S Holte

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Famciclovir reduces viral mucosal shedding in HSV-seropositive persons
    Peter Leone
    University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 34:900-7. 2007
  2. ncbi request reprint Risk of HIV infection in oral contraceptive pill users: a meta-analysis
    C C Wang
    Department of Medicine, University of Washington, Seattle 98104 2499, USA
    J Acquir Immune Defic Syndr 21:51-8. 1999
  3. ncbi request reprint High serum hepatitis C virus (HCV) RNA load predicts the presence of HCV RNA in saliva from individuals with chronic and acute HCV infection
    Chia C Wang
    Department of Medicine, University of Washington, Seattle 98104 2499, USA
    J Infect Dis 193:672-6. 2006
  4. ncbi request reprint The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1
    C C Wang
    Departments of Medicine and Epidemiology, Division of Infectious Diseases, University of Washington, Seattle, WA 98104 2499, USA
    J Infect Dis 183:1017-22. 2001
  5. doi request reprint Cervicovaginal shedding of hepatitis C viral RNA is associated with the presence of menstrual or other blood in cervicovaginal fluids
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, WA, United States
    J Clin Virol 50:4-7. 2011
  6. doi request reprint Factors predictive of significant hepatic fibrosis in adults with chronic hepatitis B and normal serum ALT
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Clin Gastroenterol 42:820-6. 2008
  7. ncbi request reprint Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance
    Chia C Wang
    Department of Medicine, Division of Infectious Diseases, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Infect Dis 196:1474-82. 2007
  8. ncbi request reprint Kinetics of hepatitis B viral load during 48 weeks of treatment with 600 mg vs 100 mg of lamivudine daily
    C C Wang
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Viral Hepat 11:443-7. 2004
  9. doi request reprint Oral mucosal reactivation rates of herpesviruses among HIV-1 seropositive persons
    Elizabeth Griffin
    University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98122, USA
    J Med Virol 80:1153-9. 2008
  10. pmc Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009

Research Grants

  1. Non-parenteral transmission of hepatitis C
    Chia Wang; Fiscal Year: 2007

Detail Information

Publications87

  1. ncbi request reprint Famciclovir reduces viral mucosal shedding in HSV-seropositive persons
    Peter Leone
    University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 34:900-7. 2007
    ..This study explores whether famciclovir reduces HSV shedding in HSV-2 seropositive persons with or without a history of symptomatic genital herpes...
  2. ncbi request reprint Risk of HIV infection in oral contraceptive pill users: a meta-analysis
    C C Wang
    Department of Medicine, University of Washington, Seattle 98104 2499, USA
    J Acquir Immune Defic Syndr 21:51-8. 1999
    ..To review the literature and present a summary estimate of the association between HIV-1 acquisition or HIV-1 serostatus and oral contraceptives...
  3. ncbi request reprint High serum hepatitis C virus (HCV) RNA load predicts the presence of HCV RNA in saliva from individuals with chronic and acute HCV infection
    Chia C Wang
    Department of Medicine, University of Washington, Seattle 98104 2499, USA
    J Infect Dis 193:672-6. 2006
    ..This association was also observed in 1 subject with acute HCV infection. Thus, our data demonstrate that salivary HCV RNA detection was associated with serum HCV RNA load in individuals who were chronically or acutely infected with HCV...
  4. ncbi request reprint The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1
    C C Wang
    Departments of Medicine and Epidemiology, Division of Infectious Diseases, University of Washington, Seattle, WA 98104 2499, USA
    J Infect Dis 183:1017-22. 2001
    ..2- and 4.2-fold after treating Candida and Trichomonas, respectively. These data suggest that HIV-1 transmission intervention strategies that incorporate diagnosis and treatment of these prevalent infections warrant evaluation...
  5. doi request reprint Cervicovaginal shedding of hepatitis C viral RNA is associated with the presence of menstrual or other blood in cervicovaginal fluids
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, WA, United States
    J Clin Virol 50:4-7. 2011
    ..The role of sexual activity in hepatitis C virus (HCV) transmission remains controversial. Studies to date have not explored the relationship between HCV shedding in cervicovaginal fluids and the presence of menstrual or other blood...
  6. doi request reprint Factors predictive of significant hepatic fibrosis in adults with chronic hepatitis B and normal serum ALT
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Clin Gastroenterol 42:820-6. 2008
    ..This study examines the prevalence and correlates of significant liver fibrosis among patients with immunotolerant hepatitis B...
  7. ncbi request reprint Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance
    Chia C Wang
    Department of Medicine, Division of Infectious Diseases, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Infect Dis 196:1474-82. 2007
    ..Acute hepatitis C virus (HCV) infection is often asymptomatic; thus, its epidemiology and natural history are difficult to define...
  8. ncbi request reprint Kinetics of hepatitis B viral load during 48 weeks of treatment with 600 mg vs 100 mg of lamivudine daily
    C C Wang
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Viral Hepat 11:443-7. 2004
    ..Studies using mathematical modelling of viral decay may be a useful method to evaluate single or combination therapy for HBV infection in vivo...
  9. doi request reprint Oral mucosal reactivation rates of herpesviruses among HIV-1 seropositive persons
    Elizabeth Griffin
    University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98122, USA
    J Med Virol 80:1153-9. 2008
    ..These data suggest that separate factors influence mucosal shedding of each of the three classes of herpesviruses but that virological interactions between the pathogens also exist...
  10. pmc Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
    ..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
  11. pmc Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5272. 2009
    ..We describe the baseline characteristics of this cohort...
  12. ncbi request reprint Testing for genital herpes: how, who, and why
    Anna Wald
    University of Washington School of Medicine, Virology Research Clinic, Seattle, Washington, USA
    Curr Clin Top Infect Dis 22:166-80. 2002
  13. pmc Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection
    H Nina Kim
    Department of Medicine, Schools of Medicine and Public Health, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Infect Dis 202:734-8. 2010
    ..In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point...
  14. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  15. doi request reprint One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection
    Joseph B Bavaro
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:383-6. 2008
    ..To evaluate the efficacy of a 1-day course of valacyclovir in reducing the duration and severity of genital herpes recurrences and to measure the frequency of viral shedding episodes subsequent to antiviral therapy...
  16. pmc Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
    ..To determine whether rapidly cleared episodes of herpes simplex virus (HSV) reactivation occur in HIV-infected adults...
  17. pmc Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
    C Celum
    Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
    N Engl J Med 362:427-39. 2010
    ..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...
  18. ncbi request reprint Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes
    Elizabeth L Brown
    Department of Epidemiology, University of Washington, Seattle, WA 98122, USA, and Department of Pediatrics, Karolinska University Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:523-9. 2007
    ..We have conducted pooled analyses of data from 3 cohorts to evaluate the effects of maternal HSV serostatus and HSV type on risk of neonatal HSV acquisition and severity...
  19. ncbi request reprint Development and use of a type-specific antibody avidity test based on herpes simplex virus type 2 glycoprotein G
    Rhoda Ashley Morrow
    Department of Laboratory Medicine, The University of Washington, Seattle, Washington, USA
    Sex Transm Dis 31:508-15. 2004
    ..It is difficult to discriminate between lesions resulting from recently acquired versus established genital herpes simplex virus type 2 (HSV-2) infection. Methods not based on history or serum IgM status are needed...
  20. pmc Healthcare seeking and sexual behavior among patients with symptomatic newly acquired genital herpes
    Julie Richards
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:1015-21. 2008
    ..An improved understanding of this relationship provides insight into the experience of having genital herpes and has implications for counseling...
  21. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  22. pmc Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
    ..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
  23. ncbi request reprint Transferred herpes simplex virus immunity after stem-cell transplantation: clinical implications
    W Garrett Nichols
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109 4417, USA
    J Infect Dis 187:801-8. 2003
    ..Serological testing of donors can identify patients who are at highest risk for HSV-related morbidity, for whom prolonged prophylaxis or donor vaccination (once available) could be considered...
  24. ncbi request reprint Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2
    Rhoda Ashley-Morrow
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 30:310-4. 2003
    ..HerpeSelect HSV-1 and HSV-2 ELISAs are glycoprotein G-based, type-specific antibody detection tests that are approved by the US Food and Drug Administration for diagnosis of genital herpes...
  25. pmc Clinical correlates of herpes simplex virus viremia among hospitalized adults
    William R Berrington
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 49:1295-301. 2009
    ..Quantification of herpes simplex virus (HSV) DNA in the peripheral blood is often used to evaluate patients suspected of having disseminated HSV infection. Few studies have examined the clinical correlates of HSV viremia among adults...
  26. pmc Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response
    Huong Q Nguyen
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 22:937-45. 2008
    ..To evaluate the role of highly active antiretroviral therapy and chemotherapy on tumor response among persons with AIDS-related Kaposi sarcoma and identify factors associated with response in a clinic setting...
  27. pmc Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
    Sunitha Tata
    Vaccine and Infectious Disease Institute, University of Washington, Seattle, USA
    J Infect Dis 201:499-504. 2010
    ..Genital shedding of herpes simplex virus (HSV) type 2 occurs frequently. Anatomic patterns of genital HSV-2 reactivation have not been intensively studied...
  28. ncbi request reprint Genital herpes
    Rachna Gupta
    Department of Medicine, University of Washington, Seattle, USA
    Lancet 370:2127-37. 2007
    ..Antiviral treatment of the infected partners and condom use reduce the risk of sexual transmission of HSV-2...
  29. pmc Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
    Soren Gantt
    Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Blood Cancer 54:670-4. 2010
    ..Kaposi sarcoma (KS) is one of the most common pediatric cancers in sub-Saharan Africa. Few data are available about the clinical presentation or response to treatment of children with epidemic (HIV-associated) KS...
  30. ncbi request reprint HSV-2 serologic testing in an HMO population: uptake and psychosocial sequelae
    Julie Richards
    Department of Medicine, University of Washington, Seattle, WA, USA
    Sex Transm Dis 34:718-25. 2007
    ..To prospectively measure the uptake of Herpes simplex virus Type 2 (HSV-2) testing and psychosocial response to a new serologic diagnosis of HSV-2 in a health maintenance organization (HMO) population...
  31. ncbi request reprint Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
    J Infect Dis 196:505-9. 2007
    ..02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection...
  32. pmc Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:595-603. 2007
    ..These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8(+) T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions...
  33. pmc Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    Ashok Cattamanchi
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Clin Vaccine Immunol 15:1638-43. 2008
    ..A DNA-based vaccination strategy against HSV-2 appears to be safe and may generate a vaccine-specific cellular immune response, but high vaccine doses are likely needed to elicit an immune response in most vaccinees...
  34. ncbi request reprint Genital herpes: antiviral therapy for symptom relief and prevention of transmission
    Rachna Gupta
    Department of Medicine, University of Washington, Virology Research Clinic, Seattle, WA 98122, USA
    Expert Opin Pharmacother 7:665-75. 2006
    ..The factors influencing the choice of therapy, such as cost, ease of dosing and acyclovir resistance are also discussed...
  35. ncbi request reprint Isolation of herpes simplex virus from the genital tract during symptomatic recurrence on the buttocks
    Katrina Kerkering
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 108:947-52. 2006
    ..To estimate the frequency of isolation of herpes simplex virus (HSV) from the genital tract when recurrent herpes lesions were present on the buttocks...
  36. ncbi request reprint A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects
    Guy de Bruyn
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Vaccine 24:914-20. 2006
    ..A replication incompetent herpes virus lacking the glycoprotein H gene has been developed as a potential therapeutic vaccine for genital herpes...
  37. ncbi request reprint Acyclovir sensitivity of sequential herpes simplex virus type 2 isolates from the genital mucosa of immunocompetent women
    Rachna Gupta
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 192:1102-7. 2005
    ..To understand the frequency and clinical significance of acyclovir-resistant isolates, we evaluated the in vitro acyclovir sensitivities of sequential isolates from 34 immunocompetent women...
  38. ncbi request reprint Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 196:266-70. 2007
    ..2% [95% CI, 0%-0.8%]; P=.006), and in 0 patients in cohort 3 (cohort 2 vs. cohort 3, P=.3). Long-term use of suppressive prophylactic ACV appears to prevent the emergence of drug-resistant HSV disease in HCT...
  39. ncbi request reprint HHV-8 infection: a model for reactivation and transmission
    Lawrence Corey
    Department of Medicine, Laboratory Medicine and Epidemiology, University of Washington, Seattle, WA, USA
    Rev Med Virol 12:47-63. 2002
    ..Hopefully continued study will address many of the critical questions that exist today regarding how this infection is transmitted and acquired...
  40. pmc Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus
    David M Koelle
    Department of Medicine, Department of Laboratory Medicine, and Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 110:537-48. 2002
    ..The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules...
  41. pmc Genital herpes and human immunodeficiency virus: double trouble
    Connie Celum
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
    Bull World Health Organ 82:447-53. 2004
    ....
  42. ncbi request reprint Clinical correlates of index values in the focus HerpeSelect ELISA for antibodies to herpes simplex virus type 2 (HSV-2)
    Rhoda Ashley Morrow
    University of Washington, Department of Laboratory Medicine, USA
    J Clin Virol 36:141-5. 2006
    ..Clinical correlates of HerpeSelect ELISA index values are poorly understood...
  43. ncbi request reprint Correlates of human herpesvirus-8 seropositivity among U.S. military members recently infected with human immunodeficiency virus
    Nancy F Crum
    Department of Medicine, Infectious Diseases Division, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
    Sex Transm Dis 30:713-8. 2003
    ..Human herpesvirus 8 (HHV-8), the cause of Kaposi's sarcoma, is common among HIV-infected persons. The exact route of transmission of HHV-8 in various populations is still debated...
  44. ncbi request reprint Maternal herpes simplex virus antibody avidity and risk of neonatal herpes
    Elizabeth L Brown
    Department of Epidemiology, University of Washington, Seattle, WA 98122, USA
    Am J Obstet Gynecol 195:115-20. 2006
    ..The objective of the study was to assess whether herpes simplex virus antibody avidity is associated with risk of transmission of herpes simplex virus to the neonate...
  45. pmc Are there benefits to starting antiretroviral therapy during primary HIV infection? Conclusions from the Seattle Primary Infection Cohort vary by control group
    J D Stekler
    Department of Medicine, University of Washington, Seattle, WA, USA
    Int J STD AIDS 23:201-6. 2012
    ..Randomized trials are needed to address benefits of cART during PHI...
  46. ncbi request reprint Two-day regimen of acyclovir for treatment of recurrent genital herpes simplex virus type 2 infection
    Anna Wald
    Departments of Medicine, Epidemiology, and Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:944-8. 2002
    ..001), and viral shedding (25 hours versus 58.5 hours; P=.04), and it increased the proportion of aborted episodes (P=.029). A 2-day course of acyclovir is a convenient alternative for treatment of recurrent genital herpes...
  47. pmc Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial
    Connie Celum
    Department of Global Health, University of Washington, Seattle, WA, USA
    Lancet 371:2109-19. 2008
    ..We investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition...
  48. ncbi request reprint The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics
    Lawrence Corey
    Department of Medicine, University of Washington Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 35:435-45. 2004
    ....
  49. pmc Internet and email use among STD clinic patients
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:960-5. 2008
    ..Little data exist on Internet and email use among STD clinic patients for research and clinical care communication...
  50. ncbi request reprint Unusual appendicitis
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, Harborview Medical Center, University of Washington, Seattle 98195, USA
    Clin Infect Dis 37:1334, 1378-9. 2003
  51. pmc Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in Uganda
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e4222. 2009
    ..Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS...
  52. ncbi request reprint Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 188:1345-51. 2003
    ..In home-collected specimens, the ratio of PCR positivity to viral-culture positivity rose from 3.8:1 in the winter to 8.8:1 in the summer months, reflecting the lability of viral-culture specimens transported during warm weather...
  53. pmc Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:12899-904. 2003
    ..We conclude that among circulating cells expressing a homing-associated receptor, during chronic herpes type 2 infection, the CD8 T cell response becomes quite focused despite the presence of many potential antigenic peptides...
  54. pmc Evasion of the mucosal innate immune system by herpes simplex virus type 2
    Tao Peng
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 83:12559-68. 2009
    ..HSV-2's blockade of the innate immune system's production of type I IFN may be a major factor in allowing the virus to break through host mucosal defenses...
  55. pmc Influenza-associated cystic fibrosis pulmonary exacerbations
    Justin R Ortiz
    Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Box 356522, 1959 NE Pacific St, Seattle, WA 98195 6522, USA
    Chest 137:852-60. 2010
    ..Although cystic fibrosis (CF) is the most common inherited respiratory disease, the burden of influenza among individuals with CF is not well characterized...
  56. pmc Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples
    Jared M Baeten
    University of Washington, WA, USA
    AIDS 24:737-44. 2010
    ....
  57. ncbi request reprint Prevalence and risk factors for infection with herpes simplex virus type-1 and -2 among lesbians
    Jeanne M Marrazzo
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 30:890-5. 2003
    ..Sexual transmission of bacterial and viral sexually transmitted disease has been reported between women. No data are available on seroprevalence of herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) among lesbians...
  58. pmc Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  59. ncbi request reprint Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection
    Anna Wald
    Department of Medicine, University of Washington, Virology Research Clinic, Seattle, WA, USA
    Clin Infect Dis 35:S173-82. 2002
    ..Potential settings for use of these tests include sexually transmitted disease clinics, prenatal clinics, and clinics that care for patients with human immunodeficiency virus. Patient interest in HSV serological tests appears high...
  60. pmc Rapid polymerase chain reaction assay to detect herpes simplex virus in the genital tract of women in labor
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 115:1209-16. 2010
    ..To develop a rapid quantitative real-time polymerase chain reaction (PCR) to detect herpes simplex virus (HSV) in the genital secretions of women that may be used in labor...
  61. ncbi request reprint Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men
    Corey Casper
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 185:990-3. 2002
    ..Reporting > or =1 HIV-positive partner (OR, 5.9; 95% CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion...
  62. ncbi request reprint Type-specific testing for herpes simplex virus
    Lara Strick
    Seattle HIV Prevention Trials Unit, 901 Boren Ave, Suite 1300, Seattle, WA 98104, USA
    Expert Rev Mol Diagn 4:443-53. 2004
    ..Populations appropriate for type-specific serologic testing for HSV include people with an uncertain clinical diagnosis, high-risk patients, partners of an HSV-infected individual, HIV-infected individuals and pregnant women...
  63. pmc A pooled analysis of the effect of condoms in preventing HSV-2 acquisition
    Emily T Martin
    Departments of Epidemiology, University of Washington, Seattle, USA
    Arch Intern Med 169:1233-40. 2009
    ..The degree of effectiveness of condom use in preventing the transmission of herpes simplex virus 2 (HSV-2) is uncertain. To address this issue, we performed a large pooled analysis...
  64. ncbi request reprint Poor correlation between genital lesions and detection of herpes simplex virus in women in labor
    Carolyn Gardella
    Department of Obstetrics and Gynecology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98195 6460, USA
    Obstet Gynecol 106:268-74. 2005
    ..To estimate the accuracy of clinical diagnosis of genital herpes for herpes simplex virus (HSV) detection among women in labor...
  65. ncbi request reprint Synergistic interactions between herpes simplex virus type-2 and human immunodeficiency virus epidemics
    Anna Wald
    Department of Medicine, Epidemiology and Laboratory Medicine, University of Washington, Seattle, WA, USA
    Herpes 11:70-6. 2004
    ....
  66. ncbi request reprint A population-based study of primary human herpesvirus 6 infection
    Danielle M Zerr
    Department of Pediatrics, University of Washington, Seattle, USA
    N Engl J Med 352:768-76. 2005
    ..Serologic studies indicate that human herpesvirus 6 (HHV-6) infects 90 percent of children by two years of age. Little is known about the acquisition, virologic course, and clinical manifestations of HHV-6 infection...
  67. ncbi request reprint Prenatal herpes simplex virus serologic screening beliefs and practices among obstetricians
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98119, USA
    Obstet Gynecol 110:1364-70. 2007
    ..To describe the beliefs and practices of obstetricians related to prenatal serologic testing for HSV infection...
  68. ncbi request reprint Herpes simplex virus type 2 (HSV-2) Western blot confirmatory testing among men testing positive for HSV-2 using the focus enzyme-linked immunosorbent assay in a sexually transmitted disease clinic
    Matthew R Golden
    Department of Medicine, University of Washington, Seattle, USA
    Sex Transm Dis 32:771-7. 2005
    ....
  69. ncbi request reprint Case report: symptomatic oral herpes simplex virus type 2 and asymptomatic genital shedding
    Laura Olin
    Department of Medicine, University of Washington, Seattle, WA 98122, USA
    Herpes 13:25-6. 2006
    ..During a symptomatic oral recurrence, HSV-2 was found in a perioral lesion as well as in the genital area...
  70. ncbi request reprint Herpes simplex virus type 2 transmission: risk factors and virus shedding
    Anna Wald
    University of Washington, Virology Research Clinic, Seattle, WA 98122, USA
    Herpes 11:130A-137A. 2004
    ..Clinical history is a poor predictor of HSV-2 infection and type-specific serological testing is recommended to detect HSV-2 seropositivity...
  71. pmc Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment
    U Malhotra
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109, USA
    J Clin Invest 107:505-17. 2001
    ..Eliciting responses to the promiscuous epitope region may be beneficial in vaccine strategies...
  72. ncbi request reprint Genital shedding of herpes simplex virus among men
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 186:S34-9. 2002
    ..4; 95% confidence interval, 1.2-15.3). The frequency of viral shedding in men with genital herpes appears comparable with that in women...
  73. pmc Quantitative stability of DNA after extended storage of clinical specimens as determined by real-time PCR
    Keith R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Microbiol 40:2609-11. 2002
    ..We therefore compared herpes simplex virus DNA levels in specimens before and after 16 months of storage. The levels of viral DNA remained stable whether the DNA was stored as purified DNA or unextracted DNA in a whole specimen...
  74. pmc Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman
    Todd Czartoski
    Molecular Virology Laboratory, University of Washington, 960 Republican St, Seattle, WA 98195, USA
    J Clin Microbiol 44:1584-6. 2006
    ..She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2...
  75. ncbi request reprint Targeted prenatal herpes simplex virus testing: can we identify women at risk of transmission to the neonate?
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 194:408-14. 2006
    ..The cost-effectiveness of these interventions would be improved if high-risk pregnancies could be easily identified for targeted testing...
  76. pmc Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa
    Amalia S Magaret
    Department of Laboratory Medicine, University of Washington, 600 Broadway, Suite 400, Seattle, WA 98122, USA
    J Clin Microbiol 45:1618-20. 2007
    ..We found that a cutoff of 50 HSV DNA copies/ml of swab specimen, a level 10-fold lower than our previous cutoff, minimizes misclassification...
  77. ncbi request reprint How does herpes simplex virus type 2 influence human immunodeficiency virus infection and pathogenesis?
    Anna Wald
    J Infect Dis 187:1509-12. 2003
  78. ncbi request reprint Diagnostics for herpes simplex virus: is PCR the new gold standard?
    Lara B Strick
    University of Washington, Seattle, Washington, USA
    Mol Diagn Ther 10:17-28. 2006
    ....
  79. ncbi request reprint The relationship between condom use and herpes simplex virus acquisition
    Anna Wald
    University of Washington, Virology Research Clinic, Seattle, Washington 98122, USA
    Ann Intern Med 143:707-13. 2005
    ..Few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (HSV-2) and HSV type 1 (HSV-1) acquisition...
  80. ncbi request reprint HIV infection and human herpesvirus-8 oral shedding among men who have sex with men
    Corey Casper
    Department of Medicine, The University of Washington, Seattle 98122, USA
    J Acquir Immune Defic Syndr 35:233-8. 2004
    ..8, 95% CI 1.0-22.8, P = 0.05), or with detectable oral leukocyte esterase (odds ratio 5.0, 95% CI 2.0-12.5, P < 0.01). CD4 count, antiretroviral therapy, and oral inflammation may influence HHV-8 oropharyngeal shedding...
  81. ncbi request reprint Targeting virological core groups: a new paradigm for controlling herpes simplex virus type 2 epidemics
    Sally Blower
    Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles UCLA, Westwood, California 90024, USA
    J Infect Dis 190:1610-7. 2004
    ..Classic modeling of sexually transmitted diseases has focused on modeling behavioral heterogeneity and designing epidemic control strategies targeted at behavioral core groups...
  82. ncbi request reprint Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant
    Zane A Brown
    Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195 6460, USA
    JAMA 289:203-9. 2003
    ..Furthermore, no data exist on whether cesarean delivery, the standard of care for women with genital herpes lesions at the time of delivery, reduces HSV transmission...
  83. ncbi request reprint Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    ..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
  84. ncbi request reprint Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 190:693-6. 2004
    ..8% vs. 11.3% of days, respectively; P=.001). Thus, mucosal HSV shedding and HSV-2 reactivation were still frequent among treated subjects, even though HAART was associated with fewer days with HSV lesions...
  85. ncbi request reprint Valacyclovir for the suppression of recurrent genital herpes in human immunodeficiency virus-infected subjects
    Edwin DeJesus
    Infectious Disease Consultants, Altamonte Springs, Florida 32701, USA
    J Infect Dis 188:1009-16. 2003
    ..There were no episodes of thrombotic microangiopathy. Valacyclovir was safe and effective for the suppression of recurrent genital herpes infection in HIV-infected individuals...
  86. pmc Longitudinal study of herpes simplex virus type 2 infection using viral dynamic modelling
    Catherine M Crespi
    Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA 90095 1772, USA
    Sex Transm Infect 83:359-64. 2007
    ..We conducted a longitudinal study of HSV-2 infection to quantify rates of change in HSV-2 reactivation, mucosal shedding and recurrences of genital lesions, using a newly available model of HSV within-host dynamics...
  87. pmc Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
    ..Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated...

Research Grants1

  1. Non-parenteral transmission of hepatitis C
    Chia Wang; Fiscal Year: 2007
    ....