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Genomes and Genes | R HolubkovSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
MIDCAB characteristics and results: the CardioThoracic Systems (CTS) registryR Holubkov
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Eur J Cardiothorac Surg 14:S25-30. 1998....- Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic RegistryRichard Holubkov
Department of Epidemiology, Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am Heart J 144:826-33. 2002..As percutaneous coronary intervention (PCI) is most commonly performed for relief of angina, it is important to identify factors associated with recurrence of anginal symptoms... - Trends in coronary revascularization 1989 to 1997: the Bypass Angioplasty Revascularization Investigation (BARI) survey of proceduresR Holubkov
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
Am J Cardiol 84:157-61. 1999..These trends are likely due to the proliferation of new devices, especially intracoronary stents, since the mid 1990s... - Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease. Results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) studyS E Reis
Department of Medicine, University of Pittsburgh, Pennsylvania, USA
J Am Coll Cardiol 33:1469-75. 1999..e., coronary velocity reserve)... - The effect of previous coronary-artery bypass surgery on the prognosis of patients with diabetes who have acute myocardial infarction. Bypass Angioplasty Revascularization Investigation InvestigatorsK M Detre
Bypass Angioplasty Revascularization Investigation Coordinating Center, University of Pittsburgh, Graduate School of Public Health, PA 15261, USA
N Engl J Med 342:989-97. 2000..We studied whether previous revascularization by coronary-artery bypass grafting (CABG), as compared with percutaneous transluminal coronary angioplasty (PTCA), influences the prognosis in such patients... - Measurement variation of aortic pulse wave velocity in the elderlyK Sutton-Tyrrell
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
Am J Hypertens 14:463-8. 2001..4 to 94.0 cm/sec and 88.7 to 112.8 cm/sec for sonographers and readers, respectively. These results indicate that the mean PWV measure is reproducible even when sonographers and readers are newly trained... - Estrogen acutely abolishes abnormal cold-induced coronary constriction in menS E Reis
Division of Cardiology, University of Pittsburgh, PA, USA
Chest 114:1556-61. 1998..The purpose of this study is to determine whether estrogen acutely abolishes abnormal coronary responses to cold exposure in men... - Usefulness of electron beam tomography to detect progression of coronary and aortic calcium in middle-aged womenK Sutton-Tyrrell
Department of Epidemiology, Graduate School of Public Health, The Cardiovascular Institute Preventive Heart Care Center, University of Pittsburgh, Pennsylvania 15261, USA
Am J Cardiol 87:560-4. 2001..Both coronary and aortic calcium were significantly associated with premenopausal cardiovascular risk factors. Thus, progression of coronary and aortic calcium using EBT can be observed over a short time in healthy middle- aged women... - Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE studyS E Reis
Cardiovascular Institute and Department of Epidemiology, University of Pittsburgh, PA, USA
Am Heart J 141:735-41. 2001..However, the prevalence and determinants of microvascular dysfunction in these women are uncertain... 
Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) studyQi Chen
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Hum Genet 72:13-22. 2003..26-10.68; P=.017) for PON2 codon 311 Cys/Cys. Our data indicate that the severity of CAD, in terms of the number of diseased vessels, may be affected by common genetic variation in the PON gene cluster, on chromosome 7...- Enhanced external counterpulsation as treatment for chronic angina in patients with left ventricular dysfunction: a report from the International EECP Patient Registry (IEPR)Ozlem Soran
Cardiovascular Institute, UPMC Health System, Pittsburgh, PA, USA
Congest Heart Fail 8:297-302. 2002..Patients with LV dysfunction achieved a less robust reduction in angina than did those without LV dysfunction. For the majority of the patients in the registry, this reduction was maintained at 6 months... - The role of PCI and CABG in the management of coronary artery disease in patients with diabetesRobert L Frye
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Curr Diab Rep 2:16-20. 2002..Outcomes following PCI and CABG are worse in patients with DM compared to those without DM. This calls for randomized trials and other studies focused on patients with DM... - Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery diseaseQi Chen
Department of Human Genetics, University of Pittsburgh, PA 15261, USA
Circulation 107:3146-51. 2003..We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population... - APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) studyQi Chen
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
Atherosclerosis 169:159-67. 2003..These data support the hypothesis that the APOE*4 allele is an independent risk factor not only for the presence of CAD and hyperlipidemia, but also for the angiographic severity of CAD in white women with a family history of disease... - Impact of age on procedural and 1-year outcome in percutaneous transluminal coronary angioplasty: a report from the NHLBI Dynamic RegistryHoward A Cohen
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am Heart J 146:513-9. 2003..After PCI, the long-term relative risk of death is similar to that expected among persons of similar ages in the general population... - Hormone therapy, lipoprotein subclasses, and coronary calcification: the Healthy Women StudyRachel H Mackey
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Arch Intern Med 165:510-5. 2005..To test this hypothesis, we evaluated differences in coronary calcification, lipids, and lipoprotein subclasses among HT users and nonusers in a longitudinal study of the menopause... - Lipoprotein subclasses and coronary artery calcium in postmenopausal women from the healthy women studyRachel H Mackey
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Cardiol 90:71i-76i. 2002..These results suggest that the measurement of lipoprotein subclasses may improve the prediction of CAD in postmenopausal women beyond that provided by the conventional lipid panel and CAD risk factors... - Coronary revascularization on balance: Robert L. Frye lectureKatherine M Detre
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Mayo Clin Proc 77:72-82. 2002..Thus, they should be regarded as the basic science of medical therapeutics and population health... - Subclinical atherosclerosis in multiple vascular beds: an index of atherosclerotic burden evaluated in postmenopausal womenKim Sutton-Tyrrell
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Atherosclerosis 160:407-16. 2002..Women with lower premenopausal risk factors did not develop high levels of subclinical atherosclerosis, suggesting that atherosclerosis is a preventable disease in women... - Comparison of patients undergoing enhanced external counterpulsation and percutaneous coronary intervention for stable angina pectorisRichard Holubkov
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Cardiol 89:1182-6. 2002..Although PCI was associated with substantially lower rates of 1-year symptoms, EECP may be a safe treatment option for selected patients with obstructive coronary disease... - Mild renal insufficiency is associated with angiographic coronary artery disease in womenSteven E Reis
Cardiovascular Institute, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Circulation 105:2826-9. 2002..4 to 7.2). CONCLUSIONS: In women with chest pain, mild renal insufficiency is an independent predictor of significant angiographic CAD. Mildly increased serum creatinine is probably a marker for unmeasured proatherogenic factors... - Large brachial artery diameter is associated with angiographic coronary artery disease in womenRichard Holubkov
Department of Epidemiology and the Cardiovascular Institute, University of Pittsburgh, PA 15213, USA
Am Heart J 143:802-7. 2002..Therefore, a simple ultrasonographic technique may be useful in the identification of women with chest pain who are at increased risk for CAD... - Quality of life of children with neurological impairment who receive a fundoplication for gastroesophageal reflux diseaseRajendu Srivastava
University of Utah Health Sciences Center, Salt Lake City, Utah 84113, USA
J Hosp Med 2:165-73. 2007..Children with neurological impairment (NI) commonly have gastroesophageal reflux disease (GERD) treated with a fundoplication. The impact of this procedure on quality of life is poorly understood... - Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancerMaureen A Murtaugh
Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
Cancer Causes Control 18:153-63. 2007..Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer... - Risk reduction behaviors and provider communication following genetic counseling and BRCA1 mutation testing in an African American kindredAnita Yeomans Kinney
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
J Genet Couns 15:293-305. 2006..Surveillance for breast cancer was preferred to prophylactic surgery and chemoprevention as a way to reduce risk for these cancers. Our data indicate that patient-provider communication about BRCA1 test results is suboptimal... - Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injuryKimberly D Statler
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Brain Res 1076:216-24. 2006..e., when discontinued with recovery to tail pinch immediately before injury). Investigators using isoflurane must consider its beneficial effects in the design and interpretation of experimental TBI research... - Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failureDennis M McNamara
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Am Coll Cardiol 44:2019-26. 2004..We evaluated the interaction of angiotensin-converting enzyme (ACE) inhibitor therapy with the effect of the ACE D/I polymorphism on heart failure survival... - Prevalence and severity of paravalvular regurgitation in the Artificial Valve Endocarditis Reduction Trial (AVERT) echocardiography studyVictor G Davila-Roman
AVERT Echocardiography Core Laboratory and the Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Coll Cardiol 44:1467-72. 2004..The purpose of this study was to determine the prevalence and severity of paravalvular regurgitation (PVR) in the Artificial Valve Endocarditis Reduction Trial (AVERT) cohort... - Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejectionManinder Bedi
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Heart Lung Transplant 23:696-700. 2004..We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients... - Identification, evaluation, and management of obesity in an academic primary care centerRichard Holubkov
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pediatrics 114:e154-9. 2004..This study highlights the need for increased awareness and identification of obesity in the primary care setting, especially among younger children and those with mild obesity... - Analysis of baseline factors associated with reduction in chest pain in patients with angina pectoris treated by enhanced external counterpulsationWilliam E Lawson
State University of New York at Stony Brook, Stony Brook, New York 11740, USA
Am J Cardiol 92:439-43. 2003.... - Paravalvular leak and other events in silzone-coated mechanical heart valves: a report from AVERTHartzell V Schaff
Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Ann Thorac Surg 73:785-92. 2002..The present analysis determined late event rates that might be used in the management of approximately 36,000 patients who have received the Silzone prosthesis... - Electrocardiogram abnormalities predict angiographic coronary artery disease in women with chest pain: results from the NHLBI WISE StudyRichard Holubkov
Epidemiology Data Center, Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania 15213, USA
Clin Cardiol 25:553-8. 2002..Prospective studies should consider resting ECG parameters in diagnostic algorithms for CAD in women... - Heterogeneity of microvascular dysfunction in women with chest pain not attributable to coronary artery disease: implications for clinical practiceOscar C Marroquin
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
Am Heart J 145:628-35. 2003..Assessment of CFR in a single coronary artery during cardiac catheterization may not provide an accurate assessment of the coronary microcirculation in women with chest pain not attributable to CAD... - Modeling and risk prediction in the current era of interventional cardiology: a report from the National Heart, Lung, and Blood Institute Dynamic RegistryDavid R Holmes
Mayo Clinic, 200 First Street SW, Rochester, Minn 55905, USA
Circulation 107:1871-6. 2003..Validation of in-hospital mortality models after percutaneous coronary interventions using multicenter data remains limited... - Relation of the pattern of diastolic augmentation during a course of enhanced external counterpulsation (EECP) to clinical benefit (from the International EECP Patient Registry [IEPR])Magge V Lakshmi
Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, 94143-0124, USA
Am J Cardiol 89:1303-5. 2002