Research Topics
| Christopher P HolstegeSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
ToxidromesChristopher P Holstege
Division of Medical Toxicology, Department of Emergency Medicine, Blue Ridge Poison Center, University of Virginia Health System, University of Virginia School of Medicine, PO Box 800774, Charlottesville, VA 22908 0774, USA
Crit Care Clin 28:479-98. 2012..Although these toxidromes can aid the clinician in narrowing the differential diagnosis, care must be exercised to realize the exceptions and limitations associated with each...- A case of cyanide poisoning and the use of arterial blood gas analysis to direct therapyChristopher P Holstege
Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Hosp Pract (1995) 38:69-74. 2010..An arterial blood gas analysis may help aid in the diagnosis of cyanide toxicity. Electrocardiographic findings in a patient with cyanide poisoning range significantly, depending on the stage of the poisoning... - Critical care toxicologyChristopher P Holstege
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, PO Box 800774, 1222 Jefferson Park Avenue, 4th Floor, Charlottesville, VA 22908 0774, USA
Emerg Med Clin North Am 26:715-39, viii-ix. 2008..Appropriate testing in the poisoned patient is reviewed. Complications of poisoning that may bring a rapid demise of the critically ill poisoned patient are highlighted and the management of those complications is discussed... 
Electrocardiographic abnormalities associated with poisoningChristopher Delk
Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22911, USA
Am J Emerg Med 25:672-87. 2007..This article reviews the various electrocardiographic abnormalities associated with these 5 classes of agents, ranging from morphological abnormalities and conduction blocks to brady- and tachyarrhythmias...- Unusual but potential agents of terroristsChristopher P Holstege
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
Emerg Med Clin North Am 25:549-66; abstract xi. 2007..It is beyond the scope of this article to review all potential terrorist agents. Rather, four potential agents have been chosen for review: sodium monofluoroacetate, trichothecene mycotoxins, vomiting agents, and saxitoxin... - ECG manifestations: the poisoned patientChristopher P Holstege
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, P O Box 800774, Charlottesville, VA 22908 0774, USA
Emerg Med Clin North Am 24:159-77, vii. 2006..The purpose of this article is to group together agents that cause similar electrocardiographic effects,review their pharmacologic actions, and discuss the electrocardiographic findings reported in the medical literature... - Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine)Christopher P Holstege
Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0699, USA
Ann Emerg Med 39:677-9. 2002..Holstege CP, Wu J, Baer AB. Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine). Ann Emerg Med. June 2002;39:677-679.].. - Cardiovascular challenges in toxicologyChristopher P Holstege
Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, 22908 0774, USA
Emerg Med Clin North Am 23:1195-217. 2005..Multiple agents exist that result in human cardiovascular toxicity. The management of the toxicity of each agent should follow a rationale approach. The first step in the care of all poisoned patients focuses on good supportive care... - Massive caffeine overdose requiring vasopressin infusion and hemodialysisChristopher P Holstege
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, Virginia 22908 0699, USA
J Toxicol Clin Toxicol 41:1003-7. 2003..We describe the highest-reported serum concentration of caffeine in a patient who survived and discuss the first-reported use of vasopressin and hemodialysis in a caffeine-poisoned patient... - Analysis of moonshine for contaminantsChristopher P Holstege
Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, P O Box 800699, Charlottesville, VA 22908 0699, USA
J Toxicol Clin Toxicol 42:597-601. 2004..Although moonshine production continues in the United States, no studies have analyzed the content of moonshine since the early 1960s. We hypothesize that moonshine continues to contain potentially toxic concentrations of contaminants... - Toxicity and drug interactions associated with herbal products: ephedra and St. John's WortChristopher P Holstege
Division of Medical Toxicology, University of Virginia, Charlottesville, VA 22908 0774, USA
Med Clin North Am 89:1225-57. 2005..Adverse reactions to herbal remedies should be reported to the FDA MedWatch at http://www.fda.gov/medwatch. As withany therapeutic agent, risk of use must always be weighed against potential benefits... - Criminal poisoning: Munchausen by proxyChristopher P Holstege
Division of Medical Toxicology, University of Virginia, P O Box 800774, Charlottesville, VA 22908, USA
Clin Lab Med 26:243-53, x. 2006..This article reviews MBP, with particular focus on poisoning agents that have been used in past reported cases... - Utilizing the laboratory in the poisoned patientDavid L Eldridge
Department of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, NC, USA
Clin Lab Med 26:13-30, vii. 2006..Clinicians should not order a broad range of tests indiscriminately, but rather thoughtfully consider appropriate tests. The results of the tests should be reviewed in the context of the clinical scenario... - Utilizing diagnostic investigations in the poisoned patientDavid L Eldridge
Department of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, NC, USA
Med Clin North Am 89:1079-105. 2005..Clinicians should not order a broad range of tests indiscriminately,but rather thoughtfully consider appropriate tests. The results'of the tests should be reviewed in the context of the clinical scenario... - Termination of drug-induced torsades de pointes with overdrive pacingNathan P Charlton
Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Am J Emerg Med 28:95-102. 2010..Despite appropriate care, including magnesium therapy, each case required overdrive pacing for resolution of TdP. Although rarely encountered, patients with drug-induced TdP can be successfully managed with overdrive pacing... - 5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdoseDavid T Lawrence
Division of Medical Toxicology, University of Virginia School of Medicine, P O Box 800774, Charlottesville, VA 22908 0774, USA
J Am Osteopath Assoc 110:545-51. 2010..The acidosis fully resolved with N-acetylcysteine treatment and supportive care including hydration... - Poison centers as information resources for volunteer EMS in a suspected chemical exposureChristian Martin Gill
Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Emerg Med 32:397-403. 2007..4% and 26.7%, respectively). Poison centers are viewed as an important information resource by EMS providers and may be the most commonly sought resource for various information needs during a suspected chemical exposure... - Accuracy of internet recommendations for prehospital care of venomous snake bitesSarah Barker
Department of Emergency Medicine, University of Virginia, Charlottesville, VA, USA
Wilderness Environ Med 21:298-302. 2010..To evaluate the accuracy of Internet information regarding the prehospital care of venomous snake bites... - Food poisoningDavid T Lawrence
Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
Emerg Med Clin North Am 25:357-73; abstract ix. 2007..This article reviews several potential food-borne poisons and describes each agent's mechanism of toxicity, expected clinical presentation, and currently accepted treatment... 
Management of the critically poisoned patientJennifer S Boyle
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Scand J Trauma Resusc Emerg Med 17:29. 2009..The goal of this article is to introduce the basic concepts for evaluation of poisoned patients and review the appropriate management of such patients based on the currently available literature...- Images in emergency medicine. Skin damage following application of suction device for snakebiteChristopher P Holstege
Department of Emergency Medicine, Division of Medical Toxicology, University of Virginia, Charlottesville, VA, USA
Ann Emerg Med 48:105, 113. 2006 - EnvenomationsEunice M Singletary
Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908-0774, USA
Med Clin North Am 89:1195-224. 2005..Clinicians should be familiar with the animals in their region that may lead to envenomation.A rational approach with use of poison center or medical toxicology consultation services ensures that cases are managed appropriately... - Injury and illness encountered in Shenandoah National ParkJoseph D Forrester
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA, USA
Wilderness Environ Med 20:318-26. 2009..The purpose of this study was to determine the incidence of such illnesses and injuries to visitors in Shenandoah National Park... - Intraventricular conduction abnormality--an electrocardiographic algorithm for rapid detection and diagnosisDaniel Garcia
Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908, USA
Am J Emerg Med 27:492-502. 2009..After a review of these IVCDs, a simplified algorithm that will aid in the electrocardiographic diagnosis of these conduction abnormalities is presented... - Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathwayLaura K Bechtel
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA, USA
Acad Emerg Med 15:368-74. 2008..One molecular signaling pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, that contributes to CCB toxicity and the efficacy of HDIT, was examined for a role in this phenomenon... - Hyperthermia and multiorgan failure after abuse of "bath salts" containing 3,4-methylenedioxypyrovaleroneHeather A Borek
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
Ann Emerg Med 60:103-5. 2012..Acute management should focus on the rapid identification of organ injury and appropriate supportive care... - Hepatotoxicity associated with herbal productsR Brent Furbee
Indiana Poison Center, Department of Emergency Medicine, Indiana University School of Medicine, Room AG373, 1701 North Senate Boulevard, Indianapolis, IN 46206, USA
Clin Lab Med 26:227-41, x. 2006..The most important clue often is the temporal relationship between initiation of the herbal product and the appearance of liver injury; of equal importance is the resolution of the injury following withdrawal of the herbal product... - Criminal poisoning: drug-facilitated sexual assaultLaura K Bechtel
Blue Ridge Poison Center, University of Virginia Health System, Charlottesville, VA 22908 0774, USA
Emerg Med Clin North Am 25:499-525; abstract x. 2007..It is imperative for emergency personnel to clearly document the history and the presenting signs and symptoms to assist laboratory personnel to hone in and detect the correct agent used in a DFSA...