECP Patient Registry [IEPR])
    Magge V Lakshmi
    Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, 94143 0124, USA
    Am J Cardiol 89:1303-5. 2002