Christopher P Holstege

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint Toxidromes
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, Blue Ridge Poison Center, University of Virginia Health System, University of Virginia School of Medicine, PO Box 800774, Charlottesville, VA 22908 0774, USA
    Crit Care Clin 28:479-98. 2012
  2. ncbi request reprint Electrocardiographic abnormalities associated with poisoning
    Christopher Delk
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Am J Emerg Med 25:672-87. 2007
  3. ncbi request reprint Unusual but potential agents of terrorists
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 25:549-66; abstract xi. 2007
  4. doi request reprint A case of cyanide poisoning and the use of arterial blood gas analysis to direct therapy
    Christopher P Holstege
    Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Hosp Pract (1995) 38:69-74. 2010
  5. ncbi request reprint Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine)
    Christopher P Holstege
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0699, USA
    Ann Emerg Med 39:677-9. 2002
  6. ncbi request reprint ECG manifestations: the poisoned patient
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, P O Box 800774, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 24:159-77, vii. 2006
  7. doi request reprint Critical care toxicology
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, PO Box 800774, 1222 Jefferson Park Avenue, 4th Floor, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 26:715-39, viii-ix. 2008
  8. ncbi request reprint Cardiovascular challenges in toxicology
    Christopher P Holstege
    Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, 22908 0774, USA
    Emerg Med Clin North Am 23:1195-217. 2005
  9. ncbi request reprint Toxicity and drug interactions associated with herbal products: ephedra and St. John's Wort
    Christopher P Holstege
    Division of Medical Toxicology, University of Virginia, Charlottesville, VA 22908 0774, USA
    Med Clin North Am 89:1225-57. 2005
  10. ncbi request reprint Massive caffeine overdose requiring vasopressin infusion and hemodialysis
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, Virginia 22908 0699, USA
    J Toxicol Clin Toxicol 41:1003-7. 2003

Collaborators

Detail Information

Publications31

  1. doi request reprint Toxidromes
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, Blue Ridge Poison Center, University of Virginia Health System, University of Virginia School of Medicine, PO Box 800774, Charlottesville, VA 22908 0774, USA
    Crit Care Clin 28:479-98. 2012
    ..Although these toxidromes can aid the clinician in narrowing the differential diagnosis, care must be exercised to realize the exceptions and limitations associated with each...
  2. ncbi request reprint Electrocardiographic abnormalities associated with poisoning
    Christopher Delk
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Am J Emerg Med 25:672-87. 2007
    ..This article reviews the various electrocardiographic abnormalities associated with these 5 classes of agents, ranging from morphological abnormalities and conduction blocks to brady- and tachyarrhythmias...
  3. ncbi request reprint Unusual but potential agents of terrorists
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 25:549-66; abstract xi. 2007
    ..It is beyond the scope of this article to review all potential terrorist agents. Rather, four potential agents have been chosen for review: sodium monofluoroacetate, trichothecene mycotoxins, vomiting agents, and saxitoxin...
  4. doi request reprint A case of cyanide poisoning and the use of arterial blood gas analysis to direct therapy
    Christopher P Holstege
    Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Hosp Pract (1995) 38:69-74. 2010
    ..An arterial blood gas analysis may help aid in the diagnosis of cyanide toxicity. Electrocardiographic findings in a patient with cyanide poisoning range significantly, depending on the stage of the poisoning...
  5. ncbi request reprint Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine)
    Christopher P Holstege
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0699, USA
    Ann Emerg Med 39:677-9. 2002
    ..Holstege CP, Wu J, Baer AB. Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine). Ann Emerg Med. June 2002;39:677-679.]..
  6. ncbi request reprint ECG manifestations: the poisoned patient
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, P O Box 800774, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 24:159-77, vii. 2006
    ..The purpose of this article is to group together agents that cause similar electrocardiographic effects,review their pharmacologic actions, and discuss the electrocardiographic findings reported in the medical literature...
  7. doi request reprint Critical care toxicology
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, PO Box 800774, 1222 Jefferson Park Avenue, 4th Floor, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 26:715-39, viii-ix. 2008
    ..Appropriate testing in the poisoned patient is reviewed. Complications of poisoning that may bring a rapid demise of the critically ill poisoned patient are highlighted and the management of those complications is discussed...
  8. ncbi request reprint Cardiovascular challenges in toxicology
    Christopher P Holstege
    Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, 22908 0774, USA
    Emerg Med Clin North Am 23:1195-217. 2005
    ..Multiple agents exist that result in human cardiovascular toxicity. The management of the toxicity of each agent should follow a rationale approach. The first step in the care of all poisoned patients focuses on good supportive care...
  9. ncbi request reprint Toxicity and drug interactions associated with herbal products: ephedra and St. John's Wort
    Christopher P Holstege
    Division of Medical Toxicology, University of Virginia, Charlottesville, VA 22908 0774, USA
    Med Clin North Am 89:1225-57. 2005
    ..Adverse reactions to herbal remedies should be reported to the FDA MedWatch at http://www.fda.gov/medwatch. As withany therapeutic agent, risk of use must always be weighed against potential benefits...
  10. ncbi request reprint Massive caffeine overdose requiring vasopressin infusion and hemodialysis
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, Virginia 22908 0699, USA
    J Toxicol Clin Toxicol 41:1003-7. 2003
    ..We describe the highest-reported serum concentration of caffeine in a patient who survived and discuss the first-reported use of vasopressin and hemodialysis in a caffeine-poisoned patient...
  11. ncbi request reprint Criminal poisoning: Munchausen by proxy
    Christopher P Holstege
    Division of Medical Toxicology, University of Virginia, P O Box 800774, Charlottesville, VA 22908, USA
    Clin Lab Med 26:243-53, x. 2006
    ..This article reviews MBP, with particular focus on poisoning agents that have been used in past reported cases...
  12. ncbi request reprint Analysis of moonshine for contaminants
    Christopher P Holstege
    Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, P O Box 800699, Charlottesville, VA 22908 0699, USA
    J Toxicol Clin Toxicol 42:597-601. 2004
    ..Although moonshine production continues in the United States, no studies have analyzed the content of moonshine since the early 1960s. We hypothesize that moonshine continues to contain potentially toxic concentrations of contaminants...
  13. doi request reprint Intranasal substituted cathinone "bath salts" psychosis potentially exacerbated by diphenhydramine
    Erik W Gunderson
    University of Virginia School of Medicine, Charlottesville, VA, USA
    J Addict Med 7:163-8. 2013
    ..It is hoped that the discussion will provide insight into the clinical aspects and challenges of addressing acute substituted cathinone toxicity, including acute psychosis, a major adverse effect of bath salts consumption...
  14. ncbi request reprint Utilizing the laboratory in the poisoned patient
    David L Eldridge
    Department of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Clin Lab Med 26:13-30, vii. 2006
    ..Clinicians should not order a broad range of tests indiscriminately, but rather thoughtfully consider appropriate tests. The results of the tests should be reviewed in the context of the clinical scenario...
  15. ncbi request reprint Utilizing diagnostic investigations in the poisoned patient
    David L Eldridge
    Department of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Med Clin North Am 89:1079-105. 2005
    ..Clinicians should not order a broad range of tests indiscriminately,but rather thoughtfully consider appropriate tests. The results'of the tests should be reviewed in the context of the clinical scenario...
  16. doi request reprint Termination of drug-induced torsades de pointes with overdrive pacing
    Nathan P Charlton
    Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Am J Emerg Med 28:95-102. 2010
    ..Despite appropriate care, including magnesium therapy, each case required overdrive pacing for resolution of TdP. Although rarely encountered, patients with drug-induced TdP can be successfully managed with overdrive pacing...
  17. ncbi request reprint 5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose
    David T Lawrence
    Division of Medical Toxicology, University of Virginia School of Medicine, P O Box 800774, Charlottesville, VA 22908 0774, USA
    J Am Osteopath Assoc 110:545-51. 2010
    ..The acidosis fully resolved with N-acetylcysteine treatment and supportive care including hydration...
  18. doi request reprint Accuracy of internet recommendations for prehospital care of venomous snake bites
    Sarah Barker
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA, USA
    Wilderness Environ Med 21:298-302. 2010
    ..To evaluate the accuracy of Internet information regarding the prehospital care of venomous snake bites...
  19. pmc Management of the critically poisoned patient
    Jennifer S Boyle
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Scand J Trauma Resusc Emerg Med 17:29. 2009
    ..The goal of this article is to introduce the basic concepts for evaluation of poisoned patients and review the appropriate management of such patients based on the currently available literature...
  20. ncbi request reprint Images in emergency medicine. Skin damage following application of suction device for snakebite
    Christopher P Holstege
    Department of Emergency Medicine, Division of Medical Toxicology, University of Virginia, Charlottesville, VA, USA
    Ann Emerg Med 48:105, 113. 2006
  21. ncbi request reprint Poison centers as information resources for volunteer EMS in a suspected chemical exposure
    Christian Martin-Gill
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Emerg Med 32:397-403. 2007
    ..4% and 26.7%, respectively). Poison centers are viewed as an important information resource by EMS providers and may be the most commonly sought resource for various information needs during a suspected chemical exposure...
  22. ncbi request reprint Food poisoning
    David T Lawrence
    Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 25:357-73; abstract ix. 2007
    ..This article reviews several potential food-borne poisons and describes each agent's mechanism of toxicity, expected clinical presentation, and currently accepted treatment...
  23. doi request reprint Survival of acute hypernatremia due to massive soy sauce ingestion
    David J Carlberg
    Department of Emergency Medicine, University of Virginia Medical Center, Charlottesville, Virginia, USA
    J Emerg Med 45:228-31. 2013
    ..Intentional massive sodium chloride ingestions are rare occurrences and are often fatal...
  24. doi request reprint Substituted cathinone products: a new trend in "bath salts" and other designer stimulant drug use
    Erik W Gunderson
    University of Virginia School of Medicine, Charlottesville, VA, USA
    J Addict Med 7:153-62. 2013
    ..It is hoped that a greater understanding of the clinical effects and use patterns will help inform policy and practice...
  25. ncbi request reprint Envenomations
    Eunice M Singletary
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
    Med Clin North Am 89:1195-224. 2005
    ..Clinicians should be familiar with the animals in their region that may lead to envenomation.A rational approach with use of poison center or medical toxicology consultation services ensures that cases are managed appropriately...
  26. doi request reprint Injury and illness encountered in Shenandoah National Park
    Joseph D Forrester
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA, USA
    Wilderness Environ Med 20:318-26. 2009
    ..The purpose of this study was to determine the incidence of such illnesses and injuries to visitors in Shenandoah National Park...
  27. doi request reprint Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathway
    Laura K Bechtel
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA, USA
    Acad Emerg Med 15:368-74. 2008
    ..One molecular signaling pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, that contributes to CCB toxicity and the efficacy of HDIT, was examined for a role in this phenomenon...
  28. ncbi request reprint Intraventricular conduction abnormality--an electrocardiographic algorithm for rapid detection and diagnosis
    Daniel Garcia
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Emerg Med 27:492-502. 2009
    ..After a review of these IVCDs, a simplified algorithm that will aid in the electrocardiographic diagnosis of these conduction abnormalities is presented...
  29. doi request reprint Hyperthermia and multiorgan failure after abuse of "bath salts" containing 3,4-methylenedioxypyrovalerone
    Heather A Borek
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Ann Emerg Med 60:103-5. 2012
    ..Acute management should focus on the rapid identification of organ injury and appropriate supportive care...
  30. ncbi request reprint Criminal poisoning: drug-facilitated sexual assault
    Laura K Bechtel
    Blue Ridge Poison Center, University of Virginia Health System, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 25:499-525; abstract x. 2007
    ..It is imperative for emergency personnel to clearly document the history and the presenting signs and symptoms to assist laboratory personnel to hone in and detect the correct agent used in a DFSA...
  31. ncbi request reprint Hepatotoxicity associated with herbal products
    R Brent Furbee
    Indiana Poison Center, Department of Emergency Medicine, Indiana University School of Medicine, Room AG373, 1701 North Senate Boulevard, Indianapolis, IN 46206, USA
    Clin Lab Med 26:227-41, x. 2006
    ..The most important clue often is the temporal relationship between initiation of the herbal product and the appearance of liver injury; of equal importance is the resolution of the injury following withdrawal of the herbal product...